ES2638190T3 - Métodos para tratar la dependencia - Google Patents
Métodos para tratar la dependencia Download PDFInfo
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- ES2638190T3 ES2638190T3 ES08797300.4T ES08797300T ES2638190T3 ES 2638190 T3 ES2638190 T3 ES 2638190T3 ES 08797300 T ES08797300 T ES 08797300T ES 2638190 T3 ES2638190 T3 ES 2638190T3
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| BRPI0815089A2 (pt) | 2007-08-06 | 2014-09-30 | Synosia Therapeutics Inc | Métodos para tratar um paciente que sofre de ou suscetível a pelo menos um sintoma de abuso de, dependência sobre, ou retirada de pelo menos uma substância, para tratar pelo menos uma fase de dependência de substância sobre pelo menos uma substância em um paciente, e para tratar pelo menos uma fase de dependência à cocaína em um paciente. |
| WO2010124089A2 (en) * | 2009-04-22 | 2010-10-28 | Synosia Therapeutics, Inc. | Methods for treating dependence |
| US9804149B2 (en) * | 2012-10-10 | 2017-10-31 | Bio-Rad Laboratories, Inc. | Patient-based results display |
| CA2919892C (en) | 2013-08-12 | 2019-06-18 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| WO2015095644A1 (en) | 2013-12-20 | 2015-06-25 | AntiOP, Inc. | Intranasal naloxone compositions and methods of making and using same |
| DK3169315T3 (da) | 2014-07-17 | 2020-08-10 | Pharmaceutical Manufacturing Res Services In | Væskefyldt doseringsform til forhindring af misbrug med øjeblikkelig frigivelse |
| JP2017531026A (ja) | 2014-10-20 | 2017-10-19 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド | 徐放性乱用抑止性液体充填剤形 |
| US20170235908A1 (en) * | 2015-11-15 | 2017-08-17 | Oriah Behaviorial Health, Inc. | Systems and Methods for Managing and Treating Substance Abuse Addiction |
| WO2019038756A1 (en) | 2017-08-20 | 2019-02-28 | Solubest Ltd. | DRY POWDER COMPOSITIONS FOR INTRANASAL DELIVERY |
| US11844859B2 (en) | 2017-08-20 | 2023-12-19 | Nasus Pharma Ltd. | Dry powder compositions for intranasal delivery |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| CN108066355A (zh) * | 2017-12-28 | 2018-05-25 | 宁夏恩多芬科技有限公司 | Nitrous Oxide作为治疗神经官能症的用途 |
| FR3093419B1 (fr) * | 2019-03-08 | 2021-06-18 | Univ Grenoble Alpes | Composition et procédé associé de mesure de l’observance thérapeutique |
| KR20220009954A (ko) | 2019-04-17 | 2022-01-25 | 컴퍼스 패쓰파인더 리미티드 | 신경인지 장애, 만성 통증을 치료하고 염증을 감소시키는 방법 |
| PT3873883T (pt) * | 2019-11-07 | 2023-03-24 | Small Pharma Ltd | Método de síntese |
| US11806320B2 (en) * | 2020-02-19 | 2023-11-07 | Endo Ventures Limited | Isoproterenol compositions and methods |
| IL312785A (en) | 2020-05-19 | 2024-07-01 | Cybin Irl Ltd | Denatured Tryptamine Derivatives and Methods of Use |
| IL300689A (en) * | 2020-08-17 | 2023-04-01 | Univ Columbia | Use of neuromelanin-sensitive MRI as a biomarker of dopamine function |
| JP7753359B2 (ja) * | 2020-10-24 | 2025-10-14 | ユニヴェルシテートスピタル バーゼル | ヒト血漿中のリゼルギン酸ジエチルアミド（ｌｓｄ）及び２，３－ジヒドロ－３－ヒドロキシ－２－オキソリセルギド（ｏ－ｈ－ｌｓｄ）を定量化するための方法 |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
| CN112690771B (zh) * | 2020-12-09 | 2022-05-24 | 华南理工大学 | 一种利用线性回归模型的人脸视频心率检测方法 |
| US12079960B2 (en) | 2021-03-11 | 2024-09-03 | Terran Biosciences Inc. | Systems, devices, and methods for harmonization of imaging datasets including biomarkers |
| CN113017632B (zh) * | 2021-03-17 | 2022-11-11 | 陈思 | 一种智慧校园心理咨询辅助方法及系统 |
| EP4486448A1 (en) | 2022-03-04 | 2025-01-08 | Reset Pharmaceuticals, Inc. | Co-crystals or salts comprising psilocin |
