ES2600729T3 - Conjugados de polímeros hiperramificados a través de enlazante escindible no enzimático - Google Patents

Conjugados de polímeros hiperramificados a través de enlazante escindible no enzimático Download PDF

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Publication number
ES2600729T3
ES2600729T3 ES09161150.9T ES09161150T ES2600729T3 ES 2600729 T3 ES2600729 T3 ES 2600729T3 ES 09161150 T ES09161150 T ES 09161150T ES 2600729 T3 ES2600729 T3 ES 2600729T3
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Spain
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hyperbranched polymer
structural unit
biologically active
cleavable linker
active structural
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Expired - Lifetime
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ES09161150.9T
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English (en)
Inventor
Dirk Vetter
Ulrich Hersel
Harald Rau
Robert Schnepf
Thomas Wegge
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Ascendis Pharma Endocrinology Division AS
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Ascendis Pharma Growth Disorders AS
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
    • Y10S977/705—Protein or peptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/754—Dendrimer, i.e. serially branching or "tree-like" structure

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Una composición que comprende: - un polímero hiperramificado unido a un núcleo; y - una unidad estructural biológicamente activa; con lo cual la unidad estructural biológicamente activa está unida al núcleo por medio de un enlazante L sustancialmente no enzimáticamente escindible y la unidad estructural biológicamente activa que se selecciona de somatropinas; y en donde la molécula hiperramificada contiene al menos dos cadenas moleculares, las cuales contienen grupos de cubrimiento C estéricamente exigentes y en donde el polímero hiperramificado contiene al menos dos cadenas moleculares, cadenas moleculares que son de longitud suficiente para estar así dispuestas de manera que forman una cavidad para acomodar la unidad estructural biológicamente activa.

Description

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Las figuras (XV) y (XVI) a continuación muestran estructuras macrocíclicas que tienen grupos de cubrimiento en los tres y cuatro EMC de la respectiva estructura macrocíclica.
imagen17
En todas las fórmulas (XI) a (XVI) mostradas de antemano, un EMC puede llevar a un grupo de cubrimiento C (como se muestra en las fórmulas) o más de uno, es decir, 2, 3, 4, 5 o incluso más grupos de cubrimiento C
Ejemplos de EPIC, DPIC y MPIC en donde el enlazador se ha escindido y la proteína no se mantiene dentro de la cavidad mediante enlaces covalentes se representan en las fórmulas (XVII) a (XX) a continuación, que incluyen
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Claims (1)

  1. imagen1
    imagen2
ES09161150.9T 2003-10-02 2004-10-01 Conjugados de polímeros hiperramificados a través de enlazante escindible no enzimático Expired - Lifetime ES2600729T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03022097A EP1525890A1 (en) 2003-10-02 2003-10-02 Protein-Proteophore complexes
EP03022097 2003-10-02

Publications (1)

Publication Number Publication Date
ES2600729T3 true ES2600729T3 (es) 2017-02-10

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
ES09161150.9T Expired - Lifetime ES2600729T3 (es) 2003-10-02 2004-10-01 Conjugados de polímeros hiperramificados a través de enlazante escindible no enzimático
ES04765740.8T Expired - Lifetime ES2451622T3 (es) 2003-10-02 2004-10-01 Conjugados de polímeros hiperramificados a través de enlazante escindible no enzimático

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ES04765740.8T Expired - Lifetime ES2451622T3 (es) 2003-10-02 2004-10-01 Conjugados de polímeros hiperramificados a través de enlazante escindible no enzimático

Country Status (10)

Country Link
US (2) US7879588B2 (es)
EP (4) EP1525890A1 (es)
CY (2) CY1114972T1 (es)
DK (2) DK2090323T3 (es)
ES (2) ES2600729T3 (es)
HU (1) HUE030243T2 (es)
PL (1) PL2090323T3 (es)
PT (1) PT2090323T (es)
SI (1) SI2090323T1 (es)
WO (1) WO2005034909A2 (es)

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Publication number Publication date
US20110172390A1 (en) 2011-07-14
EP3085388A1 (en) 2016-10-26
DK2090323T3 (en) 2016-11-07
CY1114972T1 (el) 2016-12-14
WO2005034909A3 (en) 2005-12-08
EP2090323B1 (en) 2016-07-27
HUE030243T2 (en) 2017-04-28
ES2451622T3 (es) 2014-03-28
US7879588B2 (en) 2011-02-01
EP1682186B1 (en) 2013-12-11
US8450097B2 (en) 2013-05-28
EP2090323A1 (en) 2009-08-19
EP3085388B1 (en) 2021-04-07
CY1119457T1 (el) 2018-04-04
US20070020224A1 (en) 2007-01-25
SI2090323T1 (sl) 2016-11-30
EP1525890A1 (en) 2005-04-27
EP1682186A2 (en) 2006-07-26
PL2090323T3 (pl) 2017-01-31
WO2005034909A2 (en) 2005-04-21
PT2090323T (pt) 2016-11-02
DK1682186T3 (en) 2014-03-03

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