ES2660822T3 - Inhibidores de beta-hidrolasa para tratamiento del cáncer - Google Patents

Info

Publication number

ES2660822T3

ES2660822T3 ES13838498.7T ES13838498T ES2660822T3 ES 2660822 T3 ES2660822 T3 ES 2660822T3 ES 13838498 T ES13838498 T ES 13838498T ES 2660822 T3 ES2660822 T3 ES 2660822T3

Authority

ES

Spain

Prior art keywords

amino

furanone

oxy

methyl

chlorophenyl

Prior art date

2012-09-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 238000011282 treatment Methods 0.000 title claims abstract description 31
• 206010028980 Neoplasm Diseases 0.000 title claims description 77
• 201000011510 cancer Diseases 0.000 title description 29
• 239000004093 hydrolase inhibitor Substances 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims abstract description 251
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 129
• 210000004027 cell Anatomy 0.000 claims abstract description 104
• 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 92
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims abstract description 72
• 125000003118 aryl group Chemical group 0.000 claims abstract description 68
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims abstract description 60
• 125000003710 aryl alkyl group Chemical group 0.000 claims abstract description 54
• 239000003112 inhibitor Substances 0.000 claims abstract description 46
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims abstract description 44
• 150000003839 salts Chemical class 0.000 claims abstract description 42
• 238000000034 method Methods 0.000 claims abstract description 39
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 38
• 239000012453 solvate Substances 0.000 claims abstract description 38
• 150000002148 esters Chemical class 0.000 claims abstract description 33
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 32
• 210000004881 tumor cell Anatomy 0.000 claims abstract description 22
• 239000001257 hydrogen Substances 0.000 claims abstract description 19
• 230000002062 proliferating effect Effects 0.000 claims abstract description 16
• 238000013508 migration Methods 0.000 claims abstract description 15
• 206010027476 Metastases Diseases 0.000 claims abstract description 14
• 230000009545 invasion Effects 0.000 claims abstract description 14
• 230000005012 migration Effects 0.000 claims abstract description 13
• 230000009401 metastasis Effects 0.000 claims abstract description 12
• 125000006736 (C6-C20) aryl group Chemical group 0.000 claims abstract description 10
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 9
• 230000035755 proliferation Effects 0.000 claims abstract description 9
• 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims abstract description 6
• -1 2-thiazolyl Chemical group 0.000 claims description 598
• 125000001424 substituent group Chemical group 0.000 claims description 78
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 72
• 125000000217 alkyl group Chemical group 0.000 claims description 49
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 49
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 49
• 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 46
• 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 42
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 41
• 229910003827 NRaRb Inorganic materials 0.000 claims description 41
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 37
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 34
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 25
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 24
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 23
• 201000002528 pancreatic cancer Diseases 0.000 claims description 23
• 208000008443 pancreatic carcinoma Diseases 0.000 claims description 23
• 125000001624 naphthyl group Chemical group 0.000 claims description 19
• 125000006708 (C5-C14) heteroaryl group Chemical group 0.000 claims description 14
• 125000005915 C6-C14 aryl group Chemical group 0.000 claims description 14
• 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims description 13
• 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims description 12
• 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 12
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 12
• 239000008194 pharmaceutical composition Substances 0.000 claims description 12
• 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims description 11
• 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims description 11
• 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 11
• 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims description 11
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 11
• 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims description 11
• 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims description 11
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 11
• 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims description 11
• 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 11
• SZPWXAOBLNYOHY-UHFFFAOYSA-N [C]1=CC=NC2=CC=CC=C12 Chemical group [C]1=CC=NC2=CC=CC=C12 SZPWXAOBLNYOHY-UHFFFAOYSA-N 0.000 claims description 11
• 125000001617 2,3-dimethoxy phenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] 0.000 claims description 10
• 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims description 10
• 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims description 10
• 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims description 10
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 10
• 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 10
• 125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 claims description 10
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 10
• ZCRZCMUDOWDGOB-UHFFFAOYSA-N ethanesulfonimidic acid Chemical compound CCS(N)(=O)=O ZCRZCMUDOWDGOB-UHFFFAOYSA-N 0.000 claims description 10
• 229960002317 succinimide Drugs 0.000 claims description 10
• 239000003937 drug carrier Substances 0.000 claims description 8
• KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims description 7
• 206010009944 Colon cancer Diseases 0.000 claims description 7
• 230000037396 body weight Effects 0.000 claims description 7
• 208000006990 cholangiocarcinoma Diseases 0.000 claims description 7
