BRPI0514452A - composições, métodos de fabricação e uso de compostos de guanilhidrazona - Google Patents

composições, métodos de fabricação e uso de compostos de guanilhidrazona

Info

Publication number
BRPI0514452A
BRPI0514452A BRPI0514452-3A BRPI0514452A BRPI0514452A BR PI0514452 A BRPI0514452 A BR PI0514452A BR PI0514452 A BRPI0514452 A BR PI0514452A BR PI0514452 A BRPI0514452 A BR PI0514452A
Authority
BR
Brazil
Prior art keywords
methods
compositions
manufacture
compounds
guanylhydrazone compounds
Prior art date
Application number
BRPI0514452-3A
Other languages
English (en)
Inventor
Thais M Sielecki-Dzurdz
Original Assignee
Cytokine Pharmasciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokine Pharmasciences Inc filed Critical Cytokine Pharmasciences Inc
Publication of BRPI0514452A publication Critical patent/BRPI0514452A/pt
Publication of BRPI0514452A8 publication Critical patent/BRPI0514452A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)

Abstract

COMPOSIçõES, MéTODOS DE FABRICAçãO E USO DE COMPOSTOS DE GUANILHIDRAZONA A presente invenção se relaciona aos compostos que possuem a fórmula I: sais destes; composições que compreendem um ou mais dos compostos e/ou sais destes; métodos de utilização; e métodos de fabricação.
BRPI0514452A 2004-08-17 2005-08-17 Composições, métodos de fabricação e uso de compostos de guanilhidrazona BRPI0514452A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60199204P 2004-08-17 2004-08-17
PCT/US2005/029301 WO2006023586A2 (en) 2004-08-17 2005-08-17 Guanylhydrazone compounds, compositions, methods of making and using

Publications (2)

Publication Number Publication Date
BRPI0514452A true BRPI0514452A (pt) 2008-06-10
BRPI0514452A8 BRPI0514452A8 (pt) 2018-02-06

Family

ID=35968147

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514452A BRPI0514452A8 (pt) 2004-08-17 2005-08-17 Composições, métodos de fabricação e uso de compostos de guanilhidrazona

Country Status (13)

Country Link
US (3) US7291647B2 (pt)
EP (2) EP1778265B1 (pt)
JP (2) JP5198863B2 (pt)
CN (2) CN102936212A (pt)
AU (1) AU2005277456B2 (pt)
BR (1) BRPI0514452A8 (pt)
CA (1) CA2577156C (pt)
DK (1) DK1778265T3 (pt)
ES (1) ES2422425T3 (pt)
MX (1) MX2007001928A (pt)
PL (1) PL1778265T3 (pt)
PT (1) PT1778265E (pt)
WO (1) WO2006023586A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1778265B1 (en) * 2004-08-17 2013-04-24 Ferring B.V. Guanylhydrazone compounds, compositions, methods of making and using
AU2007265631B2 (en) * 2006-06-23 2012-11-08 The Feinstein Institute For Medical Research Inhibitors of A-Beta and synuclein aggregation
RU2477271C2 (ru) * 2011-01-12 2013-03-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кабардино-Балкарский государственный университет им. Х.М. Бербекова" (КБГУ) Моно- и дикетимины на основе 4,4'-диацетилдифенилоксида и гуанидина и способ их получения
CN109580873A (zh) * 2018-12-27 2019-04-05 湖北航天化学技术研究所 一种三氨基硝酸胍纯度的测定方法
JP6992935B1 (ja) 2021-03-30 2022-01-13 三菱電機株式会社 ロボットの据付補助装置およびロボットの据付補助方法
CN116102468A (zh) * 2023-02-22 2023-05-12 中国科学技术大学 靶向人脂质运载蛋白2的先导化合物或其药学上可接受的盐及其制备方法与应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH474486A (de) * 1965-11-19 1969-06-30 Ciba Geigy Verfahren zur Herstellung neuer Diphenylharnstoffe
IT1055433B (it) * 1976-02-23 1981-12-21 Anic Spa Metodo per la purificazione di acqua di scarico contenenti composti organici di carattere anioni co e mezzi adatti allo scopo
US5272165A (en) * 1984-03-19 1993-12-21 The Rockefeller University 2-alkylidene-aminoguanidines and methods of use therefor
US7425543B2 (en) * 1992-11-16 2008-09-16 The Corporation Of Mercer University Microencapsulated materials and method of making same
US6008255A (en) 1994-01-21 1999-12-28 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
US5599984A (en) * 1994-01-21 1997-02-04 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
JP3823330B2 (ja) * 1994-11-09 2006-09-20 昭和電工株式会社 Ｎ−ホスホノメチルグリシンの単離方法
CA2271693C (en) 1996-11-15 2009-01-20 The Picower Institute For Medical Research Guanylhydrazones useful for treating diseases associated with t cell activation
US6319894B1 (en) * 1997-01-08 2001-11-20 The Picower Institute For Medical Research Complexes and combinations of fetuin with therapeutic agents
ES2250363T3 (es) * 2000-02-02 2006-04-16 Dorian Bevec Guanilhidrazonas aromaticas farmaceuticamente activas.
WO2002000613A2 (en) * 2000-06-27 2002-01-03 Axxima Pharmaceuticals Ag Inhibitors of hepatitis b virus infection
WO2003006426A1 (en) * 2001-07-13 2003-01-23 Axxima Pharmaceuticals Ag Aromatic guanylhydrazones as effective compounds against neurodiseases
AU2002336746A1 (en) * 2001-09-21 2003-04-01 Message Pharmaceuticals, Inc. Inhibitors of rnase p proteins as antibacterial compounds
WO2003072135A2 (en) * 2002-02-26 2003-09-04 North Shore-Long Island Jewish Research Insitute Inhibition of inflammatory cytokine production by stimulation of brain muscarinic receptors
EP1389480A1 (en) 2002-08-14 2004-02-18 Mondobiotech Interferon SA Therapeutical use of guanylhydrazones for the inhibition of CD83 dependent processes and dendritic cell maturation
US7244765B2 (en) * 2004-06-25 2007-07-17 Cytokine Pharmasciences, Inc Guanylhydrazone salts, compositions, processes of making and methods of using
EP1778265B1 (en) * 2004-08-17 2013-04-24 Ferring B.V. Guanylhydrazone compounds, compositions, methods of making and using

