ES2421191T3 - Antagonistas del receptor de Ah - Google Patents
Antagonistas del receptor de Ah Download PDFInfo
- Publication number
- ES2421191T3 ES2421191T3 ES07728657T ES07728657T ES2421191T3 ES 2421191 T3 ES2421191 T3 ES 2421191T3 ES 07728657 T ES07728657 T ES 07728657T ES 07728657 T ES07728657 T ES 07728657T ES 2421191 T3 ES2421191 T3 ES 2421191T3
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- Prior art keywords
- acid
- derivatives
- compounds
- oil
- ahr
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A61K8/046—Aerosols; Foams
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
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- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79685506P | 2006-05-03 | 2006-05-03 | |
| US796855P | 2006-05-03 | ||
| PCT/EP2007/054203 WO2007128723A1 (en) | 2006-05-03 | 2007-04-30 | Ah receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2421191T3 true ES2421191T3 (es) | 2013-08-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07728657T Active ES2421191T3 (es) | 2006-05-03 | 2007-04-30 | Antagonistas del receptor de Ah |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7855310B2 (https=) |
| EP (1) | EP2023910B1 (https=) |
| JP (1) | JP5474533B2 (https=) |
| CN (1) | CN101466363B (https=) |
| ES (1) | ES2421191T3 (https=) |
| WO (1) | WO2007128723A1 (https=) |
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| EP2082736A1 (fr) | 2008-01-23 | 2009-07-29 | Jean Hilaire Saurat | Composition pharmaceutique à usage topique |
| DE102008063307A1 (de) * | 2008-12-29 | 2010-07-01 | Henkel Ag & Co. Kgaa | Sonnenschutzzusammensetzungen |
| EP2201927A3 (de) * | 2008-12-29 | 2013-05-22 | Henkel AG & Co. KGaA | Sonnenschutzzusammensetzungen |
| DE102009002226A1 (de) * | 2009-04-06 | 2010-10-07 | Henkel Ag & Co. Kgaa | Hautbehandlungsmittel gegen Hautalterung II |
| DE102009002227A1 (de) * | 2009-04-06 | 2010-10-07 | Henkel Ag & Co. Kgaa | Hautbehandlungsmittel gegen Hautalterung I |
| EP2295031B1 (de) | 2009-08-05 | 2018-01-10 | Symrise AG | Verwendung von Pterocarpanen als Anti-Cellulite-Wirkstoffe |
| EP2184339B1 (de) | 2009-10-19 | 2011-12-14 | Symrise AG | Riechstoffmischungen enthaltend Isolongifolanol und Moschus |
| ES2547309T3 (es) | 2009-10-19 | 2015-10-05 | Symrise Ag | Composiciones que contienen fragancias, que comprenden nonanoato de cetilo y/o nonanoato de estearilo |
| EP2158896A3 (de) | 2009-11-02 | 2010-09-29 | Symrise GmbH & Co. KG | Riechstoffhaltige Zusammensetzungen umfassend Neopentylglycoldiisononanoat |
| BR112012025740B1 (pt) | 2010-04-08 | 2017-12-26 | Symrise Ag | Cosmetic preparation, and use of dihydrodesidrodi-isoeugenol |
| EP2389922A1 (en) | 2010-05-25 | 2011-11-30 | Symrise AG | Cyclohexyl carbamate compounds as anti-ageing actives |
| EP2286908A3 (de) | 2010-11-19 | 2011-06-01 | Symrise AG | Lösungsvermittler für kosmetische Zubereitungen |
| EP2457554A1 (de) | 2010-11-24 | 2012-05-30 | Symrise AG | Menthol enthaltende Mischung |
| EP2356977B1 (de) | 2011-02-02 | 2017-12-27 | Symrise AG | Zubereitungen mit Holzextrakten von Gleditschien |
| EP2524959B1 (de) | 2011-05-17 | 2014-01-22 | Symrise AG | Riech- und/oder Aromastoffkompositionen enthaltend Dioxolane |
| US9116112B2 (en) | 2011-07-11 | 2015-08-25 | Jr Chem Llc | UV protective skin treatment compositions and screening methods |
| EP2404595B1 (de) | 2011-09-01 | 2015-08-05 | Symrise AG | Verfahren zur Herstellung von Indanon-Derivaten |
| EP2753315B1 (en) * | 2011-09-07 | 2017-03-01 | Deutsches Krebsforschungszentrum | Means and methods for treating and/or preventing natural ahr ligand-dependent cancer |
| DE102011082464A1 (de) | 2011-09-09 | 2011-12-01 | Symrise Ag | Riechstoffmischungen enthaltend bestimmte Isolongifolenylmethylether |
| WO2013041130A1 (de) | 2011-09-20 | 2013-03-28 | Symrise Ag | Acetale und ketale als riech- und aromastoffe |
