ES2361886T3 - Profármacos adenosina acetil 2',3'-metilideno novedosos para uso como profármacos para agonistas del receptor adenosina. - Google Patents
Profármacos adenosina acetil 2',3'-metilideno novedosos para uso como profármacos para agonistas del receptor adenosina. Download PDFInfo
- Publication number
- ES2361886T3 ES2361886T3 ES07765638T ES07765638T ES2361886T3 ES 2361886 T3 ES2361886 T3 ES 2361886T3 ES 07765638 T ES07765638 T ES 07765638T ES 07765638 T ES07765638 T ES 07765638T ES 2361886 T3 ES2361886 T3 ES 2361886T3
- Authority
- ES
- Spain
- Prior art keywords
- pain
- disease
- adenosine
- thousand
- inflammation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title abstract 6
- 239000002126 C01EB10 - Adenosine Substances 0.000 title abstract 3
- 229960005305 adenosine Drugs 0.000 title abstract 3
- 239000000556 agonist Substances 0.000 title 1
- 208000002193 Pain Diseases 0.000 claims abstract 23
- 150000001875 compounds Chemical class 0.000 claims abstract 14
- 206010061218 Inflammation Diseases 0.000 claims abstract 10
- 230000004054 inflammatory process Effects 0.000 claims abstract 10
- 239000002988 disease modifying antirheumatic drug Substances 0.000 claims abstract 5
- 239000003814 drug Substances 0.000 claims abstract 4
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract 2
- 230000001225 therapeutic effect Effects 0.000 claims abstract 2
- 230000001575 pathological effect Effects 0.000 claims 11
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 9
- 208000036487 Arthropathies Diseases 0.000 claims 7
- 208000012659 Joint disease Diseases 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 206010003246 arthritis Diseases 0.000 claims 6
- 230000006378 damage Effects 0.000 claims 6
- 206010012601 diabetes mellitus Diseases 0.000 claims 6
- 201000005569 Gout Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 201000008482 osteoarthritis Diseases 0.000 claims 5
- 208000011580 syndromic disease Diseases 0.000 claims 5
- 206010001513 AIDS related complex Diseases 0.000 claims 4
- 208000008035 Back Pain Diseases 0.000 claims 4
- 208000036142 Viral infection Diseases 0.000 claims 4
- 230000002411 adverse Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 201000006417 multiple sclerosis Diseases 0.000 claims 4
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 3
- 201000001320 Atherosclerosis Diseases 0.000 claims 3
- 208000035143 Bacterial infection Diseases 0.000 claims 3
- 206010006895 Cachexia Diseases 0.000 claims 3
- 206010063094 Cerebral malaria Diseases 0.000 claims 3
- 229940123907 Disease modifying antirheumatic drug Drugs 0.000 claims 3
- 208000001640 Fibromyalgia Diseases 0.000 claims 3
- 206010020751 Hypersensitivity Diseases 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 208000004550 Postoperative Pain Diseases 0.000 claims 3
- 206010063837 Reperfusion injury Diseases 0.000 claims 3
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 3
- 208000006011 Stroke Diseases 0.000 claims 3
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 3
- 230000008484 agonism Effects 0.000 claims 3
- 230000001363 autoimmune Effects 0.000 claims 3
- 208000022362 bacterial infectious disease Diseases 0.000 claims 3
- 206010006451 bronchitis Diseases 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 230000002757 inflammatory effect Effects 0.000 claims 3
- 208000014674 injury Diseases 0.000 claims 3
- 208000028867 ischemia Diseases 0.000 claims 3
- 210000004072 lung Anatomy 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- -1 6-amino-2- (2,5-difluorophenoxy) -9H-purin-9-yl Chemical group 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 2
- 101150051188 Adora2a gene Proteins 0.000 claims 2
- 206010002383 Angina Pectoris Diseases 0.000 claims 2
- 206010003210 Arteriosclerosis Diseases 0.000 claims 2
- 206010006811 Bursitis Diseases 0.000 claims 2
- 206010058019 Cancer Pain Diseases 0.000 claims 2
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 2
- 201000009273 Endometriosis Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 208000032456 Hemorrhagic Shock Diseases 0.000 claims 2
- 208000007514 Herpes zoster Diseases 0.000 claims 2
