ES2422425T3 - Compuestos de guanilhidrazona, composiciones, procedimientos de fabricación y uso - Google Patents

Compuestos de guanilhidrazona, composiciones, procedimientos de fabricación y uso

Info

Publication number
ES2422425T3
ES2422425T3 ES05785277T ES05785277T ES2422425T3 ES 2422425 T3 ES2422425 T3 ES 2422425T3 ES 05785277 T ES05785277 T ES 05785277T ES 05785277 T ES05785277 T ES 05785277T ES 2422425 T3 ES2422425 T3 ES 2422425T3
Authority
ES
Spain
Prior art keywords
compositions
manufacturing
use procedures
guanylhydrazone compounds
guanylhydrazone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES05785277T
Other languages
English (en)
Inventor
Thais Sielecki-Dzurdz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferring BV
Cytokine Pharmasciences Inc
Original Assignee
Ferring BV
Cytokine Pharmasciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring BV, Cytokine Pharmasciences Inc filed Critical Ferring BV
Application granted granted Critical
Publication of ES2422425T3 publication Critical patent/ES2422425T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un compuesto que tiene la fórmula:**Fórmula** o una sal del mismo; en la que X1, X2, X3 y X4 son cada uno NH2C(>=NH)-NH-N>=CCH3-; yen la que Z es:**Fórmula**
ES05785277T 2004-08-17 2005-08-17 Compuestos de guanilhidrazona, composiciones, procedimientos de fabricación y uso Active ES2422425T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60199204P 2004-08-17 2004-08-17
PCT/US2005/029301 WO2006023586A2 (en) 2004-08-17 2005-08-17 Guanylhydrazone compounds, compositions, methods of making and using

Publications (1)

Publication Number Publication Date
ES2422425T3 true ES2422425T3 (es) 2013-09-11

Family

ID=35968147

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05785277T Active ES2422425T3 (es) 2004-08-17 2005-08-17 Compuestos de guanilhidrazona, composiciones, procedimientos de fabricación y uso

Country Status (13)

Country Link
US (3) US7291647B2 (es)
EP (2) EP2543661B1 (es)
JP (2) JP5198863B2 (es)
CN (2) CN101010094B (es)
AU (1) AU2005277456B2 (es)
BR (1) BRPI0514452A8 (es)
CA (1) CA2577156C (es)
DK (1) DK1778265T3 (es)
ES (1) ES2422425T3 (es)
MX (1) MX2007001928A (es)
PL (1) PL1778265T3 (es)
PT (1) PT1778265E (es)
WO (1) WO2006023586A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101010094B (zh) * 2004-08-17 2013-05-22 辉凌公司 脒腙化合物、组合物、制备方法及使用方法
JP5432710B2 (ja) * 2006-06-23 2014-03-05 ザ・フェインスタイン・インスティチュート・フォー・メディカル・リサーチ Ａβ及びシヌクレイン凝集の阻害剤
RU2477271C2 (ru) * 2011-01-12 2013-03-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кабардино-Балкарский государственный университет им. Х.М. Бербекова" (КБГУ) Моно- и дикетимины на основе 4,4'-диацетилдифенилоксида и гуанидина и способ их получения
CN109580873A (zh) * 2018-12-27 2019-04-05 湖北航天化学技术研究所 一种三氨基硝酸胍纯度的测定方法
JP6992935B1 (ja) 2021-03-30 2022-01-13 三菱電機株式会社 ロボットの据付補助装置およびロボットの据付補助方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH474486A (de) * 1965-11-19 1969-06-30 Ciba Geigy Verfahren zur Herstellung neuer Diphenylharnstoffe
IT1055433B (it) * 1976-02-23 1981-12-21 Anic Spa Metodo per la purificazione di acqua di scarico contenenti composti organici di carattere anioni co e mezzi adatti allo scopo
US5272165A (en) * 1984-03-19 1993-12-21 The Rockefeller University 2-alkylidene-aminoguanidines and methods of use therefor
US7425543B2 (en) 1992-11-16 2008-09-16 The Corporation Of Mercer University Microencapsulated materials and method of making same
US5599984A (en) * 1994-01-21 1997-02-04 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
US6008255A (en) 1994-01-21 1999-12-28 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
JP3823330B2 (ja) * 1994-11-09 2006-09-20 昭和電工株式会社 Ｎ−ホスホノメチルグリシンの単離方法
WO1998020868A1 (en) 1996-11-15 1998-05-22 The Picower Institute For Medical Research Guanylhydrazones useful for treating diseases associated with t cell activation
US6319894B1 (en) 1997-01-08 2001-11-20 The Picower Institute For Medical Research Complexes and combinations of fetuin with therapeutic agents
US20030203969A1 (en) 2000-02-02 2003-10-30 Dorian Bevec Pharmaceutically active aromatic guanylhydrazones
AU2001269092A1 (en) * 2000-06-27 2002-01-08 Axxima Pharmaceuticals Ag Inhibitors of hepatitis b virus infection
WO2003006426A1 (en) * 2001-07-13 2003-01-23 Axxima Pharmaceuticals Ag Aromatic guanylhydrazones as effective compounds against neurodiseases
EP1435932A4 (en) * 2001-09-21 2006-12-06 Message Pharmaceuticals Inc INHIBITORS OF RNASE P PROTEINS AS ANTIBACTERIAL COMPOUNDS
EP1487494A2 (en) 2002-02-26 2004-12-22 North Shore-Long Island Jewish Research Institute Inhibition of inflammatory cytokine production by stimulation of brain muscarinic receptors
EP1389480A1 (en) * 2002-08-14 2004-02-18 Mondobiotech Interferon SA Therapeutical use of guanylhydrazones for the inhibition of CD83 dependent processes and dendritic cell maturation
US7244765B2 (en) * 2004-06-25 2007-07-17 Cytokine Pharmasciences, Inc Guanylhydrazone salts, compositions, processes of making and methods of using
CN101010094B (zh) * 2004-08-17 2013-05-22 辉凌公司 脒腙化合物、组合物、制备方法及使用方法

Also Published As

Publication number Publication date
JP2013100291A (ja) 2013-05-23
MX2007001928A (es) 2007-04-17
EP2543661A1 (en) 2013-01-09
US20060041002A1 (en) 2006-02-23
AU2005277456B2 (en) 2011-12-01
PT1778265E (pt) 2013-08-05
CN101010094B (zh) 2013-05-22
US8247455B2 (en) 2012-08-21
JP5198863B2 (ja) 2013-05-15
US7863334B2 (en) 2011-01-04
CA2577156C (en) 2013-11-26
PL1778265T3 (pl) 2013-10-31
EP1778265A4 (en) 2010-01-06
CN102936212A (zh) 2013-02-20
EP1778265A2 (en) 2007-05-02
EP2543661B1 (en) 2016-12-07
WO2006023586A3 (en) 2007-01-04
BRPI0514452A (pt) 2008-06-10
AU2005277456A1 (en) 2006-03-02
CN101010094A (zh) 2007-08-01
DK1778265T3 (da) 2013-06-24
US20110144189A1 (en) 2011-06-16
CA2577156A1 (en) 2006-03-02
BRPI0514452A8 (pt) 2018-02-06
US20080070959A1 (en) 2008-03-20
US7291647B2 (en) 2007-11-06
JP5551755B2 (ja) 2014-07-16
JP2008510703A (ja) 2008-04-10
EP1778265B1 (en) 2013-04-24
WO2006023586A2 (en) 2006-03-02

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