CY1119457T1 - Υπερδιακλαδισμενα συζευγματα πολυμερων μεσω μη ενζυματικου συνδετη με δυνατοτητα σχασης - Google Patents

Υπερδιακλαδισμενα συζευγματα πολυμερων μεσω μη ενζυματικου συνδετη με δυνατοτητα σχασης

Info

Publication number
CY1119457T1
CY1119457T1 CY20161101093T CY161101093T CY1119457T1 CY 1119457 T1 CY1119457 T1 CY 1119457T1 CY 20161101093 T CY20161101093 T CY 20161101093T CY 161101093 T CY161101093 T CY 161101093T CY 1119457 T1 CY1119457 T1 CY 1119457T1
Authority
CY
Cyprus
Prior art keywords
ultrasonable
enzymal
rating
connector
possibility
Prior art date
Application number
CY20161101093T
Other languages
English (en)
Inventor
Dirk Vetter
Ulrich Hersel
Harald Rau
Robert Schnepf
Thomas Wegge
Original Assignee
Ascendis Pharma Growth Disorders Division A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ascendis Pharma Growth Disorders Division A/S filed Critical Ascendis Pharma Growth Disorders Division A/S
Publication of CY1119457T1 publication Critical patent/CY1119457T1/el

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
    • Y10S977/705—Protein or peptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/754—Dendrimer, i.e. serially branching or "tree-like" structure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Polyethers (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η εφαρμογή αφορά μια σύνθεση που περιέχει ένα υπέρ-διακλαδισμένο πολυμερές που συνδέεται με έναν πυρήνα και ένα βιολογικά δραστικό τμήμα. Το βιολογικά δραστικό τμήμα συνδέεται με τον πυρήνα μέσω ενός ουσιαστικά μη ενζυματικά διασπάσιμου συνδέτη L. Η σύνθεση μπορεί να χρησιμοποιηθεί για την παράδοση του βιολογικά δραστικού τμήματος στον στόχο του.
CY20161101093T 2003-10-02 2016-10-27 Υπερδιακλαδισμενα συζευγματα πολυμερων μεσω μη ενζυματικου συνδετη με δυνατοτητα σχασης CY1119457T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03022097A EP1525890A1 (en) 2003-10-02 2003-10-02 Protein-Proteophore complexes
EP09161150.9A EP2090323B1 (en) 2003-10-02 2004-10-01 Hyperbranched polymer conjugates via non-enzymatic cleavable linker
EP04765740.8A EP1682186B1 (en) 2003-10-02 2004-10-01 Hyperbranched polymer conjugates via non-enzymatic cleavable linker

Publications (1)

Publication Number Publication Date
CY1119457T1 true CY1119457T1 (el) 2018-04-04

Family

ID=34384573

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20141100190T CY1114972T1 (el) 2003-10-02 2014-03-07 Υπερ-διακλαδισμενα συζευγματα πολυμερους μεσω ενος μη ενζυμικως διασπασιμου συνδετη
CY20161101093T CY1119457T1 (el) 2003-10-02 2016-10-27 Υπερδιακλαδισμενα συζευγματα πολυμερων μεσω μη ενζυματικου συνδετη με δυνατοτητα σχασης

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20141100190T CY1114972T1 (el) 2003-10-02 2014-03-07 Υπερ-διακλαδισμενα συζευγματα πολυμερους μεσω ενος μη ενζυμικως διασπασιμου συνδετη

Country Status (10)

