ES2562854T3 - Empleo de monoésteres de isosorbida como productos activos fungicidas - Google Patents
Empleo de monoésteres de isosorbida como productos activos fungicidas Download PDFInfo
- Publication number
- ES2562854T3 ES2562854T3 ES12741261.7T ES12741261T ES2562854T3 ES 2562854 T3 ES2562854 T3 ES 2562854T3 ES 12741261 T ES12741261 T ES 12741261T ES 2562854 T3 ES2562854 T3 ES 2562854T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- isosorbide
- sorbitan
- compounds
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000000855 fungicidal effect Effects 0.000 title claims abstract description 10
- 229960002479 isosorbide Drugs 0.000 title claims description 73
- KLDXJTOLSGUMSJ-JGWLITMVSA-N Isosorbide Chemical compound O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 KLDXJTOLSGUMSJ-JGWLITMVSA-N 0.000 title claims description 65
- 150000001875 compounds Chemical class 0.000 claims abstract description 63
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 17
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 11
- 239000000417 fungicide Substances 0.000 claims abstract description 9
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 79
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 36
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 26
- 238000009472 formulation Methods 0.000 claims description 22
- 239000000126 substance Substances 0.000 claims description 20
- 239000002537 cosmetic Substances 0.000 claims description 18
- -1 isosorbide diesters Chemical class 0.000 claims description 18
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 239000012459 cleaning agent Substances 0.000 claims description 13
- 239000000975 dye Substances 0.000 claims description 13
- 239000003973 paint Substances 0.000 claims description 13
- 238000005406 washing Methods 0.000 claims description 13
- 150000001735 carboxylic acids Chemical class 0.000 claims description 12
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 11
- 150000002148 esters Chemical class 0.000 claims description 11
- 229960002446 octanoic acid Drugs 0.000 claims description 11
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 10
- 239000000600 sorbitol Substances 0.000 claims description 10
- 229920006395 saturated elastomer Polymers 0.000 claims description 7
- 239000000839 emulsion Substances 0.000 claims description 5
- 150000005690 diesters Chemical class 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 27
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- 230000000845 anti-microbial effect Effects 0.000 description 19
- 241000233866 Fungi Species 0.000 description 12
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 11
- 241000894006 Bacteria Species 0.000 description 9
- 239000003755 preservative agent Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 239000004599 antimicrobial Substances 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 230000021736 acetylation Effects 0.000 description 6
- 238000006640 acetylation reaction Methods 0.000 description 6
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- OPJWPPVYCOPDCM-UHFFFAOYSA-N 2-ethylhexyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC OPJWPPVYCOPDCM-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 229920000151 polyglycol Polymers 0.000 description 4
- 239000010695 polyglycol Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- MPCAJMNYNOGXPB-UHFFFAOYSA-N 1,5-Anhydro-mannit Natural products OCC1OCC(O)C(O)C1O MPCAJMNYNOGXPB-UHFFFAOYSA-N 0.000 description 3
- MPCAJMNYNOGXPB-SLPGGIOYSA-N 1,5-anhydro-D-glucitol Chemical compound OC[C@H]1OC[C@H](O)[C@@H](O)[C@@H]1O MPCAJMNYNOGXPB-SLPGGIOYSA-N 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 241000427940 Fusarium solani Species 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 241000228143 Penicillium Species 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 239000003139 biocide Substances 0.000 description 3
- 229940095731 candida albicans Drugs 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 235000005985 organic acids Nutrition 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 230000001172 regenerating effect Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 2