- 206010022562 Intermittent claudication Diseases 0.000 claims 2
- 208000008930 Low Back Pain Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010027202 Meningitis bacterial Diseases 0.000 claims 2
- 208000007101 Muscle Cramp Diseases 0.000 claims 2
- 208000000112 Myalgia Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 208000000450 Pelvic Pain Diseases 0.000 claims 2
- 206010035664 Pneumonia Diseases 0.000 claims 2
- 206010036105 Polyneuropathy Diseases 0.000 claims 2
- 206010037660 Pyrexia Diseases 0.000 claims 2
- 206010039203 Road traffic accident Diseases 0.000 claims 2
- 206010040070 Septic Shock Diseases 0.000 claims 2
- 206010049771 Shock haemorrhagic Diseases 0.000 claims 2
- 201000002661 Spondylitis Diseases 0.000 claims 2
- 208000000491 Tendinopathy Diseases 0.000 claims 2
- 206010043255 Tendonitis Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 206010047163 Vasospasm Diseases 0.000 claims 2
- 208000026816 acute arthritis Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 206010069351 acute lung injury Diseases 0.000 claims 2
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 230000007815 allergy Effects 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 208000019664 bone resorption disease Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 208000023819 chronic asthma Diseases 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 230000002526 effect on cardiovascular system Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 210000000936 intestine Anatomy 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 230000000302 ischemic effect Effects 0.000 claims 2
- 208000011379 keloid formation Diseases 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 206010028417 myasthenia gravis Diseases 0.000 claims 2
- 208000008423 pleurisy Diseases 0.000 claims 2
- 230000007824 polyneuropathy Effects 0.000 claims 2
- 230000002685 pulmonary effect Effects 0.000 claims 2
- 208000002815 pulmonary hypertension Diseases 0.000 claims 2
- 230000008695 pulmonary vasoconstriction Effects 0.000 claims 2
- 230000010410 reperfusion Effects 0.000 claims 2
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 2
- 231100000241 scar Toxicity 0.000 claims 2
- 230000035939 shock Effects 0.000 claims 2
- 201000004415 tendinitis Diseases 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 230000009772 tissue formation Effects 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- 208000019553 vascular disease Diseases 0.000 claims 2
- 230000029663 wound healing Effects 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 206010000087 Abdominal pain upper Diseases 0.000 claims 1
- 102000007471 Adenosine A2A receptor Human genes 0.000 claims 1
- 108010085277 Adenosine A2A receptor Proteins 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims 1
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000006820 Arthralgia Diseases 0.000 claims 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010061666 Autonomic neuropathy Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 206010006482 Bronchospasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 206010008479 Chest Pain Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 206010052337 Diastolic dysfunction Diseases 0.000 claims 1
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
- 206010013971 Dyspnoea exertional Diseases 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 206010014824 Endotoxic shock Diseases 0.000 claims 1
- 208000007530 Essential hypertension Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 206010018691 Granuloma Diseases 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 206010019027 Haemothorax Diseases 0.000 claims 1
- 208000004454 Hyperalgesia Diseases 0.000 claims 1
- 208000035154 Hyperesthesia Diseases 0.000 claims 1
- 206010020802 Hypertensive crisis Diseases 0.000 claims 1
- 208000004575 Infectious Arthritis Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102100020873 Interleukin-2 Human genes 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 206010023125 Jarisch-Herxheimer reaction Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000007914 Labor Pain Diseases 0.000 claims 1
