ES267126A1 - Improvements in or relating to the production of compounds of the vitamin a series - Google Patents

Improvements in or relating to the production of compounds of the vitamin a series

Info

Publication number
ES267126A1
ES267126A1 ES0267126A ES267126A ES267126A1 ES 267126 A1 ES267126 A1 ES 267126A1 ES 0267126 A ES0267126 A ES 0267126A ES 267126 A ES267126 A ES 267126A ES 267126 A1 ES267126 A1 ES 267126A1
Authority
ES
Spain
Prior art keywords
vitamin
acid
series
imine
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0267126A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Philips Gloeilampenfabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philips Gloeilampenfabrieken NV filed Critical Philips Gloeilampenfabrieken NV
Publication of ES267126A1 publication Critical patent/ES267126A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/30—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Cyano compounds of the vitamin A series or compounds having vitamin A activity obtained therefrom by conversion are obtained by subjecting an imine of the Vitamin A series to condensation with cyanoacetic acid or with an ester or an amide of said acid. The imine may have the general formula <FORM:0975361/C1/1> in which n is 0 or 1 and R is hydrogen, or an alkyl, phenyl or aralkyl group. The imine may be reacted with the cyanoacetic acid in an ether or an aliphatic, alicyclic, aliphatic-dicyclic or aromatic hydrocarbon at a temperature between -20 DEG C. and 60 DEG C. The resulting nitrile carboxylic acid may be heated by itself or in a solution in toluene, pyridine, collidine, triethyl amine or dimethyl aniline in the presence of a cupric salt to obtain the nitrile in a particularly pure form. In examples, b -ionylidene acetonitrile, a -cyano vitamin A acid, citrylidene-cyanoacetic acid, 4-b -ionylidene -2- nitrile-prop -2- ene carboxylic acid and retinylidene cyano acetic acid are prepared.
ES0267126A 1960-05-06 1961-05-04 Improvements in or relating to the production of compounds of the vitamin a series Expired ES267126A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL251315 1960-05-06

Publications (1)

Publication Number Publication Date
ES267126A1 true ES267126A1 (en) 1961-11-01

Family

ID=19752317

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0267126A Expired ES267126A1 (en) 1960-05-06 1961-05-04 Improvements in or relating to the production of compounds of the vitamin a series

Country Status (4)

Country Link
CH (1) CH452501A (en)
DK (1) DK114130B (en)
ES (1) ES267126A1 (en)
GB (1) GB975361A (en)

Also Published As

Publication number Publication date
GB975361A (en) 1964-11-18
CH452501A (en) 1968-03-15
DK114130B (en) 1969-06-02

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