ES2449571T3 - Derivados de amino-piperidina como inhibidores de CETP - Google Patents

Derivados de amino-piperidina como inhibidores de CETP Download PDF

Info

Publication number
ES2449571T3
ES2449571T3 ES07786158.1T ES07786158T ES2449571T3 ES 2449571 T3 ES2449571 T3 ES 2449571T3 ES 07786158 T ES07786158 T ES 07786158T ES 2449571 T3 ES2449571 T3 ES 2449571T3
Authority
ES
Spain
Prior art keywords
alkyl
amino
cycloalkyl
aryl
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07786158.1T
Other languages
English (en)
Spanish (es)
Inventor
Hidetomo Imase
Yuki Iwaki
Toshio Kawanami
Takahiro Miyake
Muneto Mogi
Osamu Ohmori
Hongbo Qin
Ichiro Umemura
Ken Yamada
Kayo Yasoshima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Priority claimed from PCT/EP2007/006384 external-priority patent/WO2008009435A1/en
Application granted granted Critical
Publication of ES2449571T3 publication Critical patent/ES2449571T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES07786158.1T 2006-07-20 2007-07-18 Derivados de amino-piperidina como inhibidores de CETP Active ES2449571T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP06117541 2006-07-20
EP06117541 2006-07-20
US88705807P 2007-01-29 2007-01-29
US887058P 2007-01-29
PCT/EP2007/006384 WO2008009435A1 (en) 2006-07-20 2007-07-18 Amino-piperidine derivatives as cetp inhibitors

Publications (1)

Publication Number Publication Date
ES2449571T3 true ES2449571T3 (es) 2014-03-20

Family

ID=37680601

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07786158.1T Active ES2449571T3 (es) 2006-07-20 2007-07-18 Derivados de amino-piperidina como inhibidores de CETP

Country Status (13)

Country Link
KR (1) KR20120034774A (zh)
CN (1) CN101490035B (zh)
BR (1) BRPI0714516A2 (zh)
DK (1) DK2049517T3 (zh)
ES (1) ES2449571T3 (zh)
MY (1) MY153262A (zh)
NZ (1) NZ573439A (zh)
PT (1) PT2049517E (zh)
RU (1) RU2442782C2 (zh)
SG (1) SG173378A1 (zh)
SI (1) SI2049517T1 (zh)
UA (1) UA96942C2 (zh)
ZA (1) ZA200810008B (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112898257B (zh) * 2021-03-12 2023-01-24 天津理工大学 一种水溶性香豆素衍生物内盐的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2719311B1 (fr) * 1994-03-18 1998-06-26 Sanofi Sa Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
US6140342A (en) * 1998-09-17 2000-10-31 Pfizer Inc. Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines

Also Published As

Publication number Publication date
DK2049517T3 (en) 2014-03-03
CN101490035B (zh) 2013-02-13
BRPI0714516A2 (pt) 2014-07-08
UA96942C2 (uk) 2011-12-26
RU2009105763A (ru) 2010-08-27
SI2049517T1 (sl) 2014-04-30
MY153262A (en) 2015-01-29
SG173378A1 (en) 2011-08-29
CN101490035A (zh) 2009-07-22
KR20120034774A (ko) 2012-04-12
ZA200810008B (en) 2009-11-25
NZ573439A (en) 2012-02-24
PT2049517E (pt) 2014-03-10
RU2442782C2 (ru) 2012-02-20

Similar Documents

Publication Publication Date Title
AU2007276433B2 (en) Amino-piperidine derivatives as CETP inhibitors
US8420641B2 (en) Method of inhibiting CETP activity with 4-benzylamino-1-carboxylacyl-piperidine derivatives
JP5421282B2 (ja) 高脂血症または動脈硬化症のような疾患の処置に有用なｃｅｔｐ阻害剤としての１，２−二置換−４−ベンジルアミノ−ピロリジン誘導体
US20090181929A1 (en) Organic compounds
US20100076021A1 (en) Organic Compounds
US20100041705A1 (en) Organic Compounds
ES2449571T3 (es) Derivados de amino-piperidina como inhibidores de CETP
AU2012202172B2 (en) 4-benzylamino-1-carboxyacyl-piperidine derivatives as CETP inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis