ES2562854T3 - Empleo de monoésteres de isosorbida como productos activos fungicidas - Google Patents
Empleo de monoésteres de isosorbida como productos activos fungicidas Download PDFInfo
- Publication number
- ES2562854T3 ES2562854T3 ES12741261.7T ES12741261T ES2562854T3 ES 2562854 T3 ES2562854 T3 ES 2562854T3 ES 12741261 T ES12741261 T ES 12741261T ES 2562854 T3 ES2562854 T3 ES 2562854T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- isosorbide
- sorbitan
- compounds
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000000855 fungicidal effect Effects 0.000 title claims abstract description 10
- 229960002479 isosorbide Drugs 0.000 title claims description 73
- KLDXJTOLSGUMSJ-JGWLITMVSA-N Isosorbide Chemical compound O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 KLDXJTOLSGUMSJ-JGWLITMVSA-N 0.000 title claims description 65
- 150000001875 compounds Chemical class 0.000 claims abstract description 63
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 17
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 11
- 239000000417 fungicide Substances 0.000 claims abstract description 9
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 79
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 36
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 26
- 238000009472 formulation Methods 0.000 claims description 22
- 239000000126 substance Substances 0.000 claims description 20
- 239000002537 cosmetic Substances 0.000 claims description 18
- -1 isosorbide diesters Chemical class 0.000 claims description 18
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 239000012459 cleaning agent Substances 0.000 claims description 13
- 239000000975 dye Substances 0.000 claims description 13
- 239000003973 paint Substances 0.000 claims description 13
- 238000005406 washing Methods 0.000 claims description 13
- 150000001735 carboxylic acids Chemical class 0.000 claims description 12
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 11
- 150000002148 esters Chemical class 0.000 claims description 11
- 229960002446 octanoic acid Drugs 0.000 claims description 11
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 10
- 239000000600 sorbitol Substances 0.000 claims description 10
- 229920006395 saturated elastomer Polymers 0.000 claims description 7
- 239000000839 emulsion Substances 0.000 claims description 5
- 150000005690 diesters Chemical class 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 27
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- 230000000845 anti-microbial effect Effects 0.000 description 19
- 241000233866 Fungi Species 0.000 description 12
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 11
- 241000894006 Bacteria Species 0.000 description 9
- 239000003755 preservative agent Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 239000004599 antimicrobial Substances 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 230000021736 acetylation Effects 0.000 description 6
- 238000006640 acetylation reaction Methods 0.000 description 6
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- OPJWPPVYCOPDCM-UHFFFAOYSA-N 2-ethylhexyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC OPJWPPVYCOPDCM-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 229920000151 polyglycol Polymers 0.000 description 4
- 239000010695 polyglycol Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- MPCAJMNYNOGXPB-UHFFFAOYSA-N 1,5-Anhydro-mannit Natural products OCC1OCC(O)C(O)C1O MPCAJMNYNOGXPB-UHFFFAOYSA-N 0.000 description 3
- MPCAJMNYNOGXPB-SLPGGIOYSA-N 1,5-anhydro-D-glucitol Chemical compound OC[C@H]1OC[C@H](O)[C@@H](O)[C@@H]1O MPCAJMNYNOGXPB-SLPGGIOYSA-N 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 241000427940 Fusarium solani Species 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 241000228143 Penicillium Species 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 239000003139 biocide Substances 0.000 description 3
