ES2528348T3 - Preparación farmacéutica para el tratamiento de la hiperplasia prostática benigna - Google Patents
Preparación farmacéutica para el tratamiento de la hiperplasia prostática benigna Download PDFInfo
- Publication number
- ES2528348T3 ES2528348T3 ES12192951.7T ES12192951T ES2528348T3 ES 2528348 T3 ES2528348 T3 ES 2528348T3 ES 12192951 T ES12192951 T ES 12192951T ES 2528348 T3 ES2528348 T3 ES 2528348T3
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- pharmaceutical preparation
- benign prostatic
- bromelain
- prostatic hyperplasia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Preparación farmacéutica que comprende al menos dos proteasas para su uso en el tratamiento de la hipertrofia/hiperplasia prostática benigna, en la que la preparación es administrada por vía oral y las al menos dos proteasas son seleccionadas del grupo que consiste en bromelaína, papaína y ficina.
Description
E12192951
20-01-2015
Tabla 2: Inhibición de la formación de tubo en % en HUVEC en presencia de VEGF. Los resultados se muestran como % de inhibición de la formación de tubo, siendo 0 % la formación de tubo en las muestras tratadas sólo con VEGF.
- Bromelaína
- Natoquinasa Papaína % inhibición de la formación de tubo
- 75,00 %
- 25,00 % 0,00 % 98,11 %
- 16,67 %
- 16,67 %
- 66,67 % 93,52 %
- 25,00 %
- 25,00 %
- 50,00 % 87,75 %
- 0,00 %
- 75,00 % 25,00 % 87,42 %
- 75,00 %
- 0,00 % 25,00 % 86,34 %
- 25,00 %
- 0,00 % 75,00 % 83,77 %
- 16,67 %
- 66,67 % 16,67 % 83,65 %
- 50,00 %
- 0,00 % 50,00 % 82,73 %
- 0,00 %
- 50,00 % 50,00 % 80,01 %
- 0,00 %
- 25,00 % 75,00 % 78,26 %
- 33,33 %
- 33,33 %
- 33,33 %
- 74,14 %
- 25,00 %
- 75,00 % 0,00 % 61,57 %
- 50,00 %
- 25,00 % 25,00 % 47,78 %
- 0,00 %
- 0,00 %
- 100,00 % 39,86 %
5 La Tabla 2 muestra las longitudes de tubo expresadas como % de inhibición de la formación de tubo. Los resultados indican claramente que:
- 1.
- La formación del tubo es inhibida por mezclas de bromelaína, natoquinasa y papaína;
- 2.
- La combinación de bromelaína, natoquinasa y papaína tiene un efecto mayor que los fármacos solos.
La Figura 3(a) muestra la combinación bromelaína 25 %, natoquinasa 50 % y papaína 25 %. (B) muestra el control
10 tratado con VEGF. Mientras que en el control de VEGF es visible un patrón estrecho de tubos formados (flechas), la muestra tratada con enzima muestra amplias áreas sin formación de tubo que indican actividad antiangiogénica del cóctel de enzimas.
