ES2536969T3 - Dispositivo de spray nasal - Google Patents
Dispositivo de spray nasal Download PDFInfo
- Publication number
- ES2536969T3 ES2536969T3 ES11779089.9T ES11779089T ES2536969T3 ES 2536969 T3 ES2536969 T3 ES 2536969T3 ES 11779089 T ES11779089 T ES 11779089T ES 2536969 T3 ES2536969 T3 ES 2536969T3
- Authority
- ES
- Spain
- Prior art keywords
- aerosol
- nasal spray
- pharmaceutical formulation
- spray device
- transfer channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940097496 nasal spray Drugs 0.000 title claims abstract description 58
- 239000007922 nasal spray Substances 0.000 title claims abstract description 58
- 239000000443 aerosol Substances 0.000 claims abstract description 66
- 239000007921 spray Substances 0.000 claims abstract description 58
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 42
- 238000012546 transfer Methods 0.000 claims abstract description 32
- 239000004480 active ingredient Substances 0.000 claims abstract description 28
- 239000003380 propellant Substances 0.000 claims abstract description 21
- 210000003928 nasal cavity Anatomy 0.000 claims abstract description 20
- 239000006184 cosolvent Substances 0.000 claims abstract description 15
- 239000000203 mixture Substances 0.000 claims description 47
- 238000009472 formulation Methods 0.000 claims description 42
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical group C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims description 17
- 229950000210 beclometasone dipropionate Drugs 0.000 claims description 16
- 239000000725 suspension Substances 0.000 claims description 11
- 239000012530 fluid Substances 0.000 claims description 5
- 238000004891 communication Methods 0.000 claims description 4
- 239000007789 gas Substances 0.000 claims description 2
- 230000001133 acceleration Effects 0.000 description 24
- 108091006146 Channels Proteins 0.000 description 23
- 239000003814 drug Substances 0.000 description 22
- 230000000052 comparative effect Effects 0.000 description 14
- 229940079593 drug Drugs 0.000 description 14
- 239000000243 solution Substances 0.000 description 10
- 239000004094 surface-active agent Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 230000003993 interaction Effects 0.000 description 6
- 238000000540 analysis of variance Methods 0.000 description 5
- 230000008878 coupling Effects 0.000 description 5
- 238000010168 coupling process Methods 0.000 description 5
- 238000005859 coupling reaction Methods 0.000 description 5
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 description 5
- 150000005828 hydrofluoroalkanes Chemical class 0.000 description 5
- 238000002483 medication Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 206010061876 Obstruction Diseases 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 description 4
- 230000000717 retained effect Effects 0.000 description 4
- 238000007619 statistical method Methods 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 4
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 description 3
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- -1 alcometasone Chemical class 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 229960000289 fluticasone propionate Drugs 0.000 description 3
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 2
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 description 2
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 description 2
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 description 2
- 229960004436 budesonide Drugs 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 239000013583 drug formulation Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229940071648 metered dose inhaler Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002991 molded plastic Substances 0.000 description 2
