ES2422425T3 - Compuestos de guanilhidrazona, composiciones, procedimientos de fabricación y uso - Google Patents
Compuestos de guanilhidrazona, composiciones, procedimientos de fabricación y usoInfo
- Publication number
- ES2422425T3 ES2422425T3 ES05785277T ES05785277T ES2422425T3 ES 2422425 T3 ES2422425 T3 ES 2422425T3 ES 05785277 T ES05785277 T ES 05785277T ES 05785277 T ES05785277 T ES 05785277T ES 2422425 T3 ES2422425 T3 ES 2422425T3
- Authority
- ES
- Spain
- Prior art keywords
- compositions
- manufacturing
- use procedures
- guanylhydrazone compounds
- guanylhydrazone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
Abstract
Un compuesto que tiene la fórmula:**Fórmula** o una sal del mismo; en la que X1, X2, X3 y X4 son cada uno NH2C(>=NH)-NH-N>=CCH3-; yen la que Z es:**Fórmula**
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60199204P | 2004-08-17 | 2004-08-17 | |
PCT/US2005/029301 WO2006023586A2 (en) | 2004-08-17 | 2005-08-17 | Guanylhydrazone compounds, compositions, methods of making and using |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2422425T3 true ES2422425T3 (es) | 2013-09-11 |
Family
ID=35968147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES05785277T Active ES2422425T3 (es) | 2004-08-17 | 2005-08-17 | Compuestos de guanilhidrazona, composiciones, procedimientos de fabricación y uso |
Country Status (13)
Country | Link |
---|---|
US (3) | US7291647B2 (es) |
EP (2) | EP1778265B1 (es) |
JP (2) | JP5198863B2 (es) |
CN (2) | CN102936212A (es) |
AU (1) | AU2005277456B2 (es) |
BR (1) | BRPI0514452A8 (es) |
CA (1) | CA2577156C (es) |
DK (1) | DK1778265T3 (es) |
ES (1) | ES2422425T3 (es) |
MX (1) | MX2007001928A (es) |
PL (1) | PL1778265T3 (es) |
PT (1) | PT1778265E (es) |
WO (1) | WO2006023586A2 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1778265B1 (en) * | 2004-08-17 | 2013-04-24 | Ferring B.V. | Guanylhydrazone compounds, compositions, methods of making and using |
AU2007265631B2 (en) * | 2006-06-23 | 2012-11-08 | The Feinstein Institute For Medical Research | Inhibitors of A-Beta and synuclein aggregation |
RU2477271C2 (ru) * | 2011-01-12 | 2013-03-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кабардино-Балкарский государственный университет им. Х.М. Бербекова" (КБГУ) | Моно- и дикетимины на основе 4,4'-диацетилдифенилоксида и гуанидина и способ их получения |
CN109580873A (zh) * | 2018-12-27 | 2019-04-05 | 湖北航天化学技术研究所 | 一种三氨基硝酸胍纯度的测定方法 |
JP6992935B1 (ja) | 2021-03-30 | 2022-01-13 | 三菱電機株式会社 | ロボットの据付補助装置およびロボットの据付補助方法 |
CN116102468A (zh) * | 2023-02-22 | 2023-05-12 | 中国科学技术大学 | 靶向人脂质运载蛋白2的先导化合物或其药学上可接受的盐及其制备方法与应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH474486A (de) * | 1965-11-19 | 1969-06-30 | Ciba Geigy | Verfahren zur Herstellung neuer Diphenylharnstoffe |
IT1055433B (it) * | 1976-02-23 | 1981-12-21 | Anic Spa | Metodo per la purificazione di acqua di scarico contenenti composti organici di carattere anioni co e mezzi adatti allo scopo |
US5272165A (en) * | 1984-03-19 | 1993-12-21 | The Rockefeller University | 2-alkylidene-aminoguanidines and methods of use therefor |
US7425543B2 (en) * | 1992-11-16 | 2008-09-16 | The Corporation Of Mercer University | Microencapsulated materials and method of making same |
US6008255A (en) | 1994-01-21 | 1999-12-28 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
US5599984A (en) * | 1994-01-21 | 1997-02-04 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
JP3823330B2 (ja) * | 1994-11-09 | 2006-09-20 | 昭和電工株式会社 | N−ホスホノメチルグリシンの単離方法 |
CA2271693C (en) | 1996-11-15 | 2009-01-20 | The Picower Institute For Medical Research | Guanylhydrazones useful for treating diseases associated with t cell activation |
US6319894B1 (en) * | 1997-01-08 | 2001-11-20 | The Picower Institute For Medical Research | Complexes and combinations of fetuin with therapeutic agents |
ES2250363T3 (es) * | 2000-02-02 | 2006-04-16 | Dorian Bevec | Guanilhidrazonas aromaticas farmaceuticamente activas. |
WO2002000613A2 (en) * | 2000-06-27 | 2002-01-03 | Axxima Pharmaceuticals Ag | Inhibitors of hepatitis b virus infection |
WO2003006426A1 (en) * | 2001-07-13 | 2003-01-23 | Axxima Pharmaceuticals Ag | Aromatic guanylhydrazones as effective compounds against neurodiseases |
AU2002336746A1 (en) * | 2001-09-21 | 2003-04-01 | Message Pharmaceuticals, Inc. | Inhibitors of rnase p proteins as antibacterial compounds |
WO2003072135A2 (en) * | 2002-02-26 | 2003-09-04 | North Shore-Long Island Jewish Research Insitute | Inhibition of inflammatory cytokine production by stimulation of brain muscarinic receptors |