• 208000029742 colonic neoplasm Diseases 0.000 claims description 7
• 208000005017 glioblastoma Diseases 0.000 claims description 7
• 208000014018 liver neoplasm Diseases 0.000 claims description 7
• HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims description 7
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
• 125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims description 6
• 206010006187 Breast cancer Diseases 0.000 claims description 6
• 208000026310 Breast neoplasm Diseases 0.000 claims description 6
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 6
• 206010060862 Prostate cancer Diseases 0.000 claims description 6
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 6
• YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 6
• WRYVLBKLGDJEPA-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 WRYVLBKLGDJEPA-UHFFFAOYSA-N 0.000 claims description 6
• 201000005202 lung cancer Diseases 0.000 claims description 6
• 208000020816 lung neoplasm Diseases 0.000 claims description 6
• HJEJFKVSAXODHG-UHFFFAOYSA-N n-[5-(4-chlorophenyl)-3,4-dihydroxyfuran-2-yl]methanesulfonamide Chemical compound OC1=C(NS(=O)(=O)C)OC(C=2C=CC(Cl)=CC=2)=C1O HJEJFKVSAXODHG-UHFFFAOYSA-N 0.000 claims description 5
• NAXKDCHVHXHQRK-UHFFFAOYSA-N 1-[5-(4-chlorophenyl)-3,4-dihydroxyfuran-2-yl]pyrrolidin-2-one Chemical compound OC=1C(O)=C(C=2C=CC(Cl)=CC=2)OC=1N1CCCC1=O NAXKDCHVHXHQRK-UHFFFAOYSA-N 0.000 claims description 4
• UVBJSQGBODUPEH-UHFFFAOYSA-N 2-[3-(5-amino-4-benzylsulfonyloxy-3-oxofuran-2-yl)phenyl]acetic acid Chemical compound NC1=C(OS(=O)(=O)Cc2ccccc2)C(=O)C(O1)c1cccc(CC(O)=O)c1 UVBJSQGBODUPEH-UHFFFAOYSA-N 0.000 claims description 4
• LUMHNZAEHOKQLV-UHFFFAOYSA-N 5-amino-2-(4-chlorophenyl)-2-methyl-4-trimethylsilyloxyfuran-3-one Chemical compound C=1C=C(Cl)C=CC=1C1(C)OC(N)=C(O[Si](C)(C)C)C1=O LUMHNZAEHOKQLV-UHFFFAOYSA-N 0.000 claims description 4
• VRDRWMHTNNYGDU-UHFFFAOYSA-N 5-amino-2-(4-chlorophenyl)-4-hydroxy-2-methylfuran-3-one Chemical compound C=1C=C(Cl)C=CC=1C1(C)OC(N)=C(O)C1=O VRDRWMHTNNYGDU-UHFFFAOYSA-N 0.000 claims description 4
• XWHLBEUFQUKZHR-UHFFFAOYSA-N [2-(4-bromobutanoylamino)-5-(4-chlorophenyl)-4-hydroxyfuran-3-yl] acetate Chemical compound O1C(NC(=O)CCCBr)=C(OC(=O)C)C(O)=C1C1=CC=C(Cl)C=C1 XWHLBEUFQUKZHR-UHFFFAOYSA-N 0.000 claims description 4
• OWVQJWLKTXHRKW-UHFFFAOYSA-N [2-(benzenesulfonamido)-5-(4-chlorophenyl)-4-hydroxyfuran-3-yl] acetate Chemical compound CC(=O)OC=1C(O)=C(C=2C=CC(Cl)=CC=2)OC=1NS(=O)(=O)C1=CC=CC=C1 OWVQJWLKTXHRKW-UHFFFAOYSA-N 0.000 claims description 4
• YOJILVOCMQSCAB-UHFFFAOYSA-N [2-acetamido-5-(4-chlorophenyl)-4-hydroxyfuran-3-yl] acetate Chemical compound CC(=O)OC1=C(NC(=O)C)OC(C=2C=CC(Cl)=CC=2)=C1O YOJILVOCMQSCAB-UHFFFAOYSA-N 0.000 claims description 4
• JSENTRJIUXBCNY-UHFFFAOYSA-N [2-amino-4-oxo-5-[4-(trifluoromethyl)phenyl]furan-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C=CC(=CC=2)C(F)(F)F)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 JSENTRJIUXBCNY-UHFFFAOYSA-N 0.000 claims description 4
• RKSVAVTXWOUTKP-UHFFFAOYSA-N [2-amino-5-(2,3-dichlorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C(=C(Cl)C=CC=2)Cl)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 RKSVAVTXWOUTKP-UHFFFAOYSA-N 0.000 claims description 4
• FSAGXOYHOPYBLM-UHFFFAOYSA-N [2-amino-5-(2,4-dichlorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C(=CC(Cl)=CC=2)Cl)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 FSAGXOYHOPYBLM-UHFFFAOYSA-N 0.000 claims description 4
• NRSDXXYHJSXZIM-UHFFFAOYSA-N [2-amino-5-(2,5-dichlorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C(=CC=C(Cl)C=2)Cl)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 NRSDXXYHJSXZIM-UHFFFAOYSA-N 0.000 claims description 4
• ZINZHCFHUQQGOC-UHFFFAOYSA-N [2-amino-5-(2,5-difluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C(=CC=C(F)C=2)F)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 ZINZHCFHUQQGOC-UHFFFAOYSA-N 0.000 claims description 4
• UXLGTLOXBAKPJN-UHFFFAOYSA-N [2-amino-5-(2,6-difluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C(=CC=CC=2F)F)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 UXLGTLOXBAKPJN-UHFFFAOYSA-N 0.000 claims description 4
• FOGWFWDJRVMWKA-UHFFFAOYSA-N [2-amino-5-(2-chlorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C(=CC=CC=2)Cl)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 FOGWFWDJRVMWKA-UHFFFAOYSA-N 0.000 claims description 4
• RMXWGKXYBJIXBE-UHFFFAOYSA-N [2-amino-5-(2-fluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C(=CC=CC=2)F)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 RMXWGKXYBJIXBE-UHFFFAOYSA-N 0.000 claims description 4
• XITRFEDNNGVURT-UHFFFAOYSA-N [2-amino-5-(3,4-dichlorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C=C(Cl)C(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 XITRFEDNNGVURT-UHFFFAOYSA-N 0.000 claims description 4
• QRSZCGYMHKMZOG-UHFFFAOYSA-N [2-amino-5-(3,4-difluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C=C(F)C(F)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 QRSZCGYMHKMZOG-UHFFFAOYSA-N 0.000 claims description 4
• TYLBFGJWPMBOSE-UHFFFAOYSA-N [2-amino-5-(3,5-dichlorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C=C(Cl)C=C(Cl)C=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 TYLBFGJWPMBOSE-UHFFFAOYSA-N 0.000 claims description 4
• GCYOEKPCUFCJOL-UHFFFAOYSA-N [2-amino-5-(3,5-difluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C=C(F)C=C(F)C=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 GCYOEKPCUFCJOL-UHFFFAOYSA-N 0.000 claims description 4
• SDGJJRNVCOGVAG-UHFFFAOYSA-N [2-amino-5-(3-chlorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C=C(Cl)C=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 SDGJJRNVCOGVAG-UHFFFAOYSA-N 0.000 claims description 4
• NHVBIMUJMMJGDO-UHFFFAOYSA-N [2-amino-5-(3-fluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C=C(F)C=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 NHVBIMUJMMJGDO-UHFFFAOYSA-N 0.000 claims description 4
• UKZKOHRWARZTOS-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] (4-fluorophenyl)methanesulfonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=C(F)C=C1 UKZKOHRWARZTOS-UHFFFAOYSA-N 0.000 claims description 4
• XXJFDCICKAWHSZ-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] butane-1-sulfonate Chemical compound O=C1C(OS(=O)(=O)CCCC)=C(N)OC1C1=CC=C(Cl)C=C1 XXJFDCICKAWHSZ-UHFFFAOYSA-N 0.000 claims description 4
