ES2455266T3 - Heterociclos bicíclicos y su utilización como antagonistas del receptor CCR2 - Google Patents
Heterociclos bicíclicos y su utilización como antagonistas del receptor CCR2 Download PDFInfo
- Publication number
- ES2455266T3 ES2455266T3 ES10766012.8T ES10766012T ES2455266T3 ES 2455266 T3 ES2455266 T3 ES 2455266T3 ES 10766012 T ES10766012 T ES 10766012T ES 2455266 T3 ES2455266 T3 ES 2455266T3
- Authority
- ES
- Spain
- Prior art keywords
- hydroxy
- methyl
- spiro
- aza
- oct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09172408 | 2009-10-07 | ||
| EP09172408 | 2009-10-07 | ||
| PCT/EP2010/064770 WO2011042399A1 (en) | 2009-10-07 | 2010-10-05 | Bicyclic heterocycles and their use as ccr2 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2455266T3 true ES2455266T3 (es) | 2014-04-15 |
Family
ID=43105073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10766012.8T Active ES2455266T3 (es) | 2009-10-07 | 2010-10-05 | Heterociclos bicíclicos y su utilización como antagonistas del receptor CCR2 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8471004B2 (enExample) |
| EP (1) | EP2486042B1 (enExample) |
| JP (1) | JP5559336B2 (enExample) |
| KR (1) | KR101451487B1 (enExample) |
| CN (1) | CN102574858B (enExample) |
| AU (1) | AU2010305495A1 (enExample) |
| BR (1) | BR112012008221A2 (enExample) |
| CA (1) | CA2774215A1 (enExample) |
| ES (1) | ES2455266T3 (enExample) |
| IL (1) | IL217965A0 (enExample) |
| IN (1) | IN2012DN00764A (enExample) |
| MX (1) | MX2012002390A (enExample) |
| WO (1) | WO2011042399A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2852160A1 (en) | 2011-10-28 | 2013-05-02 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
| ES2764840T3 (es) | 2015-01-28 | 2020-06-04 | Univ Bordeaux | Uso de plerixafor para tratar y/o prevenir exacerbaciones agudas de la enfermedad pulmonar obstructiva crónica |
| JP2021534101A (ja) | 2018-08-09 | 2021-12-09 | ヴェルソー セラピューティクス, インコーポレイテッド | Ccr2及びcsf1rを標的とするためのオリゴヌクレオチド組成物ならびにその使用 |
| CN111423454B (zh) * | 2020-04-24 | 2021-06-22 | 苏州大学 | 哌嗪类化合物及其在制备趋化因子受体ccr2拮抗剂中的应用 |
| CN113979889A (zh) * | 2021-11-09 | 2022-01-28 | 西安康福诺生物科技有限公司 | 一种双官能化聚乙二醇基胺的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3740256A1 (de) | 1987-05-14 | 1988-12-08 | Bayer Ag | Thiazolo-hydantoine |
| CA2440803A1 (en) * | 2001-03-07 | 2002-09-12 | Pfizer Products Inc. | Modulators of chemokine receptor activity |
| CA2516705A1 (en) * | 2003-02-24 | 2004-09-10 | Merck & Co., Inc. | Aminocyclopentyl fused heterotricylicamide modulators of chemokine receptor activity |
| ATE411989T1 (de) * | 2004-05-26 | 2008-11-15 | Janssen Pharmaceutica Nv | Mercaptoimidazole als ccr2-rezeptorantagonisten |
| US20060199805A1 (en) * | 2005-03-04 | 2006-09-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders |
| BRPI0710512A2 (pt) * | 2006-04-20 | 2012-06-05 | Hoffmann La Roche | moduladores derivados de diazepan de receptores de quimiocinas |
| KR20100033544A (ko) | 2007-07-19 | 2010-03-30 | 에프. 호프만-라 로슈 아게 | 신규한 헤테로사이클일 화합물 및 이의 케모카인 길항제로서의 용도 |
| WO2009043747A2 (en) | 2007-10-01 | 2009-04-09 | F. Hoffmann-La Roche Ag | N-heterocyclic biaryl carboxamides as ccr receptor antagonists |
-
2010
- 2010-09-29 US US12/892,968 patent/US8471004B2/en not_active Expired - Fee Related
- 2010-10-05 CN CN201080044805.6A patent/CN102574858B/zh not_active Expired - Fee Related