EP1389480A1 (en) | 2002-08-14 | 2004-02-18 | Mondobiotech Interferon SA | Therapeutical use of guanylhydrazones for the inhibition of CD83 dependent processes and dendritic cell maturation |
US7244765B2 (en) * | 2004-06-25 | 2007-07-17 | Cytokine Pharmasciences, Inc | Guanylhydrazone salts, compositions, processes of making and methods of using |
EP1778265B1 (en) * | 2004-08-17 | 2013-04-24 | Ferring B.V. | Guanylhydrazone compounds, compositions, methods of making and using |
-
2005
- 2005-08-17 EP EP05785277.4A patent/EP1778265B1/en active Active
- 2005-08-17 CA CA2577156A patent/CA2577156C/en active Active
- 2005-08-17 EP EP12179899.5A patent/EP2543661B1/en not_active Not-in-force
- 2005-08-17 MX MX2007001928A patent/MX2007001928A/es active IP Right Grant
- 2005-08-17 US US11/205,187 patent/US7291647B2/en active Active
- 2005-08-17 CN CN2012103951620A patent/CN102936212A/zh active Pending
- 2005-08-17 DK DK05785277.4T patent/DK1778265T3/da active
- 2005-08-17 AU AU2005277456A patent/AU2005277456B2/en active Active
- 2005-08-17 BR BRPI0514452A patent/BRPI0514452A8/pt not_active Application Discontinuation
- 2005-08-17 PL PL05785277T patent/PL1778265T3/pl unknown
- 2005-08-17 PT PT57852774T patent/PT1778265E/pt unknown
- 2005-08-17 CN CN2005800281235A patent/CN101010094B/zh active Active
- 2005-08-17 ES ES05785277T patent/ES2422425T3/es active Active
- 2005-08-17 JP JP2007527986A patent/JP5198863B2/ja active Active
- 2005-08-17 WO PCT/US2005/029301 patent/WO2006023586A2/en active Application Filing
-
2007
- 2007-09-17 US US11/856,226 patent/US7863334B2/en active Active
-
2010
- 2010-12-07 US US12/961,657 patent/US8247455B2/en active Active
-
2012
- 2012-11-28 JP JP2012259862A patent/JP5551755B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
DK1778265T3 (da) | 2013-06-24 |
EP1778265A2 (en) | 2007-05-02 |
CN102936212A (zh) | 2013-02-20 |
JP5551755B2 (ja) | 2014-07-16 |
EP2543661A1 (en) | 2013-01-09 |
EP2543661B1 (en) | 2016-12-07 |
AU2005277456B2 (en) | 2011-12-01 |
US8247455B2 (en) | 2012-08-21 |
WO2006023586A2 (en) | 2006-03-02 |
CA2577156C (en) | 2013-11-26 |
CN101010094B (zh) | 2013-05-22 |
US20080070959A1 (en) | 2008-03-20 |
BRPI0514452A (pt) | 2008-06-10 |
US7863334B2 (en) | 2011-01-04 |
PL1778265T3 (pl) | 2013-10-31 |
CN101010094A (zh) | 2007-08-01 |
JP5198863B2 (ja) | 2013-05-15 |
EP1778265B1 (en) | 2013-04-24 |
CA2577156A1 (en) | 2006-03-02 |
BRPI0514452A8 (pt) | 2018-02-06 |
JP2013100291A (ja) | 2013-05-23 |
MX2007001928A (es) | 2007-04-17 |
PT1778265E (pt) | 2013-08-05 |
AU2005277456A1 (en) | 2006-03-02 |
WO2006023586A3 (en) | 2007-01-04 |
US20110144189A1 (en) | 2011-06-16 |
US20060041002A1 (en) | 2006-02-23 |
US7291647B2 (en) | 2007-11-06 |
EP1778265A4 (en) | 2010-01-06 |
JP2008510703A (ja) | 2008-04-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2422425T3 (es) | Compuestos de guanilhidrazona, composiciones, procedimientos de fabricación y uso | |
TW200745028A (en) | Novel sulphonylpyrroles | |
DE602005008996D1 (de) | Radiofluorierte peptide | |
EA200701840A1 (ru) | N-сульфонилпирролы и их применение в качестве ингибиторов гистондезацетилазы | |
TW200745027A (en) | Novel sulphonylpyrroles | |
NO20070122L (no) | Quinazolinonderivater anvendelige som vanilloidantagonister | |
EA200801199A1 (ru) | Ингибиторы киназы | |
NO20034660D0 (no) | Spiropyrazolforbindelser | |
GB0521508D0 (en) | Organic compounds | |
EA200702352A1 (ru) | Новые композиции нутрицевтиков | |
IN2012DN02609A (es) | ||
RS51616B (en) | HETEROARYL UREE DERIVATIVES USEFUL TO INHIBIT CHK1 | |
TW200715966A (en) | Synergistic fungicidal active compound combinations | |
CY1109916T1 (el) | Βενζιμιδαζολο-θειοφαινικες ενωσεις ως plk αναστολεις | |
BRPI0513149A (pt) | uso de 2-tio-3,5-diciano-4-fenil-6-aminopiridinas substituìdas no tratamento de náuseas e vÈmito | |
DOP2006000233A (es) | Inhibidores de cinasa | |
BRPI0512310A (pt) | compostos quìmicos | |
NO20081292L (no) | Pentasykliske kinaseinhibitorer | |
BRPI0601766A (pt) | composições contendo aminas e seu uso | |
EA200702290A1 (ru) | Мотилидные соединения | |
RU2006107361A (ru) | Средство, обладающее гематопротекторным действием | |
AR061628A1 (es) | Composicion herbicida de fenoxialcanoato y metodo de preparacion y uso | |
DE602004000931D1 (de) | Rückschlagventil für eine Kraftstoffpumpe | |
DK1370513T3 (da) | Æblesyreadditionssalte af terbinafin | |
ATE539762T1 (de) | Aminosäureersatz für peptidkonstruktionen |