ES2531633T3 - Derivados fusionados de pirrolidino-ciclopropano como inhibidores selectivos de la 11-beta-hidroxiesteroide deshidrogenasa de tipo 1 - Google Patents
Derivados fusionados de pirrolidino-ciclopropano como inhibidores selectivos de la 11-beta-hidroxiesteroide deshidrogenasa de tipo 1 Download PDFInfo
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- ES2531633T3 ES2531633T3 ES09777657.9T ES09777657T ES2531633T3 ES 2531633 T3 ES2531633 T3 ES 2531633T3 ES 09777657 T ES09777657 T ES 09777657T ES 2531633 T3 ES2531633 T3 ES 2531633T3
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- cyclopropane
- pyrrolo
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- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- WBWWGRHZICKQGZ-GIHLXUJPSA-N taurocholic acid Chemical compound C([C@@H]1C[C@H]2O)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@H](O)C1 WBWWGRHZICKQGZ-GIHLXUJPSA-N 0.000 description 1
- QXHLTLNUIDTFRD-UHFFFAOYSA-N tert-butyl 1-(1h-pyrrolo[2,3-b]pyridin-3-yl)-3-azabicyclo[3.1.0]hexane-3-carboxylate Chemical compound C1=CC=C2C(C34CC3CN(C4)C(=O)OC(C)(C)C)=CNC2=N1 QXHLTLNUIDTFRD-UHFFFAOYSA-N 0.000 description 1
- GQSKZYIGXYODHM-UHFFFAOYSA-N tert-butyl 2-ethylpentanoate Chemical compound CCCC(CC)C(=O)OC(C)(C)C GQSKZYIGXYODHM-UHFFFAOYSA-N 0.000 description 1
- RIFXIGDBUBXKEI-UHFFFAOYSA-N tert-butyl 3-oxopiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCC(=O)C1 RIFXIGDBUBXKEI-UHFFFAOYSA-N 0.000 description 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 1
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- 238000011200 topical administration Methods 0.000 description 1
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- 210000001585 trabecular meshwork Anatomy 0.000 description 1
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- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 150000008648 triflates Chemical class 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 description 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
- 229960001641 troglitazone Drugs 0.000 description 1
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
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- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08290822 | 2008-09-01 | ||
| EP08290822 | 2008-09-01 | ||
| PCT/EP2009/005654 WO2010022850A1 (en) | 2008-09-01 | 2009-08-05 | Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2531633T3 true ES2531633T3 (es) | 2015-03-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ES09777657.9T Active ES2531633T3 (es) | 2008-09-01 | 2009-08-05 | Derivados fusionados de pirrolidino-ciclopropano como inhibidores selectivos de la 11-beta-hidroxiesteroide deshidrogenasa de tipo 1 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8486964B2 (enExample) |
| EP (1) | EP2321317B1 (enExample) |
| JP (1) | JP5579717B2 (enExample) |
| KR (1) | KR101707580B1 (enExample) |
| CN (1) | CN102137864B (enExample) |
| AR (1) | AR073224A1 (enExample) |
| AU (1) | AU2009287118B9 (enExample) |
| BR (1) | BRPI0918288B1 (enExample) |
| CA (1) | CA2735286C (enExample) |
| EA (1) | EA020238B1 (enExample) |
| ES (1) | ES2531633T3 (enExample) |
| IL (1) | IL211447A (enExample) |
| MX (1) | MX2011002181A (enExample) |
| WO (1) | WO2010022850A1 (enExample) |
| ZA (1) | ZA201102418B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9580422B2 (en) * | 2013-10-22 | 2017-02-28 | Bristol-Myers Squibb Company | Isotopically labeled triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| MA40759A (fr) | 2014-09-26 | 2017-08-01 | Pfizer | Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation |
| EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
| CA3243547A1 (en) * | 2021-12-21 | 2023-06-29 | Corcept Therapeutics Inc | INDAZOLE GLUCOCORTICOID RECEPTOR BICYCLIC ANTAGONISTS |
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| US4088652A (en) * | 1975-07-31 | 1978-05-09 | American Cyanamid Company | Acylazabicyclohexanes |
| AU2003287909A1 (en) * | 2003-01-08 | 2004-08-10 | Mibitech Aps | Electro-therapeutic device and method of electro-therapeutic treatment |
| US7700583B2 (en) | 2003-04-11 | 2010-04-20 | High Point Pharmaceuticals, Llc | 11β-hydroxysteroid dehydrogenase type 1 active compounds |
| EP1615698B1 (en) * | 2003-04-11 | 2010-09-29 | High Point Pharmaceuticals, LLC | New amide derivatives and pharmaceutical use thereof |
| WO2006106423A2 (en) * | 2005-04-07 | 2006-10-12 | Pfizer Inc. | Amino sulfonyl derivatives as inhibitors of human 11-.beta.-hydrosysteroid dehydrogenase |
| EP1971614A1 (en) * | 2005-11-14 | 2008-09-24 | Probiodrug AG | Cyclopropyl-fused pyrrolidine derivatives as dipeptidyl peptidase iv inhibitors |
| GB0625198D0 (en) | 2006-12-18 | 2007-01-24 | Glaxo Group Ltd | Chemical compounds |
-
2009
- 2009-08-05 US US13/061,238 patent/US8486964B2/en active Active
- 2009-08-05 ES ES09777657.9T patent/ES2531633T3/es active Active
- 2009-08-05 MX MX2011002181A patent/MX2011002181A/es active IP Right Grant
- 2009-08-05 EA EA201100419A patent/EA020238B1/ru not_active IP Right Cessation
- 2009-08-05 CA CA2735286A patent/CA2735286C/en active Active
- 2009-08-05 JP JP2011524221A patent/JP5579717B2/ja active Active
- 2009-08-05 KR KR1020117007670A patent/KR101707580B1/ko not_active Expired - Fee Related
- 2009-08-05 WO PCT/EP2009/005654 patent/WO2010022850A1/en not_active Ceased
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2011
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- 2011-03-31 ZA ZA2011/02418A patent/ZA201102418B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA020238B1 (ru) | 2014-09-30 |
| BRPI0918288A2 (pt) | 2015-12-22 |
| EP2321317A1 (en) | 2011-05-18 |
| CN102137864B (zh) | 2014-12-31 |
| BRPI0918288B1 (pt) | 2018-11-06 |
| AU2009287118B2 (en) | 2014-02-27 |
| EA201100419A1 (ru) | 2011-10-31 |
| US20110172265A1 (en) | 2011-07-14 |
| JP2012501302A (ja) | 2012-01-19 |
| KR101707580B1 (ko) | 2017-02-16 |
| CA2735286A1 (en) | 2010-03-04 |
| AU2009287118A1 (en) | 2010-03-04 |
| IL211447A (en) | 2014-07-31 |
| US8486964B2 (en) | 2013-07-16 |
| CN102137864A (zh) | 2011-07-27 |
| WO2010022850A1 (en) | 2010-03-04 |
| MX2011002181A (es) | 2011-03-30 |
| IL211447A0 (en) | 2011-05-31 |
| JP5579717B2 (ja) | 2014-08-27 |
| EP2321317B1 (en) | 2014-12-24 |
| AU2009287118B9 (en) | 2014-08-07 |
| CA2735286C (en) | 2017-12-05 |
| AR073224A1 (es) | 2010-10-20 |
| KR20110059749A (ko) | 2011-06-03 |
| ZA201102418B (en) | 2011-12-28 |
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