CN103751194B - 用于治疗病症的方法和组合物 - Google Patents

用于治疗病症的方法和组合物 Download PDF

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Publication number
CN103751194B
CN103751194B CN201310718872.7A CN201310718872A CN103751194B CN 103751194 B CN103751194 B CN 103751194B CN 201310718872 A CN201310718872 A CN 201310718872A CN 103751194 B CN103751194 B CN 103751194B
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CN
China
Prior art keywords
pain
trpa1
substituted
halo
compound
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Expired - Fee Related
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CN201310718872.7A
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English (en)
Chinese (zh)
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CN103751194A (zh
Inventor
H.恩格
M.魏格勒
M.莫兰
J.郑
C.方格尔
G.R.拉尔森
D.德尔卡米诺
N.海沃德
S.P.亚当斯
A.里普卡
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Eli Lilly and Co
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Hydra Biosciences LLC
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Expired - Fee Related legal-status Critical Current
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/095Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/105Persulfides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/11Aldehydes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201310718872.7A 2007-06-22 2008-06-23 用于治疗病症的方法和组合物 Expired - Fee Related CN103751194B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US94584007P 2007-06-22 2007-06-22
US94586607P 2007-06-22 2007-06-22
US60/945,866 2007-06-22
US60/945,840 2007-06-22
CN200880103802.8A CN101801362B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物

Related Parent Applications (1)

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CN200880103802.8A Division CN101801362B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物

Publications (2)

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CN103751194A CN103751194A (zh) 2014-04-30
CN103751194B true CN103751194B (zh) 2018-01-05

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CN201310718872.7A Expired - Fee Related CN103751194B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN201711272327.4A Pending CN108042542A (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN200880103802.8A Expired - Fee Related CN101801362B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN201510111699.3A Expired - Fee Related CN104825457B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物

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CN201711272327.4A Pending CN108042542A (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN200880103802.8A Expired - Fee Related CN101801362B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物
CN201510111699.3A Expired - Fee Related CN104825457B (zh) 2007-06-22 2008-06-23 用于治疗病症的方法和组合物

Country Status (11)

Country Link
US (3) US8163761B2 (https=)
EP (3) EP3184527B1 (https=)
JP (5) JP2010530901A (https=)
CN (4) CN103751194B (https=)
AU (1) AU2008268463B2 (https=)
CA (2) CA2962043A1 (https=)
DK (1) DK2170309T3 (https=)
ES (1) ES2609912T3 (https=)
HR (1) HRP20200357T1 (https=)
SI (1) SI3184527T1 (https=)
WO (1) WO2009002933A1 (https=)

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Publication number Publication date
EP3663295A1 (en) 2020-06-10
JP2015180700A (ja) 2015-10-15
CN104825457A (zh) 2015-08-12
EP2170309B1 (en) 2016-10-26
EP3184527A1 (en) 2017-06-28
JP2017165790A (ja) 2017-09-21
WO2009002933A1 (en) 2008-12-31
CN101801362B (zh) 2014-01-22
CN103751194A (zh) 2014-04-30
AU2008268463B2 (en) 2015-03-05
CA2962043A1 (en) 2008-12-31
CA2691468C (en) 2017-05-09
US20090143377A1 (en) 2009-06-04
SI3184527T1 (sl) 2020-03-31
AU2008268463A1 (en) 2008-12-31
EP3184527B1 (en) 2020-01-29
US8163761B2 (en) 2012-04-24
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US20180133170A1 (en) 2018-05-17
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JP5932883B2 (ja) 2016-06-08
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US20130059869A1 (en) 2013-03-07
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HRP20200357T1 (hr) 2020-06-12
JP2010530901A (ja) 2010-09-16
CN108042542A (zh) 2018-05-18
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