- 229960002744 mometasone furoate Drugs 0.000 description 2
- 229960004123 mometasone furoate monohydrate Drugs 0.000 description 2
- 210000002850 nasal mucosa Anatomy 0.000 description 2
- 229940003691 nasonex Drugs 0.000 description 2
- 210000001331 nose Anatomy 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000011321 prophylaxis Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229960002117 triamcinolone acetonide Drugs 0.000 description 2
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- OBRNDARFFFHCGE-PERKLWIXSA-N (S,S)-formoterol fumarate Chemical compound OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 OBRNDARFFFHCGE-PERKLWIXSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 239000005541 ACE inhibitor Substances 0.000 description 1
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- 102000008873 Angiotensin II receptor Human genes 0.000 description 1
- 108050000824 Angiotensin II receptor Proteins 0.000 description 1
- 229940122361 Bisphosphonate Drugs 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 description 1
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- LUKZNWIVRBCLON-GXOBDPJESA-N Ciclesonide Chemical compound C1([C@H]2O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(C[C@H](O)[C@@H]3[C@@]4(C)C=CC(=O)C=C4CC[C@H]32)C)C(=O)COC(=O)C(C)C)CCCCC1 LUKZNWIVRBCLON-GXOBDPJESA-N 0.000 description 1
- VPNYRYCIDCJBOM-UHFFFAOYSA-M Glycopyrronium bromide Chemical compound [Br-].C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 VPNYRYCIDCJBOM-UHFFFAOYSA-M 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 description 1
- 229940127523 NMDA Receptor Antagonists Drugs 0.000 description 1
- JKWKMORAXJQQSR-MOPIKTETSA-N Nandrolone Decanoate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCCCCCCC)[C@@]1(C)CC2 JKWKMORAXJQQSR-MOPIKTETSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 102000004257 Potassium Channel Human genes 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 206010039094 Rhinitis perennial Diseases 0.000 description 1
- 208000036284 Rhinitis seasonal Diseases 0.000 description 1
- 239000000150 Sympathomimetic Substances 0.000 description 1
- 239000000048 adrenergic agonist Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
- BNPSSFBOAGDEEL-UHFFFAOYSA-N albuterol sulfate Chemical compound OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 BNPSSFBOAGDEEL-UHFFFAOYSA-N 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 239000002160 alpha blocker Substances 0.000 description 1
- 229940124308 alpha-adrenoreceptor antagonist Drugs 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000003416 antiarrhythmic agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127090 anticoagulant agent Drugs 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 239000000729 antidote Substances 0.000 description 1
- 229940075522 antidotes Drugs 0.000 description 1
- 239000002111 antiemetic agent Substances 0.000 description 1
- 229940125683 antiemetic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 229940082988 antihypertensives serotonin antagonists Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000000164 antipsychotic agent Substances 0.000 description 1
- 229940005529 antipsychotics Drugs 0.000 description 1
- 239000003420 antiserotonin agent Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 229940092705 beclomethasone Drugs 0.000 description 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 1
- 229960002537 betamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 1
