ES2439776T3 - Triazolopiridinas sustituidas - Google Patents
Triazolopiridinas sustituidas Download PDFInfo
- Publication number
- ES2439776T3 ES2439776T3 ES10782198.5T ES10782198T ES2439776T3 ES 2439776 T3 ES2439776 T3 ES 2439776T3 ES 10782198 T ES10782198 T ES 10782198T ES 2439776 T3 ES2439776 T3 ES 2439776T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- alkoxy
- halo
- nr8r7
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims abstract description 72
- 125000001424 substituent group Chemical group 0.000 claims abstract description 59
- 125000003118 aryl group Chemical group 0.000 claims abstract description 58
- -1 hydroxy- Chemical class 0.000 claims description 333
- 210000004027 cell Anatomy 0.000 claims description 87
- 239000000203 mixture Substances 0.000 claims description 87
- 125000005843 halogen group Chemical group 0.000 claims description 67
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 57
- 150000003839 salts Chemical class 0.000 claims description 53
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- 238000000034 method Methods 0.000 claims description 49
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 40
- 238000011282 treatment Methods 0.000 claims description 33
- 201000010099 disease Diseases 0.000 claims description 30
- 230000036755 cellular response Effects 0.000 claims description 26
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 26
- 239000012453 solvate Substances 0.000 claims description 26
- 239000003795 chemical substances by application Substances 0.000 claims description 24
- 125000001072 heteroaryl group Chemical group 0.000 claims description 21
- 230000004663 cell proliferation Effects 0.000 claims description 20
- 125000000623 heterocyclic group Chemical group 0.000 claims description 20
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 19
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09075527A EP2343294A1 (en) | 2009-11-30 | 2009-11-30 | Substituted triazolopyridines |
| EP09075527 | 2009-11-30 | ||
| PCT/EP2010/006993 WO2011063907A1 (en) | 2009-11-30 | 2010-11-17 | Substituted triazolopyridines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2439776T3 true ES2439776T3 (es) | 2014-01-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10782198.5T Active ES2439776T3 (es) | 2009-11-30 | 2010-11-17 | Triazolopiridinas sustituidas |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8551980B2 (enExample) |
| EP (2) | EP2343294A1 (enExample) |
| JP (1) | JP5805652B2 (enExample) |
| CN (1) | CN102858768B (enExample) |
| CA (1) | CA2781914A1 (enExample) |
| ES (1) | ES2439776T3 (enExample) |
| WO (1) | WO2011063907A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
| UY33452A (es) | 2010-06-16 | 2012-01-31 | Bayer Schering Pharma Ag | Triazolopiridinas sustituidas |
| TWI541243B (zh) | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
| US9212184B2 (en) | 2010-12-17 | 2015-12-15 | Bayer Intellectual Property Gmbh | 6-thio-substituted imidazo[1,2-a]pyrazines as Mps-1 inhibitors |
| WO2012080229A1 (en) | 2010-12-17 | 2012-06-21 | Bayer Pharma Aktiengesellschaft | Imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment hyperproliferative disorders |
| CA2821837A1 (en) | 2010-12-17 | 2012-06-21 | Bayer Intellectual Property Gmbh | 2-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| EP2651945A1 (en) | 2010-12-17 | 2013-10-23 | Bayer Intellectual Property GmbH | 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| CN103429591A (zh) | 2010-12-17 | 2013-12-04 | 拜耳知识产权有限责任公司 | 在治疗过度增殖性病症中用作mps-1和tkk抑制剂的6-取代的咪唑并吡嗪 |
| CA2821817A1 (en) | 2010-12-17 | 2012-06-21 | Bayer Intellectual Property Gmbh | Substituted 6-imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| JP6001049B2 (ja) | 2011-03-31 | 2016-10-05 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | Ｍｐｓ−１キナーゼ阻害剤としての置換ベンズイミダゾール類 |
| CA2832310A1 (en) | 2011-04-06 | 2012-10-11 | Bayer Intellectual Property Gmbh | Substituted imidazopyridines and intermediates thereof |