- 2010-10-05 AU AU2010305495A patent/AU2010305495A1/en not_active Abandoned
- 2010-10-05 EP EP10766012.8A patent/EP2486042B1/en not_active Not-in-force
- 2010-10-05 JP JP2012532559A patent/JP5559336B2/ja not_active Expired - Fee Related
- 2010-10-05 ES ES10766012.8T patent/ES2455266T3/es active Active
- 2010-10-05 MX MX2012002390A patent/MX2012002390A/es active IP Right Grant
- 2010-10-05 CA CA2774215A patent/CA2774215A1/en not_active Abandoned
- 2010-10-05 IN IN764DEN2012 patent/IN2012DN00764A/en unknown
- 2010-10-05 BR BR112012008221A patent/BR112012008221A2/pt not_active IP Right Cessation
- 2010-10-05 KR KR1020127008883A patent/KR101451487B1/ko not_active Expired - Fee Related
- 2010-10-05 WO PCT/EP2010/064770 patent/WO2011042399A1/en not_active Ceased
-
2012
- 2012-02-06 IL IL217965A patent/IL217965A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL217965A0 (en) | 2012-03-29 |
| BR112012008221A2 (pt) | 2016-03-08 |
| WO2011042399A1 (en) | 2011-04-14 |
| US20110082294A1 (en) | 2011-04-07 |
| EP2486042A1 (en) | 2012-08-15 |
| KR20120051090A (ko) | 2012-05-21 |
| EP2486042B1 (en) | 2014-01-22 |
| CN102574858A (zh) | 2012-07-11 |
| US8471004B2 (en) | 2013-06-25 |
| IN2012DN00764A (enExample) | 2015-06-26 |
| CN102574858B (zh) | 2015-06-24 |
| JP2013506701A (ja) | 2013-02-28 |
| MX2012002390A (es) | 2012-04-02 |
| CA2774215A1 (en) | 2011-04-14 |
| AU2010305495A1 (en) | 2012-03-15 |
| JP5559336B2 (ja) | 2014-07-23 |
| KR101451487B1 (ko) | 2014-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2666353T3 (es) | Inhibidores de JAK3 de imidazopiridazina y su uso para el tratamiento de enfermedades inflamatorias y autoinmunitarias | |
| CN103492376B (zh) | 双环杂环化合物及其治疗用途 | |
| US8921368B2 (en) | Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases | |
| ES2348122T3 (es) | Derivados de diazepano moduladores de receptores de quimioquina. | |
| JP4846665B2 (ja) | ピラゾロ[1,5−a]ピリミジン化合物 | |
| US20090054392A1 (en) | Naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analogs and their use as agonists of the wnt-beta-catenin cellular messaging system | |
| US7820680B2 (en) | HIV integrase inhibitors | |
| RS59522B1 (sr) | Naftiridinska jedinjenja kao inhibitori jak kinaze | |
| KR20180041228A (ko) | Irak4 조정제로서의 비시클릭-융합된 헤테로아릴 또는 아릴 화합물 | |
| MX2007010068A (es) | Piperazino-piperidinas con actividad antagonista de cxcr3. | |
| AU2006305104A1 (en) | Pyrazolo[1,5-a]pyrimidine compounds as cannabinoid receptor antagonists | |
| RS55739B1 (sr) | Novi derivati indolizina, postupak njihove proizvodnje i farmaceutske kompozicije koje ih sadrže za lečenje kancera | |
| EP1761542A2 (en) | Octahydropyrrolo[3,4-c]pyrrole derivatives an their use as antiviral agents | |
| ES2346985T3 (es) | Derivados de diazaespiro-(4,5)-decano y su uso como antagonistas de neurocinina. | |
| ES2455266T3 (es) | Heterociclos bicíclicos y su utilización como antagonistas del receptor CCR2 | |
| US10000484B2 (en) | Inhibitors of the renal outer medullary potassim channel | |
| RU2785126C2 (ru) | Новые соединения и их фармацевтические композиции для лечения воспалительных заболеваний | |
| RU2778478C2 (ru) | Бициклические производные дигидропиримидинкарбоксамида в качестве ингибиторов rho-киназы | |
| WO2026055782A1 (en) | Compounds and compositions for treating mc4r related conditions | |
| KR20260009350A (ko) | 멜라노코르틴 2형 수용체 안타고니스트 |