ES2633439T3 - Método no basado en enzimas para el seguimiento electrónico de un indicador biológico - Google Patents
Método no basado en enzimas para el seguimiento electrónico de un indicador biológico Download PDFInfo
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- ES2633439T3 ES2633439T3 ES14709495.7T ES14709495T ES2633439T3 ES 2633439 T3 ES2633439 T3 ES 2633439T3 ES 14709495 T ES14709495 T ES 14709495T ES 2633439 T3 ES2633439 T3 ES 2633439T3
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108603216B (zh) * | 2016-01-25 | 2022-05-17 | 美国消毒公司 | 用于检测活微生物的电容器 |
| JP2020508678A (ja) * | 2017-02-28 | 2020-03-26 | アメリカン ステリライザー カンパニー | 蛍光による微生物の検出のための回復培地 |
| CN106983517B (zh) * | 2017-03-31 | 2019-10-29 | 北京工业大学 | 一种无酶纳米柔性血糖微传感器及其制备方法 |
| US10900062B2 (en) * | 2017-07-14 | 2021-01-26 | American Sterilizer Company | Process for determining viability of test microorganisms of biological indicator and sterilization detection device for determining same |
| US10889848B2 (en) | 2017-07-14 | 2021-01-12 | American Sterilizer Company | Process for determining viability of test microorganisms of biological indicator and sterilization detection device for determining same |
| US10876144B2 (en) * | 2017-07-14 | 2020-12-29 | American Sterilizer Company | Process for determining viability of test microorganisms of biological indicator and sterilization detection device for determining same |
| US11309846B2 (en) * | 2017-08-25 | 2022-04-19 | University Of South Florida | Cascode common source transimpedance amplifiers for analyte monitoring systems |
| US20210236677A1 (en) * | 2018-05-17 | 2021-08-05 | Tuttnauer Ltd. | Sterilization monitor |
| US11850320B2 (en) * | 2018-12-20 | 2023-12-26 | Asp Global Manufacturing Gmbh | Liquid-chemical sterilization system with biological indicator |
| CN113518630B (zh) * | 2018-12-28 | 2024-01-26 | 爱思帕全球制造有限公司 | 用于指示处理的物品、系统和方法 |
| CA3137416A1 (en) | 2019-04-24 | 2020-10-29 | 3M Innovative Properties Company | Sterilization indicator sensor with a sterilant-responsive switch |
| US11603551B2 (en) | 2020-12-02 | 2023-03-14 | Steritec Products Mfg. Co., Inc. | Biological indicators, and systems and methods for determining efficacy of sterilization |
| US20220178922A1 (en) * | 2020-12-03 | 2022-06-09 | Merit Medical Systems, Inc. | Pathogen sampling and testing |
| WO2022150191A1 (en) | 2021-01-06 | 2022-07-14 | Crosstex International, Inc. | Biological indicator reader, system and methods of use |
| CN112881484B (zh) * | 2021-01-14 | 2021-11-16 | 东北大学 | 一种非酶血糖检测的3d电极制备方法 |
| AU2024206375A1 (en) * | 2023-01-08 | 2025-07-03 | American Sterilizer Company | Process indicator isolation chamber for medical device processor |
| CN116590133A (zh) * | 2023-04-06 | 2023-08-15 | 杭州奥明瑞康医学检验实验室有限公司 | 一种快速检测灭菌效果的芯片 |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS636451A (ja) | 1986-06-27 | 1988-01-12 | Terumo Corp | 酵素センサ |
| US4935346A (en) | 1986-08-13 | 1990-06-19 | Lifescan, Inc. | Minimum procedure system for the determination of analytes |
| US5593852A (en) | 1993-12-02 | 1997-01-14 | Heller; Adam | Subcutaneous glucose electrode |
| US5413690A (en) | 1993-07-23 | 1995-05-09 | Boehringer Mannheim Corporation | Potentiometric biosensor and the method of its use |
| AU722471B2 (en) | 1995-10-17 | 2000-08-03 | Lifescan, Inc. | Blood glucose strip having reduced sensitivity to hematocrit |
| US5962215A (en) | 1996-04-05 | 1999-10-05 | Mercury Diagnostics, Inc. | Methods for testing the concentration of an analyte in a body fluid |
| AU6157898A (en) | 1997-02-06 | 1998-08-26 | E. Heller & Company | Small volume (in vitro) analyte sensor |
| US20050033132A1 (en) | 1997-03-04 | 2005-02-10 | Shults Mark C. | Analyte measuring device |
| US6862465B2 (en) | 1997-03-04 | 2005-03-01 | Dexcom, Inc. | Device and method for determining analyte levels |
| US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
| US5770393A (en) * | 1997-04-01 | 1998-06-23 | Steris Corporation | Biological indicator for detection of early metabolic activity |
| US6168957B1 (en) | 1997-06-25 | 2001-01-02 | Lifescan, Inc. | Diagnostic test strip having on-strip calibration |
| BR9811609A (pt) * | 1997-09-05 | 2000-09-05 | Abbott Lab | Sensor eletroquìmico com áreas de elétrodo equalizadas |
