ES2599153T3 - Molécula de ARNi para la timidilato sintasa y uso de la misma - Google Patents
Molécula de ARNi para la timidilato sintasa y uso de la misma Download PDFInfo
- Publication number
- ES2599153T3 ES2599153T3 ES10758615.8T ES10758615T ES2599153T3 ES 2599153 T3 ES2599153 T3 ES 2599153T3 ES 10758615 T ES10758615 T ES 10758615T ES 2599153 T3 ES2599153 T3 ES 2599153T3
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- thymidylate synthase
- rnai molecule
- seq
- nucleotide sequence
- rnai
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01045—Thymidylate synthase (2.1.1.45)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una molécula de ARNi que es capaz de suprimir la expresión de la timidilato sintasa por la acción de un ARNi que comprende un dominio de ARN de doble cadena compuesto por una cadena con sentido que consiste en la secuencia de nucleótidos representada por SEQ ID NO: 1 hibridada con una cadena antisentido que consiste en la secuencia de nucleótidos representada por SEQ ID NO: 2, en donde la cadena con sentido está unida a la cadena antisentido mediante una región enlazadora.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009086463 | 2009-03-31 | ||
JP2009086463 | 2009-03-31 | ||
PCT/JP2010/055521 WO2010113844A1 (ja) | 2009-03-31 | 2010-03-29 | チミジル酸合成酵素に対するRNAi分子およびその用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2599153T3 true ES2599153T3 (es) | 2017-01-31 |
Family
ID=42828134
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10758615.8T Active ES2599153T3 (es) | 2009-03-31 | 2010-03-29 | Molécula de ARNi para la timidilato sintasa y uso de la misma |
Country Status (14)
Country | Link |
---|---|
US (1) | US8524876B2 (es) |
EP (1) | EP2415870B1 (es) |
JP (1) | JP5687188B2 (es) |
KR (1) | KR101579638B1 (es) |
CN (2) | CN107090454A (es) |
DK (1) | DK2415870T3 (es) |
ES (1) | ES2599153T3 (es) |
HR (1) | HRP20161293T1 (es) |
HU (1) | HUE029171T2 (es) |
PL (1) | PL2415870T3 (es) |
PT (1) | PT2415870T (es) |
RU (1) | RU2535993C2 (es) |
TW (1) | TWI526211B (es) |
WO (1) | WO2010113844A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8592572B2 (en) | 2011-05-23 | 2013-11-26 | Delta-Fly Pharma, Inc. | Liposome containing shRNA molecule targeting a thymidylate synthase and use thereof |
US20120301537A1 (en) * | 2011-05-23 | 2012-11-29 | Delta-Fly Pharma, Inc. | LIPOSOME CONTAINING shRNA MOLECULE TARGETING A THYMIDYLATE SYNTHASE AND USE THEREOF |
US20140255471A1 (en) * | 2013-03-11 | 2014-09-11 | Wake Forest University Health Sciences | Method of treating brain tumors |
PL2992874T3 (pl) | 2013-04-30 | 2019-01-31 | Delta-Fly Pharma, Inc. | Liposomy do podawania miejscowego i ich zastosowanie |
JP5934848B1 (ja) | 2014-10-30 | 2016-06-15 | Delta−Fly Pharma株式会社 | 局所投与用リポプレックスの新規製造方法及び該リポプレックスを使用する抗腫瘍剤 |
JP2023167428A (ja) | 2022-05-12 | 2023-11-24 | コニカミノルタ株式会社 | 光学フィルムの製造方法、光学フィルム、偏光板及び液晶表示装置 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4910510B1 (es) | 1968-01-26 | 1974-03-11 | ||
CA2087540C (en) | 1991-05-27 | 1999-01-19 | Tetsuhiko Shirasaka | Composition, method and kit for potentiating antitumor activity and for curing tumor |