• VCNOSHCOKRGAFH-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] ethanesulfonate Chemical compound O=C1C(OS(=O)(=O)CC)=C(N)OC1C1=CC=C(Cl)C=C1 VCNOSHCOKRGAFH-UHFFFAOYSA-N 0.000 claims description 4
• AFTCLAGEFNWDOX-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] methanesulfonate Chemical compound O=C1C(OS(=O)(=O)C)=C(N)OC1C1=CC=C(Cl)C=C1 AFTCLAGEFNWDOX-UHFFFAOYSA-N 0.000 claims description 4
• OWVBFOSPAPHJPY-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] propane-1-sulfonate Chemical compound O=C1C(OS(=O)(=O)CCC)=C(N)OC1C1=CC=C(Cl)C=C1 OWVBFOSPAPHJPY-UHFFFAOYSA-N 0.000 claims description 4
• SYCCMZVSTUCIHF-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] propane-2-sulfonate Chemical compound O=C1C(OS(=O)(=O)C(C)C)=C(N)OC1C1=CC=C(Cl)C=C1 SYCCMZVSTUCIHF-UHFFFAOYSA-N 0.000 claims description 4
• SLYSOBIJVWDZBX-UHFFFAOYSA-N [2-amino-5-(4-fluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C=CC(F)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 SLYSOBIJVWDZBX-UHFFFAOYSA-N 0.000 claims description 4
• WFNHVZXNKPPPBO-UHFFFAOYSA-N [2-benzamido-5-(4-chlorophenyl)-4-hydroxyfuran-3-yl] acetate Chemical compound CC(=O)OC=1C(O)=C(C=2C=CC(Cl)=CC=2)OC=1NC(=O)C1=CC=CC=C1 WFNHVZXNKPPPBO-UHFFFAOYSA-N 0.000 claims description 4
• YGGYXRLVTAYOMN-UHFFFAOYSA-N [3-acetyloxy-5-(4-chlorophenyl)-4-hydroxyfuran-2-yl]carbamic acid Chemical compound C(C)(=O)OC1=C(OC(=C1O)C1=CC=C(C=C1)Cl)NC(O)=O YGGYXRLVTAYOMN-UHFFFAOYSA-N 0.000 claims description 4
• KSEDCPKLLWHSHW-UHFFFAOYSA-N [5-(4-chlorophenyl)-2-(2,5-dioxopyrrolidin-1-yl)-4-hydroxyfuran-3-yl] acetate Chemical compound CC(=O)OC=1C(O)=C(C=2C=CC(Cl)=CC=2)OC=1N1C(=O)CCC1=O KSEDCPKLLWHSHW-UHFFFAOYSA-N 0.000 claims description 4
• OGHXRSPEMPMFOE-UHFFFAOYSA-N [5-(4-chlorophenyl)-2-(ethylsulfonylamino)-4-hydroxyfuran-3-yl] acetate Chemical compound CC(=O)OC1=C(NS(=O)(=O)CC)OC(C=2C=CC(Cl)=CC=2)=C1O OGHXRSPEMPMFOE-UHFFFAOYSA-N 0.000 claims description 4
• VDQHKMUPBQTWTQ-UHFFFAOYSA-N [5-(4-chlorophenyl)-4-hydroxy-2-(2-oxopyrrolidin-1-yl)furan-3-yl] acetate Chemical compound CC(=O)OC=1C(O)=C(C=2C=CC(Cl)=CC=2)OC=1N1CCCC1=O VDQHKMUPBQTWTQ-UHFFFAOYSA-N 0.000 claims description 4
• FVIJYPJRMDJNGO-UHFFFAOYSA-N [5-(4-chlorophenyl)-4-hydroxy-2-(methanesulfonamido)furan-3-yl] acetate Chemical compound O1C(NS(C)(=O)=O)=C(OC(=O)C)C(O)=C1C1=CC=C(Cl)C=C1 FVIJYPJRMDJNGO-UHFFFAOYSA-N 0.000 claims description 4
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
• DJGXIYUUEOOIOJ-UHFFFAOYSA-N n-[5-(4-chlorophenyl)-3,4-dihydroxyfuran-2-yl]acetamide Chemical compound OC1=C(NC(=O)C)OC(C=2C=CC(Cl)=CC=2)=C1O DJGXIYUUEOOIOJ-UHFFFAOYSA-N 0.000 claims description 4
• DPLHXRNPGUNHRQ-UHFFFAOYSA-N n-[5-(4-chlorophenyl)-3,4-dihydroxyfuran-2-yl]benzamide Chemical compound OC=1C(O)=C(C=2C=CC(Cl)=CC=2)OC=1NC(=O)C1=CC=CC=C1 DPLHXRNPGUNHRQ-UHFFFAOYSA-N 0.000 claims description 4
• XMIREYMMILAEME-UHFFFAOYSA-N n-[5-(4-chlorophenyl)-3,4-dihydroxyfuran-2-yl]benzenesulfonamide Chemical compound OC=1C(O)=C(C=2C=CC(Cl)=CC=2)OC=1NS(=O)(=O)C1=CC=CC=C1 XMIREYMMILAEME-UHFFFAOYSA-N 0.000 claims description 4
• WWHUSZQHRUNRSB-UHFFFAOYSA-N n-[5-(4-chlorophenyl)-3,4-dihydroxyfuran-2-yl]ethanesulfonamide Chemical compound OC1=C(NS(=O)(=O)CC)OC(C=2C=CC(Cl)=CC=2)=C1O WWHUSZQHRUNRSB-UHFFFAOYSA-N 0.000 claims description 4
• VRGPSZZFSFLPEF-UHFFFAOYSA-N o-[2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] n-phenylcarbamothioate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OC(=S)NC1=CC=CC=C1 VRGPSZZFSFLPEF-UHFFFAOYSA-N 0.000 claims description 4
• KZMXJOUETCOJAX-UHFFFAOYSA-N 1-[5-(4-chlorophenyl)-3,4-dihydroxyfuran-2-yl]pyrrolidine-2,5-dione Chemical compound OC=1C(O)=C(C=2C=CC(Cl)=CC=2)OC=1N1C(=O)CCC1=O KZMXJOUETCOJAX-UHFFFAOYSA-N 0.000 claims description 3
• JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims description 3
• TYAYBWQIEWVCKO-UHFFFAOYSA-N [2-(3-bromopropylsulfonylamino)-5-(4-chlorophenyl)-4-hydroxyfuran-3-yl] acetate Chemical compound O1C(NS(=O)(=O)CCCBr)=C(OC(=O)C)C(O)=C1C1=CC=C(Cl)C=C1 TYAYBWQIEWVCKO-UHFFFAOYSA-N 0.000 claims description 3
• UEIXZUNCVZXURR-UHFFFAOYSA-N [2-amino-5-(2,3-difluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C(=C(F)C=CC=2)F)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 UEIXZUNCVZXURR-UHFFFAOYSA-N 0.000 claims description 3
• UZMVSVRIMLYTFC-UHFFFAOYSA-N [2-amino-5-(2,3-dimethoxyphenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound COC1=CC=CC(C2C(C(OS(=O)(=O)CC=3C=CC=CC=3)=C(N)O2)=O)=C1OC UZMVSVRIMLYTFC-UHFFFAOYSA-N 0.000 claims description 3
• MRANPYZDQRPVMQ-UHFFFAOYSA-N [2-amino-5-(2,4-difluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C(=CC(F)=CC=2)F)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 MRANPYZDQRPVMQ-UHFFFAOYSA-N 0.000 claims description 3
• UTLRIETUSATVLU-UHFFFAOYSA-N [2-amino-5-(2,4-dimethoxyphenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound COC1=CC(OC)=CC=C1C1C(=O)C(OS(=O)(=O)CC=2C=CC=CC=2)=C(N)O1 UTLRIETUSATVLU-UHFFFAOYSA-N 0.000 claims description 3
• ABEXEQNVKLVRTN-UHFFFAOYSA-N [2-amino-5-(2,5-dimethoxyphenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound COC1=CC=C(OC)C(C2C(C(OS(=O)(=O)CC=3C=CC=CC=3)=C(N)O2)=O)=C1 ABEXEQNVKLVRTN-UHFFFAOYSA-N 0.000 claims description 3
• NWAYGVMPOGETRW-UHFFFAOYSA-N [2-amino-5-(2,6-dimethoxyphenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound COC1=CC=CC(OC)=C1C1C(=O)C(OS(=O)(=O)CC=2C=CC=CC=2)=C(N)O1 NWAYGVMPOGETRW-UHFFFAOYSA-N 0.000 claims description 3
• LBPGBBOUMNREPT-UHFFFAOYSA-N [2-amino-5-(2-chloro-4-fluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C(=CC(F)=CC=2)Cl)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 LBPGBBOUMNREPT-UHFFFAOYSA-N 0.000 claims description 3
• KFIICSGBLRSJPA-UHFFFAOYSA-N [2-amino-5-(2-chloro-5-fluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C(=CC=C(F)C=2)Cl)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 KFIICSGBLRSJPA-UHFFFAOYSA-N 0.000 claims description 3
• MDJJAEKJZSERFA-UHFFFAOYSA-N [2-amino-5-(2-chloro-6-fluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C(=CC=CC=2F)Cl)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 MDJJAEKJZSERFA-UHFFFAOYSA-N 0.000 claims description 3
• YXFYSGOXEMVSMD-UHFFFAOYSA-N [2-amino-5-(2-methoxyphenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound COC1=CC=CC=C1C1C(=O)C(OS(=O)(=O)CC=2C=CC=CC=2)=C(N)O1 YXFYSGOXEMVSMD-UHFFFAOYSA-N 0.000 claims description 3
• ORZDSIAWTHZDNR-UHFFFAOYSA-N [2-amino-5-(3,4-dimethoxyphenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound C1=C(OC)C(OC)=CC=C1C1C(=O)C(OS(=O)(=O)CC=2C=CC=CC=2)=C(N)O1 ORZDSIAWTHZDNR-UHFFFAOYSA-N 0.000 claims description 3
• NNENVKFNMNCPJU-UHFFFAOYSA-N [2-amino-5-(3,5-dimethoxyphenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound COC1=CC(OC)=CC(C2C(C(OS(=O)(=O)CC=3C=CC=CC=3)=C(N)O2)=O)=C1 NNENVKFNMNCPJU-UHFFFAOYSA-N 0.000 claims description 3
• PBYZWRBKXRHUSG-UHFFFAOYSA-N [2-amino-5-(3-chloro-2-fluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C(=C(Cl)C=CC=2)F)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 PBYZWRBKXRHUSG-UHFFFAOYSA-N 0.000 claims description 3
• VLJVMMHJHOBTIG-UHFFFAOYSA-N [2-amino-5-(3-chloro-4-fluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C=C(Cl)C(F)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 VLJVMMHJHOBTIG-UHFFFAOYSA-N 0.000 claims description 3
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• UHJBGKUXTPVWDM-UHFFFAOYSA-N [2-amino-5-(4-chloro-3-fluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C=C(F)C(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 UHJBGKUXTPVWDM-UHFFFAOYSA-N 0.000 claims description 3
• UYXCYZNQEZHASZ-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] (2,3-difluorophenyl)methanesulfonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC(F)=C1F UYXCYZNQEZHASZ-UHFFFAOYSA-N 0.000 claims description 3
• HVOUTIYPOJWWID-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] (2,4-difluorophenyl)methanesulfonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=C(F)C=C1F HVOUTIYPOJWWID-UHFFFAOYSA-N 0.000 claims description 3
• MIKDTVFNXYIVLQ-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] (2,5-difluorophenyl)methanesulfonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC(F)=CC=C1F MIKDTVFNXYIVLQ-UHFFFAOYSA-N 0.000 claims description 3
• LFKMWBLRJXWLQC-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] (2,6-difluorophenyl)methanesulfonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=C(F)C=CC=C1F LFKMWBLRJXWLQC-UHFFFAOYSA-N 0.000 claims description 3
• XMOFJKYRTMNLTH-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] (2-chlorophenyl)methanesulfonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1Cl XMOFJKYRTMNLTH-UHFFFAOYSA-N 0.000 claims description 3
• PQRFUHXGSWNJJY-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] (2-fluorophenyl)methanesulfonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1F PQRFUHXGSWNJJY-UHFFFAOYSA-N 0.000 claims description 3
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• GEEZEAFSZZXKSG-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] (3,5-difluorophenyl)methanesulfonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC(F)=CC(F)=C1 GEEZEAFSZZXKSG-UHFFFAOYSA-N 0.000 claims description 3
• XEBLZDZCMRFRQZ-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] (3-chlorophenyl)methanesulfonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC(Cl)=C1 XEBLZDZCMRFRQZ-UHFFFAOYSA-N 0.000 claims description 3
• PVNMDJFPQFAMPP-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] (3-fluorophenyl)methanesulfonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC(F)=C1 PVNMDJFPQFAMPP-UHFFFAOYSA-N 0.000 claims description 3
• SJGZPIFYDMIPFP-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] (4-chlorophenyl)methanesulfonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=C(Cl)C=C1 SJGZPIFYDMIPFP-UHFFFAOYSA-N 0.000 claims description 3
• PHDONEHIUVSMSZ-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] [2-(trifluoromethyl)phenyl]methanesulfonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1C(F)(F)F PHDONEHIUVSMSZ-UHFFFAOYSA-N 0.000 claims description 3
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• PQZJZFNOOOYYHV-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] benzyl carbonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OC(=O)OCC1=CC=CC=C1 PQZJZFNOOOYYHV-UHFFFAOYSA-N 0.000 claims description 3
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• JRLWQKCAWHOXQG-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] pyridin-4-ylmethanesulfonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=NC=C1 JRLWQKCAWHOXQG-UHFFFAOYSA-N 0.000 claims description 3
• NNHGKCQLDVXYIJ-UHFFFAOYSA-N [2-amino-5-(4-methoxyphenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound C1=CC(OC)=CC=C1C1C(=O)C(OS(=O)(=O)CC=2C=CC=CC=2)=C(N)O1 NNHGKCQLDVXYIJ-UHFFFAOYSA-N 0.000 claims description 3
• ZLYROBROQFRTAR-UHFFFAOYSA-N [5-(4-chlorophenyl)-3,4-dihydroxyfuran-2-yl]carbamic acid Chemical compound OC1=C(OC(=C1O)C1=CC=C(C=C1)Cl)NC(O)=O ZLYROBROQFRTAR-UHFFFAOYSA-N 0.000 claims description 3
• SBUIECPAMJDFHG-UHFFFAOYSA-N o-[2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] n-benzylcarbamothioate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OC(=S)NCC1=CC=CC=C1 SBUIECPAMJDFHG-UHFFFAOYSA-N 0.000 claims description 3
• RBMNZNDOGRAYCO-UHFFFAOYSA-N (2-amino-4-oxo-5-phenylfuran-3-yl) phenylmethanesulfonate Chemical compound O=C1C(C=2C=CC=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 RBMNZNDOGRAYCO-UHFFFAOYSA-N 0.000 claims description 2
• MXZGXHAHEYGDPX-UHFFFAOYSA-N (2-amino-4-oxo-5-pyridin-2-ylfuran-3-yl) phenylmethanesulfonate Chemical compound O=C1C(C=2N=CC=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 MXZGXHAHEYGDPX-UHFFFAOYSA-N 0.000 claims description 2
• VUFCEWCXUGOJHE-UHFFFAOYSA-N (2-amino-4-oxo-5-pyridin-3-ylfuran-3-yl) phenylmethanesulfonate Chemical compound O=C1C(C=2C=NC=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 VUFCEWCXUGOJHE-UHFFFAOYSA-N 0.000 claims description 2
• LPLKWAFFHXFBLQ-UHFFFAOYSA-N (2-amino-4-oxo-5-pyridin-4-ylfuran-3-yl) phenylmethanesulfonate Chemical compound O=C1C(C=2C=CN=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 LPLKWAFFHXFBLQ-UHFFFAOYSA-N 0.000 claims description 2
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• KAXAKEVSULRWTP-UHFFFAOYSA-N (2-amino-4-oxo-5-quinolin-3-ylfuran-3-yl) phenylmethanesulfonate Chemical compound O=C1C(C=2C=C3C=CC=CC3=NC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 KAXAKEVSULRWTP-UHFFFAOYSA-N 0.000 claims description 2
