ES2600789T3 - Tratamiento de infecciones por VIH-1 latentes usando auranofina o trióxido de arsénico - Google Patents
Tratamiento de infecciones por VIH-1 latentes usando auranofina o trióxido de arsénico Download PDFInfo
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- ES2600789T3 ES2600789T3 ES09759664.7T ES09759664T ES2600789T3 ES 2600789 T3 ES2600789 T3 ES 2600789T3 ES 09759664 T ES09759664 T ES 09759664T ES 2600789 T3 ES2600789 T3 ES 2600789T3
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- hiv
- cells
- auranofin
- hdaci
- treatment
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0819857 | 2008-10-29 | ||
| GB0819857A GB0819857D0 (en) | 2008-10-29 | 2008-10-29 | Antiviral therapy |
| GB0908952A GB0908952D0 (en) | 2009-05-22 | 2009-05-22 | Antiviral therapy |
| GB0908952 | 2009-05-22 | ||
| PCT/EP2009/007958 WO2010049182A2 (en) | 2008-10-29 | 2009-10-29 | Treatment of retroviral reservoirs exploiting oxidative stress |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2600789T3 true ES2600789T3 (es) | 2017-02-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| ES09759664.7T Active ES2600789T3 (es) | 2008-10-29 | 2009-10-29 | Tratamiento de infecciones por VIH-1 latentes usando auranofina o trióxido de arsénico |
Country Status (6)
| Country | Link |
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| US (3) | US8785493B2 (https=) |
| EP (1) | EP2349245B1 (https=) |
| JP (1) | JP5779503B2 (https=) |
| ES (1) | ES2600789T3 (https=) |
| PL (1) | PL2349245T3 (https=) |
| WO (1) | WO2010049182A2 (https=) |
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| EP2330894B8 (en) | 2008-09-03 | 2017-04-19 | BioMarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors |
| US9719069B2 (en) | 2009-01-27 | 2017-08-01 | University Of Utah Research Foundation | Methods and compositions relating to viral latency |
| GB201011921D0 (en) * | 2010-07-15 | 2010-09-01 | Sutan Anwar | Method for gas chromatography analysis and maintenance |
| US9540395B2 (en) | 2011-02-28 | 2017-01-10 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| CN102727523A (zh) * | 2011-04-02 | 2012-10-17 | 复旦大学 | 一种具有抗hiv潜伏作用的药物及其用途 |
| WO2014143666A1 (en) | 2013-03-15 | 2014-09-18 | Biomarin Pharmaceutical Inc. | Hdac inhibitors |
| US9730928B2 (en) * | 2013-06-14 | 2017-08-15 | Univeristy Of Utah Research Foundation | Trizol-1-OL analogs anti-retroviral latency drugs |
| WO2015051035A1 (en) * | 2013-10-01 | 2015-04-09 | The J. David Gladstone Institutes | Compositions, systems and methods for gene expression noise drug screening and uses thereof |
| KR20230075528A (ko) * | 2016-05-03 | 2023-05-31 | 갈레라 랩스, 엘엘씨 | 암 치료를 위한 조합 요법 |
| EP3463476A2 (en) * | 2017-03-23 | 2019-04-10 | Istituto Superiore di Sanità | Buthionine sulfoximine and a metallodrug for the treatment of cancer, hiv or a rheumatic disease |
| WO2021211792A1 (en) * | 2020-04-15 | 2021-10-21 | Georgia State University Research Foundation, Inc. | Treatment of coronavirus infections with auranofin |
| CN115093359B (zh) * | 2022-06-23 | 2023-06-09 | 山东第一医科大学(山东省医学科学院) | 一种化合物、药物组合物及其在扩张血管或抗病毒领域的应用 |
| CN116947763A (zh) * | 2023-07-11 | 2023-10-27 | 郑州大学 | 2-巯基-5-氰基-6-芳基嘧啶杂环类化合物、制备方法和应用 |
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| AU2002361797A1 (en) * | 2001-12-19 | 2003-07-09 | The Regents Of The University Of California | Cell lines with latent immunodeficiency virus and methods of use thereof |
| AU2002351898A1 (en) * | 2001-12-21 | 2003-07-09 | Universite Libre De Bruxelles | Method for obtaining the elimination of integrated and functional viruses from infected mammal cells |
| US8247613B2 (en) * | 2006-04-17 | 2012-08-21 | The J. David Gladstone Institutes | Methods and compositions for the synergistic activation of latent HIV |
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2009
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- 2009-10-29 WO PCT/EP2009/007958 patent/WO2010049182A2/en not_active Ceased
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2014
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2016
- 2016-12-21 US US15/386,336 patent/US20170157174A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP5779503B2 (ja) | 2015-09-16 |
| US20170157174A1 (en) | 2017-06-08 |
| EP2349245A2 (en) | 2011-08-03 |
| US20150024065A1 (en) | 2015-01-22 |
| WO2010049182A2 (en) | 2010-05-06 |
| US20110305774A1 (en) | 2011-12-15 |
| JP2012506884A (ja) | 2012-03-22 |
| EP2349245B1 (en) | 2016-08-03 |
| US8785493B2 (en) | 2014-07-22 |
| PL2349245T3 (pl) | 2017-07-31 |
| WO2010049182A3 (en) | 2010-12-02 |
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