RU2491067C2 - Способы лечения зависимости - Google Patents
Способы лечения зависимости Download PDFInfo
- Publication number
- RU2491067C2 RU2491067C2 RU2010108249/15A RU2010108249A RU2491067C2 RU 2491067 C2 RU2491067 C2 RU 2491067C2 RU 2010108249/15 A RU2010108249/15 A RU 2010108249/15A RU 2010108249 A RU2010108249 A RU 2010108249A RU 2491067 C2 RU2491067 C2 RU 2491067C2
- Authority
- RU
- Russia
- Prior art keywords
- cocaine
- compound
- patient
- use according
- symptom
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 8
- 206010012335 Dependence Diseases 0.000 title abstract 2
- 229940126062 Compound A Drugs 0.000 claims abstract 19
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims abstract 19
- 208000022497 Cocaine-Related disease Diseases 0.000 claims abstract 12
- 201000006145 cocaine dependence Diseases 0.000 claims abstract 8
- 206010013663 drug dependence Diseases 0.000 claims abstract 8
- 208000024891 symptom Diseases 0.000 claims abstract 7
- 230000005764 inhibitory process Effects 0.000 claims abstract 5
- 230000000694 effects Effects 0.000 claims abstract 4
- YZZVIKDAOTXDEB-JTQLQIEISA-N nepicastat Chemical compound NCC1=CNC(=S)N1[C@@H]1CC2=CC(F)=CC(F)=C2CC1 YZZVIKDAOTXDEB-JTQLQIEISA-N 0.000 claims abstract 4
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims abstract 3
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims abstract 2
- 238000012423 maintenance Methods 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 38
- 229960003920 cocaine Drugs 0.000 claims 19
- 206010013654 Drug abuse Diseases 0.000 claims 4
- 201000001272 cocaine abuse Diseases 0.000 claims 4
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 3
- 235000019788 craving Nutrition 0.000 claims 3
- 230000002085 persistent effect Effects 0.000 claims 3
- 206010013754 Drug withdrawal syndrome Diseases 0.000 claims 2
- 206010022998 Irritability Diseases 0.000 claims 2
- 238000013019 agitation Methods 0.000 claims 2
- 230000003920 cognitive function Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 206010021654 increased appetite Diseases 0.000 claims 2
- 230000002035 prolonged effect Effects 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- 208000022925 sleep disturbance Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010002942 Apathy Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 206010008479 Chest Pain Diseases 0.000 claims 1
- 206010013954 Dysphoria Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 241001539473 Euphoria Species 0.000 claims 1
- 206010015535 Euphoric mood Diseases 0.000 claims 1
- 206010016059 Facial pain Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000004044 Hypesthesia Diseases 0.000 claims 1
- 208000006550 Mydriasis Diseases 0.000 claims 1
- 206010028735 Nasal congestion Diseases 0.000 claims 1
- 206010052437 Nasal discomfort Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 206010033557 Palpitations Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 238000009225 cognitive behavioral therapy Methods 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 230000006735 deficit Effects 0.000 claims 1
- 208000002173 dizziness Diseases 0.000 claims 1
- 208000001780 epistaxis Diseases 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 230000003340 mental effect Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 230000008058 pain sensation Effects 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 230000035807 sensation Effects 0.000 claims 1
- 208000013220 shortness of breath Diseases 0.000 claims 1
- 201000009032 substance abuse Diseases 0.000 claims 1