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 2
- 241001331781 Aspergillus brasiliensis Species 0.000 description 2
- 241001465318 Aspergillus terreus Species 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000588919 Citrobacter freundii Species 0.000 description 2
- 208000001840 Dandruff Diseases 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000588915 Klebsiella aerogenes Species 0.000 description 2
- 241000588747 Klebsiella pneumoniae Species 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 241000588767 Proteus vulgaris Species 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 241000589781 Pseudomonas oleovorans Species 0.000 description 2
- 244000178231 Rosmarinus officinalis Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 241001136556 Talaromyces minioluteus Species 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 229940105988 dimethyl lauramine Drugs 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229940092559 enterobacter aerogenes Drugs 0.000 description 2
- 230000032050 esterification Effects 0.000 description 2
- 238000005886 esterification reaction Methods 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- YWFWDNVOPHGWMX-UHFFFAOYSA-N n,n-dimethyldodecan-1-amine Chemical compound CCCCCCCCCCCCN(C)C YWFWDNVOPHGWMX-UHFFFAOYSA-N 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 150000003077 polyols Chemical class 0.000 description 2
- 229940007042 proteus vulgaris Drugs 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 2
- 201000004647 tinea pedis Diseases 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- VUWCWMOCWKCZTA-UHFFFAOYSA-N 1,2-thiazol-4-one Chemical class O=C1CSN=C1 VUWCWMOCWKCZTA-UHFFFAOYSA-N 0.000 description 1
- 229940084778 1,4-sorbitan Drugs 0.000 description 1
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical class OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
- 229940063655 aluminum stearate Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- MXWJVTOOROXGIU-UHFFFAOYSA-N atrazine Chemical compound CCNC1=NC(Cl)=NC(NC(C)C)=N1 MXWJVTOOROXGIU-UHFFFAOYSA-N 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000000035 biogenic effect Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
- 239000007957 coemulsifier Substances 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004851 dishwashing Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 150000001261 hydroxy acids Chemical class 0.000 description 1
- 229960004592 isopropanol Drugs 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229950001046 piroctone Drugs 0.000 description 1
- 229940081510 piroctone olamine Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- RMGVATURDVPNOZ-UHFFFAOYSA-M potassium;hexadecyl hydrogen phosphate Chemical compound [K+].CCCCCCCCCCCCCCCCOP(O)([O-])=O RMGVATURDVPNOZ-UHFFFAOYSA-M 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 235000015639 rosmarinus officinalis Nutrition 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229940100515 sorbitan Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- KJIOQYGWTQBHNH-UHFFFAOYSA-N undecanol Chemical compound CCCCCCCCCCCO KJIOQYGWTQBHNH-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Agronomy & Crop Science (AREA)
- Birds (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102011109435 | 2011-08-04 | ||
| DE102011109435 | 2011-08-04 | ||
| PCT/EP2012/003246 WO2013017257A1 (de) | 2011-08-04 | 2012-07-31 | Verwendung von isosorbidmonoestern als antimikrobielle wirkstoffe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2562854T3 true ES2562854T3 (es) | 2016-03-08 |
Family
ID=46601751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12741261.7T Active ES2562854T3 (es) | 2011-08-04 | 2012-07-31 | Empleo de monoésteres de isosorbida como productos activos fungicidas |
Country Status (7)
| Country | Link |
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| EP (1) | EP2739146B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6027112B2 (cg-RX-API-DMAC7.html) |
