ES2421504T3 - Derivados de dihidrobenzoxatiazepinas, procedimiento para su preparación y composiciones farmacéuticas que los contienen, así como su utilización como moduladores de los receptores ampa - Google Patents
Derivados de dihidrobenzoxatiazepinas, procedimiento para su preparación y composiciones farmacéuticas que los contienen, así como su utilización como moduladores de los receptores ampaInfo
- Publication number
- ES2421504T3 ES2421504T3 ES11290413T ES11290413T ES2421504T3 ES 2421504 T3 ES2421504 T3 ES 2421504T3 ES 11290413 T ES11290413 T ES 11290413T ES 11290413 T ES11290413 T ES 11290413T ES 2421504 T3 ES2421504 T3 ES 2421504T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- linear
- branched
- well
- dihydrobenzoxathiazepine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 102000003678 AMPA Receptors Human genes 0.000 title 1
- 108090000078 AMPA Receptors Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000006684 polyhaloalkyl group Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
- C07D291/08—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
Compuestos de fórmula (I): **Fórmula** donde R1 representa un átomo de hidrógeno, un grupo ciano, un grupo alcoxicarbonilo(C 1-C6) lineal o ramificado, un grupo alquil(C1-C6)-sulfonilaminoalquilo(C1-C6) lineal o ramificado, un grupo N-hidroxicarboximidamida o un grupo heterocíclico, sus enantiómeros y sus diastereoisómeros, así como sus sales de adición a un ácido o una base farmacéuticamente aceptables, entendiéndose por el concepto "grupo heterocíclico" un grupo aromático monocíclico de 5 miembros que contiene de uno a cuatro heteroátomos, idénticos o diferentes, seleccionados entre nitrógeno, oxígeno y azufre, pudiendo dicho grupo heterocíclico estar sustituido en caso dado con uno o más sustituyentes, iguales o diferentes, seleccionados entre alquilo(C1-C6) lineal o ramificado o polihaloalquilo(C1-C6) lineal o ramificado.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1003683A FR2964969B1 (fr) | 2010-09-16 | 2010-09-16 | Nouveaux derives dihydrobenzoxathiazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2421504T3 true ES2421504T3 (es) | 2013-09-03 |
Family
ID=43067253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES11290413T Active ES2421504T3 (es) | 2010-09-16 | 2011-09-15 | Derivados de dihidrobenzoxatiazepinas, procedimiento para su preparación y composiciones farmacéuticas que los contienen, así como su utilización como moduladores de los receptores ampa |
Country Status (40)
Country | Link |
---|---|
US (1) | US8569285B2 (es) |
EP (1) | EP2431360B1 (es) |
JP (1) | JP2013537216A (es) |
KR (1) | KR20130054438A (es) |
CN (1) | CN103153973A (es) |
AP (1) | AP2013006793A0 (es) |
AR (1) | AR082973A1 (es) |
AU (1) | AU2011213898A1 (es) |
BR (1) | BR112013005967A2 (es) |
CA (1) | CA2752131C (es) |
CL (1) | CL2013000655A1 (es) |
CO (1) | CO6680709A2 (es) |
CR (1) | CR20130105A (es) |
CU (1) | CU20130037A7 (es) |
CY (1) | CY1114110T1 (es) |
DK (1) | DK2431360T3 (es) |
EA (1) | EA201300340A1 (es) |
EC (1) | ECSP13012489A (es) |
ES (1) | ES2421504T3 (es) |
FR (1) | FR2964969B1 (es) |
GE (1) | GEP20156247B (es) |
GT (1) | GT201300067A (es) |
HR (1) | HRP20130505T1 (es) |
IL (1) | IL225209A0 (es) |
MA (1) | MA34529B1 (es) |
ME (1) | ME01524B (es) |
MX (1) | MX2013002892A (es) |
NI (1) | NI201300028A (es) |
PE (1) | PE20131342A1 (es) |
PL (1) | PL2431360T3 (es) |
PT (1) | PT2431360E (es) |
RS (1) | RS52835B (es) |
SA (1) | SA111320755B1 (es) |
SG (1) | SG188380A1 (es) |
SI (1) | SI2431360T1 (es) |
TW (1) | TWI421080B (es) |
UA (1) | UA105320C2 (es) |
UY (1) | UY33574A (es) |
WO (1) | WO2012035216A1 (es) |
ZA (1) | ZA201106353B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111518058B (zh) * | 2020-05-29 | 2021-03-09 | 四川大学华西医院 | 一种噁噻嗪类化合物及其用途 |
CN111559990B (zh) * | 2020-05-29 | 2021-03-09 | 四川大学华西医院 | 一种小分子噁噻嗪类衍生物及其应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0101280A3 (en) * | 1998-02-18 | 2003-02-28 | Neurosearch As | Positive ampa receptor modulator compounds and their use |
TWI232863B (en) * | 2001-06-11 | 2005-05-21 | Akzo Nobel Nv | Benzoxazepine derivatives |
CN101029051B (zh) * | 2001-06-14 | 2010-06-09 | 欧加农股份有限公司 | 作为AMPA受体正性调节剂的(噻吩并)-[f]-氧杂吖庚因-5-酮衍生物 |
FR2856064B1 (fr) * | 2003-06-13 | 2005-08-19 | Servier Lab | Nouveaux derives de benzothiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
-
2010
- 2010-09-16 FR FR1003683A patent/FR2964969B1/fr not_active Expired - Fee Related
-
2011
- 2011-08-24 UY UY0001033574A patent/UY33574A/es unknown
- 2011-08-25 AU AU2011213898A patent/AU2011213898A1/en not_active Abandoned
- 2011-08-30 ZA ZA2011/06353A patent/ZA201106353B/en unknown
- 2011-09-07 CA CA2752131A patent/CA2752131C/fr not_active Expired - Fee Related
- 2011-09-07 TW TW100132314A patent/TWI421080B/zh not_active IP Right Cessation
- 2011-09-14 SA SA111320755A patent/SA111320755B1/ar unknown
- 2011-09-14 AR ARP110103332A patent/AR082973A1/es unknown
- 2011-09-15 ME MEP-2013-82A patent/ME01524B/me unknown
- 2011-09-15 MA MA35744A patent/MA34529B1/fr unknown
- 2011-09-15 BR BR112013005967A patent/BR112013005967A2/pt not_active Application Discontinuation
- 2011-09-15 RS RS20130274A patent/RS52835B/en unknown
- 2011-09-15 KR KR1020137009580A patent/KR20130054438A/ko not_active Application Discontinuation
- 2011-09-15 CN CN2011800437978A patent/CN103153973A/zh active Pending
- 2011-09-15 GE GEAP201113048A patent/GEP20156247B/en unknown
- 2011-09-15 SG SG2013015904A patent/SG188380A1/en unknown
- 2011-09-15 EA EA201300340A patent/EA201300340A1/ru unknown
- 2011-09-15 MX MX2013002892A patent/MX2013002892A/es active IP Right Grant
- 2011-09-15 PE PE2013000377A patent/PE20131342A1/es not_active Application Discontinuation
- 2011-09-15 SI SI201130030T patent/SI2431360T1/sl unknown
- 2011-09-15 ES ES11290413T patent/ES2421504T3/es active Active
- 2011-09-15 PL PL11290413T patent/PL2431360T3/pl unknown
- 2011-09-15 PT PT112904131T patent/PT2431360E/pt unknown
- 2011-09-15 JP JP2013528735A patent/JP2013537216A/ja active Pending
- 2011-09-15 WO PCT/FR2011/000502 patent/WO2012035216A1/fr active Application Filing
- 2011-09-15 UA UAA201304534A patent/UA105320C2/ru unknown
- 2011-09-15 US US13/200,045 patent/US8569285B2/en not_active Expired - Fee Related
- 2011-09-15 EP EP11290413.1A patent/EP2431360B1/fr active Active
- 2011-09-15 AP AP2013006793A patent/AP2013006793A0/xx unknown
- 2011-09-15 DK DK11290413.1T patent/DK2431360T3/da active
-
2013
- 2013-03-08 CL CL2013000655A patent/CL2013000655A1/es unknown
- 2013-03-11 CR CR20130105A patent/CR20130105A/es unknown
- 2013-03-12 CO CO13049160A patent/CO6680709A2/es not_active Application Discontinuation
- 2013-03-14 CU CU2013000037A patent/CU20130037A7/es unknown
- 2013-03-14 IL IL225209A patent/IL225209A0/en unknown
- 2013-03-14 GT GT201300067A patent/GT201300067A/es unknown
- 2013-03-14 NI NI201300028A patent/NI201300028A/es unknown
- 2013-03-15 EC ECSP13012489 patent/ECSP13012489A/es unknown
- 2013-06-07 HR HRP20130505AT patent/HRP20130505T1/hr unknown
- 2013-07-03 CY CY20131100553T patent/CY1114110T1/el unknown
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