- 201000006152 substance dependence Diseases 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 230000001960 triggered effect Effects 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 4
- 229950005868 nepicastat Drugs 0.000 abstract 3
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 2
- 229960003638 dopamine Drugs 0.000 abstract 2
- 229960002748 norepinephrine Drugs 0.000 abstract 2
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 2
- 108010015720 Dopamine beta-Hydroxylase Proteins 0.000 abstract 1
- 102100033156 Dopamine beta-hydroxylase Human genes 0.000 abstract 1
- 241000700159 Rattus Species 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 230000003930 cognitive ability Effects 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000006742 locomotor activity Effects 0.000 abstract 1
- 230000036651 mood Effects 0.000 abstract 1
- 230000007958 sleep Effects 0.000 abstract 1
- 238000011699 spontaneously hypertensive rat Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Images
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61K31/415—1,2-Diazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93532307P | 2007-08-06 | 2007-08-06 | |
| US60/935,323 | 2007-08-06 | ||
| US95655507P | 2007-08-17 | 2007-08-17 | |
| US60/956,555 | 2007-08-17 | ||
| US96059107P | 2007-10-04 | 2007-10-04 | |
| US60/960,591 | 2007-10-04 | ||
| PCT/US2008/072357 WO2009021055A1 (en) | 2007-08-06 | 2008-08-06 | Methods for treating dependence |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010108249A RU2010108249A (ru) | 2011-09-20 |
| RU2491067C2 true RU2491067C2 (ru) | 2013-08-27 |
Family
ID=40341713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010108249/15A RU2491067C2 (ru) | 2007-08-06 | 2008-08-06 | Способы лечения зависимости |
Country Status (16)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0815089A2 (pt) | 2007-08-06 | 2014-09-30 | Synosia Therapeutics Inc | Métodos para tratar um paciente que sofre de ou suscetível a pelo menos um sintoma de abuso de, dependência sobre, ou retirada de pelo menos uma substância, para tratar pelo menos uma fase de dependência de substância sobre pelo menos uma substância em um paciente, e para tratar pelo menos uma fase de dependência à cocaína em um paciente. |
| WO2010124089A2 (en) * | 2009-04-22 | 2010-10-28 | Synosia Therapeutics, Inc. | Methods for treating dependence |
| US9804149B2 (en) * | 2012-10-10 | 2017-10-31 | Bio-Rad Laboratories, Inc. | Patient-based results display |
| CA2919892C (en) | 2013-08-12 | 2019-06-18 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| WO2015095644A1 (en) | 2013-12-20 | 2015-06-25 | AntiOP, Inc. | Intranasal naloxone compositions and methods of making and using same |
| DK3169315T3 (da) | 2014-07-17 | 2020-08-10 | Pharmaceutical Manufacturing Res Services In | Væskefyldt doseringsform til forhindring af misbrug med øjeblikkelig frigivelse |
| JP2017531026A (ja) | 2014-10-20 | 2017-10-19 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド | 徐放性乱用抑止性液体充填剤形 |
| US20170235908A1 (en) * | 2015-11-15 | 2017-08-17 | Oriah Behaviorial Health, Inc. | Systems and Methods for Managing and Treating Substance Abuse Addiction |
| WO2019038756A1 (en) | 2017-08-20 | 2019-02-28 | Solubest Ltd. | DRY POWDER COMPOSITIONS FOR INTRANASAL DELIVERY |
| US11844859B2 (en) | 2017-08-20 | 2023-12-19 | Nasus Pharma Ltd. | Dry powder compositions for intranasal delivery |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| CN108066355A (zh) * | 2017-12-28 | 2018-05-25 | 宁夏恩多芬科技有限公司 | Nitrous Oxide作为治疗神经官能症的用途 |
| FR3093419B1 (fr) * | 2019-03-08 | 2021-06-18 | Univ Grenoble Alpes | Composition et procédé associé de mesure de l’observance thérapeutique |