- 201000008197 Laryngitis Diseases 0.000 claims 1
- 208000007177 Left Ventricular Hypertrophy Diseases 0.000 claims 1
- 206010050219 Lumbar radiculopathy Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 208000016604 Lyme disease Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010028116 Mucosal inflammation Diseases 0.000 claims 1
- 201000010927 Mucositis Diseases 0.000 claims 1
- 206010049565 Muscle fatigue Diseases 0.000 claims 1
- 206010028735 Nasal congestion Diseases 0.000 claims 1
- 206010028836 Neck pain Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010029888 Obliterative bronchiolitis Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 206010033647 Pancreatitis acute Diseases 0.000 claims 1
- 206010061339 Perineal pain Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 201000007100 Pharyngitis Diseases 0.000 claims 1
- 208000002151 Pleural effusion Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 201000001068 Prinzmetal angina Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000010378 Pulmonary Embolism Diseases 0.000 claims 1
- 206010037423 Pulmonary oedema Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 241000270295 Serpentes Species 0.000 claims 1
- 201000010001 Silicosis Diseases 0.000 claims 1
- 208000007718 Stable Angina Diseases 0.000 claims 1
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 claims 1
- 206010071436 Systolic dysfunction Diseases 0.000 claims 1
- 208000028911 Temporomandibular Joint disease Diseases 0.000 claims 1
- 206010043220 Temporomandibular joint syndrome Diseases 0.000 claims 1
- 208000001435 Thromboembolism Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 206010044248 Toxic shock syndrome Diseases 0.000 claims 1
- 231100000650 Toxic shock syndrome Toxicity 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 208000009325 Variant Angina Pectoris Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- BFBWSTUFQBVHMI-IOSLPCCCSA-N [(3ar,4r,6r,6ar)-4-(6-amino-2-methoxypurin-9-yl)-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methanol Chemical compound C12=NC(OC)=NC(N)=C2N=CN1[C@H]1[C@@H]2OCO[C@@H]2[C@@H](CO)O1 BFBWSTUFQBVHMI-IOSLPCCCSA-N 0.000 claims 1
- GINVFPGFWPIOPX-JJNLEZRASA-N [(3ar,4r,6r,6ar)-4-[6-amino-2-(2,2-difluoroethoxy)purin-9-yl]-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methanol Chemical compound NC1=NC(OCC(F)F)=NC2=C1N=CN2[C@H]1[C@@H]2OCO[C@@H]2[C@@H](CO)O1 GINVFPGFWPIOPX-JJNLEZRASA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 208000024716 acute asthma Diseases 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 201000003229 acute pancreatitis Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 1
- 229960003942 amphotericin b Drugs 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 206010003230 arteritis Diseases 0.000 claims 1
- 230000002917 arthritic effect Effects 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 201000009904 bacterial meningitis Diseases 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 201000009267 bronchiectasis Diseases 0.000 claims 1
- 201000003848 bronchiolitis obliterans Diseases 0.000 claims 1
- 208000023367 bronchiolitis obliterans with obstructive pulmonary disease Diseases 0.000 claims 1
- 230000007885 bronchoconstriction Effects 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000035606 childbirth Effects 0.000 claims 1
- 208000007451 chronic bronchitis Diseases 0.000 claims 1
- 235000019504 cigarettes Nutrition 0.000 claims 1
- 208000024980 claudication Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000010247 contact dermatitis Diseases 0.000 claims 1
- 238000011109 contamination Methods 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 235000013365 dairy product Nutrition 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010014599 encephalitis Diseases 0.000 claims 1
- 230000002327 eosinophilic effect Effects 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 230000002008 hemorrhagic effect Effects 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 230000009610 hypersensitivity Effects 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000002085 irritant Substances 0.000 claims 1
