ES2614923T3 - Combinación de antibióticos para tratar una enfermedad autoinmune - Google Patents
Combinación de antibióticos para tratar una enfermedad autoinmune Download PDFInfo
- Publication number
- ES2614923T3 ES2614923T3 ES12834382.9T ES12834382T ES2614923T3 ES 2614923 T3 ES2614923 T3 ES 2614923T3 ES 12834382 T ES12834382 T ES 12834382T ES 2614923 T3 ES2614923 T3 ES 2614923T3
- Authority
- ES
- Spain
- Prior art keywords
- eae
- mice
- disease
- treatment
- vehicle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000003115 biocidal effect Effects 0.000 title description 2
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 238000011282 treatment Methods 0.000 abstract description 28
- WDQPAMHFFCXSNU-BGABXYSRSA-N clofazimine Chemical compound C12=CC=CC=C2N=C2C=C(NC=3C=CC(Cl)=CC=3)C(=N/C(C)C)/C=C2N1C1=CC=C(Cl)C=C1 WDQPAMHFFCXSNU-BGABXYSRSA-N 0.000 abstract description 7
- 229960004287 clofazimine Drugs 0.000 abstract description 7
- ZWBTYMGEBZUQTK-PVLSIAFMSA-N [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,32-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23-dioxospiro[8,33-dioxa-24,27,29-triazapentacyclo[23.6.1.14,7.05,31.026,30]tritriaconta-1(32),2,4,9,19,21,24,26,30-nonaene-28,4'-piperidine]-13-yl] acetate Chemical compound CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c4NC5(CCN(CC(C)C)CC5)N=c4c(=NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C ZWBTYMGEBZUQTK-PVLSIAFMSA-N 0.000 abstract description 5
- 229960002626 clarithromycin Drugs 0.000 abstract description 5
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 abstract description 5
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- LHYQAEFVHIZFLR-UHFFFAOYSA-L 4-(4-diazonio-3-methoxyphenyl)-2-methoxybenzenediazonium;dichloride Chemical compound [Cl-].[Cl-].C1=C([N+]#N)C(OC)=CC(C=2C=C(OC)C([N+]#N)=CC=2)=C1 LHYQAEFVHIZFLR-UHFFFAOYSA-L 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161536824P | 2011-09-20 | 2011-09-20 | |
| US201161536824P | 2011-09-20 | ||
| US201161537229P | 2011-09-21 | 2011-09-21 | |
| US201161537229P | 2011-09-21 | ||
| PCT/IB2012/002252 WO2013041963A2 (en) | 2011-09-20 | 2012-09-19 | A composition and method for treating an autoimmune disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2614923T3 true ES2614923T3 (es) | 2017-06-02 |
Family
ID=47914967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12834382.9T Active ES2614923T3 (es) | 2011-09-20 | 2012-09-19 | Combinación de antibióticos para tratar una enfermedad autoinmune |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9901638B2 (https=) |
| EP (1) | EP2758061B1 (https=) |
| JP (1) | JP6035340B2 (https=) |
| KR (1) | KR101987512B1 (https=) |
| CN (1) | CN103813797B (https=) |
| AU (1) | AU2012311235B2 (https=) |
| BR (1) | BR112014006473A2 (https=) |
| CA (1) | CA2849255C (https=) |
| CL (1) | CL2014000671A1 (https=) |
| DK (1) | DK2758061T3 (https=) |
| ES (1) | ES2614923T3 (https=) |
| HU (1) | HUE032959T2 (https=) |
| IL (1) | IL231489A (https=) |
| IN (1) | IN2014CN02908A (https=) |
| MX (1) | MX347660B (https=) |
| PL (1) | PL2758061T3 (https=) |
| PT (1) | PT2758061T (https=) |
| RU (1) | RU2621129C2 (https=) |
| SG (1) | SG11201400386RA (https=) |
| TW (1) | TWI573590B (https=) |
| WO (1) | WO2013041963A2 (https=) |
| ZA (1) | ZA201401954B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20160089363A1 (en) * | 2013-04-30 | 2016-03-31 | Thomas Julius Borody | Compositions and methods for treating microbiota-related psychotropic conditions and diseases |
| EP3145510B8 (en) * | 2014-05-22 | 2021-10-27 | Kuenstner, John, Todd | Treatment of diseases using combination of ultraviolet blood irradiation and antibiotics |
| CN107106525B (zh) * | 2014-10-24 | 2021-03-19 | 红山生物医药有限公司 | 用于抑制单链rna病毒复制的治疗 |
| CA2997671A1 (en) * | 2015-10-06 | 2017-04-13 | Redhill Biopharma Ltd. | Combination therapies for treating cancer |
| CA3022515A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
| US11524037B2 (en) | 2017-09-08 | 2022-12-13 | Evelo Biosciences, Inc. | Bacterial extracellular vesicles |
| WO2022003421A2 (en) * | 2020-06-30 | 2022-01-06 | Redhill Biopharma Ltd. | Triple antibiotic fixed-dose combination products, dosing regimen, methods, and kits for treating pulmonary non-tuberculosis mycobacterial infections |
| US20250205229A1 (en) * | 2022-03-22 | 2025-06-26 | Kyoto University | Drug for treating or preventing charcot-marie-tooth disease |
| CN116649295A (zh) * | 2023-03-20 | 2023-08-29 | 广西医科大学第一附属医院 | GluN1359-378多肽主动免疫PTZ诱发癫痫及认知障碍的动物模型、建立方法及其应用 |
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| AR012304A1 (es) | 1997-04-01 | 2000-10-18 | Borody Thomas J | Composiciones y metodos para el tratamiento de enfermedades intestinales inflamatorias y el uso de dicha composicion para preparar medicamentos paradichos tratamientos. |
| US7488580B1 (en) | 2005-03-10 | 2009-02-10 | University Of Central Florida Research Foundation, Inc. | Protocol for detection of Mycobacterium avium subspecies paratuberculosis in blood |
| US20090054380A1 (en) * | 2005-12-20 | 2009-02-26 | Greenstein Robert J | Methods for diagnosing and treating a mycobacterium avium subspecies paratuberculosis infection |
| US20080275063A1 (en) | 2007-04-24 | 2008-11-06 | Heike Schauerte | Inhibitors of protein kinases |
| EP2200613B1 (en) * | 2007-09-21 | 2018-09-05 | The Johns Hopkins University | Phenazine derivatives and uses thereof |
| PT2247291T (pt) | 2008-02-08 | 2019-02-01 | Red Hill Biopharma Ltd | Métodos e composições para tratamento de doença inflamatória do intestino |
| US20120237472A1 (en) | 2009-07-24 | 2012-09-20 | The Johns Hopkins University | Methods and compositions for treating or preventing autoimmune diseases using immunomodulatory agents |
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