- 229940095731 candida albicans Drugs 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 235000005985 organic acids Nutrition 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 230000001172 regenerating effect Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 2
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 2
- 241001331781 Aspergillus brasiliensis Species 0.000 description 2
- 241001465318 Aspergillus terreus Species 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000588919 Citrobacter freundii Species 0.000 description 2
- 208000001840 Dandruff Diseases 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000588915 Klebsiella aerogenes Species 0.000 description 2
- 241000588747 Klebsiella pneumoniae Species 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 241000588767 Proteus vulgaris Species 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 241000589781 Pseudomonas oleovorans Species 0.000 description 2
- 244000178231 Rosmarinus officinalis Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 241001136556 Talaromyces minioluteus Species 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 229940105988 dimethyl lauramine Drugs 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229940092559 enterobacter aerogenes Drugs 0.000 description 2
- 230000032050 esterification Effects 0.000 description 2
- 238000005886 esterification reaction Methods 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- YWFWDNVOPHGWMX-UHFFFAOYSA-N n,n-dimethyldodecan-1-amine Chemical compound CCCCCCCCCCCCN(C)C YWFWDNVOPHGWMX-UHFFFAOYSA-N 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 150000003077 polyols Chemical class 0.000 description 2
- 229940007042 proteus vulgaris Drugs 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 2
- 201000004647 tinea pedis Diseases 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- VUWCWMOCWKCZTA-UHFFFAOYSA-N 1,2-thiazol-4-one Chemical class O=C1CSN=C1 VUWCWMOCWKCZTA-UHFFFAOYSA-N 0.000 description 1
- 229940084778 1,4-sorbitan Drugs 0.000 description 1
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical class OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
- 229940063655 aluminum stearate Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- MXWJVTOOROXGIU-UHFFFAOYSA-N atrazine Chemical compound CCNC1=NC(Cl)=NC(NC(C)C)=N1 MXWJVTOOROXGIU-UHFFFAOYSA-N 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000000035 biogenic effect Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
- 239000007957 coemulsifier Substances 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004851 dishwashing Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 150000001261 hydroxy acids Chemical class 0.000 description 1
- 229960004592 isopropanol Drugs 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229950001046 piroctone Drugs 0.000 description 1
- 229940081510 piroctone olamine Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- RMGVATURDVPNOZ-UHFFFAOYSA-M potassium;hexadecyl hydrogen phosphate Chemical compound [K+].CCCCCCCCCCCCCCCCOP(O)([O-])=O RMGVATURDVPNOZ-UHFFFAOYSA-M 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 235000015639 rosmarinus officinalis Nutrition 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229940100515 sorbitan Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- KJIOQYGWTQBHNH-UHFFFAOYSA-N undecanol Chemical compound CCCCCCCCCCCO KJIOQYGWTQBHNH-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Birds (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102011109435 | 2011-08-04 | ||
| DE102011109435 | 2011-08-04 | ||
| PCT/EP2012/003246 WO2013017257A1 (de) | 2011-08-04 | 2012-07-31 | Verwendung von isosorbidmonoestern als antimikrobielle wirkstoffe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2562854T3 true ES2562854T3 (es) | 2016-03-08 |
Family
ID=46601751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12741261.7T Active ES2562854T3 (es) | 2011-08-04 | 2012-07-31 | Empleo de monoésteres de isosorbida como productos activos fungicidas |
Country Status (7)
| Country | Link |
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| EP (1) | EP2739146B1 (enExample) |
