ES2587381T3 - Uso de sapacitabina para tratar una enfermedad proliferativa - Google Patents

Uso de sapacitabina para tratar una enfermedad proliferativa Download PDF

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Publication number
ES2587381T3
ES2587381T3 ES08737080.5T ES08737080T ES2587381T3 ES 2587381 T3 ES2587381 T3 ES 2587381T3 ES 08737080 T ES08737080 T ES 08737080T ES 2587381 T3 ES2587381 T3 ES 2587381T3
Authority
ES
Spain
Prior art keywords
sapacitabine
treatment cycle
cndac
days
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08737080.5T
Other languages
English (en)
Spanish (es)
Inventor
Judy Chiao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cyclacel Ltd
Original Assignee
Cyclacel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0708021A external-priority patent/GB0708021D0/en
Priority claimed from GB0723723A external-priority patent/GB0723723D0/en
Application filed by Cyclacel Ltd filed Critical Cyclacel Ltd
Application granted granted Critical
Publication of ES2587381T3 publication Critical patent/ES2587381T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
ES08737080.5T 2007-04-25 2008-04-24 Uso de sapacitabina para tratar una enfermedad proliferativa Active ES2587381T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0708021A GB0708021D0 (en) 2007-04-25 2007-04-25 Use
GB0708021 2007-04-25
GB0723723 2007-12-04
GB0723723A GB0723723D0 (en) 2007-12-04 2007-12-04 Use
PCT/GB2008/001424 WO2008132443A1 (en) 2007-04-25 2008-04-24 Use of sapacitabine to treat proliferative disease

Publications (1)

Publication Number Publication Date
ES2587381T3 true ES2587381T3 (es) 2016-10-24

Family

ID=39719125

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08737080.5T Active ES2587381T3 (es) 2007-04-25 2008-04-24 Uso de sapacitabina para tratar una enfermedad proliferativa

Country Status (6)

Country Link
US (2) US8536188B2 (enExample)
EP (1) EP2148676B1 (enExample)
JP (2) JP5852309B2 (enExample)
ES (1) ES2587381T3 (enExample)
PL (1) PL2148676T3 (enExample)
WO (1) WO2008132443A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
PL2148676T3 (pl) 2007-04-25 2016-12-30 Stosowanie sapacytabiny do leczenia choroby proliferacyjnej
EP2303283A2 (en) * 2008-05-15 2011-04-06 Katholieke Universiteit Leuven K.U. Leuven R&D Anti-cancer combination therapy
US10226478B2 (en) 2011-04-14 2019-03-12 Cyclacel Limited Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia
EP2874631A1 (en) 2012-05-15 2015-05-27 Cyclacel Limited Dosage regimen for sapacitabine and seliciclib
DK2941233T3 (da) * 2013-01-07 2020-10-19 Univ Pennsylvania Sammensætninger og fremgangsmåder til behandling af kutant T-celle-lymfom
WO2021079129A1 (en) 2019-10-24 2021-04-29 Cyclacel Limited Dosing regimen
US11957701B2 (en) 2020-07-17 2024-04-16 Delta-Fly Pharma, Inc. Therapy and new therapeutic agent for blood cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04008707A (es) * 2002-03-08 2006-03-08 Novartis Ag Combinaciones que comprenden derivados de epotilona y agentes de alquilacion.
US20050014716A1 (en) * 2003-05-21 2005-01-20 Wang Jin Wei Pancreatic cancer treatment
WO2006069208A2 (en) * 2004-12-21 2006-06-29 Schering Corporation Novel farnesyl protein transferase inhibitors as antitumor agents
JP5576591B2 (ja) * 2005-01-26 2014-08-20 大鵬薬品工業株式会社 α，α，α−トリフルオロチミジンとチミジンホスホリラーゼ阻害剤とを配合した抗癌剤
US20090227674A1 (en) * 2005-08-18 2009-09-10 Richon Victoria M Combination methods fo saha and targretin for treating cancer
GB0526419D0 (en) * 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
GB0609530D0 (en) 2006-05-12 2006-06-21 Cyclacel Ltd Combination
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
PL2148676T3 (pl) 2007-04-25 2016-12-30 Stosowanie sapacytabiny do leczenia choroby proliferacyjnej

Also Published As

Publication number Publication date
JP5852309B2 (ja) 2016-02-03
JP5892565B2 (ja) 2016-03-23
JP2010525042A (ja) 2010-07-22
PL2148676T3 (pl) 2016-12-30
US9675631B2 (en) 2017-06-13
EP2148676A1 (en) 2010-02-03
US20140142058A1 (en) 2014-05-22
EP2148676B1 (en) 2016-05-25
WO2008132443A1 (en) 2008-11-06
JP2015013877A (ja) 2015-01-22
US8536188B2 (en) 2013-09-17
US20100125084A1 (en) 2010-05-20

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