La influencia de preparaciones que comprenden bromelaína en combinación con otras enzimas sobre las células
15 endoteliales de próstata humana (HProsEC) se ha analizado de forma análoga al ejemplo 2, con modificaciones menores. Brevemente, las células se privaron de nutrientes durante 24 horas en medio basal endotelial-2 (MV) (Lonza, Verviers) suplementado con ácido ascórbico e hidrocortisona. Las células se sembraron a una densidad de
10.000 por pocillo en microplacas de titulación de 96 pocillos recubiertas con Matrigel y se incubaron en ausencia o presencia de 5 ng de VEGF/ml con combinaciones de enzimas (bromelaína 100 % o enzima 50 % y bromelaína 20 50 % a 12,5 μg/ml total). Después de 6 horas, los tubos se fotografiaron y se midieron usando el software ImageJ (Instituto Nacional de Salud, Bethesda, EE.UU.). Se han obtenido los siguientes resultados: enzima + bromelaína % inhibición del tubo Formación gen enzima 25 % Inhibición de formación de tubos
enzima + bromelaína Brinasa 21,00 % 81,00 %
11
Claims (1)
-
imagen1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0196207A AT506095A1 (de) | 2007-12-03 | 2007-12-03 | Verwendung von proteasen |
AT19622007 | 2007-12-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2528348T3 true ES2528348T3 (es) | 2015-02-09 |
Family
ID=40404976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES12192951.7T Active ES2528348T3 (es) | 2007-12-03 | 2008-12-03 | Preparación farmacéutica para el tratamiento de la hiperplasia prostática benigna |
Country Status (11)
Country | Link |
---|---|
US (1) | US8231870B2 (es) |
EP (2) | EP2224948A1 (es) |
JP (1) | JP2011505385A (es) |
AT (1) | AT506095A1 (es) |
CA (1) | CA2705986C (es) |
DK (1) | DK2559439T3 (es) |
ES (1) | ES2528348T3 (es) |
MX (1) | MX2010005629A (es) |
PL (1) | PL2559439T3 (es) |
RU (1) | RU2485971C2 (es) |
WO (1) | WO2009070818A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI482629B (zh) * | 2008-07-01 | 2015-05-01 | Tobishi Pharmaceutical Co | 下泌尿道疾病治療劑及下泌尿道症狀改善劑 |
WO2010029453A1 (en) * | 2008-09-10 | 2010-03-18 | Pt.Dexa Medica | Composition of thrombolytic agent and anti thrombosis and also its production method |
ES2647566T3 (es) * | 2011-01-31 | 2017-12-22 | Lucolas-M.D. Ltd. | Combinaciones de inhibidores de aromatasa y antioxidantes |
AU2012253379A1 (en) | 2011-05-12 | 2013-11-21 | Healthpoint, Ltd. | Wound debridement compositions containing seaprose and methods of wound treatment using same |
AU2013259360B2 (en) * | 2012-05-11 | 2017-07-13 | Smith & Nephew, Inc. | Use of Seaprose to remove bacterial biofilm |
ITMI20121997A1 (it) * | 2012-11-23 | 2014-05-24 | Velleja Res Srl | Composizioni fibrinolitiche per la prevenzione e il trattamento degli stati flebotrombotici |
US10086053B2 (en) | 2012-12-06 | 2018-10-02 | Giuseppe CARPIGNOLI | Therapeutic vegetable substances |
ITTO20121050A1 (it) * | 2012-12-06 | 2014-06-07 | Giuseppe Carpignoli | Sostanze vegetali ad effetto curativo |
CN110755599A (zh) * | 2013-10-23 | 2020-02-07 | 珍白斯凯尔有限公司 | 用于治疗和预防良性前列腺增生的组合物 |
HUP1400294A2 (hu) | 2014-06-13 | 2015-12-28 | Skillpharm Kft | Clopidogrel új alkalmazása |
WO2016032944A1 (en) * | 2014-08-25 | 2016-03-03 | Anatara Lifesciences Limited | Anti-diarrhea formulation which avoids antimicrobial resistance |
AU2017304271A1 (en) | 2016-07-27 | 2019-02-28 | Smith & Nephew, Inc. | Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces |
IT201600081379A1 (it) * | 2016-08-03 | 2018-02-03 | Neilos S R L | Composizione farmaceutica per uso nel trattamento delle patologie prostatiche. |
US11413300B2 (en) | 2017-01-30 | 2022-08-16 | Smith & Nephew, Inc. | Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces |
JP7207877B2 (ja) * | 2018-06-27 | 2023-01-18 | 小林製薬株式会社 | ナットウキナーゼを含む食品 |
JP7207878B2 (ja) * | 2018-06-27 | 2023-01-18 | 小林製薬株式会社 | ナットウキナーゼを含む食品 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5045690A (en) | 1989-01-27 | 1990-08-24 | Immunolytics, Inc. | Composition and method for treating benign prostatic hypertrophy |
JPH05229983A (ja) * | 1992-02-21 | 1993-09-07 | Sankyo Co Ltd | レトロジヒドロカルコン化合物 |
DE4305460C2 (de) | 1993-02-23 | 1997-09-04 | Albert Dr Scheller | Pharmazeutische oder kosmetische, Enzyme enthaltende Zubereitung, Verfahren zu deren Herstellung und deren Verwendung |
JP3978250B2 (ja) * | 1996-08-16 | 2007-09-19 | 株式会社フジモト・コーポレーション | テストステロン5α−リダクターゼ阻害剤 |
US20010025059A1 (en) * | 2000-01-10 | 2001-09-27 | Kastke Floyd A. | Composition and method for treating non-bacterial prostatitis |
ZA200002342B (en) | 2000-05-12 | 2001-01-11 | Pharmachoice Healthcare Propri | Nutritional supplement. |
EP1443954B1 (en) | 2001-10-26 | 2010-11-24 | The Scripps Research Institute | Targeted thrombosis by tissue factor polypeptides |
AU2002333006A1 (en) * | 2002-09-19 | 2004-04-08 | Gilberto De Nucci | Pharmaceutical composition comprising carriers for products |
LV13161B (en) * | 2004-02-16 | 2005-07-20 | Maris Skromanis | Proteolytic pharmaceutical composition |
US20060024385A1 (en) | 2004-07-27 | 2006-02-02 | Pedersen Mark A | Metabolic capacity enhancing compositions and methods for use in a mammal |
US7758594B2 (en) | 2005-05-20 | 2010-07-20 | Neotract, Inc. | Devices, systems and methods for treating benign prostatic hyperplasia and other conditions |
RU2306145C1 (ru) * | 2006-03-28 | 2007-09-20 | Олег Викторович Бейдик | Средство для лечения хронического простатита |
-
2007
- 2007-12-03 AT AT0196207A patent/AT506095A1/de not_active Application Discontinuation
-
2008
- 2008-12-03 RU RU2010127336/15A patent/RU2485971C2/ru not_active IP Right Cessation
- 2008-12-03 JP JP2010536280A patent/JP2011505385A/ja active Pending
- 2008-12-03 DK DK12192951.7T patent/DK2559439T3/en active
- 2008-12-03 WO PCT/AT2008/000428 patent/WO2009070818A1/en active Application Filing
- 2008-12-03 ES ES12192951.7T patent/ES2528348T3/es active Active
- 2008-12-03 EP EP08856631A patent/EP2224948A1/en not_active Withdrawn
- 2008-12-03 CA CA2705986A patent/CA2705986C/en not_active Expired - Fee Related
- 2008-12-03 US US12/745,776 patent/US8231870B2/en active Active
- 2008-12-03 MX MX2010005629A patent/MX2010005629A/es active IP Right Grant
- 2008-12-03 PL PL12192951T patent/PL2559439T3/pl unknown
- 2008-12-03 EP EP12192951.7A patent/EP2559439B1/en not_active Not-in-force
Also Published As
Publication number | Publication date |
---|---|
PL2559439T3 (pl) | 2015-04-30 |
RU2485971C2 (ru) | 2013-06-27 |
CA2705986A1 (en) | 2009-06-11 |
DK2559439T3 (en) | 2014-12-08 |
MX2010005629A (es) | 2010-08-18 |
US20100254968A1 (en) | 2010-10-07 |
RU2010127336A (ru) | 2012-01-10 |
EP2559439B1 (en) | 2014-11-26 |
EP2224948A1 (en) | 2010-09-08 |
AT506095A1 (de) | 2009-06-15 |
US8231870B2 (en) | 2012-07-31 |
WO2009070818A1 (en) | 2009-06-11 |
CA2705986C (en) | 2017-06-13 |
JP2011505385A (ja) | 2011-02-24 |
EP2559439A1 (en) | 2013-02-20 |
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