Country Link
US (2) US7879588B2 (el)
EP (4) EP1525890A1 (el)
CY (2) CY1114972T1 (el)
DK (2) DK2090323T3 (el)
ES (2) ES2451622T3 (el)
HU (1) HUE030243T2 (el)
PL (1) PL2090323T3 (el)
PT (1) PT2090323T (el)
SI (1) SI2090323T1 (el)
WO (1) WO2005034909A2 (el)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6350609B1 (en) * 1997-06-20 2002-02-26 New York University Electrospraying for mass fabrication of chips and libraries
US7723296B2 (en) 2001-01-18 2010-05-25 Genzyme Corporation Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
MXPA05002444A (es) 2002-09-06 2005-09-30 Insert Therapeutics Inc Polimeros a base de ciclodextrina para el suministro de agentes terapeuticos.
CA2824093C (en) * 2004-03-23 2016-10-25 Complex Biosystems Gmbh Polymeric prodrug with a self-immolative linker
US7968085B2 (en) 2004-07-05 2011-06-28 Ascendis Pharma A/S Hydrogel formulations
EP1625856A1 (en) * 2004-08-13 2006-02-15 Complex Biosystems GmbH Hydrogel polymeric conjugates of a prodrug
EP2111872B1 (en) * 2004-07-05 2020-12-23 Ascendis Pharma GmbH Hydrogel conjugates
EP1877099B1 (en) 2005-04-06 2012-09-19 Genzyme Corporation Therapeutic conjugates comprising a lysosomal enzyme, polysialic acid and a targeting moiety
US8445024B2 (en) 2005-10-25 2013-05-21 Evonik Degussa Gmbh Preparations containing hyperbranched polymers
EP1948271B1 (en) 2005-11-17 2013-10-02 Zogenix, Inc. Delivery of viscous formulations by needle-free injection
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
TW201509433A (zh) * 2006-12-13 2015-03-16 Cerulean Pharma Inc 用於醫物傳遞之以環糊精為基之聚合物
LT2457920T (lt) 2007-01-18 2018-02-12 Genzyme Corporation Oligosacharidai, apimantys aminooksigrupę, ir jų konjugatai
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
EP1982698A1 (de) * 2007-04-18 2008-10-22 Evonik Degussa GmbH Präparate zur gesteuerten Freisetzung von bioaktiven Naturstoffen
US9353170B2 (en) 2007-06-08 2016-05-31 Sanofi-Aventis Deutschland Gmbh Long-acting transient polymer conjugates of exendin
JP5484339B2 (ja) 2007-10-05 2014-05-07 ウェイン ステート ユニバーシティー 合成物の持続的な放出のためのデンドリマー
CN102014625A (zh) 2008-04-28 2011-04-13 佐吉尼克斯股份有限公司 用于治疗偏头痛的新制剂
EP2113256A1 (en) 2008-04-29 2009-11-04 Ascendis Pharma AS PEGylated rhGH compounds
LT3050576T (lt) 2008-04-29 2021-07-12 Ascendis Pharma Endocrinology Division A/S Pegiliuoti rekombinantinio žmogaus augimo hormono junginiai
DE102008042923A1 (de) 2008-10-17 2010-04-22 Evonik Goldschmidt Gmbh Präparate zur gesteuerten Freisetzung von Wirkstoffen
CA2747230C (en) 2008-12-16 2019-06-11 Genzyme Corporation Oligosaccharide-protein conjugates
CN102413843A (zh) 2009-03-05 2012-04-11 阿森迪斯药物股份有限公司 干扰素α载体前药
ES2608457T3 (es) 2009-05-20 2017-04-11 Biomarin Pharmaceutical Inc. Variantes de péptido natriurético de tipo C
UA108475C2 (uk) 2009-07-31 2015-05-12 Санофі-Авентіс Дойчланд Гмбх Композиція інсуліну тривалої дії
JP5738291B2 (ja) 2009-07-31 2015-06-24 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング インスリンリンカー複合体を含むプロドラッグ
US10058837B2 (en) 2009-08-28 2018-08-28 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
US8758780B2 (en) 2009-10-06 2014-06-24 Ascendis Pharma As Subcutaneous paliperidone composition
BR112012010249A2 (pt) 2009-10-29 2015-09-22 Ascendis Pharma As esterilização de hidrógeis biodegradáveis
AU2010332958B2 (en) 2009-12-15 2014-09-18 Ascendis Pharma Endocrinology Division A/S Dry growth hormone composition transiently linked to a polymer carrier
FR2955111B1 (fr) * 2010-01-12 2013-05-31 Biomerieux Sa Procede de preparation de composes polybiotinyles
EP2525830B1 (en) 2010-01-22 2016-05-11 Ascendis Pharma A/S Dipeptide-based prodrug linkers for aliphatic amine-containing drugs
US9561285B2 (en) 2010-01-22 2017-02-07 Ascendis Pharma As Carrier-linked carbamate prodrug linkers
EP2525829A1 (en) 2010-01-22 2012-11-28 Ascendis Pharma A/S Dipeptide-based prodrug linkers for aromatic amine-containing drugs
WO2012030675A1 (en) * 2010-08-28 2012-03-08 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for plasmid gene transfection using polymer-modified microbubbles
EP2438930A1 (en) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrugs comprising an exendin linker conjugate
EP2592103A1 (en) 2011-11-08 2013-05-15 Adriacell S.p.A. Polymer aldehyde derivatives
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
KR20170009934A (ko) * 2014-05-23 2017-01-25 쓰리엠 이노베이티브 프로퍼티즈 컴파니 불연속 실리콘 접착제 물품
EP3220892B1 (en) 2014-11-21 2021-10-13 Ascendis Pharma Endocrinology Division A/S Long-acting growth hormone dosage forms
US20200188524A1 (en) * 2016-09-22 2020-06-18 University Of Washington Molecular logic gates for controlled material degradation
EP3960203A1 (en) 2020-08-25 2022-03-02 Université de Liège Complexes for the delivery of proteinaceous agents
WO2022046531A1 (en) 2020-08-28 2022-03-03 Isco International, Llc Method and system for mitigating passive intermodulation (pim) by performing polarization adjusting
US11476574B1 (en) 2022-03-31 2022-10-18 Isco International, Llc Method and system for driving polarization shifting to mitigate interference
US11476585B1 (en) 2022-03-31 2022-10-18 Isco International, Llc Polarization shifting devices and systems for interference mitigation
US11502404B1 (en) 2022-03-31 2022-11-15 Isco International, Llc Method and system for detecting interference and controlling polarization shifting to mitigate the interference
US11515652B1 (en) 2022-05-26 2022-11-29 Isco International, Llc Dual shifter devices and systems for polarization rotation to mitigate interference
US11509071B1 (en) 2022-05-26 2022-11-22 Isco International, Llc Multi-band polarization rotation for interference mitigation
US11509072B1 (en) 2022-05-26 2022-11-22 Isco International, Llc Radio frequency (RF) polarization rotation devices and systems for interference mitigation
US11949489B1 (en) 2022-10-17 2024-04-02 Isco International, Llc Method and system for improving multiple-input-multiple-output (MIMO) beam isolation via alternating polarization
US11956058B1 (en) 2022-10-17 2024-04-09 Isco International, Llc Method and system for mobile device signal to interference plus noise ratio (SINR) improvement via polarization adjusting/optimization
US11985692B2 (en) 2022-10-17 2024-05-14 Isco International, Llc Method and system for antenna integrated radio (AIR) downlink and uplink beam polarization adaptation
US11990976B2 (en) 2022-10-17 2024-05-21 Isco International, Llc Method and system for polarization adaptation to reduce propagation loss for a multiple-input-multiple-output (MIMO) antenna
CN116496492B (zh) * 2023-04-04 2024-09-06 兰州大学 植酸和多肽双重修饰的聚酰胺-胺型树枝状聚合物及其制备方法和应用
CN117959250A (zh) * 2024-03-27 2024-05-03 长春生物制品研究所有限责任公司 一种重组人白细胞介素-1受体拮抗剂注射液

