ES2446307T3 - Piridazinas tetrasustituidas antagonistas de la ruta de Hedgehog - Google Patents
Piridazinas tetrasustituidas antagonistas de la ruta de Hedgehog Download PDFInfo
- Publication number
- ES2446307T3 ES2446307T3 ES09752071.2T ES09752071T ES2446307T3 ES 2446307 T3 ES2446307 T3 ES 2446307T3 ES 09752071 T ES09752071 T ES 09752071T ES 2446307 T3 ES2446307 T3 ES 2446307T3
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- Prior art keywords
- cancer
- pharmaceutically acceptable
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11536208P | 2008-11-17 | 2008-11-17 | |
| US115362P | 2008-11-17 | ||
| PCT/US2009/063696 WO2010056620A1 (en) | 2008-11-17 | 2009-11-09 | Tetrasubstituted pyridazines hedgehog pathway antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2446307T3 true ES2446307T3 (es) | 2014-03-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09752071.2T Active ES2446307T3 (es) | 2008-11-17 | 2009-11-09 | Piridazinas tetrasustituidas antagonistas de la ruta de Hedgehog |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8445493B2 (enExample) |
| EP (1) | EP2358703B1 (enExample) |
| JP (1) | JP5518088B2 (enExample) |
| KR (1) | KR101335770B1 (enExample) |
| CN (1) | CN102216292B (enExample) |
| AU (1) | AU2009314288B2 (enExample) |
| BR (1) | BRPI0921777A2 (enExample) |
| CA (1) | CA2743264C (enExample) |
| EA (1) | EA018372B1 (enExample) |
| ES (1) | ES2446307T3 (enExample) |
| MX (1) | MX2011005176A (enExample) |
| WO (1) | WO2010056620A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101260116B1 (ko) | 2008-04-29 | 2013-05-02 | 일라이 릴리 앤드 캄파니 | 이치환된 프탈라진 헤지호그 경로 길항제 |
| US20100041663A1 (en) * | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| CA2742539C (en) | 2008-11-03 | 2014-05-06 | Eli Lilly And Company | Disubstituted phthalazine hedgehog pathway antagonists |
| ES2392759T3 (es) | 2008-11-17 | 2012-12-13 | Eli Lilly And Company | Piridazina tetrasustituida como antagonistas de la vía Hedgehog. |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
| GB201309508D0 (en) | 2013-05-28 | 2013-07-10 | Redx Pharma Ltd | Compounds |
| GB2528298A (en) * | 2014-07-16 | 2016-01-20 | Redx Pharma Plc | Compounds |
| KR20230107568A (ko) | 2020-10-13 | 2023-07-17 | 엔데버 바이오메디신스, 인크. | 섬유증 치료 방법 |
| WO2025188802A1 (en) | 2024-03-05 | 2025-09-12 | Endeavor Biomedicines, Inc. | Methods of improving lung function |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB1293565A (en) | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| MY117098A (en) | 1996-01-15 | 2004-05-31 | Janssen Pharmaceutica Nv | Angiogenesis inhibiting pyridazinamines |
| US6432970B2 (en) | 1998-04-09 | 2002-08-13 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| WO1999052534A1 (en) | 1998-04-09 | 1999-10-21 | Johns Hopkins University School Of Medicine | Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways |
| GB0013674D0 (en) | 1999-06-08 | 2000-07-26 | Lorantis Ltd | Therapeutic use |
| EP1997494A3 (en) | 2002-04-22 | 2009-06-10 | Johns Hopkins University School of Medicine | Modulators of hedgehog signaling pathways, compositions and uses related thereto |
| AU2003265853A1 (en) | 2002-08-29 | 2004-03-19 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
| WO2005033288A2 (en) | 2003-09-29 | 2005-04-14 | The Johns Hopkins University | Hedgehog pathway antagonists |
| TW200533356A (en) | 2004-02-24 | 2005-10-16 | Mitsubishi Pharma Corp | Fused pyridazine derivatives |
| JP5221952B2 (ja) | 2004-05-08 | 2013-06-26 | ノバルティス・インターナショナル・ファーマシューティカル・リミテッド | ３−アリール−５，６−ジ置換ピリダジン類 |
| KR20150002863A (ko) | 2004-09-02 | 2015-01-07 | 제넨테크, 인크. | 헤지호그 신호전달에 대한 피리딜 억제제 |
| EP1900731A1 (de) | 2006-09-07 | 2008-03-19 | Bayer Schering Pharma Aktiengesellschaft | N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren |
| DK2137162T3 (en) * | 2007-03-15 | 2018-11-26 | Novartis Ag | Organic compounds and their applications |
| CA2690378A1 (en) | 2007-06-25 | 2008-12-31 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
| WO2009035568A1 (en) | 2007-09-07 | 2009-03-19 | Amgen Inc. | Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling |
| KR101260116B1 (ko) | 2008-04-29 | 2013-05-02 | 일라이 릴리 앤드 캄파니 | 이치환된 프탈라진 헤지호그 경로 길항제 |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| CA2742539C (en) | 2008-11-03 | 2014-05-06 | Eli Lilly And Company | Disubstituted phthalazine hedgehog pathway antagonists |
| ES2392759T3 (es) | 2008-11-17 | 2012-12-13 | Eli Lilly And Company | Piridazina tetrasustituida como antagonistas de la vía Hedgehog. |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
-
2009
- 2009-11-09 EA EA201170700A patent/EA018372B1/ru not_active IP Right Cessation
- 2009-11-09 ES ES09752071.2T patent/ES2446307T3/es active Active
- 2009-11-09 MX MX2011005176A patent/MX2011005176A/es active IP Right Grant
- 2009-11-09 US US13/122,225 patent/US8445493B2/en not_active Expired - Fee Related
- 2009-11-09 CA CA2743264A patent/CA2743264C/en not_active Expired - Fee Related
- 2009-11-09 WO PCT/US2009/063696 patent/WO2010056620A1/en not_active Ceased
- 2009-11-09 EP EP09752071.2A patent/EP2358703B1/en not_active Not-in-force
- 2009-11-09 AU AU2009314288A patent/AU2009314288B2/en not_active Ceased
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- 2009-11-09 KR KR1020117011132A patent/KR101335770B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012509265A (ja) | 2012-04-19 |
| EA201170700A1 (ru) | 2011-10-31 |
| AU2009314288A1 (en) | 2010-05-20 |
| US20110178093A1 (en) | 2011-07-21 |
| EA018372B1 (ru) | 2013-07-30 |
| AU2009314288B2 (en) | 2013-05-02 |
| KR20110075020A (ko) | 2011-07-05 |
| CN102216292B (zh) | 2014-08-13 |
| CA2743264C (en) | 2014-02-18 |
| EP2358703B1 (en) | 2013-12-25 |
| JP5518088B2 (ja) | 2014-06-11 |
| KR101335770B1 (ko) | 2013-12-12 |
| WO2010056620A1 (en) | 2010-05-20 |
| MX2011005176A (es) | 2011-05-30 |
| US8445493B2 (en) | 2013-05-21 |
| CA2743264A1 (en) | 2010-05-20 |
| CN102216292A (zh) | 2011-10-12 |
| EP2358703A1 (en) | 2011-08-24 |
| BRPI0921777A2 (pt) | 2016-01-12 |
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