• PAIDHPMHDNRGQD-UHFFFAOYSA-N (2-amino-4-oxo-5-quinolin-4-ylfuran-3-yl) phenylmethanesulfonate Chemical compound O=C1C(C=2C3=CC=CC=C3N=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 PAIDHPMHDNRGQD-UHFFFAOYSA-N 0.000 claims description 2
• YKQMEMPNBDFOCB-UHFFFAOYSA-N (2-amino-5-naphthalen-1-yl-4-oxofuran-3-yl) phenylmethanesulfonate Chemical compound O=C1C(C=2C3=CC=CC=C3C=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 YKQMEMPNBDFOCB-UHFFFAOYSA-N 0.000 claims description 2
• NWJKACQHXANJDX-UHFFFAOYSA-N (2-amino-5-naphthalen-2-yl-4-oxofuran-3-yl) phenylmethanesulfonate Chemical compound O=C1C(C=2C=C3C=CC=CC3=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 NWJKACQHXANJDX-UHFFFAOYSA-N 0.000 claims description 2
• 229910020364 ClSO2 Inorganic materials 0.000 claims description 2
• QYCYHUVCQXMBMA-UHFFFAOYSA-N [2-amino-4-oxo-5-(1,3-thiazol-2-yl)furan-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2SC=CN=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 QYCYHUVCQXMBMA-UHFFFAOYSA-N 0.000 claims description 2
• CGQRROWINGCADB-UHFFFAOYSA-N [2-amino-4-oxo-5-[2-(trifluoromethyl)phenyl]furan-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C(=CC=CC=2)C(F)(F)F)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 CGQRROWINGCADB-UHFFFAOYSA-N 0.000 claims description 2
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• CSOJGNWXIRSATJ-UHFFFAOYSA-N [2-amino-5-(4-chloro-2-fluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C(=CC(Cl)=CC=2)F)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 CSOJGNWXIRSATJ-UHFFFAOYSA-N 0.000 claims description 2
• UJILAMQOIKOPBX-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] (3-methylphenyl)methanesulfonate Chemical compound CC1=CC=CC(CS(=O)(=O)OC=2C(C(OC=2N)C=2C=CC(Cl)=CC=2)=O)=C1 UJILAMQOIKOPBX-UHFFFAOYSA-N 0.000 claims description 2
• YTYMXPMWSYESTI-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] (4-methylphenyl)methanesulfonate Chemical compound C1=CC(C)=CC=C1CS(=O)(=O)OC1=C(N)OC(C=2C=CC(Cl)=CC=2)C1=O YTYMXPMWSYESTI-UHFFFAOYSA-N 0.000 claims description 2
• LXPPIHHITDDBRP-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] 1-phenylethanesulfonate Chemical compound NC=1OC(C=2C=CC(Cl)=CC=2)C(=O)C=1OS(=O)(=O)C(C)C1=CC=CC=C1 LXPPIHHITDDBRP-UHFFFAOYSA-N 0.000 claims description 2
• YPBMTTACUUQVEN-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] 2-phenylpropane-2-sulfonate Chemical compound NC=1OC(C=2C=CC(Cl)=CC=2)C(=O)C=1OS(=O)(=O)C(C)(C)C1=CC=CC=C1 YPBMTTACUUQVEN-UHFFFAOYSA-N 0.000 claims description 2
• RIMFMCDTOULGNC-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] naphthalen-1-ylmethanesulfonate Chemical compound O1C(N)=C(OS(=O)(=O)CC=2C3=CC=CC=C3C=CC=2)C(=O)C1C1=CC=C(Cl)C=C1 RIMFMCDTOULGNC-UHFFFAOYSA-N 0.000 claims description 2
• ZUXYDUXMQLXBKF-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] naphthalen-2-ylmethanesulfonate Chemical compound O1C(N)=C(OS(=O)(=O)CC=2C=C3C=CC=CC3=CC=2)C(=O)C1C1=CC=C(Cl)C=C1 ZUXYDUXMQLXBKF-UHFFFAOYSA-N 0.000 claims description 2
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• YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 claims description 2
• 125000001475 halogen functional group Chemical group 0.000 claims 25
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• JZEIIVBPVPQRST-UHFFFAOYSA-N [2-acetamido-5-(furan-2-yl)-4-hydroxyfuran-3-yl] acetate Chemical compound CC(=O)OC1=C(NC(=O)C)OC(C=2OC=CC=2)=C1O JZEIIVBPVPQRST-UHFFFAOYSA-N 0.000 description 1
• HBMISTQAMUXTQQ-UHFFFAOYSA-N [2-amino-4-oxo-5-(1,3-thiazol-2-yl)furan-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=NC=CS1 HBMISTQAMUXTQQ-UHFFFAOYSA-N 0.000 description 1
• YUQKKNQBFGXOKN-UHFFFAOYSA-N [2-amino-4-oxo-5-(1,3-thiazol-2-yl)furan-3-yl] benzenesulfonate Chemical compound O=C1C(C=2SC=CN=2)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 YUQKKNQBFGXOKN-UHFFFAOYSA-N 0.000 description 1
• IAZUJSBYPKUENN-UHFFFAOYSA-N [2-amino-5-(2,3-dichlorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC=CC(Cl)=C1Cl IAZUJSBYPKUENN-UHFFFAOYSA-N 0.000 description 1
• VRJDKZLPFQTSCX-UHFFFAOYSA-N [2-amino-5-(2,3-dichlorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C(=C(Cl)C=CC=2)Cl)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 VRJDKZLPFQTSCX-UHFFFAOYSA-N 0.000 description 1
• WHSNAVZHMKCVDP-UHFFFAOYSA-N [2-amino-5-(2,3-dichlorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC=CC(Cl)=C1Cl WHSNAVZHMKCVDP-UHFFFAOYSA-N 0.000 description 1
• MXIGMWGLAZDIBP-UHFFFAOYSA-N [2-amino-5-(2,3-difluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound CC(=O)OC1=C(N)OC(C1=O)c1cccc(F)c1F MXIGMWGLAZDIBP-UHFFFAOYSA-N 0.000 description 1
• SZPQTUZCIQHRCN-UHFFFAOYSA-N [2-amino-5-(2,3-difluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C(=C(F)C=CC=2)F)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 SZPQTUZCIQHRCN-UHFFFAOYSA-N 0.000 description 1
• PFCRHOBCDYQPJM-UHFFFAOYSA-N [2-amino-5-(2,3-dimethoxyphenyl)-4-oxofuran-3-yl] acetate Chemical compound COC1=CC=CC(C2C(C(OC(C)=O)=C(N)O2)=O)=C1OC PFCRHOBCDYQPJM-UHFFFAOYSA-N 0.000 description 1
• SFNMSLUOLHZDSK-UHFFFAOYSA-N [2-amino-5-(2,3-dimethoxyphenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound COC1=CC=CC(C2C(C(OS(=O)(=O)C=3C=CC=CC=3)=C(N)O2)=O)=C1OC SFNMSLUOLHZDSK-UHFFFAOYSA-N 0.000 description 1
• ZYCNUHAHVIJHJY-UHFFFAOYSA-N [2-amino-5-(2,3-dimethoxyphenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound COc1cccc(c1OC)C1(C)OC(N)=C(OC(C)=O)C1=O ZYCNUHAHVIJHJY-UHFFFAOYSA-N 0.000 description 1
• KXOOYLLKBAEHSY-UHFFFAOYSA-N [2-amino-5-(2,4-dichlorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC=C(Cl)C=C1Cl KXOOYLLKBAEHSY-UHFFFAOYSA-N 0.000 description 1
• OHHRFXAVRNIYLS-UHFFFAOYSA-N [2-amino-5-(2,4-dichlorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C(=CC(Cl)=CC=2)Cl)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 OHHRFXAVRNIYLS-UHFFFAOYSA-N 0.000 description 1
• IJSWZKDLUPRKFT-UHFFFAOYSA-N [2-amino-5-(2,4-dichlorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC=C(Cl)C=C1Cl IJSWZKDLUPRKFT-UHFFFAOYSA-N 0.000 description 1
• GFZBICPYEYJDEF-UHFFFAOYSA-N [2-amino-5-(2,4-difluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC=C(F)C=C1F GFZBICPYEYJDEF-UHFFFAOYSA-N 0.000 description 1
• SNAUJVRREQYERY-UHFFFAOYSA-N [2-amino-5-(2,4-difluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C(=CC(F)=CC=2)F)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 SNAUJVRREQYERY-UHFFFAOYSA-N 0.000 description 1