- 231100000021 irritant Toxicity 0.000 claims 1
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 230000036210 malignancy Effects 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000009826 neoplastic cell growth Effects 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000008816 organ damage Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- 208000008494 pericarditis Diseases 0.000 claims 1
- 208000030613 peripheral artery disease Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 206010035653 pneumoconiosis Diseases 0.000 claims 1
- 201000003144 pneumothorax Diseases 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 208000005333 pulmonary edema Diseases 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 201000001223 septic arthritis Diseases 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 208000005198 spinal stenosis Diseases 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000000451 tissue damage Effects 0.000 claims 1
- 231100000827 tissue damage Toxicity 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 1
- 239000002753 trypsin inhibitor Substances 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 208000001319 vasomotor rhinitis Diseases 0.000 claims 1
- 210000003462 vein Anatomy 0.000 claims 1
- 239000002435 venom Substances 0.000 claims 1
- 210000001048 venom Anatomy 0.000 claims 1
- 231100000611 venom Toxicity 0.000 claims 1
- 201000005539 vernal conjunctivitis Diseases 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 abstract 3
- 239000000651 prodrug Substances 0.000 abstract 3
- 239000003435 antirheumatic agent Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
- 150000003838 adenosines Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 229940126701 oral medication Drugs 0.000 abstract 1
- 239000003379 purinergic P1 receptor agonist Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0601396 | 2006-06-27 | ||
| SE0601396 | 2006-06-27 | ||
| US837308P | 2006-08-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2361886T3 true ES2361886T3 (es) | 2011-06-24 |
Family
ID=38545430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07765638T Active ES2361886T3 (es) | 2006-06-27 | 2007-06-26 | Profármacos adenosina acetil 2',3'-metilideno novedosos para uso como profármacos para agonistas del receptor adenosina. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7906518B2 (enExample) |
| EP (1) | EP2066685B1 (enExample) |
| JP (1) | JP2009541436A (enExample) |
| CN (1) | CN101479290A (enExample) |
| AT (1) | ATE500263T1 (enExample) |
| AU (1) | AU2007263726A1 (enExample) |
| BR (1) | BRPI0713901A2 (enExample) |
| CA (1) | CA2657973A1 (enExample) |
| DE (1) | DE602007012904D1 (enExample) |
| ES (1) | ES2361886T3 (enExample) |
| RU (1) | RU2009102512A (enExample) |
| WO (1) | WO2008000743A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102014959B (zh) * | 2008-03-10 | 2016-01-20 | 康奈尔大学 | 血脑屏障通透性的调节 |
| WO2010080540A1 (en) * | 2008-12-18 | 2010-07-15 | Inspire Pharmaceuticals, Inc. | Method for treating inflammatory conditions |
| RU2478392C2 (ru) * | 2011-05-20 | 2013-04-10 | Евгений Петрович Измайлов | Способ консервативного и физиотерапевтического лечения серозно-геморрагического плеврита |
| RU2478391C2 (ru) * | 2011-05-20 | 2013-04-10 | Евгений Петрович Измайлов | Способ физиотерапевтического и консервативного лечения плеврита |
| US9822141B2 (en) | 2012-08-01 | 2017-11-21 | Lewis And Clark Pharmaceuticals, Inc. | N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists |
| EP2879683B1 (en) * | 2012-08-01 | 2020-01-22 | Lewis and Clark Pharmaceuticals, Inc. | N-alkyl-alkynyladenosine-5-uronamide compounds as agonists of a2a receptor |
| US11541071B1 (en) * | 2021-12-16 | 2023-01-03 | Ascletis BioScience Co., Ltd | Nucleoside derivatives and methods of use thereof |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968914A (en) | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
| US5691188A (en) * | 1994-02-14 | 1997-11-25 | American Cyanamid Company | Transformed yeast cells expressing heterologous G-protein coupled receptor |
