ES2476368T3 - Tratamiento de la artritis reumatoide con una combinación de laquinimod y metotrexato - Google Patents

Tratamiento de la artritis reumatoide con una combinación de laquinimod y metotrexato Download PDF

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Publication number
ES2476368T3
ES2476368T3 ES11751300.2T ES11751300T ES2476368T3 ES 2476368 T3 ES2476368 T3 ES 2476368T3 ES 11751300 T ES11751300 T ES 11751300T ES 2476368 T3 ES2476368 T3 ES 2476368T3
Authority
ES
Spain
Prior art keywords
laquinimod
pharmaceutically acceptable
acceptable salt
methotrexate
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11751300.2T
Other languages
English (en)
Spanish (es)
Inventor
Eran Blaugrund
Nora Tarcic
Joel Kaye
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44531858&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2476368(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Application granted granted Critical
Publication of ES2476368T3 publication Critical patent/ES2476368T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES11751300.2T 2010-03-03 2011-03-02 Tratamiento de la artritis reumatoide con una combinación de laquinimod y metotrexato Active ES2476368T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33937510P 2010-03-03 2010-03-03
US339375P 2010-03-03
PCT/US2011/026885 WO2011109531A1 (en) 2010-03-03 2011-03-02 Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate

Publications (1)

Publication Number Publication Date
ES2476368T3 true ES2476368T3 (es) 2014-07-14

Family

ID=44531858

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11751300.2T Active ES2476368T3 (es) 2010-03-03 2011-03-02 Tratamiento de la artritis reumatoide con una combinación de laquinimod y metotrexato

Country Status (22)

Country Link
US (1) US8501766B2 (cg-RX-API-DMAC7.html)
EP (1) EP2542079B1 (cg-RX-API-DMAC7.html)
JP (1) JP5819328B2 (cg-RX-API-DMAC7.html)
KR (1) KR20130014523A (cg-RX-API-DMAC7.html)
CN (2) CN102781240A (cg-RX-API-DMAC7.html)
AU (1) AU2011223697B2 (cg-RX-API-DMAC7.html)
BR (1) BR112012022187A2 (cg-RX-API-DMAC7.html)
CA (1) CA2791709A1 (cg-RX-API-DMAC7.html)
CL (1) CL2012002424A1 (cg-RX-API-DMAC7.html)
CO (1) CO6630085A2 (cg-RX-API-DMAC7.html)
DK (1) DK2542079T3 (cg-RX-API-DMAC7.html)
EA (1) EA201290860A1 (cg-RX-API-DMAC7.html)
ES (1) ES2476368T3 (cg-RX-API-DMAC7.html)
MX (1) MX2012010066A (cg-RX-API-DMAC7.html)
NZ (1) NZ602478A (cg-RX-API-DMAC7.html)
PE (1) PE20130690A1 (cg-RX-API-DMAC7.html)
PH (1) PH12012501740A1 (cg-RX-API-DMAC7.html)
PT (1) PT2542079E (cg-RX-API-DMAC7.html)
SG (1) SG183513A1 (cg-RX-API-DMAC7.html)
SI (1) SI2542079T1 (cg-RX-API-DMAC7.html)
WO (1) WO2011109531A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201207128B (cg-RX-API-DMAC7.html)

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ATE532515T1 (de) 2006-06-12 2011-11-15 Teva Pharma Stabile laquinimod-zubereitungen
RS53199B (sr) 2007-12-20 2014-06-30 Teva Pharmaceutical Industries Ltd. Stabilni preparati lakvinimoda
EP2337779B1 (en) * 2008-09-03 2017-04-19 Teva Pharmaceutical Industries Ltd. 2-oxo-1,2-dihydro-quinoline modulators of immune function
AU2010260455A1 (en) * 2009-06-19 2012-02-02 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with laquinimod
JP5882208B2 (ja) * 2009-07-30 2016-03-09 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドによるクローン病の治療
RS55071B1 (sr) 2009-08-10 2016-12-30 Teva Pharma Tretman poremećaja koji su u vezi sa bdnf primenom lakvinimoda
BR112012021905A2 (pt) * 2010-03-03 2015-09-29 Teva Pharma tratamento de nefrite lúpica usando laquinimod
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TW201350467A (zh) 2012-05-08 2013-12-16 Teva Pharma Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
EP2916915A4 (en) 2012-11-07 2016-06-22 Teva Pharma LAQUINIMOD AMINE SALTS
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WO2015168103A1 (en) 2014-04-29 2015-11-05 Teva Pharmaceutical Industries Ltd. Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status
CN115281149A (zh) * 2021-05-12 2022-11-04 四川大学华西医院 一种临床前类风湿关节炎(Pre-RA)小鼠模型

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Also Published As

Publication number Publication date
CA2791709A1 (en) 2011-09-09
CN102781240A (zh) 2012-11-14
DK2542079T3 (da) 2014-08-25
PE20130690A1 (es) 2013-07-07
NZ602478A (en) 2014-09-26
EP2542079A4 (en) 2013-07-24
AU2011223697A1 (en) 2012-10-11
CL2012002424A1 (es) 2012-12-21
AU2011223697B2 (en) 2016-07-14
EA201290860A1 (ru) 2013-04-30
CO6630085A2 (es) 2013-03-01
ZA201207128B (en) 2014-04-30
WO2011109531A1 (en) 2011-09-09
KR20130014523A (ko) 2013-02-07
US8501766B2 (en) 2013-08-06
MX2012010066A (es) 2012-10-03
BR112012022187A2 (pt) 2015-09-22
SG183513A1 (en) 2012-09-27
CN105796556A (zh) 2016-07-27
EP2542079B1 (en) 2014-05-21
EP2542079A1 (en) 2013-01-09
PH12012501740A1 (en) 2012-11-12
US20110218203A1 (en) 2011-09-08
JP5819328B2 (ja) 2015-11-24
PT2542079E (pt) 2014-07-18
SI2542079T1 (sl) 2014-08-29
JP2013521304A (ja) 2013-06-10

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