• ISFGFJGJOFKYSG-UHFFFAOYSA-N [2-amino-5-(2,4-difluorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC=C(F)C=C1F ISFGFJGJOFKYSG-UHFFFAOYSA-N 0.000 description 1
• VIMXSEYLOLBBKO-UHFFFAOYSA-N [2-amino-5-(2,4-dimethoxyphenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound COC1=CC(OC)=CC=C1C1C(=O)C(OS(=O)(=O)C=2C=CC=CC=2)=C(N)O1 VIMXSEYLOLBBKO-UHFFFAOYSA-N 0.000 description 1
• DLUHDFMIUBOWTD-UHFFFAOYSA-N [2-amino-5-(2,4-dimethoxyphenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound COc1ccc(c(OC)c1)C1(C)OC(N)=C(OC(C)=O)C1=O DLUHDFMIUBOWTD-UHFFFAOYSA-N 0.000 description 1
• ILEDDHIDOILLGM-UHFFFAOYSA-N [2-amino-5-(2,5-dichlorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC(Cl)=CC=C1Cl ILEDDHIDOILLGM-UHFFFAOYSA-N 0.000 description 1
• XEOWHUIHICYMTA-UHFFFAOYSA-N [2-amino-5-(2,5-dichlorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C(=CC=C(Cl)C=2)Cl)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 XEOWHUIHICYMTA-UHFFFAOYSA-N 0.000 description 1
• RNOLXSXGBMEJCT-UHFFFAOYSA-N [2-amino-5-(2,5-dichlorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC(Cl)=CC=C1Cl RNOLXSXGBMEJCT-UHFFFAOYSA-N 0.000 description 1
• MYKYSAFTRITHJG-UHFFFAOYSA-N [2-amino-5-(2,5-difluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC(F)=CC=C1F MYKYSAFTRITHJG-UHFFFAOYSA-N 0.000 description 1
• RNRJGZXQGGOSKH-UHFFFAOYSA-N [2-amino-5-(2,5-difluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound NC1=C(OS(=O)(=O)c2ccccc2)C(=O)C(O1)c1cc(F)ccc1F RNRJGZXQGGOSKH-UHFFFAOYSA-N 0.000 description 1
• DZXJSUDKVNVBAM-UHFFFAOYSA-N [2-amino-5-(2,5-difluorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC(F)=CC=C1F DZXJSUDKVNVBAM-UHFFFAOYSA-N 0.000 description 1
• GZEOSTIBUAQHSZ-UHFFFAOYSA-N [2-amino-5-(2,5-dimethoxyphenyl)-4-oxofuran-3-yl] acetate Chemical compound COC1=CC=C(OC)C(C2C(C(OC(C)=O)=C(N)O2)=O)=C1 GZEOSTIBUAQHSZ-UHFFFAOYSA-N 0.000 description 1
• GWLBRJJMJBABLD-UHFFFAOYSA-N [2-amino-5-(2,5-dimethoxyphenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound COC1=CC=C(OC)C(C2C(C(OS(=O)(=O)C=3C=CC=CC=3)=C(N)O2)=O)=C1 GWLBRJJMJBABLD-UHFFFAOYSA-N 0.000 description 1
• DGJAJVNMEWSBDK-UHFFFAOYSA-N [2-amino-5-(2,5-dimethoxyphenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound COc1ccc(OC)c(c1)C1(C)OC(N)=C(OC(C)=O)C1=O DGJAJVNMEWSBDK-UHFFFAOYSA-N 0.000 description 1
• IODUIQVANHEXKN-UHFFFAOYSA-N [2-amino-5-(2,6-dichlorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=C(Cl)C=CC=C1Cl IODUIQVANHEXKN-UHFFFAOYSA-N 0.000 description 1
• IEKWYOUMOLCHKW-UHFFFAOYSA-N [2-amino-5-(2,6-dichlorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C(=CC=CC=2Cl)Cl)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 IEKWYOUMOLCHKW-UHFFFAOYSA-N 0.000 description 1
• FUAZXQIGWXKSTA-UHFFFAOYSA-N [2-amino-5-(2,6-dichlorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=C(Cl)C=CC=C1Cl FUAZXQIGWXKSTA-UHFFFAOYSA-N 0.000 description 1
• BQHVRSFIKAIJEL-UHFFFAOYSA-N [2-amino-5-(2,6-difluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=C(F)C=CC=C1F BQHVRSFIKAIJEL-UHFFFAOYSA-N 0.000 description 1
• BXUALRSNSBTXQB-UHFFFAOYSA-N [2-amino-5-(2,6-difluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C(=CC=CC=2F)F)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 BXUALRSNSBTXQB-UHFFFAOYSA-N 0.000 description 1
• IPAJEBBSTXYVCR-UHFFFAOYSA-N [2-amino-5-(2,6-difluorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=C(F)C=CC=C1F IPAJEBBSTXYVCR-UHFFFAOYSA-N 0.000 description 1
• NRDXIJFRXBQGEH-UHFFFAOYSA-N [2-amino-5-(2,6-dimethoxyphenyl)-4-oxofuran-3-yl] acetate Chemical compound COC1=CC=CC(OC)=C1C1C(=O)C(OC(C)=O)=C(N)O1 NRDXIJFRXBQGEH-UHFFFAOYSA-N 0.000 description 1
• WYHTXEHHZIYMMP-UHFFFAOYSA-N [2-amino-5-(2,6-dimethoxyphenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound COC1=CC=CC(OC)=C1C1C(=O)C(OS(=O)(=O)C=2C=CC=CC=2)=C(N)O1 WYHTXEHHZIYMMP-UHFFFAOYSA-N 0.000 description 1
• CKBDABZTHILGTH-UHFFFAOYSA-N [2-amino-5-(2,6-dimethoxyphenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound COc1cccc(OC)c1C1(C)OC(N)=C(OC(C)=O)C1=O CKBDABZTHILGTH-UHFFFAOYSA-N 0.000 description 1
• YOWYZJWQVOLGOH-UHFFFAOYSA-N [2-amino-5-(2-chloro-4-fluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC=C(F)C=C1Cl YOWYZJWQVOLGOH-UHFFFAOYSA-N 0.000 description 1
• GXLRGKKDYSCJPR-UHFFFAOYSA-N [2-amino-5-(2-chloro-4-fluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C(=CC(F)=CC=2)Cl)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 GXLRGKKDYSCJPR-UHFFFAOYSA-N 0.000 description 1
• ZPJWRKRCXMROJV-UHFFFAOYSA-N [2-amino-5-(2-chloro-4-fluorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC=C(F)C=C1Cl ZPJWRKRCXMROJV-UHFFFAOYSA-N 0.000 description 1
• BRQIHLGKUQAROQ-UHFFFAOYSA-N [2-amino-5-(2-chloro-5-fluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC(F)=CC=C1Cl BRQIHLGKUQAROQ-UHFFFAOYSA-N 0.000 description 1
• PKMDHALYVILUCA-UHFFFAOYSA-N [2-amino-5-(2-chloro-5-fluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C(=CC=C(F)C=2)Cl)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 PKMDHALYVILUCA-UHFFFAOYSA-N 0.000 description 1
• DKHJMFILTVWGBB-UHFFFAOYSA-N [2-amino-5-(2-chloro-5-fluorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC(F)=CC=C1Cl DKHJMFILTVWGBB-UHFFFAOYSA-N 0.000 description 1
• DLXSDJVYRAGRJE-UHFFFAOYSA-N [2-amino-5-(2-chloro-6-fluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=C(F)C=CC=C1Cl DLXSDJVYRAGRJE-UHFFFAOYSA-N 0.000 description 1
• KPKFBCUEFMLDGC-UHFFFAOYSA-N [2-amino-5-(2-chloro-6-fluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C(=CC=CC=2F)Cl)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 KPKFBCUEFMLDGC-UHFFFAOYSA-N 0.000 description 1
• USCVGGPTWJKLCN-UHFFFAOYSA-N [2-amino-5-(2-chloro-6-fluorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=C(F)C=CC=C1Cl USCVGGPTWJKLCN-UHFFFAOYSA-N 0.000 description 1
• GRZPSWNJXULSOA-UHFFFAOYSA-N [2-amino-5-(2-chlorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC=CC=C1Cl GRZPSWNJXULSOA-UHFFFAOYSA-N 0.000 description 1
• LANZQBDLGIUMFO-UHFFFAOYSA-N [2-amino-5-(2-chlorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C(=CC=CC=2)Cl)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 LANZQBDLGIUMFO-UHFFFAOYSA-N 0.000 description 1
• GDMNOGWOYRQEOW-UHFFFAOYSA-N [2-amino-5-(2-chlorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC=CC=C1Cl GDMNOGWOYRQEOW-UHFFFAOYSA-N 0.000 description 1
