ES2402564T3 - Uso de EEF1A como biomarcador para el cribado de inhibidores de METAP2 - Google Patents
Uso de EEF1A como biomarcador para el cribado de inhibidores de METAP2 Download PDFInfo
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- ES2402564T3 ES2402564T3 ES09778819T ES09778819T ES2402564T3 ES 2402564 T3 ES2402564 T3 ES 2402564T3 ES 09778819 T ES09778819 T ES 09778819T ES 09778819 T ES09778819 T ES 09778819T ES 2402564 T3 ES2402564 T3 ES 2402564T3
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
- G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
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- G—PHYSICS
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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Applications Claiming Priority (3)
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| EP08019432 | 2008-11-06 | ||
| EP08019432 | 2008-11-06 | ||
| PCT/EP2009/007102 WO2010051882A1 (en) | 2008-11-06 | 2009-10-05 | Use of eef1a as biomarker and a method of screening metap2 inhibitors |
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| ES2402564T3 true ES2402564T3 (es) | 2013-05-06 |
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| WO (1) | WO2010051882A1 (enExample) |
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| WO2015069489A1 (en) | 2013-11-06 | 2015-05-14 | Merck Patent Gmbh | Predictive biomarker for hypoxia-activated prodrug therapy |
| KR101712982B1 (ko) * | 2015-07-31 | 2017-03-07 | 고려대학교 산학협력단 | 비알콜성지방간 조절인자 14-3-3 단백질 |
| WO2018148638A1 (en) * | 2017-02-10 | 2018-08-16 | Zafgen, Inc. | Pharmaceutical compositions of metap-2 inhibitors |
| CN108611352B (zh) * | 2018-04-20 | 2020-08-07 | 华南农业大学 | 一种拟禾本科根结线虫翻译延长因子Mg-eEF1A及其防治植物病害的应用 |
| CA3170118A1 (en) * | 2020-02-06 | 2021-08-12 | The Regents Of The University Of California | Elongation factor 1-alpha inhibitors and uses thereof |
| CN116395718B (zh) * | 2023-04-12 | 2024-12-17 | 中国科学院长春应用化学研究所 | 一种弱碱性钠盐纳米药物、其制备方法及其应用 |
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| WO1998056372A1 (en) * | 1997-06-09 | 1998-12-17 | Massachusetts Institute Of Technology | TYPE 2 METHIONINE AMINOPEPTIDASE (MetAP2) INHIBITORS AND USES THEROF |
| EP1337854A2 (en) * | 2000-11-14 | 2003-08-27 | Novartis AG | Method for screening anti-proliferative compounds and inhibiting tumor growth |
| US20020182701A1 (en) * | 2001-08-30 | 2002-12-05 | Saint Louis University | Dominant negative variants of methionine aminopeptidase 2 (MetAP2) and clinical uses thereof |
| US20030232383A1 (en) | 2001-11-02 | 2003-12-18 | Sylvia Daunert | Novel reagentless sensing system for measuring carbohydrates based on the galactose/glucose binding protein |
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- 2009-10-05 AU AU2009313167A patent/AU2009313167C1/en active Active
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Also Published As
| Publication number | Publication date |
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| US20110275088A1 (en) | 2011-11-10 |
| EP2344665B1 (en) | 2013-01-23 |
| AU2009313167C1 (en) | 2014-06-12 |
| IL212664A0 (en) | 2011-07-31 |
| AU2009313167A1 (en) | 2011-06-23 |
| US9151743B2 (en) | 2015-10-06 |
| JP5347028B2 (ja) | 2013-11-20 |
| CA2742737C (en) | 2018-05-29 |
| CA2742737A1 (en) | 2010-05-14 |
| JP2012507268A (ja) | 2012-03-29 |
| WO2010051882A1 (en) | 2010-05-14 |
| EP2344665A1 (en) | 2011-07-20 |
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