ES2608005T3 - Método para preparar una matriz cromatográfica - Google Patents

Método para preparar una matriz cromatográfica Download PDF

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Publication number
ES2608005T3
ES2608005T3 ES05787430.7T ES05787430T ES2608005T3 ES 2608005 T3 ES2608005 T3 ES 2608005T3 ES 05787430 T ES05787430 T ES 05787430T ES 2608005 T3 ES2608005 T3 ES 2608005T3
Authority
ES
Spain
Prior art keywords
polysaccharide
substituted
chromatographic matrix
gel
prepare
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES05787430.7T
Other languages
English (en)
Inventor
Hans Berg
Maria Holm
David Buckley
Anders Hagvall
Eva Holmgren
Henrik Ihre
Anders Larsson
Dag LINDSTRÖM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Bioprocess R&D AB
Original Assignee
GE Healthcare Bioprocess R&D AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0402322A external-priority patent/SE0402322D0/xx
Priority claimed from SE0403173A external-priority patent/SE0403173D0/sv
Application filed by GE Healthcare Bioprocess R&D AB filed Critical GE Healthcare Bioprocess R&D AB
Application granted granted Critical
Publication of ES2608005T3 publication Critical patent/ES2608005T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/291—Gel sorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/262—Synthetic macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B01J20/267—Cross-linked polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un método para preparar una matriz cromatográfica de polisacárido reticulada, cuyo método comprende: (a) proporcionar una solución acuosa de al menos un polisacárido gelificable, en el que al menos parte de los grupos hidroxilo están sustituidos con grupos éter que no son susceptibles al ataque nucleófilo y que se seleccionan del grupo que consiste en éteres de metilo, etilo, propilo, butilo, hidroxipropilo, hidroxibutilo e hidroxietilo; (b) proporcionar gotitas esencialmente esféricas de la solución de polisacárido sustituido; (c) formar un gel de la solución de polisacárido sustituido; y (d) reticular el gel, en donde la parte de los grupos hidroxilo en el polisacárido que se sustituye es 1-20%.

Description

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Claims (1)

  1. imagen1
ES05787430.7T 2004-09-22 2005-09-21 Método para preparar una matriz cromatográfica Active ES2608005T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE0402322 2004-09-22
SE0402322A SE0402322D0 (sv) 2004-09-22 2004-09-22 Method of preparing a chromatography matrix
SE0403173A SE0403173D0 (sv) 2004-12-27 2004-12-27 Method of preparing a chromatography matrix
SE0403173 2004-12-27
PCT/SE2005/001408 WO2006033634A1 (en) 2004-09-22 2005-09-21 Method of preparing a chromatography matrix

Publications (1)

Publication Number Publication Date
ES2608005T3 true ES2608005T3 (es) 2017-04-05

Family

ID=36090313

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05787430.7T Active ES2608005T3 (es) 2004-09-22 2005-09-21 Método para preparar una matriz cromatográfica

Country Status (9)