| AU2023340289A1 (en) | 2022-09-16 | 2025-03-13 | Asieris Pharmaceuticals (Shanghai) Co., Ltd. | Polymorphic form of nepicastat acid addition salt, preparation method therefor and use thereof |
| WO2024178082A2 (en) * | 2023-02-22 | 2024-08-29 | Freedom Biosciences, Inc. | Composition of opioid receptor modulator and mdma for use thereof |
| CN120754106B (zh) * | 2025-09-02 | 2025-12-09 | 合肥工业大学 | 化合物sch23390在制备治疗铅中毒药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03500411A (ja) * | 1987-10-07 | 1991-01-31 | マトリックス テクノロジーズ インコーポレーテッド | コカイン中毒の処置および治療薬 |
| US5593367A (en) * | 1995-08-18 | 1997-01-14 | Deere & Company | Switchable ignition and starter control system |
| EP0883609A1 (en) * | 1996-02-23 | 1998-12-16 | Pharmeco Laboratories, Inc. | Selective d1 dopamine receptor agonists and partial agonists/antagonists |
| US5958896A (en) * | 1997-08-08 | 1999-09-28 | The Mclean Hospital | Cytidine-containing and cytosine-containing compounds as treatments for stimulant exposure |
| US6541520B1 (en) * | 1998-08-05 | 2003-04-01 | Brookhaven Science Associates | Treatment of addiction and addiction-related behavior |
| DE60214527T2 (de) * | 2001-01-17 | 2007-04-05 | Hythiam, Inc., Los Angeles | Verwendung von flumazenil bei der entwicklung eines arzneimittels zur behandlung von alkoholabhängigkeit |
| US20030040015A1 (en) * | 2001-03-07 | 2003-02-27 | Kwang-Soo Kim | Methods and reagents for identifying compounds and mutations that modulate dopamine beta-hydroxylase activity |
| SE0104388D0 (sv) * | 2001-12-27 | 2001-12-27 | Pharmacia Ab | New formulation and use and manufacture thereof |
| EP1603595B1 (en) * | 2003-02-27 | 2010-11-10 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treatment of drug dependence |
| RU2252756C1 (ru) * | 2003-12-23 | 2005-05-27 | Хохлов Александр Петрович | Препарат против алкоголизма и наркомании, способ получения такого препарата |
| AU2008229203B2 (en) * | 2007-03-16 | 2014-05-29 | Emory University | Methods and compositions for treatment of drug addiction |
| MX2010000938A (es) * | 2007-07-23 | 2010-07-01 | Synosia Therapeutics Inc | Uso de (4-metoxi-7-morfolin-4-il-benzotiazol-2-il)-amida del ácido 4-hidroxi-4-metil-piperidin-1-carboxílico para el tratamiento del trastorno por estrés postraumático. |
| WO2009015244A1 (en) * | 2007-07-23 | 2009-01-29 | Synosia Therapeutics | Rufinamide for the treatment of post-traumatic stress disorder |
| AU2008279091A1 (en) * | 2007-07-23 | 2009-01-29 | Biotie Therapies, Inc | Treatment of post-traumatic stress disorder |
| BRPI0815089A2 (pt) | 2007-08-06 | 2014-09-30 | Synosia Therapeutics Inc | Métodos para tratar um paciente que sofre de ou suscetível a pelo menos um sintoma de abuso de, dependência sobre, ou retirada de pelo menos uma substância, para tratar pelo menos uma fase de dependência de substância sobre pelo menos uma substância em um paciente, e para tratar pelo menos uma fase de dependência à cocaína em um paciente. |
| EP2218804A4 (en) | 2007-11-26 | 2011-08-24 | Bridgestone Corp | GALVANIZATION BATH FROM COPPER-ZINC ALLOY AND PLATING PROCESS WITH GALVANIZING BATH FROM COPPER-ZINC ALLOY |
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| JP2010535801A (ja) | 2010-11-25 |
| BRPI0815089A2 (pt) | 2014-09-30 |
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| WO2009021055A1 (en) | 2009-02-12 |
| EP2182804A1 (en) | 2010-05-12 |
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