ES2568260T3 - Compuestos de pirimidin hidroxi amida como inhibidores de proteína desacetilasa y métodos de uso de los mismos - Google Patents

Compuestos de pirimidin hidroxi amida como inhibidores de proteína desacetilasa y métodos de uso de los mismos Download PDF

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Publication number
ES2568260T3
ES2568260T3 ES11840803.8T ES11840803T ES2568260T3 ES 2568260 T3 ES2568260 T3 ES 2568260T3 ES 11840803 T ES11840803 T ES 11840803T ES 2568260 T3 ES2568260 T3 ES 2568260T3
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compound
disease
cancer
optionally substituted
compounds
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Spanish (es)
Inventor
John H. Van Duzer
Ralph Mazitschek
Yanbing Ding
Nan Yu
Yun Cao
Yong Liu
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Acetylon Pharmaceuticals Inc
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Acetylon Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biomedical Technology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
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ES11840803.8T 2010-11-16 2011-11-15 Compuestos de pirimidin hidroxi amida como inhibidores de proteína desacetilasa y métodos de uso de los mismos Active ES2568260T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41415810P 2010-11-16 2010-11-16
US414158P 2010-11-16
US201161503286P 2011-06-30 2011-06-30
US201161503286P 2011-06-30
PCT/US2011/060791 WO2012068109A2 (en) 2010-11-16 2011-11-15 Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof

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ES2568260T3 true ES2568260T3 (es) 2016-04-28

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ES11840803.8T Active ES2568260T3 (es) 2010-11-16 2011-11-15 Compuestos de pirimidin hidroxi amida como inhibidores de proteína desacetilasa y métodos de uso de los mismos

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US (3) US8614223B2 (cg-RX-API-DMAC7.html)
EP (2) EP2640709B1 (cg-RX-API-DMAC7.html)
JP (2) JP6041808B2 (cg-RX-API-DMAC7.html)
KR (1) KR20130115300A (cg-RX-API-DMAC7.html)
CN (2) CN107011270A (cg-RX-API-DMAC7.html)
AU (2) AU2011329028B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013011868A2 (cg-RX-API-DMAC7.html)
CA (1) CA2818125A1 (cg-RX-API-DMAC7.html)
CL (1) CL2013001381A1 (cg-RX-API-DMAC7.html)
EA (2) EA025345B1 (cg-RX-API-DMAC7.html)
ES (1) ES2568260T3 (cg-RX-API-DMAC7.html)
IL (2) IL226326A0 (cg-RX-API-DMAC7.html)
MX (1) MX2013005392A (cg-RX-API-DMAC7.html)
NZ (2) NZ710405A (cg-RX-API-DMAC7.html)
PH (2) PH12013500964A1 (cg-RX-API-DMAC7.html)
PL (1) PL2640709T3 (cg-RX-API-DMAC7.html)
PT (1) PT2640709T (cg-RX-API-DMAC7.html)
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Families Citing this family (55)

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Publication number Priority date Publication date Assignee Title
PL2526093T3 (pl) 2010-01-22 2017-02-28 Acetylon Pharmaceuticals, Inc. Odwrócone związki amidowe jako inhibitory deacetylazy białkowej oraz sposoby ich stosowania
WO2012068109A2 (en) 2010-11-16 2012-05-24 Acetylon Pharmaceuticals Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
CA2868302A1 (en) 2012-03-23 2013-09-26 Dennis M. Brown Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
EP2839037B1 (en) 2012-04-19 2018-12-26 Acetylon Pharmaceuticals, Inc. Biomarkers to identify patients that will respond to treatment and treating such patients
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