NZ575061A - 5-substituted isoindoline compounds - Google Patents

Info

Publication number

NZ575061A

NZ575061A NZ575061A NZ57506107A NZ575061A NZ 575061 A NZ575061 A NZ 575061A NZ 575061 A NZ575061 A NZ 575061A NZ 57506107 A NZ57506107 A NZ 57506107A NZ 575061 A NZ575061 A NZ 575061A

Authority

NZ

New Zealand

Prior art keywords

compound

alkyl

mmol

halogen

optionally substituted

Prior art date

2006-08-30

Links

• Espacenet
• Global Dossier
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• -1 5-substituted isoindoline compounds Chemical class 0.000 title claims abstract description 62
• 150000001875 compounds Chemical class 0.000 claims abstract description 137
• 238000000034 method Methods 0.000 claims abstract description 27
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 105
• 125000000217 alkyl group Chemical group 0.000 claims description 66
• 229910052736 halogen Inorganic materials 0.000 claims description 60
• 150000002367 halogens Chemical class 0.000 claims description 60
• 239000002552 dosage form Substances 0.000 claims description 56
• 208000035475 disorder Diseases 0.000 claims description 55
• 201000010099 disease Diseases 0.000 claims description 50
• 206010028980 Neoplasm Diseases 0.000 claims description 44
• 238000011282 treatment Methods 0.000 claims description 44
• 239000013543 active substance Substances 0.000 claims description 35
• 239000003814 drug Substances 0.000 claims description 33
• 239000008194 pharmaceutical composition Substances 0.000 claims description 33
• 125000003118 aryl group Chemical group 0.000 claims description 32
• 201000011510 cancer Diseases 0.000 claims description 32
• 150000003839 salts Chemical class 0.000 claims description 32
• 239000012453 solvate Substances 0.000 claims description 31
• 210000004027 cell Anatomy 0.000 claims description 29
• 125000003545 alkoxy group Chemical group 0.000 claims description 25
• 125000001072 heteroaryl group Chemical group 0.000 claims description 23
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
• 208000002193 Pain Diseases 0.000 claims description 18
• 208000011580 syndromic disease Diseases 0.000 claims description 17
• 125000000623 heterocyclic group Chemical group 0.000 claims description 15
• 229910052760 oxygen Inorganic materials 0.000 claims description 13
• 230000006378 damage Effects 0.000 claims description 12
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
• 230000033115 angiogenesis Effects 0.000 claims description 11
• 208000002780 macular degeneration Diseases 0.000 claims description 11
• 229910052717 sulfur Inorganic materials 0.000 claims description 11
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 10
• 210000003169 central nervous system Anatomy 0.000 claims description 9
• 208000014674 injury Diseases 0.000 claims description 9
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• 208000015114 central nervous system disease Diseases 0.000 claims description 4
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
• 230000001394 metastastic effect Effects 0.000 claims description 4
• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims description 4
• 206010003571 Astrocytoma Diseases 0.000 claims description 3
• 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims description 3
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• 125000004043 oxo group Chemical group O=* 0.000 claims description 3
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
• 102200082402 rs751610198 Human genes 0.000 claims description 3
• 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 2
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
• 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 claims description 2
• 125000004115 pentoxy group Chemical group [*]OC([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 2
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• 125000003944 tolyl group Chemical group 0.000 claims 1
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• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 247
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