RU2279277C2 (ru) * | 2000-03-31 | 2006-07-10 | Энджиоджен Фармасьютикалз Лтд. | Лечение разделенными дозами агентов с сосудоразрушающей активностью |
AU2003236649A1 (en) * | 2002-05-15 | 2003-12-02 | Falko Fend | Egf receptor antagonists in the treatment of gastric cancer |
EP2305812A3 (en) * | 2002-11-14 | 2012-06-06 | Dharmacon, Inc. | Fuctional and hyperfunctional sirna |
JP2007513611A (ja) * | 2003-11-26 | 2007-05-31 | ザ クイーンズ ユニヴァーシティ オブ ベルファスト | 癌治療 |
JP4543188B2 (ja) | 2004-03-10 | 2010-09-15 | 学校法人日本医科大学 | ヒトチミジル酸合成酵素に対するRNAiとして作用するRNA配列 |
KR100844477B1 (ko) * | 2004-06-09 | 2008-07-07 | 다이호야쿠힌고교 가부시키가이샤 | 항종양 효과 증강제, 항종양제 및 암 치료 방법 |
WO2007032428A1 (ja) * | 2005-09-14 | 2007-03-22 | Takara Bio Inc. | shRNA発現のための有効な新規ループ配列 |
WO2008035481A1 (fr) | 2006-09-19 | 2008-03-27 | Mitsubishi Electric Corporation | Actionneur |
US20090318453A1 (en) | 2006-09-22 | 2009-12-24 | Taiho Pharmaceutical Co., Ltd | Postoperative adjuvant chemotherapy for gastric cancer |
WO2008124927A1 (en) * | 2007-04-13 | 2008-10-23 | Vincent Research & Consulting Inc. | Sirna against thymidylate synthase and uses thereof in cancer treatment regimens |
JP2009086463A (ja) | 2007-10-01 | 2009-04-23 | Fuji Xerox Co Ltd | 無端状部材回転駆動装置および画像形成装置 |
-
2010
- 2010-03-29 HU HUE10758615A patent/HUE029171T2/hu unknown
- 2010-03-29 DK DK10758615.8T patent/DK2415870T3/en active
- 2010-03-29 CN CN201710095720.4A patent/CN107090454A/zh active Pending
- 2010-03-29 ES ES10758615.8T patent/ES2599153T3/es active Active
- 2010-03-29 PL PL10758615T patent/PL2415870T3/pl unknown
- 2010-03-29 CN CN2010800155816A patent/CN102369283A/zh active Pending
- 2010-03-29 EP EP10758615.8A patent/EP2415870B1/en active Active
- 2010-03-29 JP JP2011507173A patent/JP5687188B2/ja active Active
- 2010-03-29 US US13/258,591 patent/US8524876B2/en active Active
- 2010-03-29 PT PT107586158T patent/PT2415870T/pt unknown
- 2010-03-29 RU RU2011143753/10A patent/RU2535993C2/ru active
- 2010-03-29 WO PCT/JP2010/055521 patent/WO2010113844A1/ja active Application Filing
- 2010-03-29 KR KR1020117025598A patent/KR101579638B1/ko active IP Right Grant
- 2010-03-31 TW TW099110007A patent/TWI526211B/zh active
-
2016
- 2016-10-07 HR HRP20161293TT patent/HRP20161293T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
EP2415870A9 (en) | 2012-07-11 |
US8524876B2 (en) | 2013-09-03 |
JPWO2010113844A1 (ja) | 2012-10-11 |
JP5687188B2 (ja) | 2015-03-18 |
HUE029171T2 (hu) | 2017-02-28 |
EP2415870B1 (en) | 2016-07-20 |
US20120016012A1 (en) | 2012-01-19 |
RU2011143753A (ru) | 2013-05-10 |
EP2415870A1 (en) | 2012-02-08 |
KR20110135980A (ko) | 2011-12-20 |
RU2535993C2 (ru) | 2014-12-20 |
WO2010113844A1 (ja) | 2010-10-07 |
CN107090454A (zh) | 2017-08-25 |
TW201038278A (en) | 2010-11-01 |
HRP20161293T1 (hr) | 2016-11-18 |
KR101579638B1 (ko) | 2015-12-22 |
PT2415870T (pt) | 2016-10-25 |
TWI526211B (zh) | 2016-03-21 |
DK2415870T3 (en) | 2016-10-10 |
CN102369283A (zh) | 2012-03-07 |
PL2415870T3 (pl) | 2017-01-31 |
EP2415870A4 (en) | 2012-11-28 |
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