ES2538078T3 - Bacteria productora de alcohol isopropílico y método para producir alcohol isopropílico - Google Patents
Bacteria productora de alcohol isopropílico y método para producir alcohol isopropílico Download PDFInfo
- Publication number
- ES2538078T3 ES2538078T3 ES10817144.8T ES10817144T ES2538078T3 ES 2538078 T3 ES2538078 T3 ES 2538078T3 ES 10817144 T ES10817144 T ES 10817144T ES 2538078 T3 ES2538078 T3 ES 2538078T3
- Authority
- ES
- Spain
- Prior art keywords
- isopropyl alcohol
- escherichia coli
- genus
- gene
- bacterium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 title abstract description 102
- 241000894006 Bacteria Species 0.000 title description 52
- 238000000034 method Methods 0.000 title description 15
- 241000588724 Escherichia coli Species 0.000 abstract description 47
- 108090000623 proteins and genes Proteins 0.000 abstract description 28
- 229930006000 Sucrose Natural products 0.000 abstract description 13
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract description 13
- 239000005720 sucrose Substances 0.000 abstract description 13
- 108010021809 Alcohol dehydrogenase Proteins 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 10
- 108091022873 acetoacetate decarboxylase Proteins 0.000 abstract description 8
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 102000007698 Alcohol dehydrogenase Human genes 0.000 abstract description 6
- 108060008225 Thiolase Proteins 0.000 abstract description 5
- 108090000992 Transferases Proteins 0.000 abstract description 5
- 102000002932 Thiolase Human genes 0.000 abstract description 4
- 102000004357 Transferases Human genes 0.000 abstract description 4
- 101710173142 Beta-fructofuranosidase, cell wall isozyme Proteins 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 description 22
- 108020004414 DNA Proteins 0.000 description 21
- 102000004190 Enzymes Human genes 0.000 description 19
- 241000196324 Embryophyta Species 0.000 description 16
- 241000193403 Clostridium Species 0.000 description 15
- 239000012634 fragment Substances 0.000 description 14
- 230000001580 bacterial effect Effects 0.000 description 12
- 239000013612 plasmid Substances 0.000 description 11
- 241000193401 Clostridium acetobutylicum Species 0.000 description 9
- 239000002994 raw material Substances 0.000 description 9
- 239000006142 Luria-Bertani Agar Substances 0.000 description 8
- 241000193454 Clostridium beijerinckii Species 0.000 description 7
- 229960000723 ampicillin Drugs 0.000 description 7
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- 241000588722 Escherichia Species 0.000 description 6
- 229910052799 carbon Inorganic materials 0.000 description 6
- 108091008146 restriction endonucleases Proteins 0.000 description 6
- 101150018392 cscA gene Proteins 0.000 description 5
- 229960005091 chloramphenicol Drugs 0.000 description 4
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 4
- 230000002255 enzymatic effect Effects 0.000 description 4
- 239000013604 expression vector Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 229930091371 Fructose Natural products 0.000 description 3
- 239000005715 Fructose Substances 0.000 description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 102000003960 Ligases Human genes 0.000 description 3
- 108090000364 Ligases Proteins 0.000 description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 241000589173 Bradyrhizobium Species 0.000 description 2
- 241000589174 Bradyrhizobium japonicum Species 0.000 description 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 2
- 241000222178 Candida tropicalis Species 0.000 description 2
- 241000863012 Caulobacter Species 0.000 description 2
- 241000010804 Caulobacter vibrioides Species 0.000 description 2
- 241001464948 Coprococcus Species 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 241000194033 Enterococcus Species 0.000 description 2
- 241000194032 Enterococcus faecalis Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241001608234 Faecalibacterium Species 0.000 description 2
- 241000605980 Faecalibacterium prausnitzii Species 0.000 description 2
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 241000205062 Halobacterium Species 0.000 description 2
- 241000589180 Rhizobium Species 0.000 description 2
- 241000605947 Roseburia Species 0.000 description 2
- 241000398180 Roseburia intestinalis Species 0.000 description 2
- 241000187747 Streptomyces Species 0.000 description 2
- 241000145545 Streptomyces collinus Species 0.000 description 2
- 241000223104 Trypanosoma Species 0.000 description 2
- 241000223105 Trypanosoma brucei Species 0.000 description 2
- 241000589651 Zoogloea Species 0.000 description 2
