ES2385754T3 - Receptores heterodiméricos solubles y usos de estos - Google Patents
Receptores heterodiméricos solubles y usos de estos Download PDFInfo
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- ES2385754T3 ES2385754T3 ES07786810T ES07786810T ES2385754T3 ES 2385754 T3 ES2385754 T3 ES 2385754T3 ES 07786810 T ES07786810 T ES 07786810T ES 07786810 T ES07786810 T ES 07786810T ES 2385754 T3 ES2385754 T3 ES 2385754T3
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
Landscapes
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- Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
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- Plant Pathology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP06115901 | 2006-06-22 | ||
| EP06115901 | 2006-06-22 | ||
| PCT/EP2007/056276 WO2007147898A1 (en) | 2006-06-22 | 2007-06-22 | Soluble heterodimeric receptors and uses thereof |
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| ES2385754T3 true ES2385754T3 (es) | 2012-07-31 |
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| ES07786810T Active ES2385754T3 (es) | 2006-06-22 | 2007-06-22 | Receptores heterodiméricos solubles y usos de estos |
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| US (1) | US7932055B2 (https=) |
| EP (1) | EP2035452B1 (https=) |
| JP (1) | JP5368301B2 (https=) |
| AT (1) | ATE555383T1 (https=) |
| ES (1) | ES2385754T3 (https=) |
| WO (1) | WO2007147898A1 (https=) |
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| US10865233B2 (en) | 2008-12-18 | 2020-12-15 | Dana-Farber Cancer Institute, Inc. | NKG2D-fc for immunotherapy |
| DK3143134T3 (da) | 2014-05-15 | 2021-01-04 | Nat Univ Singapore | Modificerede, naturlige dræberceller og anvendelser deraf |
| US10329348B2 (en) | 2014-10-23 | 2019-06-25 | Innate Pharma | Treatment of cancers using anti-NKG2A agents |
| EP3373970A4 (en) | 2015-11-13 | 2019-07-10 | Dana Farber Cancer Institute, Inc. | NKG2D IG FUSION PROTEIN FOR CANCER IMMUNOTHERAPY |
| WO2017156461A2 (en) * | 2016-03-10 | 2017-09-14 | Aperisys, Inc. | Antigen-binding fusion proteins with modified hsp70 domains |
| CA3056591A1 (en) | 2017-03-27 | 2018-10-04 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| BR112019019917A2 (pt) | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
| CN108101975B (zh) * | 2017-12-14 | 2020-05-15 | 中国科学院昆明动物研究所 | 一种森林山蛭抗血栓多肽Sylvestin及其体外表达制备方法和应用 |
| EP3749685A4 (en) * | 2018-02-09 | 2021-12-22 | National University of Singapore | ACTIVATOR CHEMERIC RECEPTORS AND THEIR USES IN NATURAL KILLING CELL IMMUNOTHERAPY |
| WO2019175182A1 (en) | 2018-03-13 | 2019-09-19 | Innate Pharma | Treatment of head and neck cancer |
| JP7334985B2 (ja) | 2018-04-02 | 2023-08-29 | ナショナル ユニヴァーシティー オブ シンガポール | 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和 |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| CA3120563A1 (en) | 2018-11-26 | 2020-06-04 | Nkarta, Inc. | Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy |
| MX2021006194A (es) * | 2018-12-02 | 2021-06-30 | Fate Therapeutics Inc | Inmunoterapias mediante el uso de celulas efectoras potenciadas derivadas de ipsc. |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY |
| JP2022532430A (ja) * | 2019-05-16 | 2022-07-14 | シャタック ラボ，インコーポレイテッド | Ｎｋ細胞指向性キメラタンパク質 |
| GB201909509D0 (en) * | 2019-07-02 | 2019-08-14 | Immunocore Ltd | Peptide-MHC complexes |
| EP3999850A1 (en) * | 2019-07-16 | 2022-05-25 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) | Nmda receptor constructs to detect and isolate nmdar autoantibodies |
| CN111303296B (zh) * | 2019-12-16 | 2021-01-29 | 启辰生生物科技(珠海)有限公司 | 双功能融合多肽、细胞和药物组合物及应用 |
| CN111122848A (zh) * | 2019-12-30 | 2020-05-08 | 浙江工业大学 | 一种用于筛选hgfr靶向抗体的elisa试剂盒及应用 |