| US6498149B1 (en) | 1997-06-03 | 2002-12-24 | Tsuneatsu Mori | Natural antitumor or antiviral substances and use of the same |
| US6117878A (en) * | 1998-02-24 | 2000-09-12 | University Of Virginia | 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors |
| US6958324B2 (en) * | 1998-12-02 | 2005-10-25 | Inotek Pharmaceuticals Corporation | Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease |
| US6214807B1 (en) * | 1999-06-22 | 2001-04-10 | Cv Therapeutics, Inc. | C-pyrazole 2A A receptor agonists |
| AU2001238342A1 (en) * | 2000-02-17 | 2001-08-27 | Cv Therapeutics, Inc. | Method for identifying and using A2B adenosine receptor antagonists to mediate mammalian cell proliferation |
| US6995148B2 (en) * | 2001-04-05 | 2006-02-07 | University Of Pittsburgh | Adenosine cyclic ketals: novel adenosine analogues for pharmacotherapy |
| US6713638B2 (en) * | 2001-05-18 | 2004-03-30 | Joel M. Linden | 2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors |
| GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| GB0228723D0 (en) | 2002-12-09 | 2003-01-15 | Cambridge Biotechnology Ltd | Treatment of pain |
| GB0305150D0 (en) | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Use of therapeutic compounds |
| GB0305149D0 (en) | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Compounds for the treatment of pain |
| JP2007506804A (ja) * | 2003-06-09 | 2007-03-22 | エンダセア， インコーポレイテッド | Ａ１アデノシンレセプターアンタゴニスト |
| DE602004017005D1 (de) * | 2003-07-22 | 2008-11-20 | Cv Therapeutics Inc | A1 adenosin-rezeptor-antagonisten |
| BRPI0412577A (pt) * | 2003-07-31 | 2006-09-19 | Sanofi Aventis | derivados de aminoquinolina e seu uso como ligantes de adenosina a3 |
| US7504497B2 (en) * | 2003-10-21 | 2009-03-17 | Inspire Pharmaceuticals, Inc. | Orally bioavailable compounds and methods for inhibiting platelet aggregation |
| EP1685135B1 (en) * | 2003-10-21 | 2010-05-26 | Inspire Pharmaceuticals, Inc. | TETRAHYDRO-FURO[3,4-d]DIOXOLE COMPOUNDS AND COMPOSITIONS AND METHOD FOR INHIBITING PLATELET AGGREGATION |
| JP2007509180A (ja) * | 2003-10-21 | 2007-04-12 | インスパイアー ファーマシューティカルズ，インコーポレイティド | 疼痛を治療するための、非ヌクレオチド組成物および方法 |
| MXPA06010075A (es) * | 2004-03-05 | 2007-04-10 | Cambridge Biotechnology Ltd | Compuestos terapeuticos. |
| AU2005231440B9 (en) * | 2004-04-02 | 2012-02-23 | Dogwood Pharmaceuticals, Inc. | Selective antagonists of A2A adenosine receptors |
| JP2007536241A (ja) * | 2004-05-03 | 2007-12-13 | ユニバーシティ オブ バージニア パテント ファウンデーション | 糖尿病性腎症の処置のためのａ２ａアデノシンレセプターアゴニスト |
| JP2008508319A (ja) * | 2004-07-29 | 2008-03-21 | メタバシス・セラピューティクス・インコーポレイテッド | 新規ヌクレオシド誘導体 |
| WO2006031505A1 (en) * | 2004-09-09 | 2006-03-23 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Purine derivatives as a3 and a1 adenosine receptor agonists |
| US8461128B2 (en) * | 2005-04-15 | 2013-06-11 | Sloan-Kettering Institute For Cancer Research | Anti-microbial agents and uses thereof |
| US7514417B2 (en) * | 2005-05-19 | 2009-04-07 | Cv Therapeutics, Inc. | A1 adenosine receptor agonists |
| GB0514809D0 (en) * | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| KR101383228B1 (ko) * | 2006-01-26 | 2014-04-09 | 더 가번먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 레프리젠티드 바이 더 세크러터리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비스즈 | Ａ3 아데노신 수용체 알로스테릭 조절제 |
| WO2007092936A2 (en) * | 2006-02-08 | 2007-08-16 | University Of Virginia Patent Foundation | Method to treat gastric lesions |
| EP1989210A2 (en) * | 2006-03-02 | 2008-11-12 | Cv Therapeutics, Inc. | A2a adenosine receptor antagonists |
| JP5250848B2 (ja) * | 2006-03-17 | 2013-07-31 | ギリアード サイエンシーズ， インコーポレイテッド | Ａ２ｂアデノシン受容体拮抗物質を用いる肝疾患の予防および処置の方法 |
| US20070299089A1 (en) * | 2006-06-22 | 2007-12-27 | Cv Therapeutics, Inc. | Use of A2A Adenosine Receptor Agonists in the Treatment of Ischemia |
| EP1903044A1 (en) * | 2006-09-14 | 2008-03-26 | Novartis AG | Adenosine Derivatives as A2A Receptor Agonists |
| US7723343B2 (en) * | 2007-03-30 | 2010-05-25 | King Pharmaceuticals Research And Development, Inc. | Adenosine A2A receptor antagonists |