- 241000589153 Zoogloea ramigera Species 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- OJFDKHTZOUZBOS-CITAKDKDSA-N acetoacetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 OJFDKHTZOUZBOS-CITAKDKDSA-N 0.000 description 2
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- 101150008413 atoD gene Proteins 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 108010051210 beta-Fructofuranosidase Proteins 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 229940032049 enterococcus faecalis Drugs 0.000 description 2
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000006798 recombination Effects 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 241000423302 Clostridium acetobutylicum ATCC 824 Species 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 description 1
- 241000194105 Paenibacillus polymyxa Species 0.000 description 1
- 244000089486 Phragmites australis subsp australis Species 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 241000831652 Salinivibrio sharmensis Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- WDJHALXBUFZDSR-UHFFFAOYSA-M acetoacetate Chemical compound CC(=O)CC([O-])=O WDJHALXBUFZDSR-UHFFFAOYSA-M 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000013611 chromosomal DNA Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000001573 invertase Substances 0.000 description 1
- 235000011073 invertase Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01016—Acetyl-CoA C-acyltransferase (2.3.1.16)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01004—Acetoacetate decarboxylase (4.1.1.4)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009214694 | 2009-09-16 | ||
| JP2009214694 | 2009-09-16 | ||
| PCT/JP2010/065770 WO2011034031A1 (ja) | 2009-09-16 | 2010-09-13 | イソプロピルアルコール生産細菌及びイソプロピルアルコール生産方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2538078T3 true ES2538078T3 (es) | 2015-06-17 |
Family
ID=43758635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10817144.8T Active ES2538078T3 (es) | 2009-09-16 | 2010-09-13 | Bacteria productora de alcohol isopropílico y método para producir alcohol isopropílico |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9096842B2 (enExample) |
| EP (1) | EP2479255B1 (enExample) |
| JP (1) | JP5568562B2 (enExample) |
| CN (1) | CN102498203B (enExample) |
| BR (1) | BR112012005872B1 (enExample) |
| CA (1) | CA2774038C (enExample) |
| ES (1) | ES2538078T3 (enExample) |
| IN (1) | IN2012DN02338A (enExample) |
| SG (1) | SG179183A1 (enExample) |
| TW (1) | TWI509072B (enExample) |
| WO (1) | WO2011034031A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI563093B (en) * | 2011-08-11 | 2016-12-21 | Mitsui Chemicals Inc | Method of producing isopropyl alcohol by continuous culture |
| JPWO2024004833A1 (enExample) | 2022-06-30 | 2024-01-04 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2212447C2 (ru) | 2000-04-26 | 2003-09-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Штамм escherichia coli - продуцент аминокислоты (варианты) и способ получения аминокислот (варианты) |
| KR101504618B1 (ko) | 2007-06-01 | 2015-03-23 | 솔라짐, 인코포레이티드 | 미생물에서 오일의 생성 |
| WO2009008377A1 (ja) * | 2007-07-11 | 2009-01-15 | Mitsui Chemicals, Inc. | イソプロピルアルコール生産細菌及びこれを用いたイソプロピルアルコール生産方法 |
| CN101970648A (zh) | 2007-12-18 | 2011-02-09 | 韩国科学技术院 | 具有使用蔗糖作为碳源能力的重组微生物 |
-
2010
- 2010-09-13 JP JP2011531922A patent/JP5568562B2/ja active Active
- 2010-09-13 US US13/496,194 patent/US9096842B2/en active Active
- 2010-09-13 CA CA2774038A patent/CA2774038C/en active Active
- 2010-09-13 BR BR112012005872-0A patent/BR112012005872B1/pt active IP Right Grant
- 2010-09-13 ES ES10817144.8T patent/ES2538078T3/es active Active
- 2010-09-13 WO PCT/JP2010/065770 patent/WO2011034031A1/ja not_active Ceased
- 2010-09-13 IN IN2338DEN2012 patent/IN2012DN02338A/en unknown
- 2010-09-13 SG SG2012018719A patent/SG179183A1/en unknown
- 2010-09-13 EP EP10817144.8A patent/EP2479255B1/en active Active
- 2010-09-13 CN CN201080039906.4A patent/CN102498203B/zh active Active
- 2010-09-16 TW TW099131435A patent/TWI509072B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2479255A1 (en) | 2012-07-25 |
| US9096842B2 (en) | 2015-08-04 |
| IN2012DN02338A (enExample) | 2015-08-21 |
| JPWO2011034031A1 (ja) | 2013-02-14 |
| TW201114901A (en) | 2011-05-01 |
| TWI509072B (zh) | 2015-11-21 |
| WO2011034031A1 (ja) | 2011-03-24 |
| EP2479255B1 (en) | 2015-03-04 |
| CA2774038A1 (en) | 2011-03-24 |
| CA2774038C (en) | 2015-05-05 |
| BR112012005872B1 (pt) | 2021-10-26 |
| BR112012005872A2 (pt) | 2020-08-18 |
| US20120237992A1 (en) | 2012-09-20 |
| CN102498203A (zh) | 2012-06-13 |
| JP5568562B2 (ja) | 2014-08-06 |
| CN102498203B (zh) | 2015-01-07 |
| EP2479255A4 (en) | 2013-07-31 |
| SG179183A1 (en) | 2012-04-27 |
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