ES2571539T3 - Nuevos compuestos de hexahidropirroloimidazolona - Google Patents
Nuevos compuestos de hexahidropirroloimidazolonaInfo
- Publication number
- ES2571539T3 ES2571539T3 ES12719369T ES12719369T ES2571539T3 ES 2571539 T3 ES2571539 T3 ES 2571539T3 ES 12719369 T ES12719369 T ES 12719369T ES 12719369 T ES12719369 T ES 12719369T ES 2571539 T3 ES2571539 T3 ES 2571539T3
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- heteroaryl
- phenyl
- alkyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Compuestos de la fórmula (I)**Fórmula** en la que: R1 es alquilo, haloalquilo, alcoxialquilo, haloalcoxialquilo, hidroxialquilo, fenilo, fenilo sustituido, fenilalquilo, fenilalquilo sustituido, fenoxialquilo, fenoxialquilo sustituido, heteroarilo, heteroarilo sustituido, heteroarilalquilo o heteroarilalquilo sustituido, dichos fenilo sustituido, fenilalquilo sustituido, fenoxialquilo sustituido, heteroarilo sustituido y heteroarilalquilo sustituido están sustituidos de una a tres veces por sustituyentes elegidos con independencia entre alquilo, cicloalquilo, cicloalquilalquilo, halógeno, haloalquilo, hidroxi, hidroxialquilo, alcoxi, alcoxialquilo, haloalcoxi, hidroxihaloalquilo y alcoxihaloalquilo; R2 es fenilo, fenilo sustituido, heteroarilo o heteroarilo sustituido, dichos fenilo sustituido y heteroarilo sustituido están sustituidos de una a tres veces por sustituyentes elegidos con independencia entre alquilo, cicloalquilo, cicloalquilalquilo, halógeno, haloalquilo, hidroxi, hidroxialquilo, alcoxi, alcoxialquilo, haloalcoxi, hidroxihaloalquilo y alcoxihaloalquilo; R3 es hidrógeno, hidroxi o alcoxi, en el caso de que R3 sea hidroxi o alcoxi, entonces A es un enlace; R4 es hidrógeno, alquilo o cicloalquilo; R5 es hidrógeno, alquilo o cicloalquilo; A es -O-, -OC(O)-, -NR4C(O)O-, -NR4-, -C(O)NR4-, -NR4C(O)NR5-, -S(O)2NR4-, -NR4S(O)NR5-, -NR4S(O)2NR5-, -S-, -S(O)-, -S(O)2- o un enlace, en el caso de que A sea un enlace, entonces R1 es alcoxialquilo o haloalcoxialquilo; o las sales farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11165232 | 2011-05-09 | ||
PCT/EP2012/058173 WO2012152663A1 (en) | 2011-05-09 | 2012-05-04 | New hexahydropyrroloimidazolone compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2571539T3 true ES2571539T3 (es) | 2016-05-25 |
Family
ID=46044696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES12719369T Active ES2571539T3 (es) | 2011-05-09 | 2012-05-04 | Nuevos compuestos de hexahidropirroloimidazolona |
Country Status (12)
Country | Link |
---|---|
US (1) | US8497288B2 (es) |
EP (1) | EP2707371B1 (es) |
JP (1) | JP6126080B2 (es) |
KR (1) | KR20140029478A (es) |
CN (1) | CN103517905B (es) |
BR (1) | BR112013028945A2 (es) |
CA (1) | CA2834497A1 (es) |
ES (1) | ES2571539T3 (es) |
HK (1) | HK1191946A1 (es) |
MX (1) | MX344429B (es) |
RU (1) | RU2013153191A (es) |
WO (1) | WO2012152663A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112390734A (zh) * | 2019-08-15 | 2021-02-23 | 中国科学院大连化学物理研究所 | 磺酰胺衍生物、其药物组合物和应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001007052A1 (en) * | 1999-07-21 | 2001-02-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
