ES2543419T3 - Proceso de injerto de polímeros bioactivos en materiales protésicos - Google Patents

Proceso de injerto de polímeros bioactivos en materiales protésicos Download PDF

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Publication number
ES2543419T3
ES2543419T3 ES07815059.6T ES07815059T ES2543419T3 ES 2543419 T3 ES2543419 T3 ES 2543419T3 ES 07815059 T ES07815059 T ES 07815059T ES 2543419 T3 ES2543419 T3 ES 2543419T3
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Prior art keywords
titanium
prosthetic material
titanium alloy
grafting process
alloy prosthetic
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English (en)
Inventor
Véronique MIGONNEY
Gérard Helary
Flavie Noirclere
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Universite Sorbonne Paris Nord Paris 13
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Universite Sorbonne Paris Nord Paris 13
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F292/00—Macromolecular compounds obtained by polymerising monomers on to inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A61C8/0016—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy polymeric material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/84—Preparations for artificial teeth, for filling teeth or for capping teeth comprising metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F291/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/003—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/10—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to inorganic materials
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D4/00—Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; Coating compositions, based on monomers of macromolecular compounds of groups C09D183/00 - C09D183/16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Ceramic Engineering (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Graft Or Block Polymers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Proceso de injerto de polímeros bioactivos sobre un material protésico de titanio o de aleación de titanio que comprende las siguientes etapas: - la generación de especies activas donadoras de radicales libres en la superficie del material protésico de titanio o de aleación de titanio por oxidación de dicho material protésico de titanio o de aleación de titanio; - la generación de radicales libres en la superficie del material protésico de titanio o de aleación de titanio por reacción térmica a una temperatura comprendida entre 40 y 100ºC; y - la colocación de dicho material protésico de titanio o de aleación de titanio sobre el que se generan los radicales libres en presencia de al menos un monómero portador de una función que permite una polimerización radicalaria, permitiendo la polimerización radicalaria de dicho monómero la formación de un polímero bioactivo, realizándose dicha polimerización radicalaria en ausencia de oxígeno.

Description

imagen1
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E07815059
23-07-2015
imagen6
en las que M representa un ión metálico, preferiblemente un metal alcalino.
El metal alcalino se elige preferiblemente de sodio y potasio, ventajosamente sodio.
Entre los radicales alquilo de C1 a C6, lineales o ramificados, se pueden citar, en particular, los radicales metilo, etilo, 5 n-propilo, isopropilo, n-butilo o t-butilo, pentilo, y hexilo.
Entre los monómeros de fórmula (I), se pueden citar, en particular, ácido acrílico (AA), ácido metacrílico (MA), ácido etacrílico (EA), sus sales correspondientes (en particular sales de metal alcalino, preferiblemente de sodio) y sus mezclas. Se prefiere el ácido metacrílico.
Entre los monómeros de fórmula (II), se pueden citar, en particular, acrilamida de N-(sulfonato de fenil sodio) 10 (NaAS), metacrilamida de N-(sulfonato de fenil sodio) (NaMS), estireno sulfonato de sodio (NaSS) y sus mezclas. Se prefiere el estireno sulfonato de sodio.
Como ilustración, cuando A del monómero de fórmula (II) presenta la fórmula (III), el copolímero injertado sobre el material protésico puede estar representado más específicamente por la siguiente fórmula general (V):
imagen7
15 en la que R, R', y M son tal como se han definido anteriormente, y n representa un número real comprendido entre 10 y 1000.
La prima significa que la cantidad, la razón y el encadenamiento de las unidades monoméricas presentes en los copolímeros varían. Esta variación está relacionada directamente con los parámetros del proceso de polimerización, tales como por ejemplo la cantidad de cada monómero que se utiliza.
20 Los pesos moleculares de los polímeros injertados de acuerdo con el proceso de la presenta la invención pueden variar en gran medida y se eligen o se controlan por el experto en la materia en función de su aplicación o uso posterior. Para dar un orden de magnitud, el peso molecular promedio en peso puede variar de 1 000 a 100 000 daltons.
Para esto, las cantidades de los monómeros de fórmulas (I) y (II) pueden variar en gran medida y dependen en
25 particular de las propiedades deseadas para los copolímeros. Preferiblemente, la razón molar de (I) sobre (II) varía de 90/10 a 10/90, ventajosamente de 80/20 a 20/80. Los copolímeros de acuerdo con la invención presentan en particular las siguientes fracciones molares de (I) sobre (II): 90/10, 80/20, 70/30, 60/40, 50/50, 40/60, 30/70, 20/80 y 10/90 (estas fracciones corresponden en realidad a las fracciones de los monómeros introducidos, variando las fracciones de los monómeros incorporados en los copolímeros obtenidos por análisis RMN un máximo de ± 2
30 respecto a aquellas mencionadas anteriormente).
7
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Claims (1)

