ES2432066T3 - Síntesis de 3-{[(2R)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1H-indol - Google Patents

Síntesis de 3-{[(2R)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1H-indol Download PDF

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Publication number
ES2432066T3
ES2432066T3 ES09751896T ES09751896T ES2432066T3 ES 2432066 T3 ES2432066 T3 ES 2432066T3 ES 09751896 T ES09751896 T ES 09751896T ES 09751896 T ES09751896 T ES 09751896T ES 2432066 T3 ES2432066 T3 ES 2432066T3
Authority
ES
Spain
Prior art keywords
salt
eletriptan
formula
acid
oxalic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09751896T
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English (en)
Spanish (es)
Inventor
Siro Serafini
Andrea Castellin
Claudio Dal Santo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fabbrica Italiana Sintetici SpA (FIS)
Original Assignee
Fabbrica Italiana Sintetici SpA (FIS)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application granted granted Critical
Publication of ES2432066T3 publication Critical patent/ES2432066T3/es
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
ES09751896T 2009-04-22 2009-11-09 Síntesis de 3-{[(2R)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1H-indol Active ES2432066T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI20090678 2009-04-22
ITMI2009A000678A IT1393700B1 (it) 2009-04-22 2009-04-22 Sintesi di 3-{[(2r)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1h-indolo
PCT/EP2009/064850 WO2010121673A1 (en) 2009-04-22 2009-11-09 Synthesis of 3-{[(2r)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1h-indole

Publications (1)

Publication Number Publication Date
ES2432066T3 true ES2432066T3 (es) 2013-11-29

Family

ID=41314669

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09751896T Active ES2432066T3 (es) 2009-04-22 2009-11-09 Síntesis de 3-{[(2R)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1H-indol

Country Status (8)

Country Link
US (1) US8426612B2 (https=)
EP (1) EP2421853B1 (https=)
JP (1) JP5663559B2 (https=)
CN (1) CN102414198B (https=)
CA (1) CA2756234C (https=)
ES (1) ES2432066T3 (https=)
IT (1) IT1393700B1 (https=)
WO (1) WO2010121673A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102786514B (zh) * 2012-07-26 2014-01-29 武汉人福医药集团股份有限公司 依来曲普坦的制备方法
CN104341397A (zh) * 2013-07-31 2015-02-11 上海威智医药科技有限公司 具晶型的依来曲普坦自由碱及其制法和应用
CN105175397B (zh) * 2015-09-15 2017-10-10 上海现代哈森（商丘）药业有限公司 一种氢溴酸依立曲坦合成方法
JP2019502761A (ja) * 2016-01-21 2019-01-31 ラボラトリオス レヴィ エセエレ （（ｒ）−３−［（−１−メチルピロリジン−２−イル）メチル］−５−（２−フェニルスルホニルエチル）−１ｈ−インドールを作製する方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL170330B1 (pl) 1990-10-15 1996-11-29 Pfizer Sposób wytwarzania nowych pochodnych indolu PL PL PL PL PL PL
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9923314D0 (en) * 1999-10-01 1999-12-08 Pfizer Ltd Acylation process
US20030166704A1 (en) 2000-12-20 2003-09-04 Pfizer Inc. New process
GB0031094D0 (en) * 2000-12-20 2001-01-31 Pfizer Ltd New Process
JP2006522790A (ja) 2003-04-11 2006-10-05 ファイザー・インク エレトリプタンと重炭酸ナトリウムを含む医薬組み合わせ物
GB0317229D0 (en) * 2003-07-23 2003-08-27 Pfizer Ltd Improved process
US6927296B2 (en) * 2003-07-23 2005-08-09 Pfizer Inc. Process
EP2093224A1 (en) 2007-05-01 2009-08-26 Plus Chemicals B.V. Process for preparing eletriptan hydrobromide form beta
US20080319205A1 (en) * 2007-05-29 2008-12-25 Roman Bednar Process for preparing 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole
WO2009077858A2 (en) 2007-12-17 2009-06-25 Actavis Group Ptc Ehf Novel hemioxalate salt of eletriptan
US20090299077A1 (en) 2008-05-22 2009-12-03 Vinod Kumar Kansal Salts of (R)-5-(2phenylsulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole, 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole and of eletriptan

Also Published As

Publication number Publication date
JP2012524736A (ja) 2012-10-18
IT1393700B1 (it) 2012-05-08
CA2756234A1 (en) 2010-10-28
EP2421853A1 (en) 2012-02-29
JP5663559B2 (ja) 2015-02-04
US20110166364A1 (en) 2011-07-07
EP2421853B1 (en) 2013-07-24
CA2756234C (en) 2017-01-03
CN102414198A (zh) 2012-04-11
WO2010121673A1 (en) 2010-10-28
ITMI20090678A1 (it) 2010-10-23
CN102414198B (zh) 2014-11-12
US8426612B2 (en) 2013-04-23

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