• CXVQTAKFWFDBRJ-UHFFFAOYSA-N [2-amino-5-(2-fluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC=CC=C1F CXVQTAKFWFDBRJ-UHFFFAOYSA-N 0.000 description 1
• UXUIDNZBMAWGOL-UHFFFAOYSA-N [2-amino-5-(2-fluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C(=CC=CC=2)F)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 UXUIDNZBMAWGOL-UHFFFAOYSA-N 0.000 description 1
• YMQVMZZYYRZUEF-UHFFFAOYSA-N [2-amino-5-(2-methoxyphenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound COc1ccccc1C1OC(N)=C(OS(=O)(=O)c2ccccc2)C1=O YMQVMZZYYRZUEF-UHFFFAOYSA-N 0.000 description 1
• GGROGJPCDXAHNK-UHFFFAOYSA-N [2-amino-5-(2-methoxyphenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound COC1=CC=CC=C1C1(C)C(=O)C(OC(C)=O)=C(N)O1 GGROGJPCDXAHNK-UHFFFAOYSA-N 0.000 description 1
• UAXZJDXJNUQGQI-UHFFFAOYSA-N [2-amino-5-(3,4-dichlorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC=C(Cl)C(Cl)=C1 UAXZJDXJNUQGQI-UHFFFAOYSA-N 0.000 description 1
• AVKMPECSIBQYRX-UHFFFAOYSA-N [2-amino-5-(3,4-dichlorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C=C(Cl)C(Cl)=CC=2)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 AVKMPECSIBQYRX-UHFFFAOYSA-N 0.000 description 1
• KBLBNCUEDDUEEI-UHFFFAOYSA-N [2-amino-5-(3,4-dichlorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC=C(Cl)C(Cl)=C1 KBLBNCUEDDUEEI-UHFFFAOYSA-N 0.000 description 1
• UTHXJPXONYGHOD-UHFFFAOYSA-N [2-amino-5-(3,4-difluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC=C(F)C(F)=C1 UTHXJPXONYGHOD-UHFFFAOYSA-N 0.000 description 1
• BXVAYUGHSCEXDY-UHFFFAOYSA-N [2-amino-5-(3,4-difluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound NC1=C(OS(=O)(=O)c2ccccc2)C(=O)C(O1)c1ccc(F)c(F)c1 BXVAYUGHSCEXDY-UHFFFAOYSA-N 0.000 description 1
• CXXVCCDYVAVBLL-UHFFFAOYSA-N [2-amino-5-(3,4-difluorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC=C(F)C(F)=C1 CXXVCCDYVAVBLL-UHFFFAOYSA-N 0.000 description 1
• FIZAOYJRNDGYRX-UHFFFAOYSA-N [2-amino-5-(3,4-dimethoxyphenyl)-4-oxofuran-3-yl] acetate Chemical compound C1=C(OC)C(OC)=CC=C1C1C(=O)C(OC(C)=O)=C(N)O1 FIZAOYJRNDGYRX-UHFFFAOYSA-N 0.000 description 1
• USJCDHLBHAYGSR-UHFFFAOYSA-N [2-amino-5-(3,4-dimethoxyphenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound C1=C(OC)C(OC)=CC=C1C1C(=O)C(OS(=O)(=O)C=2C=CC=CC=2)=C(N)O1 USJCDHLBHAYGSR-UHFFFAOYSA-N 0.000 description 1
• SJAKAHOSCAZZPW-UHFFFAOYSA-N [2-amino-5-(3,4-dimethoxyphenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound COc1ccc(cc1OC)C1(C)OC(N)=C(OC(C)=O)C1=O SJAKAHOSCAZZPW-UHFFFAOYSA-N 0.000 description 1
• ZQSUGUORWWFBKC-UHFFFAOYSA-N [2-amino-5-(3,5-dichlorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC(Cl)=CC(Cl)=C1 ZQSUGUORWWFBKC-UHFFFAOYSA-N 0.000 description 1
• INDXVQDMMXFVLI-UHFFFAOYSA-N [2-amino-5-(3,5-dichlorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C=C(Cl)C=C(Cl)C=2)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 INDXVQDMMXFVLI-UHFFFAOYSA-N 0.000 description 1
• JYBATYLRAVUYBP-UHFFFAOYSA-N [2-amino-5-(3,5-dichlorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC(Cl)=CC(Cl)=C1 JYBATYLRAVUYBP-UHFFFAOYSA-N 0.000 description 1
• ZEHANCIPCFXJGP-UHFFFAOYSA-N [2-amino-5-(3,5-difluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC(F)=CC(F)=C1 ZEHANCIPCFXJGP-UHFFFAOYSA-N 0.000 description 1
• PMAUEXFYSIEQRE-UHFFFAOYSA-N [2-amino-5-(3,5-difluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C=C(F)C=C(F)C=2)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 PMAUEXFYSIEQRE-UHFFFAOYSA-N 0.000 description 1
• FGSLDKGEKUFQAM-UHFFFAOYSA-N [2-amino-5-(3,5-difluorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC(F)=CC(F)=C1 FGSLDKGEKUFQAM-UHFFFAOYSA-N 0.000 description 1
• LMFIEEHVCBAMGC-UHFFFAOYSA-N [2-amino-5-(3,5-dimethoxyphenyl)-4-oxofuran-3-yl] acetate Chemical compound COC1=CC(OC)=CC(C2C(C(OC(C)=O)=C(N)O2)=O)=C1 LMFIEEHVCBAMGC-UHFFFAOYSA-N 0.000 description 1
• WPQXMLHJJFCBSI-UHFFFAOYSA-N [2-amino-5-(3,5-dimethoxyphenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound COC1=CC(OC)=CC(C2C(C(OS(=O)(=O)C=3C=CC=CC=3)=C(N)O2)=O)=C1 WPQXMLHJJFCBSI-UHFFFAOYSA-N 0.000 description 1
• VYQQDWDKWRZYGA-UHFFFAOYSA-N [2-amino-5-(3,5-dimethoxyphenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound COc1cc(OC)cc(c1)C1(C)OC(N)=C(OC(C)=O)C1=O VYQQDWDKWRZYGA-UHFFFAOYSA-N 0.000 description 1
• GQIDGFDRMXDMBO-UHFFFAOYSA-N [2-amino-5-(3-chloro-2-fluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC=CC(Cl)=C1F GQIDGFDRMXDMBO-UHFFFAOYSA-N 0.000 description 1
• WXALLPITIJSDEZ-UHFFFAOYSA-N [2-amino-5-(3-chloro-2-fluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C(=C(Cl)C=CC=2)F)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 WXALLPITIJSDEZ-UHFFFAOYSA-N 0.000 description 1
• RVDXPOYLFZKYTB-UHFFFAOYSA-N [2-amino-5-(3-chloro-2-fluorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC=CC(Cl)=C1F RVDXPOYLFZKYTB-UHFFFAOYSA-N 0.000 description 1
• ZFZMVSXPMFIPMY-UHFFFAOYSA-N [2-amino-5-(3-chloro-4-fluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC=C(F)C(Cl)=C1 ZFZMVSXPMFIPMY-UHFFFAOYSA-N 0.000 description 1
• NFIMSGQJMGVLMV-UHFFFAOYSA-N [2-amino-5-(3-chloro-4-fluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C=C(Cl)C(F)=CC=2)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 NFIMSGQJMGVLMV-UHFFFAOYSA-N 0.000 description 1
• BEKQIWWQZVQOJP-UHFFFAOYSA-N [2-amino-5-(3-chloro-4-fluorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC=C(F)C(Cl)=C1 BEKQIWWQZVQOJP-UHFFFAOYSA-N 0.000 description 1
• RSTVETSPNBACFW-UHFFFAOYSA-N [2-amino-5-(3-chloro-5-fluorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound ClC=1C=C(C=C(C1)F)C1OC(=C(C1=O)OS(=O)(=O)CC1=CC=CC=C1)N RSTVETSPNBACFW-UHFFFAOYSA-N 0.000 description 1
• IEIHWFWAOPLJIR-UHFFFAOYSA-N [2-amino-5-(3-chlorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC=CC(Cl)=C1 IEIHWFWAOPLJIR-UHFFFAOYSA-N 0.000 description 1
• KBDYIBDVAAJASV-UHFFFAOYSA-N [2-amino-5-(3-chlorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound NC1=C(OS(=O)(=O)c2ccccc2)C(=O)C(O1)c1cccc(Cl)c1 KBDYIBDVAAJASV-UHFFFAOYSA-N 0.000 description 1
• YIRLPPZXWWAUKH-UHFFFAOYSA-N [2-amino-5-(3-fluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC=CC(F)=C1 YIRLPPZXWWAUKH-UHFFFAOYSA-N 0.000 description 1
• DPKFANMMFRDNGH-UHFFFAOYSA-N [2-amino-5-(3-fluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound NC1=C(OS(=O)(=O)c2ccccc2)C(=O)C(O1)c1cccc(F)c1 DPKFANMMFRDNGH-UHFFFAOYSA-N 0.000 description 1