| WO2008124150A1 (en) * | 2007-04-09 | 2008-10-16 | University Of Virginia Patent Foundation | Method of treating enteritis, intestinal damage, and diarrhea from c. difficile with an a2a adenosine receptor agonist |
| US20080262001A1 (en) * | 2007-04-23 | 2008-10-23 | Adenosine Therapeutics, Llc | Agonists of a2a adenosine receptors for treating recurrent tumor growth in the liver following resection |
| US8153781B2 (en) * | 2007-06-29 | 2012-04-10 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Dendrimer conjugates of agonists and antagonists of the GPCR superfamily |
| EP2200615A1 (en) * | 2007-10-16 | 2010-06-30 | Gilead Palo Alto, Inc. | A3 adenosine receptor antagonists |
| WO2009061516A1 (en) * | 2007-11-08 | 2009-05-14 | New York University School Of Medicine | Medical implants containing adenosine receptor agonists and methods for inhibiting medical implant loosening |
| JP2011509305A (ja) * | 2008-01-09 | 2011-03-24 | ピージーエックスヘルス、リミテッド、ライアビリティー、カンパニー | Ａ２ａｒアゴニストによる神経障害性疼痛の髄腔内治療 |
| JP2011511802A (ja) * | 2008-02-07 | 2011-04-14 | ギリアード・パロ・アルト・インコーポレイテッド | Ａｂｃａ−１を上昇させる化合物およびかかる化合物の使用方法 |
-
2007
- 2007-06-26 WO PCT/EP2007/056375 patent/WO2008000743A2/en not_active Ceased
- 2007-06-26 CN CNA2007800246476A patent/CN101479290A/zh active Pending
- 2007-06-26 EP EP07765638A patent/EP2066685B1/en active Active
- 2007-06-26 BR BRPI0713901-2A patent/BRPI0713901A2/pt not_active IP Right Cessation
- 2007-06-26 US US11/823,335 patent/US7906518B2/en not_active Expired - Fee Related
- 2007-06-26 JP JP2009517173A patent/JP2009541436A/ja active Pending
- 2007-06-26 ES ES07765638T patent/ES2361886T3/es active Active
- 2007-06-26 DE DE602007012904T patent/DE602007012904D1/de active Active
- 2007-06-26 RU RU2009102512/04A patent/RU2009102512A/ru not_active Application Discontinuation
- 2007-06-26 AU AU2007263726A patent/AU2007263726A1/en not_active Abandoned
- 2007-06-26 CA CA002657973A patent/CA2657973A1/en not_active Abandoned
- 2007-06-26 AT AT07765638T patent/ATE500263T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2657973A1 (en) | 2008-01-03 |
| WO2008000743A2 (en) | 2008-01-03 |
| RU2009102512A (ru) | 2010-08-10 |
| EP2066685B1 (en) | 2011-03-02 |
| ATE500263T1 (de) | 2011-03-15 |
| WO2008000743A3 (en) | 2008-02-21 |
| AU2007263726A1 (en) | 2008-01-03 |
| US7906518B2 (en) | 2011-03-15 |
| EP2066685A2 (en) | 2009-06-10 |
| US20080027081A1 (en) | 2008-01-31 |
| JP2009541436A (ja) | 2009-11-26 |
| DE602007012904D1 (de) | 2011-04-14 |
| CN101479290A (zh) | 2009-07-08 |
| BRPI0713901A2 (pt) | 2013-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2361886T3 (es) | Profármacos adenosina acetil 2',3'-metilideno novedosos para uso como profármacos para agonistas del receptor adenosina. | |
| ES2732482T3 (es) | Compuestos de carbamoilpiridona policíclica y su utilización farmacéutica | |
| ES2390803T3 (es) | Inhibidores de las enzimas activadoras E1 | |
| ES2199365T3 (es) | Compuestos con propiedades antihipertensivas, cardioprotectoras, anti-isquemicas y antilipoliticas. | |
| ES2805835T3 (es) | Compuestos policíclicos como inhibidores de quinasa de tirosina de Bruton | |
| JP2007526291A (ja) | アデノシン受容体アゴニスト | |
| WO2010057101A2 (en) | Compounds useful as hiv blockers | |
| WO2020151636A1 (zh) | Pde9抑制剂及其用途 | |
| EP2081946B1 (en) | Adenosine derivatives for the treatment of pain | |
| Kiesman et al. | Norbornyllactone-substituted xanthines as adenosine A1 receptor antagonists | |
| US7820811B2 (en) | Pro-drugs of adenosine receptor agonists | |
| ES2358351T3 (es) | Agonistas del receptor de adenosina a1. | |
| HK1129117A (en) | Novel 2',3'-methylidene acetyl adenosine prodrugs for use as prodrugs for adenosine receptor agonists novel 2',3'-methylidene acetyl adenosine prodrugs for use as prodrugs for adenosine receptor agonists | |
| US7691825B2 (en) | Adenosine A2B receptor agonists | |
| HK1129109A (en) | 2-0'-methyladenosine derivatives and their use as agonists or antagonists of an adenosine receptor | |
| JP6115897B2 (ja) | 抗ｂ型肝炎ウイルス薬 | |
| JP2012102114A (ja) | アデノシン受容体アゴニスト | |
| NZ742484B2 (en) | Polycyclic compounds as inhibitors of bruton's tyrosine kinase | |
| CN105968113A (zh) | 一种新型三唑并嘧啶衍生物及其应用 | |
| HK1172628A1 (zh) | 2'-氟-6'-亞甲基碳環核苷和治療病毒感染的方法 |