ES2439776T3 - Triazolopiridinas sustituidas - Google Patents
Triazolopiridinas sustituidas Download PDFInfo
- Publication number
- ES2439776T3 ES2439776T3 ES10782198.5T ES10782198T ES2439776T3 ES 2439776 T3 ES2439776 T3 ES 2439776T3 ES 10782198 T ES10782198 T ES 10782198T ES 2439776 T3 ES2439776 T3 ES 2439776T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- alkoxy
- halo
- nr8r7
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims abstract description 72
- 125000001424 substituent group Chemical group 0.000 claims abstract description 59
- 125000003118 aryl group Chemical group 0.000 claims abstract description 58
- -1 hydroxy- Chemical class 0.000 claims description 333
- 210000004027 cell Anatomy 0.000 claims description 87
- 239000000203 mixture Substances 0.000 claims description 87
- 125000005843 halogen group Chemical group 0.000 claims description 67
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 57
- 150000003839 salts Chemical class 0.000 claims description 53
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- 238000000034 method Methods 0.000 claims description 49
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 40
- 238000011282 treatment Methods 0.000 claims description 33
- 201000010099 disease Diseases 0.000 claims description 30
- 230000036755 cellular response Effects 0.000 claims description 26
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 26
- 239000012453 solvate Substances 0.000 claims description 26
- 239000003795 chemical substances by application Substances 0.000 claims description 24
- 125000001072 heteroaryl group Chemical group 0.000 claims description 21
- 230000004663 cell proliferation Effects 0.000 claims description 20
- 125000000623 heterocyclic group Chemical group 0.000 claims description 20
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 19
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09075527 | 2009-11-30 | ||
| EP09075527A EP2343294A1 (en) | 2009-11-30 | 2009-11-30 | Substituted triazolopyridines |
| PCT/EP2010/006993 WO2011063907A1 (en) | 2009-11-30 | 2010-11-17 | Substituted triazolopyridines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2439776T3 true ES2439776T3 (es) | 2014-01-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10782198.5T Active ES2439776T3 (es) | 2009-11-30 | 2010-11-17 | Triazolopiridinas sustituidas |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8551980B2 (enExample) |
| EP (2) | EP2343294A1 (enExample) |
| JP (1) | JP5805652B2 (enExample) |
| CN (1) | CN102858768B (enExample) |
| CA (1) | CA2781914A1 (enExample) |
| ES (1) | ES2439776T3 (enExample) |
| WO (1) | WO2011063907A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
| UY33452A (es) | 2010-06-16 | 2012-01-31 | Bayer Schering Pharma Ag | Triazolopiridinas sustituidas |
| TWI541243B (zh) | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
| JP2013545776A (ja) | 2010-12-17 | 2013-12-26 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 過剰増殖性障害の治療におけるｍｐｓ−１およびｔｋｋ阻害剤として使用するための６置換イミダゾピラジン |
| ES2544609T3 (es) | 2010-12-17 | 2015-09-02 | Bayer Intellectual Property Gmbh | Imidazopirazinas 2-sustituidas para uso como inhibidores de Mps-1 y TTK en el tratamiento de trastornos hiper-proliferativos |
| CA2821817A1 (en) | 2010-12-17 | 2012-06-21 | Bayer Intellectual Property Gmbh | Substituted 6-imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| EP2651947B1 (en) | 2010-12-17 | 2014-12-10 | Bayer Intellectual Property GmbH | 6-thio-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| CA2821819A1 (en) | 2010-12-17 | 2012-06-21 | Marcus Koppitz | 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| JP2014503521A (ja) | 2010-12-17 | 2014-02-13 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 過増殖性障害の処置におけるｍｐｓ−１およびｔｋｋ阻害剤としての使用のための、イミダゾピラジン類 |
| US9388140B2 (en) | 2011-03-31 | 2016-07-12 | Bayer Intellectual Property Gmbh | Substituted benzimidazoles |
| WO2012136531A1 (en) | 2011-04-06 | 2012-10-11 | Bayer Pharma Aktiengesellschaft | Substituted imidazopyridines and intermediates thereof |
| WO2012160029A1 (en) | 2011-05-23 | 2012-11-29 | Bayer Intellectual Property Gmbh | Substituted triazolopyridines |
| UA112096C2 (uk) * | 2011-12-12 | 2016-07-25 | Байєр Інтеллектуал Проперті Гмбх | Заміщені триазолопіридини та їх застосування як інгібіторів ttk |
| WO2013135612A1 (en) | 2012-03-14 | 2013-09-19 | Bayer Intellectual Property Gmbh | Substituted imidazopyridazines |
| CA2868302A1 (en) | 2012-03-23 | 2013-09-26 | Dennis M. Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
| SG11201408419QA (en) | 2012-07-10 | 2015-01-29 | Bayer Pharma AG | Method for preparing substituted triazolopyridines |
| WO2014020043A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
| WO2014020041A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
| AR096469A1 (es) * | 2013-06-06 | 2015-12-30 | Bayer Pharma AG | Composiciones farmacéuticas que comprenden compuestos del tipo triazolpiridinas |
| HK1222849A1 (zh) * | 2013-06-07 | 2017-07-14 | Bayer Pharma Aktiengesellschaft | 具有作爲mps-1抑制剂的活性的取代的三唑并吡啶类 |
| AP2015008898A0 (en) * | 2013-06-11 | 2015-12-31 | Bayer Pharma AG | Prodrug derivatives of substituted triazolopyridines |