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| ES (1) | ES2562854T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013017257A1 (cg-RX-API-DMAC7.html) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009022445A1 (de) | 2009-05-23 | 2009-12-24 | Clariant International Limited | Zusammensetzung enthaltend Sorbitanmonocaprylat und Alkohol |
| JP6086910B2 (ja) | 2011-08-04 | 2017-03-01 | クラリアント・インターナシヨナル・リミテツド | 増粘剤としてのイソソルビドモノエステルの使用 |
| EP2739152B1 (de) | 2011-08-04 | 2016-09-28 | Clariant International Ltd. | Zusammensetzungen enthaltend isosorbidmonoester und alkohole, die mindestens eine aromatische gruppe enthalten |
| WO2013017261A1 (de) | 2011-08-04 | 2013-02-07 | Clariant International Ltd | Zusammensetzung enthaltend isosorbidmonoester und isosorbiddiester |
| ES2638892T3 (es) | 2011-08-04 | 2017-10-24 | Clariant International Ltd. | Uso de diésteres de isosorbida como espesante |
| CN103717071B (zh) | 2011-08-04 | 2016-01-06 | 克拉里安特国际有限公司 | 包含异山梨醇单酯和n-羟基吡啶酮的组合物 |
| WO2013109568A1 (en) * | 2012-01-17 | 2013-07-25 | Croda, Inc. | Seal swell additive |
| EP2990024B1 (en) | 2014-08-26 | 2019-09-25 | Oleon N.V. | Pigment concentrate |
| DK3273951T3 (da) | 2015-03-27 | 2020-11-02 | Symbionyx Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til behandling af psoriasis |
| US10597402B2 (en) | 2015-03-27 | 2020-03-24 | Sytheon Limited | Compositions and methods for restoring epidermal integrity and function and treating dermatological diseases |
| CN107427006B (zh) * | 2015-04-01 | 2020-09-25 | 巴斯夫欧洲公司 | 具有防腐活性的异山梨醇醚衍生物 |
| US10294238B2 (en) * | 2015-04-24 | 2019-05-21 | Basf Se | Isosorbide diester as pearlizing agent and opacifier |
| BR112017023144B1 (pt) | 2015-04-30 | 2021-05-18 | Clariant International Ltd | composições cosméticas compreendendo ésteres de estolídeo, seu processo de preparação e métodos de tratamento de cabelo |
| KR101959994B1 (ko) | 2017-07-25 | 2019-03-21 | 순천대학교 산학협력단 | 항균활성을 나타내는 이소소르비드 유도체 및 이를 유효성분으로 포함하는 항균용 조성물 |
| FR3074423B1 (fr) * | 2017-12-01 | 2020-03-06 | Roquette Freres | Utilisation de dinahydrohexitol en hygiene bucco dentaire pour reduire le developpement de souches bacteriennes |
| US20220193025A1 (en) * | 2019-03-28 | 2022-06-23 | Roquette Freres | Use of dianhydrohexitol to eliminate the cosmetic effects of acne, dandruff and bad odors |
| FR3094217A1 (fr) * | 2019-03-28 | 2020-10-02 | Roquette Freres | Utilisation de dianhydrohexitol pour la conservation des préparations cosmétiques |
| EP4637352A2 (en) * | 2022-12-20 | 2025-10-29 | Clariant International Ltd | Antimicrobial combinations |
| EP4424298A3 (en) * | 2024-05-18 | 2025-04-09 | Clariant International Ltd | Antimicrobial compositions |
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| US3331742A (en) | 1963-07-02 | 1967-07-18 | Drew Chem Corp | Sterile mono- and di-glyceride pharmaceutical vehicle product for water and/or oil-soluble therapeutic substances |
| US3394009A (en) * | 1964-07-24 | 1968-07-23 | Atlas Chem Ind | Preparation of baked products |
| DE2234009C3 (de) | 1972-07-11 | 1979-01-11 | Hoechst Ag, 6000 Frankfurt | Kosmetische Zubereitungen |
| JPS557017A (en) * | 1978-06-28 | 1980-01-18 | Kao Corp | Preparation of ground fish meat |
| GB2126089B (en) | 1982-08-06 | 1985-11-06 | Sutton Lab Inc | Composition of matter containing imidazolidinyl urea and parabens |
| JPS59175408A (ja) | 1983-03-23 | 1984-10-04 | Nippon Saafuakutanto Kogyo Kk | 化粧料 |
| US4637930A (en) | 1984-02-08 | 1987-01-20 | Yamanouchi Pharmaceutical Co, Ltd. | Transdermal formulation of nicardipine hydrochloride |
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| JPH08173787A (ja) | 1994-08-12 | 1996-07-09 | Lion Corp | 界面活性剤組成物 |
| JPH08187070A (ja) * | 1994-11-10 | 1996-07-23 | Lion Corp | 飲食品用抗菌剤及び飲食品 |
| JPH09291016A (ja) | 1996-04-25 | 1997-11-11 | Sunstar Inc | 頭髪化粧料 |
| US6413529B1 (en) | 1999-04-13 | 2002-07-02 | The Procter & Gamble Company | Antimicrobial wipes which provide improved residual benefit versus gram negative bacteria |