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507466A (en) 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
WO1995024221A1 (en) 1986-08-18 1995-09-14 The Dow Chemical Company Bioactive and/or targeted dendrimer conjugates
DE3786000T3 (de) 1986-08-18 1997-08-21 Dow Chemical Co Conjugate dichter Sterne.
DE4310141A1 (de) * 1993-03-29 1994-10-06 Boehringer Mannheim Gmbh Homobidentale trifunktionelle Linker
US5643575A (en) * 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
IE80468B1 (en) * 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US6585956B2 (en) * 1997-07-07 2003-07-01 The Dow Chemical Company Dendritic-platinate drug delivery system
EP1037649B1 (en) 1997-12-17 2009-09-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
JP2000306221A (ja) * 1999-04-22 2000-11-02 Nec Corp 磁気抵抗効果ヘッドおよびその製造方法
US6309633B1 (en) * 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
ITFO990015A1 (it) * 1999-07-23 2001-01-23 Verdini Antonio "dendrimeri polipeptidici quali trasportatori unimolecolari di farmaci e sostanze biologicamente attive".
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
US6410680B1 (en) * 2000-06-21 2002-06-25 Dendrimolecular, Inc. Dendrimer constructs and metal complexes thereof having superoxide dismutase activity
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
AU2002240515A1 (en) * 2001-02-21 2002-09-12 Batelle Memorial Institute Proteins in a porous support
US20030068361A1 (en) 2001-10-09 2003-04-10 Rimona Margalit Liposome-encapsulated insulin formulations
US20030171285A1 (en) * 2001-11-20 2003-09-11 Finn Rory F. Chemically-modified human growth hormone conjugates
WO2003057716A2 (en) * 2002-01-08 2003-07-17 New River Pharmaceuticals, Inc. Dendritic encapsulation of active agents
AU2003300380B2 (en) 2002-12-30 2008-11-06 Nektar Therapeutics Multi-arm polypeptide-poly(ethylene glycol) block copolymers as drug delivery vehicles