Also Published As

Publication number Publication date
DK1778265T3 (da) 2013-06-24
EP1778265A2 (en) 2007-05-02
CN102936212A (zh) 2013-02-20
JP5551755B2 (ja) 2014-07-16
EP2543661A1 (en) 2013-01-09
EP2543661B1 (en) 2016-12-07
AU2005277456B2 (en) 2011-12-01
US8247455B2 (en) 2012-08-21
WO2006023586A2 (en) 2006-03-02
CA2577156C (en) 2013-11-26
CN101010094B (zh) 2013-05-22
US20080070959A1 (en) 2008-03-20
US7863334B2 (en) 2011-01-04
PL1778265T3 (pl) 2013-10-31
CN101010094A (zh) 2007-08-01
JP5198863B2 (ja) 2013-05-15
EP1778265B1 (en) 2013-04-24
CA2577156A1 (en) 2006-03-02
ES2422425T3 (es) 2013-09-11
BRPI0514452A8 (pt) 2018-02-06
JP2013100291A (ja) 2013-05-23
MX2007001928A (es) 2007-04-17
PT1778265E (pt) 2013-08-05
AU2005277456A1 (en) 2006-03-02
WO2006023586A3 (en) 2007-01-04
US20110144189A1 (en) 2011-06-16
US20060041002A1 (en) 2006-02-23
US7291647B2 (en) 2007-11-06
EP1778265A4 (en) 2010-01-06
JP2008510703A (ja) 2008-04-10

Similar Documents

Publication Publication Date Title
BRPI0520870B8 (pt) compostos intermediários para a preparação de alfa-mercaptoacetanilidas de s-triazolila
EA200702670A1 (ru) Препарат тиенопиридинового ингибитора агрегации тромбоцитов
ME01992B (me) Jedinjenje diarilhidantoina
BRPI0913457A2 (pt) "composto, composição farmacêutica, e, uso do composto"
BRPI0715579A2 (pt) "composto, composição farmacêutica e uso de um composto"
BRPI0514372A (pt) inibidores de tiazol de frutose 1, 6-bisfosfatase
CR10157A (es) Compuestos químicos
NO20071880L (no) Diagnostic Compounds
EA200800321A1 (ru) Ингибиторы гистондеацетилазы
AR083234A1 (es) Composicion pesticida y su uso
RS51646B (en) TRICYCLIC UNITS AND THEIR USE AS MODULATORS OF GLUCOCORTICOID RECEPTORS
ATE554066T1 (de) Entzündungshemmende substituierte cyclobutendionverbindungen
EA200702352A1 (ru) Новые композиции нутрицевтиков
BRPI0515918A (pt) sais de composto heterocìclico de ligação à quimiocina e métodos para seu uso
UY29327A1 (es) Derivados de n-(heteroaril)- 1 h- indol-2-carboxamidas, su preparacion y su aplicacion en terapeutica
BRPI0408353A (pt) composto, composição farmacêutica, métodos para o tratamento de neoplasias suscetìveis e para o tratamento de infecções virais, e, uso de um composto
BRPI0514452A (pt) composições, métodos de fabricação e uso de compostos de guanilhidrazona
RS52108B (en) 3-SUBSTITUTED [1,2,3] -BENZOTRIAZINONE UNIT TO INCREASE GLUTAMATERGIC SYNAPTIC ANSWERS
EA200801366A1 (ru) Производные 3,6-дигидро-2-оксо-6н-1,3,4-тиадиазина
BRPI0601766A (pt) composições contendo aminas e seu uso
UY30788A1 (es) Compuestos quimicos
UY30356A1 (es) Derivados de 3-halo-n-(2.(4-fluorofenil)-4-oxobutil)-n-metil-5-(trifluorometil)benzamida y composiciones de los mismos.
EA200900780A1 (ru) Аналоги эпотилона, модифицированные в положениях c12-c13, как противораковые лекарственные средства
BRPI0512558A (pt) compostos quìmicos
CR9565A (es) Derivados del 4,5-diarilpirrol, su preparacion y su aplicacion en terapeutica

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: FERRING B.V. (NL)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: C07C 233/33 (2006.01), C07C 281/18 (2006.01), C07D

B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]