ES2549610T3 - Método de diagnóstico para detectar la lesión renal aguda a través del uso de la proteína de choque térmico de 72 como un biomarcador sensible - Google Patents

Método de diagnóstico para detectar la lesión renal aguda a través del uso de la proteína de choque térmico de 72 como un biomarcador sensible Download PDF

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Publication number
ES2549610T3
ES2549610T3 ES10831836.1T ES10831836T ES2549610T3 ES 2549610 T3 ES2549610 T3 ES 2549610T3 ES 10831836 T ES10831836 T ES 10831836T ES 2549610 T3 ES2549610 T3 ES 2549610T3
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diagnostic method
thermal shock
shock protein
biomarker
kidney injury
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Norma Araceli Bobadilla Sandoval
Jonatan Barrera Chimal
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NAC AUTONOMA DE MEXICO, University of
Universidad Nacional Autonoma de Mexico
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NAC AUTONOMA DE MEXICO, University of
Universidad Nacional Autonoma de Mexico
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un método de diagnóstico, no invasivo, confiable y de fácil realización para detectar insuficiencia renal aguda temprana a través de medir Ia concentración de un biomarcador en muestras de orina, seleccionado a las proteínas de choque térmico de Ia familia 70 KDa, más específicamente se refiere a Ia identificación de Ia proteína de choque térmico 72 y Ia identificación de este biomarcador es detectado mediante ELISA y Western blot o bien el nivel de RNAm mediante RT-PCR en tiempo real. Esta invención contribuye a solucionar el problema que existe actualmente en Ia clínica de no poder detectar desde etapas tempranas a Ia Insuficiencia Renal Aguda y Ia intensidad del daño renal para así y poder intervenir oportunamente al paciente con una terapia efectiva.

Description

imagen1
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Tabla 1. Características generales y función renal en donadores de riñón sanos y pacientes con lesión renal aguda séptica
Número de Género Edad (años) Diagnósticos SCr de línea SCr en AKI Seguimiento Resultado/Último SCr sujeto base (mg/dL) (mg/dL) después de (mg/dL) muestreo (días)
Donantes vivos de riñones sanos
1 27 Sano 0.82 NA NA NA 2 25 Sano 0.95 NA NA NA 3 32 Sano 0.85 NA NA NA 4 42 Sano 0.77 NA NA NA 5 35 Sano 0.56 NA NA NA
Pacientes con lesión renal aguda séptica
1 Mujer 51 Neumonía adquirida en la comunidad y 0.50 1.2 122 Recuperación/0.62 Obesidad mórbida
2 Hombre 49 Sepsis abdominal 0.60 3.42 28 Muerte 3 Hombre 24 Neumonía adquirida en la comunidad y Lupus 0.32 0.83 24 Sin recuperación/2.42 sistémico 4 Mujer 39 Neumonía adquirida en la comunidad y 0.49 1.19 45 Recuperación /0.48 Meningitis & Choque séptico
5 Mujer 84 Neumonía adquirida en la comunidad 0.73 1.14 1 Muerte
6 Hombre 34 Neumonía adquirida en la comunidad 0.75 1.86 61 Mejoría/1.12
7 Mujer 84 Neumonía adquirida en la comunidad y Fallo 0.93 3.11 40 Recuperación/1.04 cardiaco
8 Mujer 35 Lupus sistémico y Neumonía adquirida en la 0.44 2.19 5 Mejoría/1.29 comunidad
9 Hombre 46 Artritis séptica y Diabetes mellitus 0.72 5.75 138 Recuperación/0.77
imagen8

Claims (1)

  1. imagen1
ES10831836.1T 2009-11-23 2010-11-23 Método de diagnóstico para detectar la lesión renal aguda a través del uso de la proteína de choque térmico de 72 como un biomarcador sensible Active ES2549610T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
MX2009012633A MX2009012633A (es) 2009-11-23 2009-11-23 Metodo de diagnostico para detectar la lesion renal aguda a traves del uso de la proteina de choque termico de 72 kda como un biomarcador sensible.
MX09012633 2009-11-23
PCT/MX2010/000138 WO2011062469A2 (es) 2009-11-23 2010-11-23 Método de diagnóstico para detectar la lesión renal aguda a través del uso de la proteína de choque térmico de 72 kda como un biomarcador sensible

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ES2549610T3 true ES2549610T3 (es) 2015-10-29

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US (1) US20130065239A1 (es)
EP (1) EP2506016B1 (es)
JP (1) JP5755657B2 (es)
CN (1) CN102762985B (es)
CA (1) CA2781754C (es)
ES (1) ES2549610T3 (es)
MX (1) MX2009012633A (es)
WO (1) WO2011062469A2 (es)

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ES2667066T3 (es) 2010-05-24 2018-05-09 The Trustees Of Columbia University In The City Of New York Proteínas NGAL mutantes y usos de las mismas
AU2011269775B2 (en) 2010-06-23 2015-01-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
KR20140074307A (ko) * 2011-08-26 2014-06-17 아스튜트 메디컬 인코포레이티드 신장 손상 및 신부전의 진단 및 예후진단을 위한 방법 및 조성물
CN102879584A (zh) * 2012-09-26 2013-01-16 中国人民解放军军事医学科学院基础医学研究所 一种人血液hsp70抗体胶体金标检测试纸条及其制备方法
WO2014081980A2 (en) 2012-11-21 2014-05-30 The Trustees Of Columbia University In The City Of New York Mutant ngal proteins and uses thereof
KR101468047B1 (ko) * 2013-01-16 2014-12-02 고려대학교 산학협력단 열충격단백질군의 mRNA 발현 양상 분석을 통한 사인 추정방법
WO2018145117A1 (en) 2017-02-06 2018-08-09 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN107045594B (zh) * 2017-04-25 2018-06-26 吉林大学 一种脊柱损伤测量中x射线标志物的数字化系统
WO2020125806A1 (en) 2018-12-17 2020-06-25 Shanghai United Imaging Intelligence Co., Ltd. Systems and methods for image segmentation
CN109754394B (zh) * 2018-12-28 2021-02-23 上海联影智能医疗科技有限公司 三维医学图像处理装置及方法
CN111007255A (zh) * 2019-12-10 2020-04-14 江苏三联生物工程有限公司 一种用于肾损伤标志物检测的蛋白芯片及其制备方法

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JP4035591B2 (ja) * 2003-01-24 2008-01-23 株式会社三重ティーエルオー 血管障害病態改善剤
US7833732B2 (en) * 2005-07-21 2010-11-16 The John Hopkins University Acute renal injury

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CA2781754C (en) 2019-09-03
EP2506016A2 (en) 2012-10-03
WO2011062469A3 (es) 2011-11-24
JP5755657B2 (ja) 2015-07-29
CN102762985A (zh) 2012-10-31
US20130065239A1 (en) 2013-03-14
JP2013511735A (ja) 2013-04-04
WO2011062469A2 (es) 2011-05-26
EP2506016A4 (en) 2013-01-23
MX2009012633A (es) 2011-05-24
WO2011062469A8 (es) 2012-01-12
CN102762985B (zh) 2015-06-17
CA2781754A1 (en) 2011-05-26
EP2506016B1 (en) 2015-07-08

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