Also Published As

Publication number Publication date
US8450097B2 (en) 2013-05-28
ES2600729T3 (es) 2017-02-10
SI2090323T1 (sl) 2016-11-30
EP2090323B1 (en) 2016-07-27
ES2451622T3 (es) 2014-03-28
US20110172390A1 (en) 2011-07-14
EP2090323A1 (en) 2009-08-19
WO2005034909A2 (en) 2005-04-21
WO2005034909A3 (en) 2005-12-08
DK2090323T3 (en) 2016-11-07
US7879588B2 (en) 2011-02-01
CY1114972T1 (el) 2016-12-14
EP3085388A1 (en) 2016-10-26
EP1682186B1 (en) 2013-12-11
EP1525890A1 (en) 2005-04-27
US20070020224A1 (en) 2007-01-25
EP1682186A2 (en) 2006-07-26
EP3085388B1 (en) 2021-04-07
HUE030243T2 (en) 2017-04-28
PT2090323T (pt) 2016-11-02
PL2090323T3 (pl) 2017-01-31
DK1682186T3 (en) 2014-03-03

Similar Documents

Publication Publication Date Title
CY1119457T1 (el) Υπερδιακλαδισμενα συζευγματα πολυμερων μεσω μη ενζυματικου συνδετη με δυνατοτητα σχασης
CY1119742T1 (el) Βιολογικα συστηματα μεταφορας πολλαπλου-συστατικου
CY1119943T1 (el) Πεγκυλιωμενα σακχαρα και γλυκοπεπτιδια διασυνδεδεμενα με γλυκερολη
RS52891B (en) GASTRORE-RESISTANT PHARMACEUTICAL FORMULATIONS CONTAINING RIFAXIMINE
DE60012722D1 (de) Polymerzusammensetzung mit niedriger emission
EA200501863A1 (ru) Полимерные производные, имеющие специфические атомные структуры
EP1881020A4 (en) POLYMERIC DERIVATIVE OF A METABOLIC ANTAGONIST OF CYTIDINE
EP1789447A4 (en) METHOD OF DELIVERING RNA INTERFERENCE AND USE THEREOF
WO2004108070A3 (en) Releasable polymeric conjugates based on aliphatic biodegradable linkers
DE60331458D1 (de) Kombinationschemotherapie mit chlorotoxin
CY1120831T1 (el) Μεθοδοι μειωσης της συσσωματωσης toy il-1ra
TW200635576A (en) Releasable polymeric conjugates based on aliphatic biodegradable linkers
ATE427948T1 (de) Folat-mimetika und deren folatrezeptorbindende konjugate
ATE450097T1 (de) Datenschutzgerechte verknüpfung von zeichenfolgen
DE50113310D1 (de) Kraftstoffördereinheit
DE60044030D1 (de) Markerkomplexe aus konjugierten polymeren
NO20080002L (no) Formuleringer av konjugerte ostrogener og bazedoxifen
WO2009023320A3 (en) Modular linkers for conjugation of organic substances to substantially inorganic substances and methods of manufacture and use thereof
DE69910555D1 (de) Zweistufige, keilförmige gewindeverbindung mit differentialdurchmesser
EE200300355A (et) Neublastiini polümeerkonjugaadid ja meetodid nende kasutamiseks
DE60113445D1 (de) Substanzen mit verzweigten linkermolekülen
NL1021971A1 (nl) Brandstofcelinrichting.
WO2003045429A3 (en) Anti-t cell immunotoxin fusion protein and its therapeutic use
DE60118603D1 (de) Schnellkupplung mit verbindungsanzeige
ATE526281T1 (de) Gelenktes pferdegebiss mit einer stoppvorrichtung