ES2354452T3 - Reorganizaciones y mutaciones mitocondriales como herramientas de diganóstico para la detección de exposición solar, cáncer de próstata y otros cánceres. - Google Patents

Reorganizaciones y mutaciones mitocondriales como herramientas de diganóstico para la detección de exposición solar, cáncer de próstata y otros cánceres. Download PDF

Info

Publication number
ES2354452T3
ES2354452T3 ES06741413T ES06741413T ES2354452T3 ES 2354452 T3 ES2354452 T3 ES 2354452T3 ES 06741413 T ES06741413 T ES 06741413T ES 06741413 T ES06741413 T ES 06741413T ES 2354452 T3 ES2354452 T3 ES 2354452T3
Authority
ES
Spain
Prior art keywords
deletion
mtdna
mutations
prostate
pcr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06741413T
Other languages
English (en)
Spanish (es)
Inventor
Robert Thayer
Ryan Parr
Gabriel Dakubo
Jennifer Maki
Andrea Aguirre
Mark Birch-Machin
Brian Reguly
Kerry Robinson
Andrew Harbottle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitomics Inc
Original Assignee
Mitomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitomics Inc filed Critical Mitomics Inc
Application granted granted Critical
Publication of ES2354452T3 publication Critical patent/ES2354452T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18Testing for antimicrobial activity of a material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/24Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
ES06741413T 2005-04-18 2006-04-18 Reorganizaciones y mutaciones mitocondriales como herramientas de diganóstico para la detección de exposición solar, cáncer de próstata y otros cánceres. Active ES2354452T3 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US67201605P 2005-04-18 2005-04-18
US672016P 2005-04-18
US72152205P 2005-09-29 2005-09-29
US721522P 2005-09-29
US78987206P 2006-04-07 2006-04-07
US789872P 2006-04-07
PCT/CA2006/000652 WO2006111029A1 (en) 2005-04-18 2006-04-18 Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers

Publications (1)

Publication Number Publication Date
ES2354452T3 true ES2354452T3 (es) 2011-03-15

Family

ID=37114687

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06741413T Active ES2354452T3 (es) 2005-04-18 2006-04-18 Reorganizaciones y mutaciones mitocondriales como herramientas de diganóstico para la detección de exposición solar, cáncer de próstata y otros cánceres.

Country Status (15)