| DE10206759A1 (de) | 2002-02-19 | 2003-08-28 | Dragoco Gerberding Co Ag | Synergistische Mischungen von 1,2-Alkandiolen |
| JP2003238396A (ja) | 2002-02-21 | 2003-08-27 | Nisshin Pharma Inc | コエンザイムｑ１０含有乳化組成物 |
| EP1845934B1 (de) | 2005-02-03 | 2008-05-14 | Clariant Produkte (Deutschland) GmbH | Konservierungsmittel |
| FR2883877B1 (fr) | 2005-04-01 | 2008-10-10 | Roquette Freres | Procede de preparation de compositions de diester(s) de dianhydrohexitol |
| DE102006004353A1 (de) | 2006-01-30 | 2007-08-02 | Goldschmidt Gmbh | Kaltherstellbare, niedrigviskose und langzeitstabile kosmetische Emulsionen |
| US9555167B2 (en) | 2006-12-11 | 2017-01-31 | 3M Innovative Properties Company | Biocompatible antimicrobial compositions |
| DE102007028702A1 (de) | 2007-06-21 | 2008-12-24 | Evonik Oxeno Gmbh | Verfahren zur Herstellung von Dianhydrohexitol-Diestern |
| US20100113664A1 (en) | 2008-06-11 | 2010-05-06 | Ferro Corporation | Asymmetric Cyclic Diester Compounds |
| EP1972330B1 (en) | 2008-06-13 | 2012-09-12 | Clariant Finance (BVI) Limited | Cosmetic or pharmaceutical compositions comprising modified polysiloxanes with at least one carbamate group |
| DE102009001748A1 (de) * | 2009-03-23 | 2010-09-30 | Evonik Goldschmidt Gmbh | Formulierungen enthaltend Sorbitancarbonsäureester |
| EP2239315A1 (en) | 2009-04-09 | 2010-10-13 | Cognis IP Management GmbH | Isosorbide monoesters and their use in household applications |
| DE102009022444A1 (de) | 2009-05-23 | 2010-01-07 | Clariant International Limited | Zusammensetzung enthaltend Sorbitanmonocaprylat und antimikrobielle Wirkstoffe |
| DE102009022445A1 (de) | 2009-05-23 | 2009-12-24 | Clariant International Limited | Zusammensetzung enthaltend Sorbitanmonocaprylat und Alkohol |
| US8496917B2 (en) | 2009-11-13 | 2013-07-30 | Sytheon Ltd | Compositions and methods for improving skin appearance |
| ES2638892T3 (es) * | 2011-08-04 | 2017-10-24 | Clariant International Ltd. | Uso de diésteres de isosorbida como espesante |
| US20160000080A1 (en) | 2011-08-04 | 2016-01-07 | Clariant International Ltd. | Compositions containing isosorbide monoester and aliphatic vicinal diols |
| WO2013017258A1 (de) | 2011-08-04 | 2013-02-07 | Clariant International Ltd | Zusammensetzungen enthaltend isosorbidmonoester und isothiazolinone |
| EP2739152B1 (de) | 2011-08-04 | 2016-09-28 | Clariant International Ltd. | Zusammensetzungen enthaltend isosorbidmonoester und alkohole, die mindestens eine aromatische gruppe enthalten |
| WO2013017261A1 (de) | 2011-08-04 | 2013-02-07 | Clariant International Ltd | Zusammensetzung enthaltend isosorbidmonoester und isosorbiddiester |
| CN103747776B (zh) | 2011-08-04 | 2017-06-09 | 克拉里安特国际有限公司 | 包含异山梨醇二酯和紫外线过滤剂的化妆、皮肤病学或药学组合物 |
| WO2013017262A1 (de) | 2011-08-04 | 2013-02-07 | Clariant International Ltd | Zusammensetzungen enthaltend isosorbidmonoester und halogenierte antimikrobielle wirkstoffe |
| CN103717071B (zh) | 2011-08-04 | 2016-01-06 | 克拉里安特国际有限公司 | 包含异山梨醇单酯和n-羟基吡啶酮的组合物 |
| DE102011119033A1 (de) | 2011-11-22 | 2012-09-06 | Clariant International Ltd. | Verwendung von Isosorbidcaprylaten/capraten in Deodorantien und Antiperspirantien |
-
2012
- 2012-07-31 JP JP2014523222A patent/JP6027112B2/ja active Active
- 2012-07-31 WO PCT/EP2012/003246 patent/WO2013017257A1/de not_active Ceased
- 2012-07-31 BR BR112014002670A patent/BR112014002670A2/pt active Search and Examination
- 2012-07-31 EP EP12741261.7A patent/EP2739146B1/de active Active
- 2012-07-31 CN CN201280038016.0A patent/CN103747679B/zh active Active
- 2012-07-31 US US14/237,039 patent/US9730450B2/en active Active
- 2012-07-31 ES ES12741261.7T patent/ES2562854T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014002670A2 (pt) | 2017-03-01 |
| WO2013017257A1 (de) | 2013-02-07 |
| CN103747679B (zh) | 2017-07-11 |
| EP2739146B1 (de) | 2015-11-25 |
| JP2014525916A (ja) | 2014-10-02 |
| JP6027112B2 (ja) | 2016-11-16 |
| US20140315996A1 (en) | 2014-10-23 |
| EP2739146A1 (de) | 2014-06-11 |
| US9730450B2 (en) | 2017-08-15 |
| CN103747679A (zh) | 2014-04-23 |
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