- 150000004663 bisphosphonates Chemical class 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 239000000480 calcium channel blocker Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000002144 chemical decomposition reaction Methods 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 239000000544 cholinesterase inhibitor Substances 0.000 description 1
- 229960003728 ciclesonide Drugs 0.000 description 1
- 229960002842 clobetasol Drugs 0.000 description 1
- CBGUOGMQLZIXBE-XGQKBEPLSA-N clobetasol propionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CBGUOGMQLZIXBE-XGQKBEPLSA-N 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- FBHSPRKOSMHSIF-GRMWVWQJSA-N deflazacort Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(C)=N[C@@]3(C(=O)COC(=O)C)[C@@]1(C)C[C@@H]2O FBHSPRKOSMHSIF-GRMWVWQJSA-N 0.000 description 1
- 229960001145 deflazacort Drugs 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 229960002593 desoximetasone Drugs 0.000 description 1
- VWVSBHGCDBMOOT-IIEHVVJPSA-N desoximetasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@@H]2O VWVSBHGCDBMOOT-IIEHVVJPSA-N 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 229960004091 diflucortolone Drugs 0.000 description 1
- OGPWIDANBSLJPC-RFPWEZLHSA-N diflucortolone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@H](C(=O)CO)[C@@]2(C)C[C@@H]1O OGPWIDANBSLJPC-RFPWEZLHSA-N 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- 229940052760 dopamine agonists Drugs 0.000 description 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 229940033835 flonase Drugs 0.000 description 1
- AAXVEMMRQDVLJB-BULBTXNYSA-N fludrocortisone Chemical compound O=C1CC[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 AAXVEMMRQDVLJB-BULBTXNYSA-N 0.000 description 1
- 229960002011 fludrocortisone Drugs 0.000 description 1
- 229960000676 flunisolide Drugs 0.000 description 1
- 229940043075 fluocinolone Drugs 0.000 description 1
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 229960002714 fluticasone Drugs 0.000 description 1
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 description 1
- 229960002848 formoterol Drugs 0.000 description 1
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 description 1
- 229960000193 formoterol fumarate Drugs 0.000 description 1
- 239000013022 formulation composition Substances 0.000 description 1
- PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 229960002462 glycopyrronium bromide Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 229940126904 hypoglycaemic agent Drugs 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229960001361 ipratropium bromide Drugs 0.000 description 1
- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940065725 leukotriene receptor antagonists for obstructive airway diseases Drugs 0.000 description 1
- 239000003199 leukotriene receptor blocking agent Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940127212 long-acting beta 2 agonist Drugs 0.000 description 1
- 229940125389 long-acting beta agonist Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229940014206 metered dose nasal spray Drugs 0.000 description 1
- 229940066491 mucolytics Drugs 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 229960001935 nandrolone decanoate Drugs 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- 229940053050 neomycin sulfate Drugs 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 229920006120 non-fluorinated polymer Polymers 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 229960000797 oxitropium Drugs 0.000 description 1
- NVOYVOBDTVTBDX-PMEUIYRNSA-N oxitropium Chemical compound CC[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1 NVOYVOBDTVTBDX-PMEUIYRNSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 108020001213 potassium channel Proteins 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 229960004017 salmeterol Drugs 0.000 description 1