| EP2474301B1 (de) | 2011-12-14 | 2014-04-16 | Symrise AG | Riechstoffmischungen enthaltend Cyclopent-2-Enyl-Essigsäureethylester |
| EP2861304B1 (en) | 2012-06-15 | 2018-08-08 | Symrise AG | Compositions comprising hyaluronan biosynthesis promoting agents |
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| DE102012222970A1 (de) * | 2012-12-12 | 2014-06-12 | Henkel Ag & Co. Kgaa | Wirkstoffkombination zur Hautaufhellung I |
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| ES2701758T3 (es) | 2013-02-27 | 2019-02-25 | Symrise Ag | Extracto de jengibre para la protección de citoblastos |
| ES2647784T3 (es) | 2013-03-08 | 2017-12-26 | Symrise Ag | Composiciones cosméticas |
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| EP2783578A1 (en) | 2013-03-26 | 2014-10-01 | Symrise AG | Catechin reaction products |
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| US10765621B2 (en) | 2013-09-22 | 2020-09-08 | Symrise Ag | Extracts of halimione portulacoides and their application |
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| EP3062766A1 (en) | 2013-10-29 | 2016-09-07 | L'Oreal, S.A. | Use of mono ornithine ketoglutarate (mokg) |
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| EP3443950A1 (en) | 2014-07-30 | 2019-02-20 | Symrise AG | A fragrance composition |
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| CA2980730A1 (en) | 2015-03-23 | 2016-09-29 | The Brigham And Women's Hospital, Inc. | Tolerogenic nanoparticles for treating diabetes mellitus |
| ES2933563T3 (es) | 2015-04-16 | 2023-02-10 | Symrise Ag | Uso de una composición de liposoma |
| WO2016174011A1 (en) | 2015-04-28 | 2016-11-03 | Cutech Srl | Compositions comprising valerian extracts |
| EP3093002B1 (de) * | 2015-05-15 | 2018-04-25 | Symrise AG | Flüssige kühlstoffzubereitungen |
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| EP3108941B1 (en) | 2015-06-23 | 2018-05-09 | Symrise AG | Compositions comprising polyalkylene glycol derivatives |
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| WO2018196988A1 (de) | 2017-04-28 | 2018-11-01 | Symrise Ag | Ethyl-2-acetyl-2,4-dimethyl-pent-4-enoat als riechstoff |
| WO2018209412A1 (pt) * | 2017-05-17 | 2018-11-22 | Natura Cosméticos S.A. | Composição cosmética antipoluição lipossolúvel, produto cosmético, uso e método para prevenção e/ou tratamento dos sinais de envelhecimento extrínseco |
| WO2018209411A1 (pt) * | 2017-05-17 | 2018-11-22 | Natura Cosméticos S.A. | Composição cosmética de textura óleo, uso e método para prevenção e/ou tratamento dos sinais de envelhecimento extrínseco e estresse cutâneo |
| CA3069956A1 (en) | 2017-07-14 | 2019-01-17 | Keith Ervin | Biopolymeric water treatment |
| CN107529403A (zh) * | 2017-07-25 | 2018-01-02 | 西南大学 | 一种防腐保鲜剂及其在甜橙采后保鲜中的应用 |
| IT201700090929A1 (it) | 2017-08-07 | 2019-02-07 | Cutech S R L | Usi cosmetici e medici di estratti del fungo Coprinus comatus per la regolazione dell’unità pilo sebacea. |
| WO2019029808A1 (en) | 2017-08-09 | 2019-02-14 | Symrise Ag | 1,2-ALKANEDIOLS AND PROCESSES FOR PRODUCING THE SAME |
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| WO2019101641A1 (en) * | 2017-11-21 | 2019-05-31 | Bayer Aktiengesellschaft | 2-hetarylpyrimidine-4-carboxamides as aryl hydrocarbon receptor anatgonists |
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| EP3826986B1 (de) | 2018-07-23 | 2026-03-04 | Symrise AG | Neue riechstoffe mit rosengeruch |
| KR20240095376A (ko) | 2018-08-27 | 2024-06-25 | 시므라이즈 아게 | 적어도 하나의 하이드록시페논 유도체 (hydroxyphenone derivative) 를 포함하는 항균성 혼합물 |
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| CN116806825A (zh) | 2019-01-17 | 2023-09-29 | 西姆莱斯股份公司 | 一种抗微生物混合物 |
| US20220183937A1 (en) | 2019-03-11 | 2022-06-16 | Symrise Ag | Method for improving the performance of a fragrance or a fragrance mixture |
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| BR112021018763A2 (pt) | 2019-03-22 | 2021-11-23 | Symrise Ag | Peptídeos vegetais e suas aplicações (ii) |