| TN2015000543A1 (en) | 2013-06-11 | 2017-04-06 | Bayer Pharma AG | Combinations for the treatment of cancer comprising a mps-1 kinase inhibitor and a mitotic inhibitor |
| WO2015157955A1 (en) * | 2014-04-17 | 2015-10-22 | Abbvie Inc. | Heterocyclic btk inhibit ors |
| ES2966392T3 (es) | 2015-04-17 | 2024-04-22 | Crossfire Oncology Holding B V | Biomarcadores pronósticos para quimioterapia inhibidora de TTK |
| EP4486350A4 (en) * | 2022-03-04 | 2026-01-21 | Sillajen Inc | PHARMACEUTICAL COMBINATIONS INTENDED FOR USE IN THE TREATMENT OF NEOPLASTIC DISEASES |
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| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| US5880066A (en) | 1990-12-11 | 1999-03-09 | Monsanto Company | Safened herbicidal sulfonamide compositions |
| JP2878531B2 (ja) | 1991-12-16 | 1999-04-05 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
| US20030045491A1 (en) | 2001-02-23 | 2003-03-06 | Christoph Reinhard | TTK in diagnosis and as a therapeutic target in cancer |
| WO2003000659A1 (en) | 2001-06-26 | 2003-01-03 | Nissan Chemical Industries, Ltd. | Heterocycloiminophenyl compounds and fungicides and insecticides for agricultural and horticultural use |
| WO2004024063A2 (en) | 2002-09-11 | 2004-03-25 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| GB2400101A (en) | 2003-03-28 | 2004-10-06 | Biofocus Discovery Ltd | Compounds capable of binding to the active site of protein kinases |
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| JP2007514757A (ja) * | 2003-12-19 | 2007-06-07 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン阻害剤 |
| US7306631B2 (en) | 2004-03-30 | 2007-12-11 | The Procter & Gamble Company | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof |
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| CA2691448A1 (en) | 2007-08-31 | 2009-03-05 | Dominique Swinnen | Triazolopyridine compounds and their use as ask inhibitors |
| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| AU2008328882A1 (en) | 2007-11-27 | 2009-06-04 | Cellzome Limited | Amino triazoles as PI3K inhibitors |
| US8492356B2 (en) | 2007-12-21 | 2013-07-23 | University Health Network | Methods of inhibiting tumor growth using TTK antagonists |
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| WO2009155565A1 (en) | 2008-06-20 | 2009-12-23 | Genentech, Inc. | Triazolopyridine jak inhibitor compounds and methods |
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| GB2465405A (en) | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
| WO2010057877A1 (en) | 2008-11-18 | 2010-05-27 | Cellzome Limited | 7-pyridinyl- or phenyl- substituted triazolo [1, 5 -a] pyridines as pi3k inhibitors |
| HRP20160488T1 (hr) | 2008-12-19 | 2016-06-17 | Leo Pharma A/S | Triazolopiridini kao inhibitori fosfodiesteraze za liječenje kožnih bolesti |
| WO2010092015A1 (en) | 2009-02-10 | 2010-08-19 | Cellzome Limited | Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors |
| SG173610A1 (en) * | 2009-02-13 | 2011-09-29 | Fovea Pharmaceuticals Sa | [1, 2, 4] triazolo [1, 5 -a] pyridines as kinase inhibitors |
| JP6168773B2 (ja) | 2009-04-29 | 2017-07-26 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 置換イミダゾキノキサリン |
| EP2432782A1 (en) | 2009-05-20 | 2012-03-28 | Cellzome Ag | Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins |
| EP2438066A2 (en) | 2009-06-05 | 2012-04-11 | Cephalon, Inc. | PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a]PYRIDINE DERIVATIVES |
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| JP5728683B2 (ja) | 2009-09-04 | 2015-06-03 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | チロシンスレオニンキナーゼ阻害剤としての置換アミノキノキサリン |
| WO2011050245A1 (en) | 2009-10-23 | 2011-04-28 | Yangbo Feng | Bicyclic heteroaryls as kinase inhibitors |
| EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
| EP2523949B1 (en) | 2010-01-15 | 2014-08-20 | Janssen Pharmaceuticals Inc. | Novel substituted triazole derivatives as gamma secretase modulators |
| US20110190269A1 (en) | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| CN103025744A (zh) | 2010-04-30 | 2013-04-03 | 百时美施贵宝公司 | 作为α-7烟碱乙酰胆碱受体配体前药的氮杂二环胺N-氧化物化合物 |
| WO2011141713A1 (en) | 2010-05-13 | 2011-11-17 | Centro Nacional De Investigaciones Oncologicas (Cnio) | New bicyclic compounds as pi3-k and mtor inhibitors |
| US8969349B2 (en) | 2010-05-26 | 2015-03-03 | Sunovion Pharmaceuticals Inc. | Substituted quinoxalines and quinoxalinones as PDE-10 inhibitors |
| AR081960A1 (es) | 2010-06-22 | 2012-10-31 | Fovea Pharmaceuticals Sa | Compuestos heterociclicos, su preparacion y su aplicacion terapeutica |
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Also Published As
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| JP5805652B2 (ja) | 2015-11-04 |
| CA2781914A1 (en) | 2011-06-03 |
| JP2013512263A (ja) | 2013-04-11 |
| US20120328611A1 (en) | 2012-12-27 |
| CN102858768B (zh) | 2016-01-20 |
| EP2507233A1 (en) | 2012-10-10 |
| HK1180333A1 (zh) | 2013-10-18 |
| US8551980B2 (en) | 2013-10-08 |
| EP2343294A1 (en) | 2011-07-13 |
| CN102858768A (zh) | 2013-01-02 |
| WO2011063907A1 (en) | 2011-06-03 |
| EP2507233B1 (en) | 2013-11-06 |
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