ES2543709T3 - Procedimiento de diagnóstico prenatal en célula fetal aislada de sangre materna - Google Patents

Procedimiento de diagnóstico prenatal en célula fetal aislada de sangre materna Download PDF

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Publication number
ES2543709T3
ES2543709T3 ES02740785.7T ES02740785T ES2543709T3 ES 2543709 T3 ES2543709 T3 ES 2543709T3 ES 02740785 T ES02740785 T ES 02740785T ES 2543709 T3 ES2543709 T3 ES 2543709T3
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cells
fetal
origin
maternal blood
fetal origin
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ES02740785.7T
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Patrizia Paterlini-Brechot
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Assistance Publique Hopitaux de Paris APHP
Institut National de la Sante et de la Recherche Medicale INSERM
Universite Paris 5 Rene Descartes
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Assistance Publique Hopitaux de Paris APHP
Institut National de la Sante et de la Recherche Medicale INSERM
Universite Paris 5 Rene Descartes
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6879—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for sex determination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Procedimiento de diagnóstico prenatal en células fetales aisladas de sangre materna que comprende las etapas siguientes: a) la filtración de una muestra de sangre materna pura o diluida en un filtro de porosidad comprendida entre 6 y 15 μm, de forma que se concentren en el filtro según su tamaño ciertas células circulantes, y en particular células de origen fetal que tengan un tamaño comprendido entre 14 y 17 μm; b) el análisis y la caracterización de las células retenidas aisladas en el filtro para la búsqueda de la presencia de un marcador o marcadores inmunológicos y/o citológicos y/o genéticos, con el fin de identificar su naturaleza epitelial y obtener una presunción de su origen fetal o materno; y la recogida individual de la célula o células epiteliales cuyo origen fetal se supone; c) la demostración, mediante análisis genético, del origen fetal de una célula o células de origen fetal supuesto recogidas individualmente en la etapa b; y d) la búsqueda de anomalías genéticas en el genoma o genomas de células cuyo origen fetal se ha demostrado en la etapa c).

Description

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E02740785
27-07-2015
12. Dib, C., Faure, S., Fizames, C., Samson, D., Drouot, N., Vignal, A., Missasseau, P., Marc, S., Hazan, J., Seboun, E., Lathrop, M., Gyapay, G., Morissette, J. y Weissenbach, J. “A comprehensive genetic map of the human genome based on 5.264 microsatelites”. Nature 1996 380: 152-154.
13. Zhang, L., Cui, X., Schmitt, K., Hubert, R.WN., Arnheim, M. “Whole genomic amplification from a single cell: 5 implications for genetic analysis”. PNAS 1992 89: 5847-5851.
14.
Sambrook et al. “Molecular Cloning: A laboratory Manual”. 2001 3ª Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, Nuevaw York
15.
“Diagnostics prénatals et biologie moléculaire”, F. Forestier y DF Schroderet, 1997 Ed. Tec et Doc Lavoisier.
16.
Voullaire L, Wilton L, Slater H y Williamson R. Prenat. Diagn. 1999 19: 846-851
10 17. Lo YM, Patel P; Sampietro M, Gillmer MD, Fleming KA, Wainscoat JS. “Detection of single-copy fetal DNA sequence from maternal blood [carta]. Lancet 1990; 335: 1463-4.
18. Paterlini P, Gerken G, Nakajima E, et al. “Polymerase chain reaction to detect hepatitis B virus DNA and RNA sequences in primary liver cancers from patients negative for hepatitis B surface antigen”. N. Engl. J. Med. 1009;
323: 80-85. 15
15

Claims (1)

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ES02740785.7T 2001-04-30 2002-04-30 Procedimiento de diagnóstico prenatal en célula fetal aislada de sangre materna Expired - Lifetime ES2543709T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0105824 2001-04-30
FR0105824A FR2824144B1 (fr) 2001-04-30 2001-04-30 Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel
PCT/FR2002/001505 WO2002088736A2 (fr) 2001-04-30 2002-04-30 Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel

Publications (1)

Publication Number Publication Date
ES2543709T3 true ES2543709T3 (es) 2015-08-21

Family

ID=8862866

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02740785.7T Expired - Lifetime ES2543709T3 (es) 2001-04-30 2002-04-30 Procedimiento de diagnóstico prenatal en célula fetal aislada de sangre materna

Country Status (8)

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US (1) US7651838B2 (es)
EP (1) EP1383926B1 (es)
JP (1) JP4404553B2 (es)
AU (1) AU2002314224B2 (es)
CA (1) CA2452099C (es)
ES (1) ES2543709T3 (es)
FR (1) FR2824144B1 (es)
WO (1) WO2002088736A2 (es)

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FR2824144B1 (fr) 2004-09-17
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AU2002314224B2 (en) 2007-08-02
WO2002088736A3 (fr) 2003-09-25
FR2824144A1 (fr) 2002-10-31
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