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| WO2022122122A1 (en) | 2020-12-08 | 2022-06-16 | Symrise Ag | Medicament for fighting inflammatory conditions of human skin (i) |
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| WO2022122167A1 (en) | 2020-12-11 | 2022-06-16 | Symrise Ag | Medicament for preventing or treating pathologic conditions of human skin (i) |
| WO2022128054A1 (en) | 2020-12-14 | 2022-06-23 | Symrise Ag | Medicament for fighting inflammatory conditions of human skin (iv) |
| WO2022128052A1 (en) | 2020-12-14 | 2022-06-23 | Symrise Ag | Medicament for fighting inflammatory conditions of human skin |
| WO2022128057A1 (en) | 2020-12-14 | 2022-06-23 | Symrise Ag | Medicament for prevention and treatment of collagen degradation in human connecting tissue |
| WO2022128048A1 (en) | 2020-12-14 | 2022-06-23 | Symrise Ag | Medicament for preventing or treating pathologic conditions of human skin |
| WO2022128051A1 (en) | 2020-12-14 | 2022-06-23 | Symrise Ag | Medicament for fighting inflammatory conditions of human skin (ii) |
| WO2022128050A1 (en) | 2020-12-14 | 2022-06-23 | Symrise Ag | Medicament for fighting inflammation and pain |
| WO2022161593A1 (en) | 2021-01-26 | 2022-08-04 | Symrise Ag | Medicament for accelerated wound healing |
| WO2022171292A1 (en) | 2021-02-12 | 2022-08-18 | Symrise Ag | Medicament for prevention and treatment of hyperpigmentation |
| CN113087606B (zh) * | 2021-03-08 | 2022-11-11 | 中国科学院西北高原生物研究所 | 唐古特虎耳草中新的二芳基壬烷类ⅳ和ⅲ自由基抑制剂及其分离制备工艺和应用 |
| CN113087608B (zh) * | 2021-03-08 | 2022-11-11 | 中国科学院西北高原生物研究所 | 唐古特虎耳草中新的二芳基壬烷类ⅴ，ⅵ和ⅶ自由基抑制剂及其分离制备工艺和应用 |
| EP4083050A1 (en) | 2021-05-01 | 2022-11-02 | Analyticon Discovery GmbH | Microbial glycolipids |
| US20240392208A1 (en) | 2021-09-13 | 2024-11-28 | Symrise Ag | Cyclopropanated fragrance compounds |
| CN116162585A (zh) * | 2021-11-24 | 2023-05-26 | 青岛蔚蓝生物集团有限公司 | 一种用HaCaT细胞构建的皮肤细胞紫外线损伤模型 |
Family Cites Families (11)
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|---|---|---|---|---|
| US3983288A (en) * | 1974-11-04 | 1976-09-28 | Eastman Kodak Company | Fibers and fabrics containing optical brightening agents |
| JPH04134043A (ja) | 1990-09-25 | 1992-05-07 | Kao Corp | 新規α―ベンジリデンケトン誘導体、これを含有する紫外線吸収剤及びこれを含有する化粧料 |
| US6162810A (en) * | 1997-11-17 | 2000-12-19 | The Regents Of The University Of California | Inadone and tetralone compounds for inhibiting cell proliferation |
| FR2778337B1 (fr) | 1998-05-05 | 2001-08-31 | Inst Nat Sante Rech Med | Antagonistes des ligands du recepteur des arylhydrocarbures |
| FR2818128B1 (fr) * | 2000-12-18 | 2004-04-02 | Oreal | Compositions cosmetiques antisolaires a base d'un melange synergetique de filtres et utilisations |
| FR2819407B1 (fr) | 2001-01-18 | 2003-02-21 | Oreal | Compositions antisolaires a base d'un extrait d'au moins une bacterie filamenteuse non photosynthetique et d'au moins un flitre organique insoluble |
| EP1247796B1 (en) * | 2001-04-06 | 2009-05-13 | MERCK PATENT GmbH | Photoisomerizable compounds |
| FR2833164B1 (fr) * | 2001-12-07 | 2004-07-16 | Oreal | Compositions cosmetiques antisolaires a base d'un melange synergique de filtres et utilisations |
| DE10210623A1 (de) * | 2002-03-11 | 2003-09-25 | Haarmann & Reimer Gmbh | Alkoxy-substituierte Indane und deren Herstellung |
| EP1418164A1 (en) * | 2002-11-07 | 2004-05-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | New stilbene derivatives and their use as aryl hydrocarbon receptor ligand antagonists |
| FR2855755B1 (fr) * | 2003-06-05 | 2007-09-07 | Oreal | Utilisation d'au moins un filtre de la lumiere bleue pour preserve le capital de carotenoides endogenes de la peau; nouveaux filtres de la lumiere bleue; compositions cosmetiques |
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| CN101466363B (zh) | 2011-11-23 |
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