ES2616444T3 - Expresión del receptor Eph en las células madre tumorales - Google Patents

Expresión del receptor Eph en las células madre tumorales Download PDF

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Publication number
ES2616444T3
ES2616444T3 ES11778540.2T ES11778540T ES2616444T3 ES 2616444 T3 ES2616444 T3 ES 2616444T3 ES 11778540 T ES11778540 T ES 11778540T ES 2616444 T3 ES2616444 T3 ES 2616444T3
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ES
Spain
Prior art keywords
epha2
cells
gbm
derived
cmcs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11778540.2T
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English (en)
Spanish (es)
Inventor
Angelo Luigi Vescovi
Elena Binda
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STEMGEN SpA
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STEMGEN SpA
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Publication of ES2616444T3 publication Critical patent/ES2616444T3/es
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES11778540.2T 2010-10-01 2011-09-30 Expresión del receptor Eph en las células madre tumorales Active ES2616444T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10185930 2010-10-01
EP10185930A EP2446895A1 (en) 2010-10-01 2010-10-01 EPH receptor expression in tumor stem cells
PCT/EP2011/067114 WO2012042021A1 (en) 2010-10-01 2011-09-30 Eph receptor expression in tumor stem cells

Publications (1)

Publication Number Publication Date
ES2616444T3 true ES2616444T3 (es) 2017-06-13

Family

ID=43856109

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11778540.2T Active ES2616444T3 (es) 2010-10-01 2011-09-30 Expresión del receptor Eph en las células madre tumorales

Country Status (11)

Country Link
US (1) US9078857B2 (https=)
EP (2) EP2446895A1 (https=)
JP (4) JP2013540117A (https=)
KR (2) KR101719966B1 (https=)
AU (1) AU2011310109B2 (https=)
CA (1) CA2813101C (https=)
DK (1) DK2621513T3 (https=)
ES (1) ES2616444T3 (https=)
NZ (1) NZ609594A (https=)
PL (1) PL2621513T3 (https=)
WO (1) WO2012042021A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012118547A1 (en) 2010-12-08 2012-09-07 Stem Centrx, Inc. Novel modulators and methods of use
SA112330278B1 (ar) 2011-02-18 2015-10-09 ستيم سينتركس، انك. مواد ضابطة جديدة وطرق للاستخدام
EP2733206A1 (en) * 2012-11-19 2014-05-21 Naroa LLC Method for the isolation for mammalian stem cells using EphA2 and uses thereof
CN105828841A (zh) 2013-11-04 2016-08-03 辉瑞大药厂 抗-efna4抗体-药物缀合物
US9777070B2 (en) 2014-04-30 2017-10-03 Pfizer Inc Anti-PTK7 antibody-drug conjugates
JP6921755B2 (ja) 2014-12-10 2021-08-18 ハイパーステム ソシエテ アノニム 脳腫瘍幹細胞の成長、遊走および浸潤性を低下させ脳腫瘍患者の生存率を改善する方法および組成物
CN107851031B (zh) 2015-05-08 2021-05-28 佛罗乔有限责任公司 数据发现节点
IL289849B2 (en) 2015-11-10 2024-01-01 Nat Inst Biotechnology Negev Ltd Means and methods for reducing tumorigenicity of cancer stem cells
JP7680047B2 (ja) * 2020-03-31 2025-05-20 慶應義塾 ゲノム編集多能性幹細胞を用いた治療薬
WO2026022122A1 (en) * 2024-07-23 2026-01-29 Eos Research Sa Checkpoint inhibitors in the treatment of glioblastoma multiforme

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004281834A1 (en) * 2003-10-15 2005-04-28 Cerus Corporation Listeria-based EphA2 vaccines
EP1778726A4 (en) * 2004-08-16 2009-03-18 Medimmune Inc INTEGRIN ANTAGONISTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-ASSAYED CYTOTOXICITY ACTIVITY
US20070248628A1 (en) * 2005-12-06 2007-10-25 Keller Lorraine H Immunogens in cancer stem cells
US8343461B2 (en) * 2006-03-08 2013-01-01 Wake Forest University Health Sciences Molecular signature of cancer
HRP20170407T1 (hr) * 2007-08-30 2017-05-05 Daiichi Sankyo Company, Limited Anti-epha2 anitijelo

Also Published As

Publication number Publication date
CA2813101C (en) 2018-10-30
WO2012042021A1 (en) 2012-04-05
KR20130095286A (ko) 2013-08-27
JP2013540117A (ja) 2013-10-31
EP2621513A1 (en) 2013-08-07
US20120083454A1 (en) 2012-04-05
JP2016094391A (ja) 2016-05-26
AU2011310109B2 (en) 2014-11-20
EP2446895A1 (en) 2012-05-02
JP2018048151A (ja) 2018-03-29
EP2621513B1 (en) 2016-12-28
US9078857B2 (en) 2015-07-14
CA2813101A1 (en) 2012-04-05
KR101719966B1 (ko) 2017-03-24
KR20160027106A (ko) 2016-03-09
AU2011310109A1 (en) 2013-05-02
JP2020037579A (ja) 2020-03-12
DK2621513T3 (en) 2017-03-06
PL2621513T3 (pl) 2017-06-30
JP6523910B2 (ja) 2019-06-05
JP6618968B2 (ja) 2019-12-11
NZ609594A (en) 2015-01-30

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