| US6102872A (en) | 1997-11-03 | 2000-08-15 | Pacific Biometrics, Inc. | Glucose detector and method |
| US5997817A (en) | 1997-12-05 | 1999-12-07 | Roche Diagnostics Corporation | Electrochemical biosensor test strip |
| US6103033A (en) | 1998-03-04 | 2000-08-15 | Therasense, Inc. | Process for producing an electrochemical biosensor |
| GB2337122B (en) * | 1998-05-08 | 2002-11-13 | Medisense Inc | Test strip |
| US6077660A (en) | 1998-06-10 | 2000-06-20 | Abbott Laboratories | Diagnostic assay requiring a small sample of biological fluid |
| US6162397A (en) | 1998-08-13 | 2000-12-19 | Lifescan, Inc. | Visual blood glucose test strip |
| US5902731A (en) | 1998-09-28 | 1999-05-11 | Lifescan, Inc. | Diagnostics based on tetrazolium compounds |
| US6338790B1 (en) | 1998-10-08 | 2002-01-15 | Therasense, Inc. | Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator |
| US6193873B1 (en) | 1999-06-15 | 2001-02-27 | Lifescan, Inc. | Sample detection to initiate timing of an electrochemical assay |
| US7045054B1 (en) | 1999-09-20 | 2006-05-16 | Roche Diagnostics Corporation | Small volume biosensor for continuous analyte monitoring |
| US6616819B1 (en) | 1999-11-04 | 2003-09-09 | Therasense, Inc. | Small volume in vitro analyte sensor and methods |
| US6716577B1 (en) | 2000-02-02 | 2004-04-06 | Lifescan, Inc. | Electrochemical test strip for use in analyte determination |
| US6485923B1 (en) | 2000-02-02 | 2002-11-26 | Lifescan, Inc. | Reagent test strip for analyte determination having hemolyzing agent |
| IL151914A0 (en) | 2000-03-31 | 2003-04-10 | Lifescan Inc | Electrically-conductive patterns for monitoring the filling of medical devices |
| DE60123841T2 (de) | 2000-08-01 | 2007-05-16 | Charm Sciences, Inc., Lawrence | Hygieneüberwachung |
| US6555061B1 (en) | 2000-10-05 | 2003-04-29 | Lifescan, Inc. | Multi-layer reagent test strip |
| US6562625B2 (en) | 2001-02-28 | 2003-05-13 | Home Diagnostics, Inc. | Distinguishing test types through spectral analysis |
| US6855243B2 (en) | 2001-04-27 | 2005-02-15 | Lifescan, Inc. | Electrochemical test strip having a plurality of reaction chambers and methods for using the same |
| US6721586B2 (en) | 2001-06-12 | 2004-04-13 | Lifescan, Inc. | Percutaneous biological fluid sampling and analyte measurement devices and methods |
| US6723500B2 (en) | 2001-12-05 | 2004-04-20 | Lifescan, Inc. | Test strips having reaction zones and channels defined by a thermally transferred hydrophobic barrier |
| US20070208243A1 (en) | 2002-01-16 | 2007-09-06 | Nanomix, Inc. | Nanoelectronic glucose sensors |
| US7226978B2 (en) | 2002-05-22 | 2007-06-05 | Dexcom, Inc. | Techniques to improve polyurethane membranes for implantable glucose sensors |
| US7244394B2 (en) | 2002-10-03 | 2007-07-17 | Novartis Ag | Methods and kits for assays of analytes of interest in tears |
| US7303875B1 (en) | 2002-10-10 | 2007-12-04 | Nanosys, Inc. | Nano-chem-FET based biosensors |
| US7964390B2 (en) | 2002-10-11 | 2011-06-21 | Case Western Reserve University | Sensor system |
| US20050038329A1 (en) | 2002-11-20 | 2005-02-17 | Morris Carol Ann | Methods and kits for assays of rapid screening of diabetes |
| KR100554649B1 (ko) | 2003-06-09 | 2006-02-24 | 주식회사 아이센스 | 전기화학적 바이오센서 |
| ES2366030T3 (es) | 2003-10-24 | 2011-10-14 | Bayer Healthcare, Llc | Biosensor electroquímico enzimático. |
| US20050133368A1 (en) | 2003-10-31 | 2005-06-23 | Davies Oliver W.H. | Electrochemical test strip for reducing the effect of direct interference current |
| US7655119B2 (en) | 2003-10-31 | 2010-02-02 | Lifescan Scotland Limited | Meter for use in an improved method of reducing interferences in an electrochemical sensor using two different applied potentials |
| RU2006144443A (ru) | 2004-05-14 | 2008-06-20 | БАЙЕР ХЕЛТКЭР ЭлЭлСи (US) | Диагностическая индикаторная полоска для взятия пробы текучей среды и определения в ней аналита и способ ее применения |
| US20070027383A1 (en) | 2004-07-01 | 2007-02-01 | Peyser Thomas A | Patches, systems, and methods for non-invasive glucose measurement |
| US7964372B2 (en) | 2004-12-13 | 2011-06-21 | Bayer Healthcare Llc | Size self-limiting compositions and test devices for measuring analytes in biological fluids |