| JP (1) | JP6027112B2 (enExample) |
| CN (1) | CN103747679B (enExample) |
| BR (1) | BR112014002670A2 (enExample) |
| ES (1) | ES2562854T3 (enExample) |
| WO (1) | WO2013017257A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009022445A1 (de) | 2009-05-23 | 2009-12-24 | Clariant International Limited | Zusammensetzung enthaltend Sorbitanmonocaprylat und Alkohol |
| JP6205355B2 (ja) | 2011-08-04 | 2017-09-27 | クラリアント・インターナシヨナル・リミテツド | イソソルビドジエステルの増粘剤としての使用 |
| CN103717071B (zh) | 2011-08-04 | 2016-01-06 | 克拉里安特国际有限公司 | 包含异山梨醇单酯和n-羟基吡啶酮的组合物 |
| WO2013017264A1 (de) | 2011-08-04 | 2013-02-07 | Clariant International Ltd | Zusammensetzungen enthaltend isosorbidmonoester und alkohole, die mindestens eine aromatische gruppe enthalten |
| CN103717064B (zh) | 2011-08-04 | 2016-08-17 | 克拉里安特国际有限公司 | 异山梨醇单酯作为增稠剂的用途 |
| JP6579750B2 (ja) | 2011-08-04 | 2019-09-25 | クラリアント・インターナシヨナル・リミテツド | イソソルビドモノエステル及びイソソルビドジエステルを含む組成物 |
| MX358059B (es) * | 2012-01-17 | 2018-08-03 | Croda Inc | Aditivo de hinchamiento de sellos. |
| EP2990024B1 (en) | 2014-08-26 | 2019-09-25 | Oleon N.V. | Pigment concentrate |
| US10597402B2 (en) | 2015-03-27 | 2020-03-24 | Sytheon Limited | Compositions and methods for restoring epidermal integrity and function and treating dermatological diseases |
| EP3273951B1 (en) | 2015-03-27 | 2020-07-29 | Symbionyx Pharmaceuticals Inc. | Compositions and methods for treating psoriasis |
| WO2016156505A1 (en) * | 2015-04-01 | 2016-10-06 | Basf Se | Isosorbide ether derivatives with preservation activity |
| ES2770111T3 (es) * | 2015-04-24 | 2020-06-30 | Basf Se | Diésteres de isosorbida como agentes nacarantes y opacificantes |
| US10238591B2 (en) | 2015-04-30 | 2019-03-26 | Clariant International Ltd. | Cosmetic compositions comprising estolide esters and uses for hair treatment |
| KR101959994B1 (ko) | 2017-07-25 | 2019-03-21 | 순천대학교 산학협력단 | 항균활성을 나타내는 이소소르비드 유도체 및 이를 유효성분으로 포함하는 항균용 조성물 |
| FR3074423B1 (fr) * | 2017-12-01 | 2020-03-06 | Roquette Freres | Utilisation de dinahydrohexitol en hygiene bucco dentaire pour reduire le developpement de souches bacteriennes |
| FR3094217A1 (fr) * | 2019-03-28 | 2020-10-02 | Roquette Freres | Utilisation de dianhydrohexitol pour la conservation des préparations cosmétiques |
| JP7547361B2 (ja) * | 2019-03-28 | 2024-09-09 | ロケット フレール | 静菌用及び／又は殺菌用及び／又は抗真菌用の薬剤。 |
| EP4637352A2 (en) * | 2022-12-20 | 2025-10-29 | Clariant International Ltd | Antimicrobial combinations |
| EP4424298A3 (en) * | 2024-05-18 | 2025-04-09 | Clariant International Ltd | Antimicrobial compositions |
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| US3331742A (en) | 1963-07-02 | 1967-07-18 | Drew Chem Corp | Sterile mono- and di-glyceride pharmaceutical vehicle product for water and/or oil-soluble therapeutic substances |
| US3394009A (en) * | 1964-07-24 | 1968-07-23 | Atlas Chem Ind | Preparation of baked products |
| DE2234009C3 (de) | 1972-07-11 | 1979-01-11 | Hoechst Ag, 6000 Frankfurt | Kosmetische Zubereitungen |
| JPS557017A (en) * | 1978-06-28 | 1980-01-18 | Kao Corp | Preparation of ground fish meat |
| DE3328372A1 (de) | 1982-08-06 | 1984-03-01 | Sutton Laboratories, Inc., 07928 Chatham, N.J. | Imidazolidinyl-harnstoff und parabene enthaltende zusammensetzung |
| JPS59175408A (ja) | 1983-03-23 | 1984-10-04 | Nippon Saafuakutanto Kogyo Kk | 化粧料 |
| US4637930A (en) | 1984-02-08 | 1987-01-20 | Yamanouchi Pharmaceutical Co, Ltd. | Transdermal formulation of nicardipine hydrochloride |
| US4847088A (en) | 1988-04-28 | 1989-07-11 | Dow Corning Corporation | Synergistic antimicrobial composition |
| JP2743101B2 (ja) | 1989-11-27 | 1998-04-22 | チッソ株式会社 | 食品保存用エタノール製剤 |
| JPH08173787A (ja) | 1994-08-12 | 1996-07-09 | Lion Corp | 界面活性剤組成物 |
| JPH08187070A (ja) * | 1994-11-10 | 1996-07-23 | Lion Corp | 飲食品用抗菌剤及び飲食品 |
| JPH09291016A (ja) | 1996-04-25 | 1997-11-11 | Sunstar Inc | 頭髪化粧料 |
| US6413529B1 (en) | 1999-04-13 | 2002-07-02 | The Procter & Gamble Company | Antimicrobial wipes which provide improved residual benefit versus gram negative bacteria |