Country Link
EP (1) EP1793926B1 (es)
JP (1) JP5122958B2 (es)
KR (1) KR101215171B1 (es)
AU (1) AU2005287430B2 (es)
BR (1) BRPI0515586B1 (es)
CA (1) CA2577822C (es)
ES (1) ES2608005T3 (es)
RU (1) RU2367517C2 (es)
WO (1) WO2006033634A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101243425B1 (ko) 2004-10-21 2013-03-13 지이 헬스케어 바이오-사이언시스 에이비 항체의 정제 방법
ES2608638T3 (es) 2005-07-06 2017-04-12 Ge Healthcare Bioprocess R&D Ab Método para preparar una matriz de separación
WO2009014481A1 (en) 2007-07-25 2009-01-29 Ge Healthcare Bio-Sciences Ab Separation matrix
GB2452301A (en) * 2007-08-30 2009-03-04 Ge Healthcare Bio Sciences Ab Sterilization Method
BRPI0820008B1 (pt) 2007-12-03 2017-05-30 Dpx Holdings Bv sistema e método para produção de microesferas
US8372286B2 (en) 2008-02-05 2013-02-12 Ge Healthcare Bio-Sciences Ab Method for production of separation media
US11628381B2 (en) 2012-09-17 2023-04-18 W.R. Grace & Co. Conn. Chromatography media and devices
US20160243526A1 (en) * 2013-10-10 2016-08-25 Ge Healthcare Bio-Sciences Ab Method for production of a chromatography material
JP6600002B2 (ja) 2015-10-23 2019-10-30 富士フイルム株式会社 アフィニティクロマトグラフィ担体および生体物質の精製方法
JP6764464B2 (ja) * 2016-02-15 2020-09-30 東ソー株式会社 多孔性架橋セルロースゲル及びその製造方法
AU2018212974B2 (en) 2017-01-30 2023-08-24 Regeneron Pharmaceuticals, Inc. Compositions and methods for reducing bioburden in chromatography
GB201820806D0 (en) * 2018-12-20 2019-02-06 Ge Healthcare Bioprocess R&D Ab Large pore agarose
CN116262837B (zh) * 2023-01-16 2024-08-27 杭州纽龙生物科技有限公司 一种基于端烯基卤代烃活化的阴离子交换凝胶填料及其制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507851A (en) * 1966-03-24 1970-04-21 Victor Ghetie Synthesis derivatives of agarose having application in electrophoresis on gel and in chromatography
US3956273A (en) * 1971-06-07 1976-05-11 Marine Colloids, Inc. Modified agarose and agar and method of making same
SE458525B (sv) * 1985-05-23 1989-04-10 Pharmacia Ab Foerfarande foer tvaerbindning av en poroes agar- eller agarosgel
SE461149B (sv) * 1988-05-25 1990-01-15 Casco Nobel Ab Saett att framstaella partiklar av gelbildande polysackarider
JPH01265972A (ja) * 1988-10-29 1989-10-24 Kanegafuchi Chem Ind Co Ltd 体液中の有害成分の除去方法
JPH02235902A (ja) * 1989-03-09 1990-09-18 Nisshinbo Ind Inc ザンタイト架橋を有するセルロース及びセルロース誘導体粒子およびその製造方法
JPH0741167B2 (ja) * 1989-06-30 1995-05-10 株式会社クラレ 生理活性物質固定化吸着剤の製造方法および製造用キット
GB2248029A (en) * 1990-09-19 1992-03-25 Amicon Ltd Chromatography system.
SE9200827D0 (sv) * 1992-03-18 1992-03-18 Pharmacia Lkb Biotech Supet porous polysaccharide gels
TW362100B (en) * 1995-07-21 1999-06-21 Novartis Ag The preparation and use of photochemically cross-linked polysaccharide derivatives having no photopolymerisable functional groups
SE9601368D0 (sv) * 1996-04-11 1996-04-11 Pharmacia Biotech Ab Process for the production of a porous cross-linked polysaccharide gel
SE9803225D0 (sv) * 1998-09-23 1998-09-23 Amersham Pharm Biotech Ab Process for production of polysaccharide beads
JP2000154200A (ja) * 1998-11-20 2000-06-06 Kanegafuchi Chem Ind Co Ltd 化合物の固定化方法
US6159491A (en) * 1999-02-12 2000-12-12 Biovector Technologies, Inc. Prolonged release bioadhesive vaginal gel dosage form
SE9901825D0 (sv) * 1999-05-20 1999-05-20 Amersham Pharm Biotech Ab Foamed material filled with inner material
US6689715B1 (en) * 2000-02-09 2004-02-10 Hammen Corporation Tethered polymer ligands
SE0004928D0 (sv) 2000-12-29 2000-12-29 Apbiotech Ab A method for the manufacturing of porous material

Also Published As

Publication number Publication date
AU2005287430B2 (en) 2010-09-23
CA2577822A1 (en) 2006-03-30
RU2007106974A (ru) 2008-10-27
JP2008513771A (ja) 2008-05-01
BRPI0515586A (pt) 2008-07-29
CA2577822C (en) 2012-11-20
JP5122958B2 (ja) 2013-01-16
RU2367517C2 (ru) 2009-09-20
EP1793926A1 (en) 2007-06-13
BRPI0515586B1 (pt) 2015-11-03
WO2006033634A1 (en) 2006-03-30
AU2005287430A1 (en) 2006-03-30
EP1793926B1 (en) 2016-11-23
KR101215171B1 (ko) 2012-12-24
KR20070057184A (ko) 2007-06-04

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