WO2011062469A8 - Método de diagnóstico para detectar la lesión renal aguda a través del uso de la proteína de choque térmico de 72 kda como un biomarcador sensible - Google Patents

Método de diagnóstico para detectar la lesión renal aguda a través del uso de la proteína de choque térmico de 72 kda como un biomarcador sensible Download PDF

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Publication number
WO2011062469A8
WO2011062469A8 PCT/MX2010/000138 MX2010000138W WO2011062469A8 WO 2011062469 A8 WO2011062469 A8 WO 2011062469A8 MX 2010000138 W MX2010000138 W MX 2010000138W WO 2011062469 A8 WO2011062469 A8 WO 2011062469A8
Authority
WO
WIPO (PCT)
Prior art keywords
heat shock
biomarker
diagnostic method
shock protein
kidney injury
Prior art date
Application number
PCT/MX2010/000138
Other languages
English (en)
French (fr)
Other versions
WO2011062469A3 (es
WO2011062469A2 (es
Inventor
Norma Araceli Bobadilla Sandoval
Jonatan Barrera Chimal
Original Assignee
Universidad Nacional Autónoma de México
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Nacional Autónoma de México filed Critical Universidad Nacional Autónoma de México
Priority to CA2781754A priority Critical patent/CA2781754C/en
Priority to EP10831836.1A priority patent/EP2506016B1/en
Priority to US13/511,633 priority patent/US20130065239A1/en
Priority to ES10831836.1T priority patent/ES2549610T3/es
Priority to JP2012541040A priority patent/JP5755657B2/ja
Priority to CN201080062143.5A priority patent/CN102762985B/zh
Publication of WO2011062469A2 publication Critical patent/WO2011062469A2/es
Publication of WO2011062469A3 publication Critical patent/WO2011062469A3/es
Publication of WO2011062469A8 publication Critical patent/WO2011062469A8/es

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un método de diagnóstico, no invasivo, confiable y de fácil realización para detectar insuficiencia renal aguda temprana a través de medir Ia concentración de un biomarcador en muestras de orina, seleccionado a las proteínas de choque térmico de Ia familia 70 KDa, más específicamente se refiere a Ia identificación de Ia proteína de choque térmico 72 y Ia identificación de este biomarcador es detectado mediante ELISA y Western blot o bien el nivel de RNAm mediante RT-PCR en tiempo real. Esta invención contribuye a solucionar el problema que existe actualmente en Ia clínica de no poder detectar desde etapas tempranas a Ia Insuficiencia Renal Aguda y Ia intensidad del daño renal para así y poder intervenir oportunamente al paciente con una terapia efectiva.
PCT/MX2010/000138 2009-11-23 2010-11-23 Método de diagnóstico para detectar la lesión renal aguda a través del uso de la proteína de choque térmico de 72 kda como un biomarcador sensible WO2011062469A2 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2781754A CA2781754C (en) 2009-11-23 2010-11-23 Diagnostic method for detecting acute kidney injury using heat shock protein 72 as a sensitive biomarker
EP10831836.1A EP2506016B1 (en) 2009-11-23 2010-11-23 Diagnostic method for detecting acute kidney injury using heat shock protein 72 as a sensitive biomarker
US13/511,633 US20130065239A1 (en) 2009-11-23 2010-11-23 Diagnostic method for detecting acute kidney injury using heat shock protein 72 as a sensitive biomarker
ES10831836.1T ES2549610T3 (es) 2009-11-23 2010-11-23 Método de diagnóstico para detectar la lesión renal aguda a través del uso de la proteína de choque térmico de 72 como un biomarcador sensible
JP2012541040A JP5755657B2 (ja) 2009-11-23 2010-11-23 感受性バイオマーカーとして熱ショックタンパク質７２を用いる、急性腎障害を検出するための診断方法
CN201080062143.5A CN102762985B (zh) 2009-11-23 2010-11-23 使用热休克蛋白72作为敏感生物标志物来检测急性肾损伤的诊断方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MX2009012633A MX2009012633A (es) 2009-11-23 2009-11-23 Metodo de diagnostico para detectar la lesion renal aguda a traves del uso de la proteina de choque termico de 72 kda como un biomarcador sensible.
MXMX/A/2009/012633 2009-11-23

Publications (3)

Publication Number Publication Date
WO2011062469A2 WO2011062469A2 (es) 2011-05-26
WO2011062469A3 WO2011062469A3 (es) 2011-11-24
WO2011062469A8 true WO2011062469A8 (es) 2012-01-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2010/000138 WO2011062469A2 (es) 2009-11-23 2010-11-23 Método de diagnóstico para detectar la lesión renal aguda a través del uso de la proteína de choque térmico de 72 kda como un biomarcador sensible

Country Status (8)

Country Link
US (1) US20130065239A1 (es)
EP (1) EP2506016B1 (es)
JP (1) JP5755657B2 (es)
CN (1) CN102762985B (es)
CA (1) CA2781754C (es)
ES (1) ES2549610T3 (es)
MX (1) MX2009012633A (es)
WO (1) WO2011062469A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2667066T3 (es) 2010-05-24 2018-05-09 The Trustees Of Columbia University In The City Of New York Proteínas NGAL mutantes y usos de las mismas
AU2011269775B2 (en) 2010-06-23 2015-01-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
KR20140074307A (ko) * 2011-08-26 2014-06-17 아스튜트 메디컬 인코포레이티드 신장 손상 및 신부전의 진단 및 예후진단을 위한 방법 및 조성물
CN102879584A (zh) * 2012-09-26 2013-01-16 中国人民解放军军事医学科学院基础医学研究所 一种人血液hsp70抗体胶体金标检测试纸条及其制备方法
WO2014081980A2 (en) 2012-11-21 2014-05-30 The Trustees Of Columbia University In The City Of New York Mutant ngal proteins and uses thereof
KR101468047B1 (ko) * 2013-01-16 2014-12-02 고려대학교 산학협력단 열충격단백질군의 mRNA 발현 양상 분석을 통한 사인 추정방법
WO2018145117A1 (en) 2017-02-06 2018-08-09 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN107045594B (zh) * 2017-04-25 2018-06-26 吉林大学 一种脊柱损伤测量中x射线标志物的数字化系统
WO2020125806A1 (en) 2018-12-17 2020-06-25 Shanghai United Imaging Intelligence Co., Ltd. Systems and methods for image segmentation
CN109754394B (zh) * 2018-12-28 2021-02-23 上海联影智能医疗科技有限公司 三维医学图像处理装置及方法
CN111007255A (zh) * 2019-12-10 2020-04-14 江苏三联生物工程有限公司 一种用于肾损伤标志物检测的蛋白芯片及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4035591B2 (ja) * 2003-01-24 2008-01-23 株式会社三重ティーエルオー 血管障害病態改善剤
US7833732B2 (en) * 2005-07-21 2010-11-16 The John Hopkins University Acute renal injury

Also Published As

Publication number Publication date
CA2781754C (en) 2019-09-03
EP2506016A2 (en) 2012-10-03
WO2011062469A3 (es) 2011-11-24
JP5755657B2 (ja) 2015-07-29
ES2549610T3 (es) 2015-10-29
CN102762985A (zh) 2012-10-31
US20130065239A1 (en) 2013-03-14
JP2013511735A (ja) 2013-04-04
WO2011062469A2 (es) 2011-05-26
EP2506016A4 (en) 2013-01-23
MX2009012633A (es) 2011-05-24
CN102762985B (zh) 2015-06-17
CA2781754A1 (en) 2011-05-26
EP2506016B1 (en) 2015-07-08

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