ES2650791T3 - Estabilización de composiciones farmacéuticas - Google Patents

Estabilización de composiciones farmacéuticas Download PDF

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Publication number
ES2650791T3
ES2650791T3 ES13711104.3T ES13711104T ES2650791T3 ES 2650791 T3 ES2650791 T3 ES 2650791T3 ES 13711104 T ES13711104 T ES 13711104T ES 2650791 T3 ES2650791 T3 ES 2650791T3
Authority
ES
Spain
Prior art keywords
compound
formula
lactose
particulate
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13711104.3T
Other languages
English (en)
Spanish (es)
Inventor
Rudy Laurent Maria Broeckx
Walter Ferdinand Maria Filliers
Patrick Hubert J. Nieste
Alex Herman Copmans
Filip Marcel C. VANHOUTTE
Carina Leys
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Respivert Ltd
Original Assignee
Respivert Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49160309&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2650791(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Respivert Ltd filed Critical Respivert Ltd
Application granted granted Critical
Publication of ES2650791T3 publication Critical patent/ES2650791T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES13711104.3T 2012-03-13 2013-03-13 Estabilización de composiciones farmacéuticas Active ES2650791T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261610012P 2012-03-13 2012-03-13
US201261610023P 2012-03-13 2012-03-13
US201261610012P 2012-03-13
US201261610023P 2012-03-13
PCT/GB2013/050623 WO2013136075A1 (en) 2012-03-13 2013-03-13 Novel pharmaceutical formulations

Publications (1)

Publication Number Publication Date
ES2650791T3 true ES2650791T3 (es) 2018-01-22

Family

ID=49160309

Family Applications (2)

Application Number Title Priority Date Filing Date
ES13711105.0T Active ES2600705T3 (es) 2012-03-13 2013-03-13 Inhibidores de PI3 cinasa cristalinos
ES13711104.3T Active ES2650791T3 (es) 2012-03-13 2013-03-13 Estabilización de composiciones farmacéuticas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES13711105.0T Active ES2600705T3 (es) 2012-03-13 2013-03-13 Inhibidores de PI3 cinasa cristalinos

Country Status (35)

Country Link
US (3) US20150099768A1 (OSRAM)
EP (2) EP2834244B1 (OSRAM)
JP (3) JP6189874B2 (OSRAM)
KR (2) KR20140141596A (OSRAM)
CN (2) CN104302650B (OSRAM)
AU (2) AU2013234080B2 (OSRAM)
CA (2) CA2864643A1 (OSRAM)
CL (2) CL2014002386A1 (OSRAM)
CO (2) CO7051030A2 (OSRAM)
CR (2) CR20140416A (OSRAM)
CY (1) CY1118565T1 (OSRAM)
DK (1) DK2834244T3 (OSRAM)
EA (2) EA023715B1 (OSRAM)
EC (2) ECSP14018142A (OSRAM)
ES (2) ES2600705T3 (OSRAM)
GT (2) GT201400182A (OSRAM)
HR (1) HRP20161383T1 (OSRAM)
HU (1) HUE029420T2 (OSRAM)
IL (2) IL233883A0 (OSRAM)
IN (2) IN2014MN01998A (OSRAM)
LT (1) LT2834244T (OSRAM)
MX (2) MX355299B (OSRAM)
MY (1) MY171125A (OSRAM)
NI (2) NI201400100A (OSRAM)
NZ (2) NZ628072A (OSRAM)
PE (2) PE20142342A1 (OSRAM)
PH (2) PH12014501713A1 (OSRAM)
PL (1) PL2834244T3 (OSRAM)
PT (1) PT2834244T (OSRAM)
SG (2) SG11201404519UA (OSRAM)
SI (1) SI2834244T1 (OSRAM)
TW (2) TWI586378B (OSRAM)
UA (1) UA115544C2 (OSRAM)
WO (2) WO2013136076A1 (OSRAM)
ZA (2) ZA201407374B (OSRAM)

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Also Published As

Publication number Publication date
CY1118565T1 (el) 2017-07-12
JP2018008992A (ja) 2018-01-18
MY171125A (en) 2019-09-26
EA201491674A1 (ru) 2014-12-30
CO7051030A2 (es) 2014-09-10
ECSP14018142A (es) 2015-06-30
WO2013136076A1 (en) 2013-09-19
EA201491675A1 (ru) 2014-12-30
CR20140417A (es) 2014-10-31
KR20140141596A (ko) 2014-12-10
GT201400182A (es) 2015-09-17
GT201400183A (es) 2015-07-08
US20150105408A1 (en) 2015-04-16
PE20142342A1 (es) 2015-01-16
ECSP14018630A (es) 2015-09-30
AU2013234080B2 (en) 2016-12-22
MX355299B (es) 2018-04-11
MX2014010991A (es) 2014-10-13
MX357170B (es) 2018-06-27
IN2014MN02000A (OSRAM) 2015-08-14
IL233883A0 (en) 2014-09-30
PH12014501713A1 (en) 2014-10-13
EP2834244A1 (en) 2015-02-11
EA025465B1 (ru) 2016-12-30
CR20140416A (es) 2014-10-31
US20170239256A1 (en) 2017-08-24
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CA2864652A1 (en) 2013-09-19
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LT2834244T (lt) 2016-11-10
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