| WO2012160029A1 (en) | 2011-05-23 | 2012-11-29 | Bayer Intellectual Property Gmbh | Substituted triazolopyridines |
| UA112096C2 (uk) | 2011-12-12 | 2016-07-25 | Байєр Інтеллектуал Проперті Гмбх | Заміщені триазолопіридини та їх застосування як інгібіторів ttk |
| US9512126B2 (en) | 2012-03-14 | 2016-12-06 | Bayer Intellectual Property Gmbh | Substituted imidazopyridazines |
| EP2827869A4 (en) | 2012-03-23 | 2015-09-23 | Dennis Brown | COMPOSITIONS AND METHODS FOR IMPROVING THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGUE THEREOF, WITH MEISOINDIGO |
| CA2878481A1 (en) | 2012-07-10 | 2014-01-16 | Bayer Pharma Aktiengesellschaft | Method for preparing substituted triazolopyridines |
| WO2014020041A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
| WO2014020043A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
| AR096469A1 (es) * | 2013-06-06 | 2015-12-30 | Bayer Pharma AG | Composiciones farmacéuticas que comprenden compuestos del tipo triazolpiridinas |
| CN105431435A (zh) * | 2013-06-07 | 2016-03-23 | 拜耳制药股份公司 | 具有作为mps-1抑制剂的活性的取代的三唑并吡啶类 |
| CA2914742A1 (en) * | 2013-06-11 | 2014-12-18 | Bayer Pharma Aktiengesellschaft | Handovers with co-operating cells configured to provide coordinated multi-point transmission/reception |
| KR20160019492A (ko) * | 2013-06-11 | 2016-02-19 | 바이엘 파마 악티엔게젤샤프트 | 치환된 트리아졸로피리딘의 전구약물 유도체 |
| WO2015157955A1 (en) * | 2014-04-17 | 2015-10-22 | Abbvie Inc. | Heterocyclic btk inhibit ors |
| WO2016166255A1 (en) | 2015-04-17 | 2016-10-20 | Netherlands Translational Research Center B.V. | Prognostic biomarkers for ttk inhibitor chemotherapy |
| MX2024010802A (es) * | 2022-03-04 | 2024-09-11 | Sillajen Inc | Combinaciones farmaceuticas para uso en el tratamiento de enfermedades neoplasicas. |
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| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| JPH0690447B2 (ja) | 1986-09-12 | 1994-11-14 | コニカ株式会社 | ハロゲン化銀写真感光材料 |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| US5880066A (en) | 1990-12-11 | 1999-03-09 | Monsanto Company | Safened herbicidal sulfonamide compositions |
| JP2878531B2 (ja) | 1991-12-16 | 1999-04-05 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
| US20030045491A1 (en) | 2001-02-23 | 2003-03-06 | Christoph Reinhard | TTK in diagnosis and as a therapeutic target in cancer |
| WO2003000659A1 (en) | 2001-06-26 | 2003-01-03 | Nissan Chemical Industries, Ltd. | Heterocycloiminophenyl compounds and fungicides and insecticides for agricultural and horticultural use |
| EP1546182B1 (en) | 2002-09-11 | 2011-01-05 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| GB2400101A (en) | 2003-03-28 | 2004-10-06 | Biofocus Discovery Ltd | Compounds capable of binding to the active site of protein kinases |
| HU227684B1 (en) | 2003-08-29 | 2011-11-28 | Sanofi Aventis | Adamantane and azabicyclo-octane and nonane derivatives and their use as dpp-iv inhibitors |
| AU2004303876A1 (en) * | 2003-12-19 | 2005-07-07 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| US7306631B2 (en) | 2004-03-30 | 2007-12-11 | The Procter & Gamble Company | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof |
| BRPI0516819A (pt) | 2004-10-07 | 2008-09-23 | Warner Lambert Co | derivados de triazolopiridina e agentes antibacterianos |
| ATE533497T1 (de) | 2005-12-27 | 2011-12-15 | Genentech Inc | Verfahren zur verwendung von hedgehog-kinase- antagonisten zur behandlung von hedgehog- vermittelten krebs |
| CA2656855A1 (en) | 2006-07-12 | 2008-01-17 | Christoph Luthy | Triazolopyridine derivatives as herbicides |
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| EP2468886A1 (en) | 2006-12-13 | 2012-06-27 | Oncotherapy Science, Inc. | TTK as tumor marker and therapeutic target for lung cancer |
| CA2693232A1 (en) | 2007-07-18 | 2009-01-22 | Novartis Ag | Bicyclic heteroaryl compounds and their use as kinase inhibitors |
| KR20100057650A (ko) | 2007-08-23 | 2010-05-31 | 아스트라제네카 아베 | 증식성 질환의 치료를 위한 ｔｔｋ／ｍｐｓ１의 억제제로서 ２-아닐리노푸린-８-온 |
| KR20100075881A (ko) | 2007-08-31 | 2010-07-05 | 메르크 세로노 에스. 에이. | 트리아졸로피리딘 화합물 및 ａｓｋ 저해제로서 이의 용도 |
| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| SG186040A1 (en) | 2007-11-27 | 2012-12-28 | Cellzome Ltd | Amino triazoles as pi3k inhibitors |
| CA2708686A1 (en) | 2007-12-21 | 2009-07-02 | University Health Network | Methods of inhibiting tumor growth using ttk antagonists |
| BRPI0909945A2 (pt) | 2008-06-20 | 2015-07-28 | Genentech Inc | "composto, composição farmacêutica, método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak2 quinase em um paciente, kit para o tratamento de uma doença ou distúrbio responsivo à inibição da jak quinase" |
| BRPI0910021A2 (pt) | 2008-06-20 | 2015-09-01 | Genentech Inc | "composto, composição farmacêutica, método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak2 quinas em um paciente, kit para o tratamento de uma doença ou distúrbio responsivo à inibição da jak quinase" |
| WO2010010184A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | [1, 2, 4] triazolo [1, 5-a] pyridines as jak inhibitors |
| UY32049A (es) | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | Inhibidores de cmet |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| GB2465405A (en) | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
| WO2010057877A1 (en) | 2008-11-18 | 2010-05-27 | Cellzome Limited | 7-pyridinyl- or phenyl- substituted triazolo [1, 5 -a] pyridines as pi3k inhibitors |
| RU2544011C2 (ru) | 2008-12-19 | 2015-03-10 | Лео Фарма А/С | Триазолопиридины в качестве ингибиторов фосфодиэстеразы для лечения кожных заболеваний |
| WO2010092015A1 (en) | 2009-02-10 | 2010-08-19 | Cellzome Limited | Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors |
| BRPI1008850A2 (pt) * | 2009-02-13 | 2016-03-15 | Fovea Pharmaceuticals | [1,2,4]triazolo[1,5-a]piridinas como inibidores de quinase |
| CA2760077A1 (en) | 2009-04-29 | 2010-11-04 | Marcus Koppitz | Substituted imidazoquinoxalines |
| CA2759939A1 (en) | 2009-05-20 | 2010-11-25 | Cellzome Ag | Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins |
| EP2438066A2 (en) | 2009-06-05 | 2012-04-11 | Cephalon, Inc. | PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a]PYRIDINE DERIVATIVES |
| TWI462920B (zh) | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
| CA2772790C (en) | 2009-09-04 | 2017-06-27 | Benjamin Bader | Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors |
| WO2011050245A1 (en) | 2009-10-23 | 2011-04-28 | Yangbo Feng | Bicyclic heteroaryls as kinase inhibitors |
| EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
| AU2011206634B2 (en) | 2010-01-15 | 2014-11-13 | Cellzome Limited | Novel substituted bicyclic triazole derivatives as gamma secretase modulators |
| US20110190269A1 (en) | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| CN103025744A (zh) | 2010-04-30 | 2013-04-03 | 百时美施贵宝公司 | 作为α-7烟碱乙酰胆碱受体配体前药的氮杂二环胺N-氧化物化合物 |
| US20130131057A1 (en) | 2010-05-13 | 2013-05-23 | Centro Nacional De Investigaciones Oncologicas (Cnio | New bicyclic compounds as pi3-k and mtor inhibitors |
| CN103038229B (zh) | 2010-05-26 | 2016-05-11 | 桑诺维恩药品公司 | 杂芳基化合物及其使用方法 |
| TW201204723A (en) | 2010-06-22 | 2012-02-01 | Fovea Pharmaceuticals | Heterocyclic compounds, their preparation and their therapeutic application |
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- 2010-11-17 CA CA2781914A patent/CA2781914A1/en not_active Abandoned
- 2010-11-17 CN CN201080062548.9A patent/CN102858768B/zh not_active Expired - Fee Related
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- 2010-11-17 WO PCT/EP2010/006993 patent/WO2011063907A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2343294A1 (en) | 2011-07-13 |
| EP2507233A1 (en) | 2012-10-10 |
| CN102858768B (zh) | 2016-01-20 |
| US8551980B2 (en) | 2013-10-08 |
| US20120328611A1 (en) | 2012-12-27 |
| JP2013512263A (ja) | 2013-04-11 |
| HK1180333A1 (zh) | 2013-10-18 |
| JP5805652B2 (ja) | 2015-11-04 |
| WO2011063907A1 (en) | 2011-06-03 |
| CN102858768A (zh) | 2013-01-02 |
| CA2781914A1 (en) | 2011-06-03 |
| EP2507233B1 (en) | 2013-11-06 |
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