Country Link
US (4) US8008008B2 (enExample)
EP (2) EP1877559B1 (enExample)
JP (2) JP5537804B2 (enExample)
KR (1) KR101363032B1 (enExample)
CN (2) CN101248180B (enExample)
AT (1) ATE484589T1 (enExample)
AU (1) AU2006238390B2 (enExample)
CA (2) CA2606156C (enExample)
DE (1) DE602006017534D1 (enExample)
DK (1) DK1877559T3 (enExample)
ES (1) ES2354452T3 (enExample)
NZ (2) NZ587665A (enExample)
PT (1) PT1877559E (enExample)
SG (1) SG2014011837A (enExample)
WO (1) WO2006111029A1 (enExample)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1877559T3 (da) * 2005-04-18 2011-02-07 Mitomics Inc Mitochondrial mutationer og omarrangeringer som et diagnostisk værktøj for detektion af soleksponering, prostatacancer og andre cancertyper
US20130022979A1 (en) * 2005-04-18 2013-01-24 Genesis Genomics Inc. 3.4kb MITOCHONDRIAL DNA DELETION FOR USE IN THE DETECTION OF CANCER
CN100526453C (zh) * 2005-05-20 2009-08-12 麦克奥迪实业集团有限公司 激光显微切割后细胞收集方法
JP2008543300A (ja) * 2005-06-16 2008-12-04 バイオツールズ バイオテクノロジカル アンド メディカル ラボラトリーズ, エス. アー. 測定可能なシグナルの直接生成を用いた核酸検出法
US20080254530A1 (en) * 2007-02-27 2008-10-16 Gettysburg College Isolation and characterization of a single mitochondrion
NZ584815A (en) * 2007-09-26 2012-07-27 Mitomics Inc 3.4 kb mitochondrial dna deletion for use in the detection of cancer
CN101896622B (zh) * 2007-10-11 2015-07-22 米托米克斯公司 测定皮肤样本中mc1r变体和线粒体标记物的方法
WO2009046514A1 (en) * 2007-10-11 2009-04-16 Genesis Genomics Inc. Methods for non-invasive collection of skin cells for dna analysis
KR101644661B1 (ko) * 2007-11-09 2016-08-01 미토믹스 인크. 암의 검출에 사용하기 위한 약 12317-16254 잔기의 미토콘드리아 dna 결손
CA2719718C (en) 2008-03-28 2019-07-02 Mitomics, Inc. Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor
KR20110073471A (ko) * 2008-08-28 2011-06-29 아스튜트 메디컬 인코포레이티드 신손상 및 신부전의 진단 및 예후를 위한 방법 및 조성물
WO2010025434A1 (en) * 2008-08-29 2010-03-04 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US8778615B2 (en) 2008-10-21 2014-07-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ619918A (en) * 2008-10-21 2015-04-24 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2010054389A1 (en) 2008-11-10 2010-05-14 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN102272328B (zh) * 2008-11-22 2014-06-18 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
AU2010279249B2 (en) 2009-02-06 2015-08-13 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US9229010B2 (en) 2009-02-06 2016-01-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3272871B1 (en) * 2009-03-27 2020-01-15 MDNA Life Sciences Inc. Aberrant mitochondrial dna, associated fusion transcripts and translation products and hybridization probes therefor
US12129514B2 (en) 2009-04-30 2024-10-29 Molecular Loop Biosolutions, Llc Methods and compositions for evaluating genetic markers
WO2010126614A2 (en) 2009-04-30 2010-11-04 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
NZ599773A (en) 2009-11-07 2014-09-26 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP2011115098A (ja) * 2009-12-04 2011-06-16 Nippon Menaade Keshohin Kk 加齢による皮膚明度の低下を予測する皮膚評価方法
NZ702527A (en) 2009-12-20 2016-07-29 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP2013519095A (ja) 2010-02-05 2013-05-23 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
JP5998057B2 (ja) 2010-02-26 2016-11-30 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断と予後のための方法と組成物
CN104946676A (zh) * 2010-03-01 2015-09-30 米托米克斯公司 Uv相关联的mtrna融合转录体及其方法和用途
AU2011269775B2 (en) 2010-06-23 2015-01-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ605561A (en) 2010-06-23 2015-03-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
PL3246416T3 (pl) 2011-04-15 2024-09-30 The Johns Hopkins University Bezpieczny system sekwencjonowania
US9228233B2 (en) 2011-10-17 2016-01-05 Good Start Genetics, Inc. Analysis methods
EP3540440B1 (en) 2011-12-08 2022-09-28 Astute Medical, Inc. Methods and uses for evaluating renal injury and renal status
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
ES2637538T3 (es) * 2012-07-17 2017-10-13 Counsyl, Inc. Sistema y métodos para la detección de una variación genética
CA2889937C (en) 2012-10-29 2020-12-29 The Johns Hopkins University Papanicolaou test for ovarian and endometrial cancers
US9868946B2 (en) * 2012-11-05 2018-01-16 Icahn School Of Medicine At Mount Sinai Method of isolating pure mitochondrial DNA
ES2482866B1 (es) * 2012-11-22 2015-05-12 Consejo Superior De Investigaciones Científicas (Csic) Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas.
JP6681195B2 (ja) 2013-01-17 2020-04-15 アスチュート メディカル,インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
WO2014152421A1 (en) 2013-03-14 2014-09-25 Good Start Genetics, Inc. Methods for analyzing nucleic acids
US8847799B1 (en) 2013-06-03 2014-09-30 Good Start Genetics, Inc. Methods and systems for storing sequence read data
WO2015057565A1 (en) 2013-10-18 2015-04-23 Good Start Genetics, Inc. Methods for assessing a genomic region of a subject