| US8133178B2 (en) | 2006-02-22 | 2012-03-13 | Dexcom, Inc. | Analyte sensor |
| US8105244B2 (en) | 2005-11-30 | 2012-01-31 | Abbott Diabetes Care Inc. | Integrated sensor for analyzing biological samples |
| US7914460B2 (en) | 2006-08-15 | 2011-03-29 | University Of Florida Research Foundation, Inc. | Condensate glucose analyzer |
| US20080057528A1 (en) | 2006-08-30 | 2008-03-06 | Kimberly-Clark Worldwide, Inc. | Detection of hydrogen peroxide released by enzyme-catalyzed oxidation of an analyte |
| US8043845B2 (en) | 2006-09-20 | 2011-10-25 | American Sterilizer Company | Sterilization indicator |
| US7740801B2 (en) | 2006-10-31 | 2010-06-22 | Lifescan Scotland Limited | System for determination of an analyte in a bodily fluid sample that includes an electroluminescent component |
| US20080177166A1 (en) | 2007-01-18 | 2008-07-24 | Provex Technologies, Llc | Ultrasensitive amperometric saliva glucose sensor strip |
| US8812071B2 (en) | 2007-03-07 | 2014-08-19 | Echo Therapeutics, Inc. | Transdermal analyte monitoring systems and methods for analyte detection |
| US7875461B2 (en) | 2007-07-24 | 2011-01-25 | Lifescan Scotland Limited | Test strip and connector |
| US7943022B2 (en) | 2007-09-04 | 2011-05-17 | Lifescan, Inc. | Analyte test strip with improved reagent deposition |
| WO2009054516A1 (ja) | 2007-10-26 | 2009-04-30 | Arkray, Inc. | 試料検知装置およびこれを備えた測定装置 |
| US8603768B2 (en) | 2008-01-17 | 2013-12-10 | Lifescan, Inc. | System and method for measuring an analyte in a sample |
| EP2254458A1 (en) | 2008-02-04 | 2010-12-01 | Bayer HealthCare, LLC | Semiconductor based analyte sensors and methods |
| US7922985B2 (en) | 2008-06-24 | 2011-04-12 | Lifescan, Inc. | Analyte test strip for accepting diverse sample volumes |
| US8178313B2 (en) | 2008-06-24 | 2012-05-15 | Lifescan, Inc. | Method for determining an analyte in a bodily fluid |
| US8173388B2 (en) * | 2008-09-30 | 2012-05-08 | American Sterilizer Company | Self-contained biological indicator |
| GB2469071A (en) | 2009-03-31 | 2010-10-06 | Diamatrix Ltd | Electrochemical test device |
| US20100270152A1 (en) | 2009-04-24 | 2010-10-28 | Lifescan Scotland Limited | Enzymatic reagent ink |
| US20100273249A1 (en) | 2009-04-24 | 2010-10-28 | Lifescan Scotland Limited | Analytical test strips |
| US8868151B2 (en) | 2009-08-14 | 2014-10-21 | Bayer Healthcare Llc | Electrochemical impedance spectroscopy enabled continuous glucose monitoring sensor system |
| US20110048972A1 (en) | 2009-08-31 | 2011-03-03 | Lifescan Scotland Limited | Multi-analyte test strip with shared counter/reference electrode and inline electrode configuration |
| US8101065B2 (en) | 2009-12-30 | 2012-01-24 | Lifescan, Inc. | Systems, devices, and methods for improving accuracy of biosensors using fill time |
| US8742773B2 (en) | 2010-02-25 | 2014-06-03 | Lifescan Scotland Limited | Capacitance detection in electrochemical assay with improved response |
| US20110290668A1 (en) | 2010-05-27 | 2011-12-01 | Lifescan Scotland Limited | Analytical test strip with crossroads exposed electrode configuration |
| US9215995B2 (en) | 2010-06-23 | 2015-12-22 | Medtronic Minimed, Inc. | Sensor systems having multiple probes and electrode arrays |
| CN103119173B (zh) | 2010-07-20 | 2015-03-04 | 美国消毒公司 | 监测灭菌处理的方法 |
| US8409412B2 (en) | 2010-08-23 | 2013-04-02 | Lifescan Scotland, Ltd. | Enzymatic reagent inks for use in test strips having a predetermined calibration code |
| US20120097554A1 (en) | 2010-10-18 | 2012-04-26 | Medtronic Minimed, Inc. | Analyte sensors comprising electrodes having selected electrochemical and mechanical properties |
| EP2654808A1 (en) * | 2010-12-22 | 2013-10-30 | 3M Innovative Properties Company | Sterilization indicators including a porous carrier and methods |
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| MX350466B (es) | 2017-09-07 |
| CN105143460B (zh) | 2017-03-15 |
| BR112015023529B1 (pt) | 2021-11-03 |
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| AU2014238199A1 (en) | 2015-10-29 |
| US9121050B2 (en) | 2015-09-01 |
| CN105143460A (zh) | 2015-12-09 |
| US20140262829A1 (en) | 2014-09-18 |
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