ES2426350T3 - Compuestos de isoindolina sustituidos en 5 - Google Patents
Compuestos de isoindolina sustituidos en 5 Download PDFInfo
- Publication number
- ES2426350T3 ES2426350T3 ES07837606T ES07837606T ES2426350T3 ES 2426350 T3 ES2426350 T3 ES 2426350T3 ES 07837606 T ES07837606 T ES 07837606T ES 07837606 T ES07837606 T ES 07837606T ES 2426350 T3 ES2426350 T3 ES 2426350T3
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- ES
- Spain
- Prior art keywords
- mmol
- optionally substituted
- alkyl
- dioxo
- halogens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical group C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 title description 2
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- 229910052736 halogen Inorganic materials 0.000 claims abstract description 71
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 50
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- 125000003118 aryl group Chemical group 0.000 claims abstract description 36
- 150000003839 salts Chemical class 0.000 claims abstract description 32
- 239000012453 solvate Substances 0.000 claims abstract description 31
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 26
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 21
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 17
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 17
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims abstract description 16
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 13
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims abstract description 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 7
- 125000005530 alkylenedioxy group Chemical group 0.000 claims abstract description 6
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 6
- 125000004043 oxo group Chemical group O=* 0.000 claims abstract description 5
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims abstract description 3
- 125000005843 halogen group Chemical group 0.000 claims abstract 26
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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| US93778207P | 2007-06-28 | 2007-06-28 | |
| US937782P | 2007-06-28 | ||
| PCT/US2007/019182 WO2008027542A2 (en) | 2006-08-30 | 2007-08-29 | 5-substituted isoindoline compounds |
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| ES2426350T3 true ES2426350T3 (es) | 2013-10-22 |
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| ES07837606T Active ES2426350T3 (es) | 2006-08-30 | 2007-08-29 | Compuestos de isoindolina sustituidos en 5 |
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| US12448399B2 (en) | 2023-01-26 | 2025-10-21 | Arvinas Operations, Inc. | Cereblon-based KRAS degrading PROTACs and uses related thereto |
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| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
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-
2007
- 2007-08-29 CL CL200702513A patent/CL2007002513A1/es unknown
- 2007-08-29 CA CA2660806A patent/CA2660806C/en active Active
- 2007-08-29 WO PCT/US2007/019182 patent/WO2008027542A2/en not_active Ceased
- 2007-08-29 EP EP07837606.8A patent/EP2057143B1/en active Active
- 2007-08-29 JP JP2009526742A patent/JP5523831B2/ja active Active
- 2007-08-29 BR BRPI0716092-5A2A patent/BRPI0716092A2/pt not_active IP Right Cessation
- 2007-08-29 KR KR1020097006325A patent/KR20090060314A/ko not_active Withdrawn
- 2007-08-29 MX MX2009001989A patent/MX2009001989A/es active IP Right Grant
- 2007-08-29 AU AU2007290407A patent/AU2007290407A1/en not_active Abandoned
- 2007-08-29 NZ NZ575061A patent/NZ575061A/en not_active IP Right Cessation
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- 2007-08-30 TW TW096132346A patent/TW200817368A/zh unknown
- 2007-08-30 AR ARP070103860A patent/AR062606A1/es unknown
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2009
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- 2009-03-17 CO CO09027212A patent/CO6160231A2/es unknown
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2014
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| Publication number | Publication date |
|---|---|
| JP2014141521A (ja) | 2014-08-07 |
| BRPI0716092A2 (pt) | 2013-09-17 |
| EP2057143A2 (en) | 2009-05-13 |
| JP2010502627A (ja) | 2010-01-28 |
| JP5523831B2 (ja) | 2014-06-18 |
| EP2057143B1 (en) | 2013-07-24 |
| NZ575061A (en) | 2011-10-28 |
| CO6160231A2 (es) | 2010-05-20 |
| CL2007002513A1 (es) | 2008-04-04 |
| MX2009001989A (es) | 2009-03-09 |
| WO2008027542A3 (en) | 2008-04-17 |
| CA2660806C (en) | 2015-06-16 |
| AU2007290407A1 (en) | 2008-03-06 |
| CR10653A (es) | 2009-04-03 |
| KR20090060314A (ko) | 2009-06-11 |
| IL197098A0 (en) | 2009-11-18 |
| JP5853047B2 (ja) | 2016-02-09 |
| WO2008027542A2 (en) | 2008-03-06 |
| CA2660806A1 (en) | 2008-03-06 |
| PE20080768A1 (es) | 2008-06-14 |
| TW200817368A (en) | 2008-04-16 |
| AR062606A1 (es) | 2008-11-19 |
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