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
US9745611B2 (en) * 2014-05-06 2017-08-29 Genewiz Inc. Methods and kits for identifying microorganisms in a sample
WO2015175530A1 (en) 2014-05-12 2015-11-19 Gore Athurva Methods for detecting aneuploidy
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
CN104062294A (zh) * 2014-07-11 2014-09-24 青岛千士医疗科技有限公司 一种支气管/肺上皮细胞线粒体损伤的检测方法
US20160048608A1 (en) 2014-08-15 2016-02-18 Good Start Genetics, Inc. Systems and methods for genetic analysis
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
US10429399B2 (en) 2014-09-24 2019-10-01 Good Start Genetics, Inc. Process control for increased robustness of genetic assays
WO2016061562A2 (en) 2014-10-17 2016-04-21 Kodiak Sciences Inc. Butyrylcholinesterase zwitterionic polymer conjugates
EP4095261B1 (en) 2015-01-06 2025-05-28 Molecular Loop Biosciences, Inc. Screening for structural variants
EP3091083B1 (en) 2015-05-07 2017-11-08 Latvian Biomedical Research and Study Centre A kit for detecting mutation or polymorphism in the human mitochondrial dna
KR20170007181A (ko) 2015-07-10 2017-01-18 3스캔 인크. 조직학적 염색제의 공간 다중화
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
EP3465201A4 (en) 2016-06-06 2020-08-26 Astute Medical, Inc. MANAGEMENT OF ACUTE KIDNEY DAMAGE USING INSULINOMIMETIC GROWTH FACTOR BINDING PROTEIN 7 AND TISSUE METALLOPROTEINASE 2 INHIBITOR
WO2019067092A1 (en) 2017-08-07 2019-04-04 The Johns Hopkins University METHODS AND SUBSTANCES FOR THE EVALUATION AND TREATMENT OF CANCER
CN108827887B (zh) * 2018-03-19 2021-05-18 陕西学前师范学院 一种商陆基因组大小估计方法及基因组大小测量系统
EP3578671A1 (en) * 2018-06-05 2019-12-11 Universitat Autònoma De Barcelona Method for evaluating risk of cardiovascular disease
CN109360656B (zh) * 2018-08-20 2021-11-02 安徽大学 一种基于多目标演化算法的癌症检测方法
WO2020227255A1 (en) * 2019-05-06 2020-11-12 The Regents Of The University Of Michigan Targeted therapy
CN110378881B (zh) * 2019-07-05 2020-03-24 北京航空航天大学 一种基于深度学习的肿瘤定位系统
CN110358856B (zh) * 2019-07-23 2023-04-07 四川省农业科学院生物技术核技术研究所 侧耳属线粒体nad4L基因的扩增引物及其在鉴定侧耳属物种中的应用
CN113025633B (zh) * 2019-12-09 2024-08-27 武汉纽福斯生物科技有限公司 编码人nadh脱氢酶亚单位1蛋白的核酸及其应用
US20220073977A1 (en) 2020-02-14 2022-03-10 The Johns Hopkins University Methods and materials for assessing nucleic acids
WO2021248034A2 (en) * 2020-06-04 2021-12-09 The General Hospital Corporation Methods of detecting mitochondrial diseases
CN117070511B (zh) * 2023-08-16 2024-02-02 广州卿泽生物科技有限公司 一种用于扩增人类线粒体全基因组的引物组及其应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2356536A (en) * 1939-07-18 1944-08-22 Rzymkowski Johannes Developing process
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US6027883A (en) 1994-03-30 2000-02-22 Mitokor Optimal procedure for isolation of mutant mitochondrial alleles
US5565323A (en) 1994-03-30 1996-10-15 Mitokor Cytochrome oxidase mutations aiding diagnosis of sporadic alzheimer's disease
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
JPH1099085A (ja) 1996-05-16 1998-04-21 Affymetrix Inc ヒトミトコンドリアdnaの多形性
JP3251219B2 (ja) 1997-10-13 2002-01-28 雅嗣 田中 ヒトミトコンドリアdnaを用いた遺伝子検出方法
JP2002523061A (ja) 1998-08-20 2002-07-30 ザ ジョンズ ホプキンス ユニバーシティ 腫瘍マーカーとしての微細なミトコンドリア突然変異
US6605433B1 (en) 1998-08-20 2003-08-12 The Johns Hopkins University Mitochondrial dosimeter
US20020068277A1 (en) * 1998-11-20 2002-06-06 Simpson Andrew John George Method for determining nucleotide sequences using arbitrary primers and low stringency
EP1208225A2 (en) 1999-04-20 2002-05-29 Mitokor Single nucleotide polymorphisms in mitochondrial genes that segregate with alzheimer's disease
SE0003286D0 (sv) 2000-09-15 2000-09-15 Ulf Gyllensten Method and kit for human identification
US20030092019A1 (en) 2001-01-09 2003-05-15 Millennium Pharmaceuticals, Inc. Methods and compositions for diagnosing and treating neuropsychiatric disorders such as schizophrenia
WO2002101086A2 (en) * 2001-06-11 2002-12-19 1304854 Ontario Ltd. Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
US20030162174A1 (en) 2001-06-11 2003-08-28 Sutherland John W. Detecting nucleic acid deletion sequences
US20050026167A1 (en) * 2001-06-11 2005-02-03 Mark Birch-Machin Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
US20040191769A1 (en) * 2001-07-24 2004-09-30 Transgenomic, Inc. Methods, compositions, and kits for mutation detection in mitochondrial DNA
CA2356536A1 (en) * 2001-08-30 2003-02-28 Emory University Mitochondrial dna sequence alleles
SE0200817D0 (sv) * 2002-03-15 2002-03-15 Ulf Gyllensten Method and kit for detection of mutations in mitochondrial DNA
US20050244851A1 (en) * 2004-01-13 2005-11-03 Affymetrix, Inc. Methods of analysis of alternative splicing in human
DK1877559T3 (da) * 2005-04-18 2011-02-07 Mitomics Inc Mitochondrial mutationer og omarrangeringer som et diagnostisk værktøj for detektion af soleksponering, prostatacancer og andre cancertyper