| KR20220009954A (ko) | 2019-04-17 | 2022-01-25 | 컴퍼스 패쓰파인더 리미티드 | 신경인지 장애, 만성 통증을 치료하고 염증을 감소시키는 방법 |
| PT3873883T (pt) * | 2019-11-07 | 2023-03-24 | Small Pharma Ltd | Método de síntese |
| US11806320B2 (en) * | 2020-02-19 | 2023-11-07 | Endo Ventures Limited | Isoproterenol compositions and methods |
| IL312785A (en) | 2020-05-19 | 2024-07-01 | Cybin Irl Ltd | Denatured Tryptamine Derivatives and Methods of Use |
| IL300689A (en) * | 2020-08-17 | 2023-04-01 | Univ Columbia | Use of neuromelanin-sensitive MRI as a biomarker of dopamine function |
| JP7753359B2 (ja) * | 2020-10-24 | 2025-10-14 | ユニヴェルシテートスピタル バーゼル | ヒト血漿中のリゼルギン酸ジエチルアミド（ｌｓｄ）及び２，３－ジヒドロ－３－ヒドロキシ－２－オキソリセルギド（ｏ－ｈ－ｌｓｄ）を定量化するための方法 |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
| CN112690771B (zh) * | 2020-12-09 | 2022-05-24 | 华南理工大学 | 一种利用线性回归模型的人脸视频心率检测方法 |
| US12079960B2 (en) | 2021-03-11 | 2024-09-03 | Terran Biosciences Inc. | Systems, devices, and methods for harmonization of imaging datasets including biomarkers |
| CN113017632B (zh) * | 2021-03-17 | 2022-11-11 | 陈思 | 一种智慧校园心理咨询辅助方法及系统 |
| EP4486448A1 (en) | 2022-03-04 | 2025-01-08 | Reset Pharmaceuticals, Inc. | Co-crystals or salts comprising psilocin |
| AU2023340289A1 (en) | 2022-09-16 | 2025-03-13 | Asieris Pharmaceuticals (Shanghai) Co., Ltd. | Polymorphic form of nepicastat acid addition salt, preparation method therefor and use thereof |
| WO2024178082A2 (en) * | 2023-02-22 | 2024-08-29 | Freedom Biosciences, Inc. | Composition of opioid receptor modulator and mdma for use thereof |
| CN120754106B (zh) * | 2025-09-02 | 2025-12-09 | 合肥工业大学 | 化合物sch23390在制备治疗铅中毒药物中的应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6593367B1 (en) * | 1998-08-05 | 2003-07-15 | Brookhaven Science Associates | Treatment of addiction and addiction-related behavior |
| RU2252756C1 (ru) * | 2003-12-23 | 2005-05-27 | Хохлов Александр Петрович | Препарат против алкоголизма и наркомании, способ получения такого препарата |
| RU2279871C2 (ru) * | 2001-12-27 | 2006-07-20 | Фармация Аб | Жидкая фармацевтическая композиция, содержащая никотин, для введения в полость рта |
| RU2300378C2 (ru) * | 2001-01-17 | 2007-06-10 | Хитиям, Инк. | Применение флумазенила в производстве лекарства для лечения алкогольной зависимости |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03500411A (ja) * | 1987-10-07 | 1991-01-31 | マトリックス テクノロジーズ インコーポレーテッド | コカイン中毒の処置および治療薬 |
| US5593367A (en) * | 1995-08-18 | 1997-01-14 | Deere & Company | Switchable ignition and starter control system |
| EP0883609A1 (en) * | 1996-02-23 | 1998-12-16 | Pharmeco Laboratories, Inc. | Selective d1 dopamine receptor agonists and partial agonists/antagonists |
| US5958896A (en) * | 1997-08-08 | 1999-09-28 | The Mclean Hospital | Cytidine-containing and cytosine-containing compounds as treatments for stimulant exposure |
| US20030040015A1 (en) * | 2001-03-07 | 2003-02-27 | Kwang-Soo Kim | Methods and reagents for identifying compounds and mutations that modulate dopamine beta-hydroxylase activity |
| EP1603595B1 (en) * | 2003-02-27 | 2010-11-10 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treatment of drug dependence |
| AU2008229203B2 (en) * | 2007-03-16 | 2014-05-29 | Emory University | Methods and compositions for treatment of drug addiction |
| MX2010000938A (es) * | 2007-07-23 | 2010-07-01 | Synosia Therapeutics Inc | Uso de (4-metoxi-7-morfolin-4-il-benzotiazol-2-il)-amida del ácido 4-hidroxi-4-metil-piperidin-1-carboxílico para el tratamiento del trastorno por estrés postraumático. |
