ES2400257T3 - Aminopurinas sustituidas con haloarilo, sus composiciones y métodos de tratamiento asociados - Google Patents
Aminopurinas sustituidas con haloarilo, sus composiciones y métodos de tratamiento asociados Download PDFInfo
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- ES2400257T3 ES2400257T3 ES07756113T ES07756113T ES2400257T3 ES 2400257 T3 ES2400257 T3 ES 2400257T3 ES 07756113 T ES07756113 T ES 07756113T ES 07756113 T ES07756113 T ES 07756113T ES 2400257 T3 ES2400257 T3 ES 2400257T3
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- 238000000034 method Methods 0.000 title claims abstract description 152
- 239000000203 mixture Substances 0.000 title description 76
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- 125000003106 haloaryl group Chemical group 0.000 title description 2
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Endocrinology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/411,413 US7521446B2 (en) | 2005-01-13 | 2006-04-26 | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
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| PCT/US2007/010258 WO2007127382A1 (en) | 2006-04-26 | 2007-04-25 | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
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| US8603527B2 (en) | 2010-10-25 | 2013-12-10 | Signal Pharmaceuticals, Llc | Pharmaceutical formulations of a substituted diaminopurine |
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| CN109819649B (zh) | 2016-04-01 | 2023-02-28 | 西格诺药品有限公司 | 氨基嘌呤化合物的固体形式及其使用方法 |
| SG10202009589UA (en) | 2016-04-01 | 2020-10-29 | Signal Pharm Llc | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
| WO2017210399A1 (en) | 2016-06-02 | 2017-12-07 | Celgene Corporation | Animal and human anti-malarial agents |
| AR108665A1 (es) | 2016-06-02 | 2018-09-12 | Celgene Corp | Derivados de aminopurina como agentes anti-tripanosómicos y anti-leishmania |
| CN106265673B (zh) * | 2016-09-18 | 2019-09-20 | 中国农业大学 | 一种化合物的应用 |
| WO2019070827A1 (en) | 2017-10-04 | 2019-04-11 | Celgene Corporation | PROCESSES FOR THE PREPARATION OF CIS-4 [2 - {(3S, 4R) -3-FLUOROOXAN-4-YL] AMINO) -8- (2,4,6-TRICHLOROANILINO) -9H-PURIN-9-YL] -1 -MÉTHYLCYCLOHEXANE-1-carboxamide |
| CA3078368A1 (en) | 2017-10-04 | 2019-04-11 | Celgene Corporation | Compositions and methods of use of cis-4-[2-{[(3s,4r)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9h-purin-9-yl]-1-methylcyclohexane-1-carboxamide |
| CN109384788B (zh) * | 2018-10-16 | 2021-05-14 | 成都大学 | 嘌呤系列衍生物及其制备方法和用途 |
| CN111544657B (zh) * | 2020-05-11 | 2022-01-11 | 北京大学第三医院（北京大学第三临床医学院） | 一种具有良好可打印性的细胞3d打印生物墨水制备方法 |
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| US5332744A (en) * | 1989-05-30 | 1994-07-26 | Merck & Co., Inc. | Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists |
| JP2001516694A (ja) * | 1997-08-07 | 2001-10-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | プロテインキナーゼ、ｇプロテイン及びポリメラーゼのプリン阻害剤 |
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| CN1919859A (zh) | 1999-11-12 | 2007-02-28 | 法玛赛特有限公司 | 2＇－脱氧－l－核苷的合成 |
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| US7759342B2 (en) * | 2005-01-13 | 2010-07-20 | Signal Pharmaceuticals, Llc | Methods of treatment and prevention using haloaryl substituted aminopurines |
| US7521446B2 (en) | 2005-01-13 | 2009-04-21 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
| ES2567051T3 (es) | 2006-10-27 | 2016-04-19 | Signal Pharmaceuticals, Llc | Formas sólidas que comprenden 4-[9-(3S)-(tetrahidro-furan-3-il)-8-(2,4,6-trifluoro-fenilamino)-9H-purin-2-ilamino]-trans-ciclohexan-1-ol, sus composiciones y sus usos |
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Also Published As
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| WO2007127382A1 (en) | 2007-11-08 |
| CN103351389B (zh) | 2015-10-28 |
| CA2684999A1 (en) | 2007-11-08 |
| CN103351389A (zh) | 2013-10-16 |
| BRPI0710805A2 (pt) | 2011-08-16 |
| US20070060598A1 (en) | 2007-03-15 |
| US20090275564A1 (en) | 2009-11-05 |
| IL194865A (en) | 2015-08-31 |
| AU2007243287A1 (en) | 2007-11-08 |
| MX2008013616A (es) | 2009-03-06 |
| EP2010186A1 (en) | 2009-01-07 |
| ZA201103036B (en) | 2012-08-29 |
| JP2009535346A (ja) | 2009-10-01 |
| IL194865A0 (en) | 2009-08-03 |
| ZA200907418B (en) | 2011-12-28 |
| EP2010186B1 (en) | 2012-12-26 |
| CA2684999C (en) | 2013-11-26 |
| NZ572467A (en) | 2010-10-29 |
| AU2007243287B2 (en) | 2012-02-16 |
| CN101478972A (zh) | 2009-07-08 |
| ZA200809356B (en) | 2010-02-24 |
| US8101588B2 (en) | 2012-01-24 |
| KR20090013804A (ko) | 2009-02-05 |
| US7521446B2 (en) | 2009-04-21 |
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