  1. imagen1
    imagen2
ES07815059.6T 2006-06-07 2007-06-07 Proceso de injerto de polímeros bioactivos en materiales protésicos Active ES2543419T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0605073A FR2902102B1 (fr) 2006-06-07 2006-06-07 Procede de greffage de polymeres bioactifs sur des materiaux prothetiques
FR0605073 2006-06-07
PCT/FR2007/051389 WO2007141460A2 (fr) 2006-06-07 2007-06-07 Procédé de greffage de polymères bioactifs sur des matériaux prothétiques

Publications (1)

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ES2543419T3 true ES2543419T3 (es) 2015-08-19

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Country Status (7)

Country Link
US (1) US9139678B2 (es)
EP (1) EP2032663B1 (es)
JP (2) JP6062139B2 (es)
ES (1) ES2543419T3 (es)
FR (1) FR2902102B1 (es)
PL (1) PL2032663T3 (es)
WO (1) WO2007141460A2 (es)

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Publication number Priority date Publication date Assignee Title
FR2902102B1 (fr) * 2006-06-07 2011-11-18 Univ Paris 13 Procede de greffage de polymeres bioactifs sur des materiaux prothetiques
TW201315451A (zh) * 2011-10-06 2013-04-16 Metal Ind Res & Dev Ct 金屬植入物表面處理方法及其金屬植入物
JP5954798B2 (ja) * 2011-11-16 2016-07-20 東ソー有機化学株式会社 高純度パラスチレンスルホン酸（塩）、それを用いたポリスチレンスルホン酸（塩）、およびポリスチレンスルホン酸（塩）を用いた、分散剤、導電性ポリマードーパント、ナノカーボン材料水性分散体、導電性ポリマー水性分散体、ならびにポリスチレンスルホン酸（塩）の製造方法
US8545951B2 (en) 2012-02-29 2013-10-01 Kimberly-Clark Worldwide, Inc. Endotracheal tubes and other polymer substrates including an anti-fouling treatment
FR3039772B1 (fr) * 2015-08-07 2017-09-08 Univ Paris Xiii Paris-Nord Villetaneuse Procede de greffage de polymeres bioactifs sur des materiaux metalliques
FR3042715B1 (fr) * 2015-10-22 2017-12-08 Les Laboratoires Osteal Medical Procede pour greffer un polymere bioactif sur des implants
FR3042698A1 (fr) 2015-10-22 2017-04-28 Les Laboratoires Osteal Medical Dispositifs de support pour supporter des implants ou des protheses
FR3042728B1 (fr) * 2015-10-22 2017-12-08 Les Laboratoires Osteal Medical Enceinte etanche de polymerisation
EP3246002A1 (en) * 2016-05-20 2017-11-22 DENTSPLY DETREY GmbH Dental composition
FR3118699A1 (fr) 2021-01-13 2022-07-15 Activ' Biomat Implant et son procédé de fabrication
FR3131328A1 (fr) * 2021-12-23 2023-06-30 Activ' Biomat Solution de greffage
JP7365444B2 (ja) 2022-03-09 2023-10-19 東ソー・ファインケム株式会社 高純度４－（２－ブロモエチル）ベンゼンスルホン酸及びそれから誘導される高純度スチレンスルホン酸類とそのポリマー、並びにそれらの製造方法

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JPH1072681A (ja) * 1996-08-29 1998-03-17 Ishikawajima Harima Heavy Ind Co Ltd 骨伝導性を有するチタンまたはチタン合金の表面処理方法
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FR2902102B1 (fr) * 2006-06-07 2011-11-18 Univ Paris 13 Procede de greffage de polymeres bioactifs sur des materiaux prothetiques

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Publication number Publication date
US9139678B2 (en) 2015-09-22
EP2032663B1 (fr) 2015-05-06
FR2902102B1 (fr) 2011-11-18
JP2009539453A (ja) 2009-11-19
FR2902102A1 (fr) 2007-12-14
WO2007141460A2 (fr) 2007-12-13
WO2007141460A3 (fr) 2008-01-24
US20090318622A1 (en) 2009-12-24
JP2017035506A (ja) 2017-02-16
EP2032663A2 (fr) 2009-03-11
JP6062139B2 (ja) 2017-01-18
PL2032663T3 (pl) 2015-10-30

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