- 229960005018 salmeterol xinafoate Drugs 0.000 description 1
- 208000017022 seasonal allergic rhinitis Diseases 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000000952 serotonin receptor agonist Substances 0.000 description 1
- 229940127211 short-acting beta 2 agonist Drugs 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229940127230 sympathomimetic drug Drugs 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- 229960000257 tiotropium bromide Drugs 0.000 description 1
- 210000001944 turbinate Anatomy 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
- B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
- B65D83/52—Metering valves; Metering devices
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Mechanical Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Massaging Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39222310P | 2010-10-12 | 2010-10-12 | |
| US392223P | 2010-10-12 | ||
| PCT/EP2011/005118 WO2012048867A1 (en) | 2010-10-12 | 2011-10-12 | Nasal spray device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2536969T3 true ES2536969T3 (es) | 2015-06-01 |
Family
ID=44907783
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11779089.9T Active ES2536969T3 (es) | 2010-10-12 | 2011-10-12 | Dispositivo de spray nasal |
| ES15164095T Active ES2712996T3 (es) | 2010-10-12 | 2011-10-12 | Dispositivo de pulverización nasal |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15164095T Active ES2712996T3 (es) | 2010-10-12 | 2011-10-12 | Dispositivo de pulverización nasal |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20120085345A1 (https=) |
| EP (2) | EP2926855B1 (https=) |
| JP (2) | JP6050236B2 (https=) |
| KR (1) | KR101559639B1 (https=) |
| CN (3) | CN106178205A (https=) |
| AU (1) | AU2011316124B2 (https=) |
| BR (1) | BR112013008824A2 (https=) |
| CA (1) | CA2814212C (https=) |
| CL (1) | CL2013000958A1 (https=) |
| CY (1) | CY1121719T1 (https=) |
| DK (2) | DK2926855T3 (https=) |
| EA (1) | EA023795B1 (https=) |
| ES (2) | ES2536969T3 (https=) |
| HR (2) | HRP20150452T1 (https=) |
| HU (1) | HUE043276T2 (https=) |
| IL (1) | IL225712A (https=) |
| LT (1) | LT2926855T (https=) |
| MX (1) | MX336164B (https=) |
| NZ (1) | NZ608218A (https=) |
| PE (1) | PE20131492A1 (https=) |
| PL (2) | PL2627386T3 (https=) |
| PT (2) | PT2627386E (https=) |
| RS (2) | RS58574B1 (https=) |
| SG (1) | SG189892A1 (https=) |
| SI (2) | SI2926855T1 (https=) |
| SM (2) | SMT201900135T1 (https=) |
| TR (1) | TR201902415T4 (https=) |
| WO (1) | WO2012048867A1 (https=) |
| ZA (1) | ZA201301938B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201121812D0 (en) * | 2011-12-07 | 2012-02-01 | Teva Branded Pharmaceutical Prod R & D Inc | NAsal formulation |
| GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
| MX2015002027A (es) * | 2012-08-29 | 2015-06-05 | Chiesi Farma Spa | Dispositivo de inhalacion de aerosol. |
| GB201308679D0 (en) * | 2013-05-14 | 2013-06-26 | 3M Innovative Properties Co | Actuator for an inhaler |
| CN103550058B (zh) * | 2013-11-21 | 2015-08-19 | 江门大诚医疗器械有限公司 | 一种加氧清创器 |
| GB201322677D0 (en) * | 2013-12-20 | 2014-02-05 | 3M Innovative Properties Co | Actuator for an inhaler |
| GB201408229D0 (en) * | 2014-05-09 | 2014-06-25 | Norton Waterford Ltd | Aerosol device |
| US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
| WO2017008127A1 (en) * | 2015-07-16 | 2017-01-19 | Gd Pharma Pty Ltd | Spray device and dosage cartridge |
| CN106376976B (zh) * | 2016-10-13 | 2023-05-12 | 深圳市新宜康科技股份有限公司 | 一种单侧气道油气分离电子烟雾化器 |