• JCTJFPZONQIMNO-UHFFFAOYSA-N [2-amino-5-(3-fluorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound FC=1C=C(C=CC1)C1(OC(=C(C1=O)OC(C)=O)N)C JCTJFPZONQIMNO-UHFFFAOYSA-N 0.000 description 1
• MLIMHWIJFJWBQL-UHFFFAOYSA-N [2-amino-5-(3-methoxyphenyl)-4-oxofuran-3-yl] acetate Chemical compound COC1=CC=CC(C2C(C(OC(C)=O)=C(N)O2)=O)=C1 MLIMHWIJFJWBQL-UHFFFAOYSA-N 0.000 description 1
• CUGABWDCNTZOGE-UHFFFAOYSA-N [2-amino-5-(3-methoxyphenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound COC1=CC=CC(C2C(C(OS(=O)(=O)C=3C=CC=CC=3)=C(N)O2)=O)=C1 CUGABWDCNTZOGE-UHFFFAOYSA-N 0.000 description 1
• JHOPSPXYRYEGIK-UHFFFAOYSA-N [2-amino-5-(3-methoxyphenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound COC1=CC=CC(C2(C)C(C(OC(C)=O)=C(N)O2)=O)=C1 JHOPSPXYRYEGIK-UHFFFAOYSA-N 0.000 description 1
• JMDWIZXFVKUKFG-UHFFFAOYSA-N [2-amino-5-(4-chloro-2-fluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC=C(Cl)C=C1F JMDWIZXFVKUKFG-UHFFFAOYSA-N 0.000 description 1
• HPPUTYPKQIKZMI-UHFFFAOYSA-N [2-amino-5-(4-chloro-2-fluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C(=CC(Cl)=CC=2)F)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 HPPUTYPKQIKZMI-UHFFFAOYSA-N 0.000 description 1
• OPJSQASAWYBNTM-UHFFFAOYSA-N [2-amino-5-(4-chloro-2-fluorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC=C(Cl)C=C1F OPJSQASAWYBNTM-UHFFFAOYSA-N 0.000 description 1
• ZTHHJZUGYLPTGV-UHFFFAOYSA-N [2-amino-5-(4-chloro-3-fluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C=C(F)C(Cl)=CC=2)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 ZTHHJZUGYLPTGV-UHFFFAOYSA-N 0.000 description 1
• LIQFYTZKXWXMBE-UHFFFAOYSA-N [2-amino-5-(4-chloro-3-fluorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC=C(Cl)C(F)=C1 LIQFYTZKXWXMBE-UHFFFAOYSA-N 0.000 description 1
• DCLUADJQXTYUPG-UHFFFAOYSA-N [2-amino-5-(4-chlorophenyl)-4-oxofuran-3-yl] phenylmethanesulfonate Chemical compound O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1.O=C1C(C=2C=CC(Cl)=CC=2)OC(N)=C1OS(=O)(=O)CC1=CC=CC=C1 DCLUADJQXTYUPG-UHFFFAOYSA-N 0.000 description 1
• MYZQZMITYJILEQ-UHFFFAOYSA-N [2-amino-5-(4-fluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC=C(F)C=C1 MYZQZMITYJILEQ-UHFFFAOYSA-N 0.000 description 1
• AZDQFAMPQAFWRL-UHFFFAOYSA-N [2-amino-5-(4-fluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound NC1=C(OS(=O)(=O)c2ccccc2)C(=O)C(O1)c1ccc(F)cc1 AZDQFAMPQAFWRL-UHFFFAOYSA-N 0.000 description 1
• QQOLTELNVHRYTB-UHFFFAOYSA-N [2-amino-5-(4-fluorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound FC1=CC=C(C=C1)C1(OC(=C(C1=O)OC(C)=O)N)C QQOLTELNVHRYTB-UHFFFAOYSA-N 0.000 description 1
• MJJAYQGCINWIHE-UHFFFAOYSA-N [2-amino-5-(4-methoxyphenyl)-4-oxofuran-3-yl] acetate Chemical compound C1=CC(OC)=CC=C1C1C(=O)C(OC(C)=O)=C(N)O1 MJJAYQGCINWIHE-UHFFFAOYSA-N 0.000 description 1
• VMAMXMJWNVFRMV-UHFFFAOYSA-N [2-amino-5-(4-methoxyphenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound COc1ccc(cc1)C1OC(N)=C(OS(=O)(=O)c2ccccc2)C1=O VMAMXMJWNVFRMV-UHFFFAOYSA-N 0.000 description 1
• HTRVPSVQNUUJCA-UHFFFAOYSA-N [2-amino-5-(4-methoxyphenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound C1=CC(OC)=CC=C1C1(C)C(=O)C(OC(C)=O)=C(N)O1 HTRVPSVQNUUJCA-UHFFFAOYSA-N 0.000 description 1
• YUMKHZBQKMYCKH-UHFFFAOYSA-N [2-amino-5-(5-chloro-2-fluorophenyl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC(Cl)=CC=C1F YUMKHZBQKMYCKH-UHFFFAOYSA-N 0.000 description 1
• ADOZDESQAHRUOJ-UHFFFAOYSA-N [2-amino-5-(5-chloro-2-fluorophenyl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2C(=CC=C(Cl)C=2)F)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 ADOZDESQAHRUOJ-UHFFFAOYSA-N 0.000 description 1
• QDOHSEKHIJPMDN-UHFFFAOYSA-N [2-amino-5-(5-chloro-2-fluorophenyl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC(Cl)=CC=C1F QDOHSEKHIJPMDN-UHFFFAOYSA-N 0.000 description 1
• NHDWZKYBRVDANC-UHFFFAOYSA-N [2-amino-5-(furan-2-yl)-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1C1=CC=CO1 NHDWZKYBRVDANC-UHFFFAOYSA-N 0.000 description 1
• ZAUQCCGFIJTWPN-UHFFFAOYSA-N [2-amino-5-(furan-2-yl)-4-oxofuran-3-yl] benzenesulfonate Chemical compound O=C1C(C=2OC=CC=2)OC(N)=C1OS(=O)(=O)C1=CC=CC=C1 ZAUQCCGFIJTWPN-UHFFFAOYSA-N 0.000 description 1
• PXMHLVWPEOLLJM-UHFFFAOYSA-N [2-amino-5-(furan-2-yl)-5-methyl-4-oxofuran-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=CC=CO1 PXMHLVWPEOLLJM-UHFFFAOYSA-N 0.000 description 1
• FMJBZGMABZOGLE-UHFFFAOYSA-N [2-amino-5-methyl-4-oxo-5-(1,3-thiazol-2-yl)furan-3-yl] acetate Chemical compound O=C1C(OC(=O)C)=C(N)OC1(C)C1=NC=CS1 FMJBZGMABZOGLE-UHFFFAOYSA-N 0.000 description 1
• JTXRDVSERZUTHQ-UHFFFAOYSA-N [2-benzamido-4-hydroxy-5-(1,3-thiazol-2-yl)furan-3-yl] acetate Chemical compound CC(=O)Oc1c(NC(=O)c2ccccc2)oc(c1O)-c1nccs1 JTXRDVSERZUTHQ-UHFFFAOYSA-N 0.000 description 1
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• FDGWZXWNQHPYHS-UHFFFAOYSA-N [2-benzamido-4-hydroxy-5-(4-methoxyphenyl)furan-3-yl] acetate Chemical compound C1=CC(OC)=CC=C1C1=C(O)C(OC(C)=O)=C(NC(=O)C=2C=CC=CC=2)O1 FDGWZXWNQHPYHS-UHFFFAOYSA-N 0.000 description 1
• LMOWMYOACJOBBS-UHFFFAOYSA-N [2-benzamido-5-(2,3-dichlorophenyl)-4-hydroxyfuran-3-yl] acetate Chemical compound CC(=O)OC=1C(O)=C(C=2C(=C(Cl)C=CC=2)Cl)OC=1NC(=O)C1=CC=CC=C1 LMOWMYOACJOBBS-UHFFFAOYSA-N 0.000 description 1
• DJQXBQPNQCFWMF-UHFFFAOYSA-N [2-benzamido-5-(2,3-difluorophenyl)-4-hydroxyfuran-3-yl] acetate Chemical compound CC(=O)OC=1C(O)=C(C=2C(=C(F)C=CC=2)F)OC=1NC(=O)C1=CC=CC=C1 DJQXBQPNQCFWMF-UHFFFAOYSA-N 0.000 description 1
• NBKAVPYFNXNFEE-UHFFFAOYSA-N [2-benzamido-5-(2,3-dimethoxyphenyl)-4-hydroxyfuran-3-yl] acetate Chemical compound COc1cccc(-c2oc(NC(=O)c3ccccc3)c(OC(C)=O)c2O)c1OC NBKAVPYFNXNFEE-UHFFFAOYSA-N 0.000 description 1
• NXNKRWGIWWLLOD-UHFFFAOYSA-N [2-benzamido-5-(2,4-dichlorophenyl)-4-hydroxyfuran-3-yl] acetate Chemical compound CC(=O)OC=1C(O)=C(C=2C(=CC(Cl)=CC=2)Cl)OC=1NC(=O)C1=CC=CC=C1 NXNKRWGIWWLLOD-UHFFFAOYSA-N 0.000 description 1
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• HGMWMTWATUPQCP-UHFFFAOYSA-N [2-benzamido-5-(2-chloro-5-fluorophenyl)-4-hydroxyfuran-3-yl] acetate Chemical compound CC(=O)OC=1C(O)=C(C=2C(=CC=C(F)C=2)Cl)OC=1NC(=O)C1=CC=CC=C1 HGMWMTWATUPQCP-UHFFFAOYSA-N 0.000 description 1
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