ES2556235T3 - Arilsulfonamidas 2,5-disustituidas antagonistas de CCR3 - Google Patents

Arilsulfonamidas 2,5-disustituidas antagonistas de CCR3 Download PDF

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ES2556235T3
ES2556235T3 ES10714821.5T ES10714821T ES2556235T3 ES 2556235 T3 ES2556235 T3 ES 2556235T3 ES 10714821 T ES10714821 T ES 10714821T ES 2556235 T3 ES2556235 T3 ES 2556235T3
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ccr3 antagonists
integer
mixture
arylsulfonamides
disubstituted
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Tai Wei Ly
Marie Chantal Siu-Ying Tran
Erik Dean Raaum
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Axikin Pharmaceuticals Inc
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Axikin Pharmaceuticals Inc
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Abstract

Un compuesto de Fórmula II:**Fórmula** o un enantiómero, una mezcla de enantiómeros, una mezcla de dos o más diastereómeros, un tautómero o una mezcla de dos o más tautómeros del mismo; o una sal, un solvato o un hidrato farmacéuticamente aceptable del mismo; en la que: R1 y R2 son cada uno, de manera independiente, flúor, cloro o metilo; R3 es ciano o nitro; R5 es metilo, oxo o metoxicarbonilo; X es O o S; Y es -O-, -S-, -S(O)- o -S(O)2-; m es el número entero 1; n es el número entero 1 o 2; y p es el número entero 0, 1 o 2.

Description

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TABLA 1
Compuesto Nº
Ki Compuesto Nº Ki
libre
HCla libre HCla
51
D C 52
53
C 54 D C
55
E 56 C C
57
E 58 E
59
E E 60 E E
61
B 62 E
63
E E 64 E E
65
E 66 A
67
C D 68 C C
69
C D 70 D
71
E 72 E C
73
C 74 B A
75
A 76 A A
77
A A 78 C C
79
A A 80 A A
81
A B 82 D
83
C A 84 A A
85
E 86 E
87
E 88 A
89
B 90 B
91
B 92 C
93
E 94
95
D 96 C
97
D 98 C
99
B 100 A
101
E 102 E
103
E 104 B
105
E 106 E
107
A 108 A
109
E 110 E
111
E 112 E
113
E 114 E
115
E 116 E
117
E 118 B
119
A 120 E
121
A 122 D
123
B 124 A
125
E 126 B
127
E 133 E
140
E 141 E
142
E 143 E
147
E C 148 E
a. HCl: una sal de ácido clorhídrico del correspondiente compuesto.
43
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Claims (1)

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ES10714821.5T 2009-04-22 2010-04-21 Arilsulfonamidas 2,5-disustituidas antagonistas de CCR3 Active ES2556235T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17177509P 2009-04-22 2009-04-22
US171775P 2009-04-22
PCT/US2010/031828 WO2010123956A2 (en) 2009-04-22 2010-04-21 2,5-disubstituted arylsulfonamide ccr3 antagonists

Publications (1)

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ES2556235T3 true ES2556235T3 (es) 2016-01-14

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US (2) US8399456B2 (es)
EP (2) EP2727908A3 (es)
JP (1) JP2012524789A (es)
KR (1) KR20120070629A (es)
CN (2) CN104177313A (es)
AR (1) AR078120A1 (es)
AU (1) AU2010239337B2 (es)
CA (1) CA2758985A1 (es)
CL (1) CL2011002618A1 (es)
CO (1) CO6470794A2 (es)
CR (1) CR20110534A (es)
DK (1) DK2421829T3 (es)
EC (1) ECSP11011472A (es)
ES (1) ES2556235T3 (es)
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CA2758985A1 (en) 2010-10-28
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AU2010239337A1 (en) 2011-11-03
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