| TWM560309U (zh) * | 2016-11-06 | 2018-05-21 | 微邦科技股份有限公司 | 高壓液體傳輸裝置 |
| US10556072B2 (en) * | 2017-01-31 | 2020-02-11 | Dunan Microstaq, Inc. | Metering device for a metered dose inhaler |
| KR102140739B1 (ko) | 2018-04-23 | 2020-08-04 | 충남대학교산학협력단 | 상기도 분무 장치 |
| SG11202103255RA (en) * | 2018-10-08 | 2021-04-29 | Troikaa Pharmaceuticals Ltd | Oromucosal solutions of zolpidem or pharmaceutically acceptable salts thereof |
| KR20200098188A (ko) | 2019-02-12 | 2020-08-20 | 조민수 | 다기능 상기도 분무 장치 |
| CN210123827U (zh) * | 2019-05-31 | 2020-03-03 | 庆虹电子(苏州)有限公司 | 电连接器 |
| WO2021247283A1 (en) * | 2020-06-04 | 2021-12-09 | Amcyte Pharma, Inc. | Delivery of aerosolized micromolar composition concentrations |
| GB202011729D0 (en) * | 2020-07-29 | 2020-09-09 | Kindeva Drug Delivery Lp | Device for delivery of a compound to a region of the nasal cavity |
| US20220054668A1 (en) * | 2020-08-21 | 2022-02-24 | Carefusion 2200, Inc. | Lavage fluid delivery device and systems |
| FR3120534B1 (fr) * | 2021-03-09 | 2023-06-30 | Aptar France Sas | Tête de distribution nasale de produit fluide et dispositif comportant une telle tête |
| US20220331237A1 (en) * | 2021-03-23 | 2022-10-20 | 1232176 B.C. Ltd. | Device, methods and uses for treating anaphylaxis |
| CA224559S (en) | 2021-06-30 | 2023-09-28 | Rpc Formatec Gmbh | Inhaler |
| WO2024079676A1 (en) * | 2022-10-12 | 2024-04-18 | Glenmark Specialty S.A. | Novel nasal spray assembling process |
| CN116688331B (zh) * | 2023-05-29 | 2024-02-20 | 山东京卫制药有限公司 | 一种鼻气雾剂给药器及其方法 |
| US20260008071A1 (en) * | 2023-08-14 | 2026-01-08 | Majesty Holdings Co.,Ltd. | Aerosol valve and aerosol spray apparatus |
| CN116902402A (zh) * | 2023-08-14 | 2023-10-20 | 中山市美捷时包装制品有限公司 | 一种气雾剂阀门及气雾剂喷雾装置 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3361306A (en) * | 1966-03-31 | 1968-01-02 | Merck & Co Inc | Aerosol unit dispensing uniform amounts of a medically active ingredient |
| SE8704767L (sv) * | 1987-11-30 | 1989-05-31 | Sigmund Johannes Loefstedt | Ny metod foer administrering av laekemedel |
| JP2922935B2 (ja) * | 1989-08-11 | 1999-07-26 | 東興薬品工業株式会社 | 粘稠液用鼻孔内噴霧容器の使捨てアダプタ |
| JP2769925B2 (ja) | 1990-10-18 | 1998-06-25 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | ベクロメタゾン１７，２１ジプロピオネートを含んで成るエアロゾル製剤 |
| GB9705657D0 (en) * | 1997-03-19 | 1997-05-07 | Bacon Raymond J | Dispenser |
| GB9805938D0 (en) | 1998-03-19 | 1998-05-13 | Glaxo Group Ltd | Valve for aerosol container |
| GB0121568D0 (en) * | 2001-09-06 | 2001-10-24 | Optinose As | Nasal delivery device |
| US6315985B1 (en) | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
| GB0002798D0 (en) * | 2000-02-09 | 2000-03-29 | Glaxo Group Ltd | Actuator nozzle for metered dose inhaler |
| JP4472105B2 (ja) * | 2000-04-20 | 2010-06-02 | 株式会社ダイゾー | 噴霧製品 |
| GB2367011A (en) * | 2000-08-26 | 2002-03-27 | Glaxo Group Ltd | Metered dose inhaler for salmeterol |
| US20030178022A1 (en) * | 2001-12-21 | 2003-09-25 | Chiesi Farmaceutici S.P.A. | Pressurized metered dose inhaler (PMDI) actuators and medicinal aerosol solution formulation products comprising therse actuators |
| GB0226020D0 (en) * | 2002-11-07 | 2002-12-18 | Glaxo Group Ltd | A holder |
| US7448385B2 (en) * | 2004-06-07 | 2008-11-11 | Purepharm Inc. | Nasal adaptation of an oral inhaler device |
| US7055541B2 (en) | 2004-09-07 | 2006-06-06 | Ramot At Tel-Aviv University Ltd. | Method and mechanism for producing suction and periodic excitation flow |
| FR2881119B1 (fr) * | 2005-01-25 | 2010-07-30 | Valois Sas | Dispositif de distribution de produit fluide. |
| EP1792660A1 (en) * | 2005-12-02 | 2007-06-06 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device |