| DE10206759A1 (de) | 2002-02-19 | 2003-08-28 | Dragoco Gerberding Co Ag | Synergistische Mischungen von 1,2-Alkandiolen |
| JP2003238396A (ja) | 2002-02-21 | 2003-08-27 | Nisshin Pharma Inc | コエンザイムｑ１０含有乳化組成物 |
| JP5008573B2 (ja) | 2005-02-03 | 2012-08-22 | クラリアント・プロドゥクテ・（ドイチュラント）・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 防腐剤 |
| FR2883877B1 (fr) | 2005-04-01 | 2008-10-10 | Roquette Freres | Procede de preparation de compositions de diester(s) de dianhydrohexitol |
| DE102006004353A1 (de) | 2006-01-30 | 2007-08-02 | Goldschmidt Gmbh | Kaltherstellbare, niedrigviskose und langzeitstabile kosmetische Emulsionen |
| US9555167B2 (en) | 2006-12-11 | 2017-01-31 | 3M Innovative Properties Company | Biocompatible antimicrobial compositions |
| DE102007028702A1 (de) | 2007-06-21 | 2008-12-24 | Evonik Oxeno Gmbh | Verfahren zur Herstellung von Dianhydrohexitol-Diestern |
| US20100113664A1 (en) | 2008-06-11 | 2010-05-06 | Ferro Corporation | Asymmetric Cyclic Diester Compounds |
| ES2391913T3 (es) | 2008-06-13 | 2012-12-03 | Clariant Finance (Bvi) Limited | Composiciones cosméticas o farmacéuticas que comprenden polisiloxanos modificados con al menos un grupo carbamato |
| DE102009001748A1 (de) | 2009-03-23 | 2010-09-30 | Evonik Goldschmidt Gmbh | Formulierungen enthaltend Sorbitancarbonsäureester |
| EP2239315A1 (en) | 2009-04-09 | 2010-10-13 | Cognis IP Management GmbH | Isosorbide monoesters and their use in household applications |
| DE102009022444A1 (de) | 2009-05-23 | 2010-01-07 | Clariant International Limited | Zusammensetzung enthaltend Sorbitanmonocaprylat und antimikrobielle Wirkstoffe |
| DE102009022445A1 (de) | 2009-05-23 | 2009-12-24 | Clariant International Limited | Zusammensetzung enthaltend Sorbitanmonocaprylat und Alkohol |
| US8496917B2 (en) | 2009-11-13 | 2013-07-30 | Sytheon Ltd | Compositions and methods for improving skin appearance |
| US20140308224A1 (en) | 2011-08-04 | 2014-10-16 | Clariant International Ltd. | Cosmetic, dermatological or pharmaceutical compositions comprising isosorbide diesters and uv filters |
| WO2013017264A1 (de) | 2011-08-04 | 2013-02-07 | Clariant International Ltd | Zusammensetzungen enthaltend isosorbidmonoester und alkohole, die mindestens eine aromatische gruppe enthalten |
| JP6579750B2 (ja) * | 2011-08-04 | 2019-09-25 | クラリアント・インターナシヨナル・リミテツド | イソソルビドモノエステル及びイソソルビドジエステルを含む組成物 |
| JP6205355B2 (ja) * | 2011-08-04 | 2017-09-27 | クラリアント・インターナシヨナル・リミテツド | イソソルビドジエステルの増粘剤としての使用 |
| CN103747678A (zh) | 2011-08-04 | 2014-04-23 | 克拉里安特国际有限公司 | 包含异山梨醇单酯和异噻唑啉酮的组合物 |
| CN103717071B (zh) * | 2011-08-04 | 2016-01-06 | 克拉里安特国际有限公司 | 包含异山梨醇单酯和n-羟基吡啶酮的组合物 |
| US20160000080A1 (en) | 2011-08-04 | 2016-01-07 | Clariant International Ltd. | Compositions containing isosorbide monoester and aliphatic vicinal diols |
| CN103717072A (zh) | 2011-08-04 | 2014-04-09 | 克拉里安特国际有限公司 | 包含异山梨醇单酯和卤化抗微生物有效物质的组合物 |
| DE102011119033A1 (de) | 2011-11-22 | 2012-09-06 | Clariant International Ltd. | Verwendung von Isosorbidcaprylaten/capraten in Deodorantien und Antiperspirantien |
-
2012
- 2012-07-31 ES ES12741261.7T patent/ES2562854T3/es active Active
- 2012-07-31 US US14/237,039 patent/US9730450B2/en active Active
- 2012-07-31 WO PCT/EP2012/003246 patent/WO2013017257A1/de not_active Ceased
- 2012-07-31 JP JP2014523222A patent/JP6027112B2/ja active Active
- 2012-07-31 BR BR112014002670A patent/BR112014002670A2/pt active Search and Examination
- 2012-07-31 CN CN201280038016.0A patent/CN103747679B/zh active Active
- 2012-07-31 EP EP12741261.7A patent/EP2739146B1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6027112B2 (ja) | 2016-11-16 |
| CN103747679A (zh) | 2014-04-23 |
| WO2013017257A1 (de) | 2013-02-07 |
| EP2739146A1 (de) | 2014-06-11 |
| EP2739146B1 (de) | 2015-11-25 |
| US20140315996A1 (en) | 2014-10-23 |
| BR112014002670A2 (pt) | 2017-03-01 |
| CN103747679B (zh) | 2017-07-11 |
| JP2014525916A (ja) | 2014-10-02 |
| US9730450B2 (en) | 2017-08-15 |
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