| WO2009015244A1 (en) * | 2007-07-23 | 2009-01-29 | Synosia Therapeutics | Rufinamide for the treatment of post-traumatic stress disorder |
| AU2008279091A1 (en) * | 2007-07-23 | 2009-01-29 | Biotie Therapies, Inc | Treatment of post-traumatic stress disorder |
| BRPI0815089A2 (pt) | 2007-08-06 | 2014-09-30 | Synosia Therapeutics Inc | Métodos para tratar um paciente que sofre de ou suscetível a pelo menos um sintoma de abuso de, dependência sobre, ou retirada de pelo menos uma substância, para tratar pelo menos uma fase de dependência de substância sobre pelo menos uma substância em um paciente, e para tratar pelo menos uma fase de dependência à cocaína em um paciente. |
| EP2218804A4 (en) | 2007-11-26 | 2011-08-24 | Bridgestone Corp | GALVANIZATION BATH FROM COPPER-ZINC ALLOY AND PLATING PROCESS WITH GALVANIZING BATH FROM COPPER-ZINC ALLOY |
-
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- 2020-01-07 US US16/736,609 patent/US20200383951A1/en not_active Abandoned
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6593367B1 (en) * | 1998-08-05 | 2003-07-15 | Brookhaven Science Associates | Treatment of addiction and addiction-related behavior |
| RU2300378C2 (ru) * | 2001-01-17 | 2007-06-10 | Хитиям, Инк. | Применение флумазенила в производстве лекарства для лечения алкогольной зависимости |
| RU2279871C2 (ru) * | 2001-12-27 | 2006-07-20 | Фармация Аб | Жидкая фармацевтическая композиция, содержащая никотин, для введения в полость рта |
| RU2252756C1 (ru) * | 2003-12-23 | 2005-05-27 | Хохлов Александр Петрович | Препарат против алкоголизма и наркомании, способ получения такого препарата |
Non-Patent Citations (2)
| Title |
|---|
| STANLEY WC et al. Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. Br J Pharmacol. 1997 Aug; 121(8): 1803-9. [online] [Найдено из базы данных PubMed PMID: 9283721] [найдено 29.03.2012]. KURAN W. [Dopamine agonists-clinical applications beyond Parkinson's disease]. Neurol. Neurochir Pol. 2007 Mar-Apr; 41(2 Suppi 1):S54-8. Реферат [online] [Найдено из базы данных PubMed PMID: 17941460] [найдено 29.03.2012]. * |
| О'БРАЙЕН. Фармакотерапия в наркологии [онлайн] [найдено 2012-03-29] (Найдено из интернета: <URL:narcom.ru/publ/info/918), разделы «фармакологические аспекты употребления кокаина», «медикаментозное лечение» // РУКОВОДСТВО ПО МЕДИЦИНЕ «THE MERCK MANUAL». - M.: Мир, 1997, т.2, с.23, статья «зависимость кокаинового типа». * |
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| US20090041800A1 (en) | 2009-02-12 |
| CO6260015A2 (es) | 2011-03-22 |
| RU2010108249A (ru) | 2011-09-20 |
| MX357542B (es) | 2018-07-13 |
| CA2695372C (en) | 2013-01-22 |
| EP3251670A1 (en) | 2017-12-06 |
| MX2010001390A (es) | 2010-08-02 |
| JP2018154645A (ja) | 2018-10-04 |
| SG183696A1 (en) | 2012-09-27 |
| CA2695372A1 (en) | 2009-02-12 |
| CN101815438A (zh) | 2010-08-25 |
| US20200383951A1 (en) | 2020-12-10 |
| MX391921B (es) | 2025-03-21 |
| US10561638B2 (en) | 2020-02-18 |
| AU2008283903A1 (en) | 2009-02-12 |
| EP2182804B1 (en) | 2017-05-24 |
| CN106983747A (zh) | 2017-07-28 |
| ES2638190T3 (es) | 2017-10-19 |
| SG10201705968RA (en) | 2017-08-30 |
| JP2014148551A (ja) | 2014-08-21 |
| JP2020114883A (ja) | 2020-07-30 |
| JP2016210798A (ja) | 2016-12-15 |
| JP2010535801A (ja) | 2010-11-25 |
| BRPI0815089A2 (pt) | 2014-09-30 |
| NZ583192A (en) | 2012-06-29 |
| EP2182804A4 (en) | 2010-12-22 |
| PH12015502210A1 (en) | 2017-04-10 |
| IL257418A (en) | 2018-04-30 |
| US20140099336A1 (en) | 2014-04-10 |
| MX2022001510A (es) | 2022-08-11 |
| WO2009021055A1 (en) | 2009-02-12 |
| EP2182804A1 (en) | 2010-05-12 |
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