Also Published As

Publication number Publication date
WO2006111029A1 (en) 2006-10-26
EP2339032A1 (en) 2011-06-29
PT1877559E (pt) 2011-01-19
SG2014011837A (en) 2014-04-28
US20180105885A1 (en) 2018-04-19
US8008008B2 (en) 2011-08-30
EP1877559B1 (en) 2010-10-13
NZ587665A (en) 2011-11-25
DE602006017534D1 (de) 2010-11-25
DK1877559T3 (da) 2011-02-07
ATE484589T1 (de) 2010-10-15
CA2606156A1 (en) 2006-10-26
US20090192047A1 (en) 2009-07-30
KR101363032B1 (ko) 2014-02-13
US10907213B2 (en) 2021-02-02
EP1877559A4 (en) 2009-06-10
CN101248180A (zh) 2008-08-20
JP5537804B2 (ja) 2014-07-02
CN103789405A (zh) 2014-05-14
NZ562928A (en) 2011-01-28
CA2606156C (en) 2013-01-08
CN103789405B (zh) 2018-03-30
EP1877559A1 (en) 2008-01-16
EP2339032B1 (en) 2016-12-28
US9745632B2 (en) 2017-08-29
US20120058483A1 (en) 2012-03-08
CN101248180B (zh) 2013-09-25
KR20080025040A (ko) 2008-03-19
JP2012179053A (ja) 2012-09-20
JP6134890B2 (ja) 2017-05-31
AU2006238390B2 (en) 2011-07-28
CA2792443A1 (en) 2006-10-26
JP2008536496A (ja) 2008-09-11
AU2006238390A1 (en) 2006-10-26
US20150284805A1 (en) 2015-10-08

Similar Documents

Publication Publication Date Title
ES2354452T3 (es) Reorganizaciones y mutaciones mitocondriales como herramientas de diganóstico para la detección de exposición solar, cáncer de próstata y otros cánceres.
US20050026167A1 (en) Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
Shyamsundar et al. Exome sequencing with validations and expression of p16/cdkn2a shows no association with HPV in oral cancers
US20070190534A1 (en) Mitochondrial sites and genes associated with prostate cancer
JP2005506057A (ja) 健康科学のための診断ツールとしての全ミトコンドリアゲノム配列
AU2011242123B2 (en) Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers
EP1694695A1 (en) Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
HK1159190A (en) Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers
HK1159190B (en) Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers
Børsting et al. Mie Rath Refn, Mikkel Meyer Andersen, Marie‑Louise Kampmann, Jacob Tfelt‑Hansen, Erik Sørensen 4, Margit Hørup Larsen 4, Niels Morling
Bernabe et al. Genetic Approaches to Colorectal Cancer
AU2002312671A1 (en) Complete mitochondrial genome sequences as a diagnostic tool for the health sciences