ES2447815T3 - Compuestos espiro sustituidos y su utilización para la preparación de medicamentos contra el dolor - Google Patents

Compuestos espiro sustituidos y su utilización para la preparación de medicamentos contra el dolor Download PDF

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ES2447815T3
ES2447815T3 ES10012043.5T ES10012043T ES2447815T3 ES 2447815 T3 ES2447815 T3 ES 2447815T3 ES 10012043 T ES10012043 T ES 10012043T ES 2447815 T3 ES2447815 T3 ES 2447815T3
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aliphatic compound
gen
optionally substituted
cycloaliphatic group
diastereomer
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Hans Prof. Dr. Schick
Robert Dr. Frank
Melanie Dr. Reich
Ruth Dr. Jostock
Gregor Dr. Bahrenberg
Fritz Dr. Theil
Brigitta Dr. Henkel
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Gruenenthal GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/06—Anti-spasmodics
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compuestos espiro sustituidos de fórmula general I **Fórmula** donde m es 0, 1, 2, 3 o 4, n es 1, R1 representa un grupo -C(>=S)-NR8R9; o, cuando m es distinto de 0 y/o R5 es distinto de H, además un grupo -C(>=O)-NR6R7; R2 representa un grupo alifático lineal o ramificado, saturado o insaturado, no sustituido o al menos monosustituido, en caso dado incluyendo un heteroátomo como miembro de la cadena; donde los sustituyentes de los grupos alifáticos se pueden seleccionar independientemente de entre el grupo consistente en F, Cl, Br, I, -CN, -NO2, -OH, -SH y -NH2; un grupo cicloalifático saturado o insaturado, no sustituido o al menos monosustituido, en caso dado incluyendo un heteroátomo como miembro del anillo, en caso dado unido mediante un grupo alquileno, alquenileno o alquinileno, lineal o ramificado, no sustituido o al menos monosustituido, en caso dado incluyendo un heteroátomo como miembro de la cadena y/o condensado con un sistema de anillo mono- o poli-cíclico, no sustituido o al menos monosustituido; o un grupo arilo o heteroarilo no sustituido o al menos monosustituido, en caso dado unido mediante un grupo alquileno, alquenileno o alquinileno, lineal o ramificado, no sustituido o al menos monosustituido, en caso dado incluyendo un heteroátomo en la cadena, y/o condensado con un sistema de anillo mono- o poli-cíclico, no sustituido o al menos monosustituido.
ES10012043.5T 2005-05-19 2006-05-17 Compuestos espiro sustituidos y su utilización para la preparación de medicamentos contra el dolor Active ES2447815T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005023784A DE102005023784A1 (de) 2005-05-19 2005-05-19 Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
DE102005023784 2005-05-19

Publications (1)

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ES2447815T3 true ES2447815T3 (es) 2014-03-13

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ID=36646208

Family Applications (2)

Application Number Title Priority Date Filing Date
ES06742950T Active ES2370038T3 (es) 2005-05-19 2006-05-17 Compuestos espiro sustituidos y su uso para la preparación de medicamentos contra el dolor.
ES10012043.5T Active ES2447815T3 (es) 2005-05-19 2006-05-17 Compuestos espiro sustituidos y su utilización para la preparación de medicamentos contra el dolor

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ES06742950T Active ES2370038T3 (es) 2005-05-19 2006-05-17 Compuestos espiro sustituidos y su uso para la preparación de medicamentos contra el dolor.

Country Status (13)

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US (1) US20080214807A1 (es)
EP (2) EP1893620B1 (es)
JP (1) JP5376941B2 (es)
AT (1) ATE524478T1 (es)
CA (1) CA2608385A1 (es)
CY (1) CY1112137T1 (es)
DE (1) DE102005023784A1 (es)
DK (1) DK1893620T3 (es)
ES (2) ES2370038T3 (es)
PL (2) PL2292625T3 (es)
PT (1) PT1893620E (es)
SI (1) SI1893620T1 (es)
WO (1) WO2006122769A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005044813A1 (de) 2005-05-19 2007-10-04 Grünenthal GmbH Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
WO2008024497A2 (en) * 2006-08-25 2008-02-28 Vitae Pharmaceuticals, Inc. INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE TYPE 1
US8383629B2 (en) 2008-02-27 2013-02-26 Vitae Pharmaceuticals, Inc. Inhibitors of 11β-hydroxysteroid dehydrogenase type 1
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
US8765735B2 (en) * 2009-05-18 2014-07-01 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
JP2013518085A (ja) 2010-02-01 2013-05-20 ノバルティス アーゲー ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
ES2527849T3 (es) 2010-02-02 2015-01-30 Novartis Ag Derivados de ciclohexilamida como antagonistas del receptor de CRF
EP3402781B1 (en) 2016-01-13 2020-03-04 Grünenthal GmbH 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
RS60855B1 (sr) 2016-01-13 2020-10-30 Gruenenthal Gmbh Derivati 8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana
SI3402785T1 (sl) 2016-01-13 2020-07-31 Gruenenthal Gmbh Derivati 3-(karboksimetil)-8-amino-2-okso-1,3-diaza-spiro-(4.5)-dekana

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2421797A (en) * 1996-03-15 1997-10-01 Du Pont Pharmaceuticals Company Spirocycle integrin inhibitors
WO1998043962A1 (en) * 1997-03-28 1998-10-08 Du Pont Pharmaceuticals Company Heterocyclic integrin inhibitor prodrugs
JP2002514605A (ja) * 1998-05-08 2002-05-21 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア 血管形成を検出および阻害する方法
DE10130020A1 (de) * 2001-06-25 2003-12-04 Gruenenthal Gmbh Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
JP2005526137A (ja) * 2002-05-17 2005-09-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アミノテトラリン−誘動尿素のバニロイドｖｒ１受容体調節剤
DE60335635D1 (de) * 2002-05-22 2011-02-17 Amgen Inc Aminopyrimidin-derivate zur verwendung als vanilloid-rezeptor-liganden zur behandlung von schmerzen
DE102004032567A1 (de) * 2004-07-05 2006-03-02 Grünenthal GmbH Substituierte 1-Propiolyl-piperazine

Also Published As

Publication number Publication date
DK1893620T3 (da) 2012-01-16
JP5376941B2 (ja) 2013-12-25
WO2006122769A3 (de) 2007-03-15
EP1893620B1 (de) 2011-09-14
PL1893620T3 (pl) 2012-02-29
PT1893620E (pt) 2011-10-31
EP2292625A1 (de) 2011-03-09
ATE524478T1 (de) 2011-09-15
SI1893620T1 (sl) 2012-04-30
CA2608385A1 (en) 2006-11-23
PL2292625T3 (pl) 2014-04-30
JP2008540592A (ja) 2008-11-20
EP1893620A2 (de) 2008-03-05
CY1112137T1 (el) 2015-11-04
ES2370038T3 (es) 2011-12-12
US20080214807A1 (en) 2008-09-04
WO2006122769A2 (de) 2006-11-23
DE102005023784A1 (de) 2006-11-30
EP2292625B1 (de) 2013-12-25

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