ES2665910T3 - Biomarcadores relacionados con nefropatía diabética - Google Patents

Biomarcadores relacionados con nefropatía diabética Download PDF

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Publication number
ES2665910T3
ES2665910T3 ES16194985.4T ES16194985T ES2665910T3 ES 2665910 T3 ES2665910 T3 ES 2665910T3 ES 16194985 T ES16194985 T ES 16194985T ES 2665910 T3 ES2665910 T3 ES 2665910T3
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ES
Spain
Prior art keywords
diabetes
biomarker
patient
biomarkers
prediabetes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES16194985.4T
Other languages
English (en)
Spanish (es)
Inventor
Thomas Stoll
Scott Bringans
Kaye Winfield
Tammy Casey
Wendy Davis
Timothy Davis
Kirsten Peters
Richard Lipscombe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Western Australia
Proteomics International Pty Ltd
Original Assignee
University of Western Australia
Proteomics International Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2010904249A external-priority patent/AU2010904249A0/en
Application filed by University of Western Australia, Proteomics International Pty Ltd filed Critical University of Western Australia
Application granted granted Critical
Publication of ES2665910T3 publication Critical patent/ES2665910T3/es
Active legal-status Critical Current
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/775—Apolipopeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90212—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/908—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
ES16194985.4T 2010-09-21 2011-09-20 Biomarcadores relacionados con nefropatía diabética Active ES2665910T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2010904249 2010-09-21
AU2010904249A AU2010904249A0 (en) 2010-09-21 Biomarkers associated with pre-diabetes,diabetes and diabetes related conditions

Publications (1)

Publication Number Publication Date
ES2665910T3 true ES2665910T3 (es) 2018-04-30

Family

ID=45873304

Family Applications (2)

Application Number Title Priority Date Filing Date
ES18155797T Active ES2928585T3 (es) 2010-09-21 2011-09-20 Biomarcadores asociados con prediabetes, diabetes y condiciones relacionadas con diabetes
ES16194985.4T Active ES2665910T3 (es) 2010-09-21 2011-09-20 Biomarcadores relacionados con nefropatía diabética

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES18155797T Active ES2928585T3 (es) 2010-09-21 2011-09-20 Biomarcadores asociados con prediabetes, diabetes y condiciones relacionadas con diabetes

Country Status (11)

Country Link
US (5) US20130177544A1 (enExample)
EP (3) EP3151012B1 (enExample)
JP (2) JP6271250B2 (enExample)
CN (2) CN105974123A (enExample)
AU (2) AU2011305050B2 (enExample)
BR (1) BR112013006764B1 (enExample)
CA (1) CA2811654C (enExample)
ES (2) ES2928585T3 (enExample)
RU (1) RU2596486C2 (enExample)
SG (1) SG188527A1 (enExample)
WO (1) WO2012037603A1 (enExample)

