ES2383771T3 - Homoharringtonina sola o combinada con otros agentes para su utilización en el tratamiento de la leucemia mielógena crónica resistente o intolerante a los inhibidores de la proteína cinasa diferentes al STI571 - Google Patents
Homoharringtonina sola o combinada con otros agentes para su utilización en el tratamiento de la leucemia mielógena crónica resistente o intolerante a los inhibidores de la proteína cinasa diferentes al STI571 Download PDFInfo
- Publication number
- ES2383771T3 ES2383771T3 ES09172828T ES09172828T ES2383771T3 ES 2383771 T3 ES2383771 T3 ES 2383771T3 ES 09172828 T ES09172828 T ES 09172828T ES 09172828 T ES09172828 T ES 09172828T ES 2383771 T3 ES2383771 T3 ES 2383771T3
- Authority
- ES
- Spain
- Prior art keywords
- homoharringtonin
- sti571
- protein kinase
- kinase inhibitors
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229960002411 imatinib Drugs 0.000 title claims abstract description 119
- HYFHYPWGAURHIV-UHFFFAOYSA-N homoharringtonine Natural products C1=C2CCN3CCCC43C=C(OC)C(OC(=O)C(O)(CCCC(C)(C)O)CC(=O)OC)C4C2=CC2=C1OCO2 HYFHYPWGAURHIV-UHFFFAOYSA-N 0.000 title claims abstract description 117
- HYFHYPWGAURHIV-JFIAXGOJSA-N omacetaxine mepesuccinate Chemical compound C1=C2CCN3CCC[C@]43C=C(OC)[C@@H](OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)[C@H]4C2=CC2=C1OCO2 HYFHYPWGAURHIV-JFIAXGOJSA-N 0.000 title claims abstract description 115
- 238000011282 treatment Methods 0.000 title claims abstract description 51
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 title claims abstract description 48
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 title claims abstract description 47
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 title claims abstract description 47
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 title claims abstract description 27
- 239000003909 protein kinase inhibitor Substances 0.000 title claims description 78
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title claims description 72
- 239000003795 chemical substances by application Substances 0.000 title claims description 9
- 241001465754 Metazoa Species 0.000 claims abstract description 27
- 208000014767 Myeloproliferative disease Diseases 0.000 claims abstract description 6
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims abstract 3
- 230000004044 response Effects 0.000 claims description 35
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims description 28
- 102000006992 Interferon-alpha Human genes 0.000 claims description 26
- 108010047761 Interferon-alpha Proteins 0.000 claims description 26
- 239000000063 antileukemic agent Substances 0.000 claims description 25
- 238000002560 therapeutic procedure Methods 0.000 claims description 23
- 229950000038 interferon alfa Drugs 0.000 claims description 22
- 230000002489 hematologic effect Effects 0.000 claims description 21
- 210000004027 cell Anatomy 0.000 claims description 18
- 229960000684 cytarabine Drugs 0.000 claims description 17
- 239000002777 nucleoside Substances 0.000 claims description 16
- 230000002559 cytogenic effect Effects 0.000 claims description 15
- 229940124226 Farnesyltransferase inhibitor Drugs 0.000 claims description 12
- 239000003528 protein farnesyltransferase inhibitor Substances 0.000 claims description 12
- 229940043355 kinase inhibitor Drugs 0.000 claims description 11
- 210000000066 myeloid cell Anatomy 0.000 claims description 11
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 11
- 230000002195 synergetic effect Effects 0.000 claims description 11
- 102000014150 Interferons Human genes 0.000 claims description 9
- 108010050904 Interferons Proteins 0.000 claims description 9
- 229940079322 interferon Drugs 0.000 claims description 9
- 230000035755 proliferation Effects 0.000 claims description 9
- 229940121649 protein inhibitor Drugs 0.000 claims description 8
- 239000012268 protein inhibitor Substances 0.000 claims description 8
- 108091000080 Phosphotransferase Proteins 0.000 claims description 7
- 102000020233 phosphotransferase Human genes 0.000 claims description 7
- 230000004083 survival effect Effects 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 5
- 230000003463 hyperproliferative effect Effects 0.000 claims description 5
- 125000003835 nucleoside group Chemical group 0.000 claims description 5
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims description 5
- 208000028018 Lymphocytic leukaemia Diseases 0.000 claims description 4
- 102000001253 Protein Kinase Human genes 0.000 claims description 4
- 239000003112 inhibitor Substances 0.000 claims description 4
- 208000003747 lymphoid leukemia Diseases 0.000 claims description 4
- 108060006633 protein kinase Proteins 0.000 claims description 4
- XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 claims description 3
- 206010033661 Pancytopenia Diseases 0.000 claims description 3
- 230000001154 acute effect Effects 0.000 claims description 3
- 208000024389 cytopenia Diseases 0.000 claims description 3
- 229960003603 decitabine Drugs 0.000 claims description 3
- 231100000226 haematotoxicity Toxicity 0.000 claims description 3
- RXRGZNYSEHTMHC-BQBZGAKWSA-N troxacitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)OC1 RXRGZNYSEHTMHC-BQBZGAKWSA-N 0.000 claims description 3
- 229950010147 troxacitabine Drugs 0.000 claims description 3
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 230000006842 hematologic response Effects 0.000 claims description 2
- XGXNTJHZPBRBHJ-UHFFFAOYSA-N n-phenylpyrimidin-2-amine Chemical compound N=1C=CC=NC=1NC1=CC=CC=C1 XGXNTJHZPBRBHJ-UHFFFAOYSA-N 0.000 claims description 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 27
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 abstract description 6
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 abstract description 6
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 abstract description 6
- 229960002230 omacetaxine mepesuccinate Drugs 0.000 abstract description 2
- YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 description 93
- 230000002071 myeloproliferative effect Effects 0.000 description 14
- 229940079593 drug Drugs 0.000 description 10
- 239000003814 drug Substances 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 7
- 210000000265 leukocyte Anatomy 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 208000004860 Blast Crisis Diseases 0.000 description 5
- 230000002062 proliferating effect Effects 0.000 description 5
- 239000003642 reactive oxygen metabolite Substances 0.000 description 5
- 230000001939 inductive effect Effects 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 3
- 208000031953 Hereditary hemorrhagic telangiectasia Diseases 0.000 description 3
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 230000006907 apoptotic process Effects 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 208000032839 leukemia Diseases 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 241000282412 Homo Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 206010034133 Pathogen resistance Diseases 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 102000011767 Acute-Phase Proteins Human genes 0.000 description 1
- 108010062271 Acute-Phase Proteins Proteins 0.000 description 1
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 description 1
- 102000011727 Caspases Human genes 0.000 description 1
- 108010076667 Caspases Proteins 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010019837 Hepatocellular injury Diseases 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 235000021120 animal protein Nutrition 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000000719 anti-leukaemic effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000011254 conventional chemotherapy Methods 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 150000003839 salts Chemical group 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000011301 standard therapy Methods 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31696701P | 2001-09-05 | 2001-09-05 | |
| US316967P | 2001-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2383771T3 true ES2383771T3 (es) | 2012-06-26 |
Family
ID=23231501
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09172828T Expired - Lifetime ES2383771T3 (es) | 2001-09-05 | 2002-09-05 | Homoharringtonina sola o combinada con otros agentes para su utilización en el tratamiento de la leucemia mielógena crónica resistente o intolerante a los inhibidores de la proteína cinasa diferentes al STI571 |
| ES02772653T Expired - Lifetime ES2334774T3 (es) | 2001-09-05 | 2002-09-05 | Tratamiento de la leucemia mielogena cronica, resistente o intoleranteal sti571, que consiste en homoharrigtonina sola o combinada con otros agentes. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02772653T Expired - Lifetime ES2334774T3 (es) | 2001-09-05 | 2002-09-05 | Tratamiento de la leucemia mielogena cronica, resistente o intoleranteal sti571, que consiste en homoharrigtonina sola o combinada con otros agentes. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6987103B2 (enExample) |
| EP (2) | EP2177223B9 (enExample) |
| JP (2) | JP4794816B2 (enExample) |
| AT (2) | ATE548041T1 (enExample) |
| AU (1) | AU2002337410A1 (enExample) |
| CA (1) | CA2459822C (enExample) |
| CY (2) | CY1109799T1 (enExample) |
| DE (1) | DE60234708D1 (enExample) |
| DK (2) | DK2177223T3 (enExample) |
| ES (2) | ES2383771T3 (enExample) |
| PT (2) | PT2177223E (enExample) |
