ES2609912T3 - Compuestos de 2,6-dioxo, -2,3-dihidro-1h-purina útiles para el tratamiento de trastornos relacionados con la actividad del canal trpa1 - Google Patents

Compuestos de 2,6-dioxo, -2,3-dihidro-1h-purina útiles para el tratamiento de trastornos relacionados con la actividad del canal trpa1 Download PDF

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Publication number
ES2609912T3
ES2609912T3 ES08771748.4T ES08771748T ES2609912T3 ES 2609912 T3 ES2609912 T3 ES 2609912T3 ES 08771748 T ES08771748 T ES 08771748T ES 2609912 T3 ES2609912 T3 ES 2609912T3
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Spain
Prior art keywords
continued
trpa1
dioxo
alkyl
dimethyl
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Active
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ES08771748.4T
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English (en)
Spanish (es)
Inventor
Howard Ng
Manfred Weigele
Magdalene Moran
Jayhong Chong
Christopher Fanger
Glenn R. Larsen
Donato Del Camino
Neil Hayward
Steven P. Adams
Amy Ripka
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Hydra Biosciences LLC
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Hydra Biosciences LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/105—Persulfides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ES08771748.4T 2007-06-22 2008-06-23 Compuestos de 2,6-dioxo, -2,3-dihidro-1h-purina útiles para el tratamiento de trastornos relacionados con la actividad del canal trpa1 Active ES2609912T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US94586607P 2007-06-22 2007-06-22
US94584007P 2007-06-22 2007-06-22
US945866P 2007-06-22
US945840P 2007-06-22
PCT/US2008/067901 WO2009002933A1 (en) 2007-06-22 2008-06-23 Methods and compositions for treating disorders

Publications (1)

Publication Number Publication Date
ES2609912T3 true ES2609912T3 (es) 2017-04-25

Family

ID=40186010

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08771748.4T Active ES2609912T3 (es) 2007-06-22 2008-06-23 Compuestos de 2,6-dioxo, -2,3-dihidro-1h-purina útiles para el tratamiento de trastornos relacionados con la actividad del canal trpa1

Country Status (11)

Country Link
US (3) US8163761B2 (https=)
EP (3) EP3663295A1 (https=)
JP (5) JP2010530901A (https=)
CN (4) CN104825457B (https=)
AU (1) AU2008268463B2 (https=)
CA (2) CA2962043A1 (https=)
DK (1) DK2170309T3 (https=)
ES (1) ES2609912T3 (https=)
HR (1) HRP20200357T1 (https=)
SI (1) SI3184527T1 (https=)
WO (1) WO2009002933A1 (https=)

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DK2170309T3 (en) 2017-01-09
US20180133170A1 (en) 2018-05-17
JP6258266B2 (ja) 2018-01-10
EP3184527A1 (en) 2017-06-28
CA2691468C (en) 2017-05-09
CN103751194B (zh) 2018-01-05
AU2008268463A1 (en) 2008-12-31
JP5932883B2 (ja) 2016-06-08
JP2019147808A (ja) 2019-09-05
CN101801362B (zh) 2014-01-22
SI3184527T1 (sl) 2020-03-31
CN108042542A (zh) 2018-05-18
US8163761B2 (en) 2012-04-24
US20090143377A1 (en) 2009-06-04
CN101801362A (zh) 2010-08-11
CN103751194A (zh) 2014-04-30
JP2015180700A (ja) 2015-10-15
EP3663295A1 (en) 2020-06-10
AU2008268463A2 (en) 2010-02-25
CA2691468A1 (en) 2008-12-31
EP2170309A1 (en) 2010-04-07
CN104825457B (zh) 2019-11-19
AU2008268463B2 (en) 2015-03-05
CA2962043A1 (en) 2008-12-31
CN104825457A (zh) 2015-08-12
JP2010530901A (ja) 2010-09-16
EP3184527B1 (en) 2020-01-29
JP2017165790A (ja) 2017-09-21
JP2014141535A (ja) 2014-08-07
US20130059869A1 (en) 2013-03-07
EP2170309A4 (en) 2010-11-03
HRP20200357T1 (hr) 2020-06-12
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