ES2619374T3 - Procedimiento de preparación de sal derivada de diamina ópticamente activa - Google Patents

Procedimiento de preparación de sal derivada de diamina ópticamente activa Download PDF

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Publication number
ES2619374T3
ES2619374T3 ES11801000.8T ES11801000T ES2619374T3 ES 2619374 T3 ES2619374 T3 ES 2619374T3 ES 11801000 T ES11801000 T ES 11801000T ES 2619374 T3 ES2619374 T3 ES 2619374T3
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Spain
Prior art keywords
organic solvent
compound
crystals
compound represented
formula
Prior art date
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Active
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ES11801000.8T
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English (en)
Spanish (es)
Inventor
Koutarou Kawanami
Hideaki Ishikawa
Masahiro Shoji
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Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
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Publication of ES2619374T3 publication Critical patent/ES2619374T3/es
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/08Separation; Purification; Stabilisation; Use of additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42Separation; Purification; Stabilisation; Use of additives
    • C07C51/43Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02Dicarboxylic acids
    • C07C55/06Oxalic acid
    • C07C55/07Salts thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ES11801000.8T 2010-07-02 2011-07-01 Procedimiento de preparación de sal derivada de diamina ópticamente activa Active ES2619374T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2010151922 2010-07-02
JP2010151922 2010-07-02
PCT/JP2011/065192 WO2012002538A1 (ja) 2010-07-02 2011-07-01 光学活性ジアミン誘導体の塩の製造方法

Publications (1)

Publication Number Publication Date
ES2619374T3 true ES2619374T3 (es) 2017-06-26

Family

ID=45402240

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11801000.8T Active ES2619374T3 (es) 2010-07-02 2011-07-01 Procedimiento de preparación de sal derivada de diamina ópticamente activa

Country Status (12)

Country Link
US (1) US8901345B2 (de)
EP (1) EP2589590B1 (de)
JP (1) JP5780657B2 (de)
KR (1) KR101795096B1 (de)
CN (1) CN103080078B (de)
BR (1) BR112013000085B1 (de)
CA (2) CA2859191C (de)
ES (1) ES2619374T3 (de)
HU (1) HUE031961T2 (de)
IL (1) IL223813A (de)
TW (1) TWI630209B (de)
WO (1) WO2012002538A1 (de)

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WO2010104106A1 (ja) 2009-03-13 2010-09-16 第一三共株式会社 光学活性なジアミン誘導体の製造方法
EP2922833A1 (de) * 2012-11-23 2015-09-30 Daiichi Sankyo Co., Ltd. Verfahren zur herstellung von (1s, 4s, 5s)-4-brom-6oxabicyclo[3.2.1]oktan-7-on
EP2980090A4 (de) * 2013-03-29 2016-11-09 Daiichi Sankyo Co Ltd Verfahren zur herstellung von (1s, 4s, 5s -4-brom-6-oxabicyclo[3.2.1]octan-7-on
TWI602803B (zh) * 2013-03-29 2017-10-21 第一三共股份有限公司 光學活性二胺衍生物之製造方法
US9806380B2 (en) 2013-05-31 2017-10-31 General Electric Company High temperature electrochemical cell structures, and methods for making
WO2015129603A1 (ja) * 2014-02-25 2015-09-03 第一三共株式会社 活性化血液凝固第X因子(FXa)阻害剤の高純度結晶
CN104761571B (zh) * 2015-03-10 2017-03-08 山东科兴生物制品有限公司 一种依度沙班的合成方法
CN106316889B (zh) * 2015-06-15 2020-07-10 上海阳帆医药科技有限公司 依度沙班中间体的制备方法
CN107033163A (zh) * 2015-07-16 2017-08-11 浙江海正药业股份有限公司 一种依度沙班对苯甲磺酸盐新晶型及其制备方法和应用
EP3484893A1 (de) * 2016-07-13 2019-05-22 Mylan Laboratories Ltd. Salz von amingeschütztem (1s,2r,4s)-1,2-amino-n,n-dimethylcyclohexan-4-carboxamid
EP3318568A1 (de) * 2016-11-04 2018-05-09 Esteve Química, S.A. Herstellungsverfahren für edoxaban-tosylat-monohydrat
ES2722854B2 (es) * 2018-02-14 2019-12-20 Moehs Iberica Sl Procedimiento para preparar n-((1r,2s,5s)-2-((2-((5-cloropiridin-2-il)amino)-2-oxoacetil)amino)-5-(dimetilcarbamoil) ciclohexil)carbamato de terc-butilo
CN109942600B (zh) * 2019-04-15 2021-08-20 内蒙古京东药业有限公司 一种依度沙班的制备方法
US20220251112A1 (en) * 2019-07-04 2022-08-11 Glenmark Life Sciences Limited Process for preparation of edoxaban
KR102090912B1 (ko) * 2019-12-18 2020-03-18 유니셀랩 주식회사 신규한 결정형 형태의 에독사반 및 이의 제조방법
CN111606827B (zh) * 2020-06-23 2022-10-25 内蒙古京东药业有限公司 一种制备依度沙班手性胺中间体的方法
CN111606826B (zh) * 2020-07-02 2022-02-22 沧州那瑞化学科技有限公司 一种依度沙班中间体的制备方法
CN112940012B (zh) * 2021-05-17 2021-09-03 上海翰森生物医药科技有限公司 一种依度沙班及其中间体的制备方法
CN116102465A (zh) * 2023-02-17 2023-05-12 珠海市海瑞德生物科技有限公司 光学活性二胺化合物的制备方法