| EP4615978A1 (en) * | 2022-11-07 | 2025-09-17 | Senti Biosciences, Inc. | Methods and compositions for cell-surface co-localization of chimeric proteins |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6018026A (en) | 1988-01-22 | 2000-01-25 | Zymogenetics, Inc. | Biologically active dimerized and multimerized polypeptide fusions |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| JPH06506358A (ja) | 1991-03-28 | 1994-07-21 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミネソタ | ナチュラルキラー細胞に特異的なｄｎａおよびアミノ酸配列 |
| US6238890B1 (en) | 1994-02-18 | 2001-05-29 | Washington University | Single chain forms of the glycoprotein hormone quartet |
| US5783672A (en) | 1994-05-26 | 1998-07-21 | Immunex Corporation | Receptor for oncostatin M |
| ITFI940106A1 (it) | 1994-05-27 | 1995-11-27 | Menarini Ricerche Sud Spa | Molecola ibrida di formula gm-csf-l-epo o epo-l-gm-csf per la stimolaz ione eritropoietica |
| US6066322A (en) * | 1995-03-03 | 2000-05-23 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of immune disorders |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| CA2258721C (en) | 1996-07-12 | 2014-09-09 | Genentech, Inc. | Chimeric heteromultimer adhesins |
| ATE299938T1 (de) | 1997-05-02 | 2005-08-15 | Genentech Inc | Ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen |
| US20020062010A1 (en) * | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US6982142B2 (en) | 1997-12-01 | 2006-01-03 | John Wayne Cancer Institute | Methods for screening therapeutically effective agents |
| GB9725764D0 (en) * | 1997-12-04 | 1998-02-04 | Isis Innovation | HLA-E binding |
| ES2590912T3 (es) | 1997-12-08 | 2016-11-24 | Merck Patent Gmbh | Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario |
| EP1047781B1 (en) | 1998-01-23 | 2004-07-28 | Immunex Corporation | Il-18 receptors |
| EP1001030A1 (en) * | 1998-09-22 | 2000-05-17 | Boehringer Ingelheim International GmbH | Recombinant CELO virus and CELO virus DNA |
| HUP0204475A2 (en) * | 2000-02-11 | 2003-04-28 | Merck Patent Gmbh | Enhancing the circulating half-life of antibody-based fusion proteins |
| US6853997B2 (en) | 2000-06-29 | 2005-02-08 | Infoglide Corporation | System and method for sharing, mapping, transforming data between relational and hierarchical databases |
| IL137419A0 (en) | 2000-07-20 | 2001-07-24 | Yissum Res Dev Co | Nk cells activating receptors and their therapeutic and diagnostic uses |
| US20020052475A1 (en) * | 2000-07-20 | 2002-05-02 | Schering Ag | High affinity soluble interleukin-18 receptor |
| DE60123998T2 (de) | 2000-08-08 | 2007-09-06 | Zymogenetics, Inc., Seattle | Lösliche zcyctor 11 cytokinrezeptoren |
| ATE333888T1 (de) | 2000-09-15 | 2006-08-15 | Zymogenetics Inc | Verwendung eines polypeptids, welches die extrazelluläre domäne von il-20ra und il-20rb enthält, zur behandlung von entzündungen |
| CN1533438A (zh) | 2001-06-08 | 2004-09-29 | �����Ŵ��Ƽ���˾ | 在植物生产蛋白质的方法 |
| KR100453877B1 (ko) * | 2001-07-26 | 2004-10-20 | 메덱스젠 주식회사 | 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체 |
| US6833441B2 (en) | 2001-08-01 | 2004-12-21 | Abmaxis, Inc. | Compositions and methods for generating chimeric heteromultimers |
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- 2007-06-22 US US12/305,678 patent/US7932055B2/en not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| ATE555383T1 (de) | 2012-05-15 |
| EP2035452A1 (en) | 2009-03-18 |
| JP2009541274A (ja) | 2009-11-26 |
| US7932055B2 (en) | 2011-04-26 |
| JP5368301B2 (ja) | 2013-12-18 |
| WO2007147898A1 (en) | 2007-12-27 |
| EP2035452B1 (en) | 2012-04-25 |
| US20090281035A1 (en) | 2009-11-12 |
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