TW200303200A (en) * | 2002-02-07 | 2003-09-01 | Tanabe Seiyaku Co | Inhibitors of α L β 2 integrin mediated cell adhesion |
TW200407324A (en) * | 2002-05-17 | 2004-05-16 | Bristol Myers Squibb Co | Bicyclic modulators of androgen receptor function |
JP2005068145A (ja) * | 2003-08-06 | 2005-03-17 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
US7696241B2 (en) * | 2004-03-04 | 2010-04-13 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
GB0517966D0 (en) * | 2005-09-02 | 2005-10-12 | Novartis Ag | Organic compounds |
US8124636B2 (en) * | 2008-04-30 | 2012-02-28 | Hoffmann-La Roche Inc. | Imidazolidinone derivatives as 11B-HSD1 inhibitors |
BRPI0914933B1 (pt) | 2008-06-30 | 2018-09-25 | Monsanto Technology Llc | Polipeptídeo exibindo atividade de aspartato quinase (ak) que não é sujeito a inibição por produto final, polinucleotídeo codificando o mesmo, construto de dna recombinante,microrganismo transformado, produto alimentício, farelo ou farinha, bem como métodos de transformação de uma célula de planta, de produção de uma planta transformada e de aumento do teor de aminoácido livre total de uma planta. |
US8673917B2 (en) * | 2008-09-09 | 2014-03-18 | Sanofi | 2-heteroaryl-pyrrolo [3,4-C]pyrrole derivatives, and use thereof as SCD inhibitors |
US8329904B2 (en) | 2009-05-12 | 2012-12-11 | Hoffmann-La Roche Inc. | Azacyclic derivatives |
US8501768B2 (en) * | 2011-05-17 | 2013-08-06 | Hoffmann-La Roche Inc. | Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds |
-
2012
- 2012-05-02 US US13/461,835 patent/US8497288B2/en not_active Expired - Fee Related
- 2012-05-04 ES ES12719369T patent/ES2571539T3/es active Active
- 2012-05-04 CA CA2834497A patent/CA2834497A1/en not_active Abandoned
- 2012-05-04 WO PCT/EP2012/058173 patent/WO2012152663A1/en active Application Filing
- 2012-05-04 RU RU2013153191/04A patent/RU2013153191A/ru not_active Application Discontinuation
- 2012-05-04 KR KR1020137032278A patent/KR20140029478A/ko not_active Application Discontinuation
- 2012-05-04 EP EP12719369.6A patent/EP2707371B1/en not_active Not-in-force
- 2012-05-04 MX MX2013013021A patent/MX344429B/es active IP Right Grant
- 2012-05-04 BR BR112013028945A patent/BR112013028945A2/pt not_active IP Right Cessation
- 2012-05-04 JP JP2014509681A patent/JP6126080B2/ja active Active
- 2012-05-04 CN CN201280022252.3A patent/CN103517905B/zh not_active Expired - Fee Related
-
2014
- 2014-05-30 HK HK14105125.1A patent/HK1191946A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP6126080B2 (ja) | 2017-05-10 |
EP2707371B1 (en) | 2016-04-20 |
US20120289549A1 (en) | 2012-11-15 |
CN103517905B (zh) | 2016-08-24 |
WO2012152663A1 (en) | 2012-11-15 |
CA2834497A1 (en) | 2012-12-15 |
BR112013028945A2 (pt) | 2018-04-10 |
HK1191946A1 (zh) | 2014-08-08 |
MX2013013021A (es) | 2013-12-02 |
JP2014516949A (ja) | 2014-07-17 |
US8497288B2 (en) | 2013-07-30 |
MX344429B (es) | 2016-12-15 |
EP2707371A1 (en) | 2014-03-19 |
CN103517905A (zh) | 2014-01-15 |
KR20140029478A (ko) | 2014-03-10 |
RU2013153191A (ru) | 2015-06-20 |
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