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US4582570A (en) * 1981-07-24 1986-04-15 Merix Corporation Azeotropic dehydration distillation process
FR2590575B1 (fr) * 1985-11-25 1988-01-29 Interox Sa Procede pour la fabrication d'oxydes d'amines tertiaires aromatiques et produits ainsi obtenus
US5149855A (en) 1989-12-26 1992-09-22 Mitsubishi Rayon Co., Ltd. Process for racemizing optically active carboxylic acid esters
US5055600A (en) 1990-04-24 1991-10-08 Rockwell International Corporation Glycidyl azide polymer (gap) synthesis by molten salt method
US5677469A (en) 1995-05-18 1997-10-14 Sepracor, Inc. Process for resolving chiral acids with 1-aminoindan-2-ols
JPH11180899A (ja) 1997-12-15 1999-07-06 Mitsui Chem Inc 活性メチレンアルキル化化合物の製造法
JP3680203B2 (ja) 1999-06-01 2005-08-10 東洋化成工業株式会社 4−アセチルアミノベンゼンスルホニルアジドの製造方法
JP2001151724A (ja) 1999-11-19 2001-06-05 Kuraray Co Ltd 光学活性な2,2,4−トリメチル−3−シクロヘキセンカルボン酸の製造方法
TWI290136B (en) * 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
EP1405852B9 (de) 2001-06-20 2013-03-27 Daiichi Sankyo Company, Limited Diaminderivate
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KR20050110612A (ko) 2002-12-25 2005-11-23 다이이찌 세이야꾸 가부시기가이샤 디아민 유도체
HUE028247T2 (en) 2003-04-08 2016-12-28 Novartis Ag A solid oral composition comprising S1P receptor agonist and sugar alcohol
KR101170179B1 (ko) 2003-11-12 2012-07-31 다이이찌 산쿄 가부시키가이샤 티아졸 유도체의 제조법
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
CA2621640C (en) * 2005-09-16 2013-10-29 Daiichi Sankyo Company, Limited Optically active diamine derivative and process for producing the same
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TW200909437A (en) 2007-06-21 2009-03-01 Daiichi Sankyo Co Ltd Process for the preparation of diamine-derivatives
WO2010021093A1 (ja) * 2008-08-18 2010-02-25 第一三共株式会社 不斉有機触媒
ES2600783T3 (es) 2008-12-19 2017-02-10 Daiichi Sankyo Company, Limited Régimen de dosificación de edoxabán
JP2010254615A (ja) 2009-04-24 2010-11-11 Daiichi Sankyo Co Ltd ジアミン誘導体の結晶

Also Published As

Publication number Publication date
CA2859191A1 (en) 2012-01-05
KR101795096B1 (ko) 2017-12-01
CN103080078B (zh) 2015-02-11
WO2012002538A1 (ja) 2012-01-05
KR20130118220A (ko) 2013-10-29
EP2589590A1 (de) 2013-05-08
BR112013000085A2 (pt) 2016-05-10
BR112013000085B1 (pt) 2022-04-19
EP2589590A4 (de) 2015-08-05
TW201206948A (en) 2012-02-16
CA2804262C (en) 2016-04-05
CN103080078A (zh) 2013-05-01
US8901345B2 (en) 2014-12-02
TWI630209B (zh) 2018-07-21
CA2804262A1 (en) 2012-01-05
IL223813A0 (en) 2013-03-05
EP2589590B1 (de) 2016-12-28
IL223813A (en) 2016-09-29
JPWO2012002538A1 (ja) 2013-08-29
CA2859191C (en) 2016-05-17
JP5780657B2 (ja) 2015-09-16
HUE031961T2 (en) 2017-09-28
US20130165657A1 (en) 2013-06-27

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