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US9928345B2 (en) 2012-06-08 2018-03-27 Liposciences, Inc. Multiple-marker risk parameters predictive of conversion to diabetes
JP6062439B2 (ja) * 2012-08-30 2017-01-18 シスメックス株式会社 早期腎障害の評価マーカーとその測定方法
HK1216765A1 (zh) 2013-03-14 2016-12-02 奥特拉西斯公司 使用所测分析物改进疾病诊断的方法
CN103473569A (zh) * 2013-09-22 2013-12-25 江苏美伦影像系统有限公司 基于svm的医学影像分类方法
JP5925391B2 (ja) * 2013-10-16 2016-05-25 日本水産株式会社 ペプチド又はその酸付加塩、飲食品、及び糖尿病予防等の組成物
AU2015240454B2 (en) 2014-04-04 2019-08-22 Mayo Foundation For Medical Education And Research Isotyping immunoglobulins using accurate molecular mass
WO2017053932A1 (en) 2015-09-24 2017-03-30 Mayo Foundation For Medical Education And Research Identification of immunoglobulin free light chains by mass spectrometry
RU2018127709A (ru) 2016-01-22 2020-02-25 Отрэйсис, Инк. Системы и способы улучшения диагностики заболеваний
WO2018049001A1 (en) 2016-09-07 2018-03-15 Mayo Foundation For Medical Education And Research Identification and monitoring of cleaved immunoglobulins by molecular mass
EP3540439B1 (en) * 2016-11-11 2024-04-24 Tohoku University Method for assessing sugar uptake ability of liver
PL3358355T3 (pl) * 2017-02-04 2024-04-08 Warszawski Uniwersytet Medyczny Zastosowanie surowiczych peroksyredoksyn dwucysteinowych (2-Cys-PRDX) jako biomarkerów przewlekłej choroby nerek (PChN, ang. CKD) takiej jak toczniowe zapalenie nerek (LN), nefropatia IgA (IgAN) i autosomalna dominująca wielotorbielowatość nerek (ADPKD) użytecznych do diagnozowania tych chorób i sposoby różnicowania tych chorób
CN106645757B (zh) * 2017-03-13 2019-01-15 新疆医科大学 一种诊断早发糖尿病mody的血清蛋白标志物组及其应用
US10983108B2 (en) * 2017-03-31 2021-04-20 Quest Diagnostics Investments Llc Methods for quantitation of insulin and C-peptide
CN107144620A (zh) * 2017-03-31 2017-09-08 兰州百源基因技术有限公司 糖尿病肾病检测标志物
CN108732253A (zh) * 2017-04-14 2018-11-02 杭州量康科技有限公司 用于血清蛋白质定量测定的肽段组合物及测定方法
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EP3681528B1 (en) 2017-09-13 2025-07-23 Mayo Foundation for Medical Education and Research Identification and monitoring of apoptosis inhibitor of macrophage
RU2687256C1 (ru) * 2018-03-26 2019-05-08 Федеральное Государственное бюджетное образовательное учреждение высшего образования Дагестанский государственный медицинский университет Министерства здравоохранения Российской Федерации Даггосмедуниверситет Способ персонализированного лечения хронической болезни почек у больных с диабетической нефропатией
TWI822802B (zh) * 2018-06-21 2023-11-21 中國醫藥大學 腎病變蛋白生物標記及其應用
CN112888793A (zh) 2018-08-08 2021-06-01 里珍纳龙药品有限公司 使用lc-ms/ms对蛋白质生物标志物进行定量
CN110286234B (zh) * 2019-07-02 2023-03-24 安肽和(杭州)医疗科技有限公司 尿液中妊娠糖尿病的蛋白质标志物及其在早期诊断中的用途
CN115023615A (zh) * 2020-01-10 2022-09-06 私募蛋白质体操作有限公司 确定葡萄糖耐量减低的方法
CN111876479A (zh) * 2020-06-29 2020-11-03 中国人民解放军总医院 基于尿沉渣特定微小rna无创鉴别诊断糖尿病肾病/非糖尿病性肾病方面的应用
CN117310148A (zh) * 2023-09-11 2023-12-29 杭州珞米医疗科技有限公司 一种蛋白标志物作为生物标志物的用途
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CN121075656A (zh) * 2025-10-31 2025-12-05 中南大学 糖尿病的风险检测方法、装置、计算机设备和介质

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Also Published As

Publication number Publication date
HK1256827A1 (en) 2019-10-04
CN103299192B (zh) 2016-05-11
JP2013541706A (ja) 2013-11-14
AU2015202230B2 (en) 2017-08-03
BR112013006764A2 (pt) 2016-06-28
CN103299192A (zh) 2013-09-11
US20190107546A1 (en) 2019-04-11
EP3343226B1 (en) 2022-07-27
SG188527A1 (en) 2013-04-30
EP2619592A4 (en) 2014-05-07
ES2928585T3 (es) 2022-11-21
RU2013113927A (ru) 2014-10-27
US20140249049A1 (en) 2014-09-04
US9146243B2 (en) 2015-09-29
EP2619592A1 (en) 2013-07-31
RU2596486C2 (ru) 2016-09-10
BR112013006764B1 (pt) 2020-11-03
CA2811654A1 (en) 2012-03-29
JP2017223682A (ja) 2017-12-21
US20170299613A1 (en) 2017-10-19
CA2811654C (en) 2020-06-30
US10191067B2 (en) 2019-01-29
US9733259B2 (en) 2017-08-15
AU2011305050A1 (en) 2013-03-28
CN105974123A (zh) 2016-09-28
AU2015202230A1 (en) 2015-05-21
EP3151012A1 (en) 2017-04-05
US20130177544A1 (en) 2013-07-11
US20150355198A1 (en) 2015-12-10
WO2012037603A1 (en) 2012-03-29
JP6271250B2 (ja) 2018-01-31
AU2011305050B2 (en) 2015-05-21
EP3151012B1 (en) 2018-03-21
EP3343226A1 (en) 2018-07-04

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