| WO (1) | WO2003020252A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6613753B2 (en) * | 2001-02-21 | 2003-09-02 | Supergen, Inc. | Restore cancer-suppressing functions to neoplastic cells through DNA hypomethylation |
| US6905669B2 (en) * | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
| US6998391B2 (en) * | 2002-02-07 | 2006-02-14 | Supergen.Inc. | Method for treating diseases associated with abnormal kinase activity |
| US20040192652A1 (en) * | 2002-12-06 | 2004-09-30 | Giles Francis J. | Pharmaceutical combinations and methods for the treatment of leukemia |
| US20050037992A1 (en) * | 2003-07-22 | 2005-02-17 | John Lyons | Composition and method for treating neurological disorders |
| US20050059682A1 (en) * | 2003-09-12 | 2005-03-17 | Supergen, Inc., A Delaware Corporation | Compositions and methods for treatment of cancer |
| US7250416B2 (en) | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
| US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
| US20070117776A1 (en) * | 2005-11-04 | 2007-05-24 | John Lyons | Low Dose Therapy Of DNA Methylation Inhibitors |
| JP2009532440A (ja) * | 2006-04-07 | 2009-09-10 | ノバルティス アクチエンゲゼルシャフト | ａ）ピリミジルアミノベンズアミド化合物、およびｂ）Ｔｈｒ３１５Ｉｌｅキナーゼ阻害剤を含む、組合せ剤 |
| EP2049096A4 (en) * | 2006-08-02 | 2012-05-09 | Univ South Florida | METHOD FOR TREATING CHRONIC MYELOGENIC LEUKEMIA CELLS |
| CN103285015B (zh) * | 2007-04-13 | 2016-04-27 | 化学基因制药公司 | 三尖杉碱口服剂型 |
| WO2009073885A1 (en) * | 2007-12-07 | 2009-06-11 | Chemgenex Pharmaceuticals, Inc. | Leukemic stem cell ablation |
| JP5617175B2 (ja) | 2008-04-17 | 2014-11-05 | 富士電機株式会社 | ワイドバンドギャップ半導体装置とその製造方法 |
| CA2839102A1 (en) * | 2011-06-29 | 2013-01-03 | The Penn State Research Foundation | Compositions, methods and kits for treating leukemia |
| EP2750768B1 (en) | 2011-08-30 | 2018-10-03 | Astex Pharmaceuticals, Inc. | Decitabine derivative formulations |
| MX2018000016A (es) | 2015-07-02 | 2019-01-31 | Otsuka Pharma Co Ltd | Composiciones farmaceuticas liofilizadas. |
| CA3071755A1 (en) | 2017-08-03 | 2019-02-07 | Otsuka Pharmaceutical Co., Ltd. | Drug compound and purification methods thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030148955A1 (en) * | 1999-04-19 | 2003-08-07 | Pluenneke John D. | Soluble tumor necrosis factor receptor treatment of medical disorders |
-
2002
- 2002-09-05 AT AT09172828T patent/ATE548041T1/de active
- 2002-09-05 PT PT09172828T patent/PT2177223E/pt unknown
- 2002-09-05 CA CA2459822A patent/CA2459822C/en not_active Expired - Fee Related
- 2002-09-05 EP EP20090172828 patent/EP2177223B9/en not_active Expired - Lifetime
- 2002-09-05 AU AU2002337410A patent/AU2002337410A1/en not_active Abandoned
- 2002-09-05 WO PCT/IB2002/003992 patent/WO2003020252A2/en not_active Ceased
- 2002-09-05 AT AT02772653T patent/ATE451106T1/de active
- 2002-09-05 DK DK09172828.7T patent/DK2177223T3/da active
- 2002-09-05 ES ES09172828T patent/ES2383771T3/es not_active Expired - Lifetime
- 2002-09-05 PT PT02772653T patent/PT1443933E/pt unknown
- 2002-09-05 JP JP2003524561A patent/JP4794816B2/ja not_active Expired - Fee Related
- 2002-09-05 DK DK02772653.8T patent/DK1443933T3/da active
- 2002-09-05 DE DE60234708T patent/DE60234708D1/de not_active Expired - Lifetime
- 2002-09-05 ES ES02772653T patent/ES2334774T3/es not_active Expired - Lifetime
- 2002-09-05 EP EP02772653A patent/EP1443933B1/en not_active Expired - Lifetime
-
2003
- 2003-03-27 US US10/397,267 patent/US6987103B2/en active Active
-
2009
- 2009-02-02 JP JP2009021692A patent/JP2009102408A/ja active Pending
-
2010
- 2010-02-10 CY CY20101100126T patent/CY1109799T1/el unknown
-
2012
- 2012-06-06 CY CY20121100501T patent/CY1112817T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009102408A (ja) | 2009-05-14 |
| CA2459822C (en) | 2013-01-29 |
| PT2177223E (pt) | 2012-05-23 |
| DE60234708D1 (de) | 2010-01-21 |
| AU2002337410A1 (en) | 2003-03-18 |
| EP2177223A2 (en) | 2010-04-21 |
| WO2003020252A2 (en) | 2003-03-13 |
| CY1109799T1 (el) | 2014-09-10 |
| JP4794816B2 (ja) | 2011-10-19 |
| EP2177223B1 (en) | 2012-03-07 |
| EP2177223B9 (en) | 2012-10-31 |
| EP1443933A2 (en) | 2004-08-11 |
| EP2177223A3 (en) | 2010-05-19 |
| HK1143732A1 (en) | 2011-01-14 |
| ATE451106T1 (de) | 2009-12-15 |
| US20040019036A1 (en) | 2004-01-29 |
| JP2005508896A (ja) | 2005-04-07 |
| ATE548041T1 (de) | 2012-03-15 |
| PT1443933E (pt) | 2010-01-27 |
| HK1067562A1 (en) | 2005-04-15 |
| EP1443933B1 (en) | 2009-12-09 |
| CY1112817T1 (el) | 2016-02-10 |
| CA2459822A1 (en) | 2003-03-13 |
| US6987103B2 (en) | 2006-01-17 |
| WO2003020252A3 (en) | 2003-06-19 |
| DK1443933T3 (da) | 2010-01-25 |
| ES2334774T3 (es) | 2010-03-16 |
| DK2177223T3 (da) | 2012-04-10 |
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