| CA2661129A1 (en) * | 2006-08-22 | 2008-02-28 | Glaxo Group Limited | Actuator for an inhaler |
| RU2009105642A (ru) | 2006-08-22 | 2010-09-27 | Глаксо Груп Лимитед (GB) | Средство приведения в действие для ингалятора |
| MX2009009061A (es) * | 2007-02-28 | 2009-11-12 | Abbott Respiratory Llc | Sistema de atomizacion a base de boquilla. |
| EP2011534A1 (en) * | 2007-07-03 | 2009-01-07 | CHIESI FARMACEUTICI S.p.A. | Metered dose inhaler actuator |
| DE102007063213B3 (de) * | 2007-12-20 | 2009-06-18 | Ing. Erich Pfeiffer Gmbh | Austragsvorrichtung zur nasalen Anwendung |
-
2011
- 2011-10-12 PL PL11779089T patent/PL2627386T3/pl unknown
- 2011-10-12 AU AU2011316124A patent/AU2011316124B2/en not_active Ceased
- 2011-10-12 PL PL15164095T patent/PL2926855T3/pl unknown
- 2011-10-12 EP EP15164095.0A patent/EP2926855B1/en active Active
- 2011-10-12 DK DK15164095.0T patent/DK2926855T3/en active
- 2011-10-12 US US13/271,940 patent/US20120085345A1/en not_active Abandoned
- 2011-10-12 HR HRP20150452TT patent/HRP20150452T1/hr unknown
- 2011-10-12 ES ES11779089.9T patent/ES2536969T3/es active Active
- 2011-10-12 CN CN201610527858.2A patent/CN106178205A/zh active Pending
- 2011-10-12 PE PE2013000844A patent/PE20131492A1/es active IP Right Grant
- 2011-10-12 SM SM20190135T patent/SMT201900135T1/it unknown
- 2011-10-12 KR KR1020137012194A patent/KR101559639B1/ko active Active
- 2011-10-12 CN CN201180049278.2A patent/CN103282070B/zh active Active
- 2011-10-12 WO PCT/EP2011/005118 patent/WO2012048867A1/en not_active Ceased
- 2011-10-12 TR TR2019/02415T patent/TR201902415T4/tr unknown
- 2011-10-12 EP EP11779089.9A patent/EP2627386B1/en active Active
- 2011-10-12 SI SI201131681T patent/SI2926855T1/sl unknown
- 2011-10-12 SI SI201130496T patent/SI2627386T1/sl unknown
- 2011-10-12 PT PT117790899T patent/PT2627386E/pt unknown
- 2011-10-12 EA EA201390490A patent/EA023795B1/ru not_active IP Right Cessation
- 2011-10-12 PT PT15164095T patent/PT2926855T/pt unknown
- 2011-10-12 CN CN201610529254.1A patent/CN106178206A/zh active Pending
- 2011-10-12 BR BR112013008824A patent/BR112013008824A2/pt not_active Application Discontinuation
- 2011-10-12 RS RS20190258A patent/RS58574B1/sr unknown
- 2011-10-12 MX MX2013003840A patent/MX336164B/es unknown
- 2011-10-12 JP JP2013533127A patent/JP6050236B2/ja active Active
- 2011-10-12 HU HUE15164095A patent/HUE043276T2/hu unknown
- 2011-10-12 ES ES15164095T patent/ES2712996T3/es active Active
- 2011-10-12 LT LTEP15164095.0T patent/LT2926855T/lt unknown
- 2011-10-12 SG SG2013027925A patent/SG189892A1/en unknown
- 2011-10-12 NZ NZ608218A patent/NZ608218A/en unknown
- 2011-10-12 DK DK11779089.9T patent/DK2627386T3/en active
- 2011-10-12 RS RS20150283A patent/RS54037B1/sr unknown
- 2011-10-12 CA CA2814212A patent/CA2814212C/en active Active
-
2013
- 2013-03-14 ZA ZA2013/01938A patent/ZA201301938B/en unknown
- 2013-04-10 CL CL2013000958A patent/CL2013000958A1/es unknown
- 2013-04-11 IL IL225712A patent/IL225712A/en active IP Right Grant
-
2015
- 2015-03-27 JP JP2015065534A patent/JP6023247B2/ja active Active
- 2015-05-15 SM SM201500114T patent/SMT201500114B/xx unknown
- 2015-09-25 US US14/865,823 patent/US10188811B2/en active Active
-
2019
- 2019-02-21 HR HRP20190337TT patent/HRP20190337T1/hr unknown
- 2019-02-26 CY CY20191100236T patent/CY1121719T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2536969T3 (es) | Dispositivo de spray nasal | |
| ES2908435T3 (es) | Dispositivo de aerosol | |
| ES2560029T3 (es) | Formulación nasal | |
| AU2015201102B2 (en) | Nasal spray device | |
| HK1214990B (en) | Nasal spray device | |
| HK1186994B (en) | Nasal spray device | |
| HK1186994A (en) | Nasal spray device |